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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8HVR

Cryo-EM structure of AfsR-dependent transcription activation complex with afsS promoter

Functional Information from GO Data
ChainGOidnamespacecontents
A0000428cellular_componentDNA-directed RNA polymerase complex
A0003677molecular_functionDNA binding
A0003899molecular_functionDNA-directed RNA polymerase activity
A0005737cellular_componentcytoplasm
A0006351biological_processDNA-templated transcription
A0009295cellular_componentnucleoid
A0016740molecular_functiontransferase activity
A0016779molecular_functionnucleotidyltransferase activity
A0034062molecular_function5'-3' RNA polymerase activity
A0046983molecular_functionprotein dimerization activity
B0000428cellular_componentDNA-directed RNA polymerase complex
B0003677molecular_functionDNA binding
B0003899molecular_functionDNA-directed RNA polymerase activity
B0005737cellular_componentcytoplasm
B0006351biological_processDNA-templated transcription
B0009295cellular_componentnucleoid
B0016740molecular_functiontransferase activity
B0016779molecular_functionnucleotidyltransferase activity
B0034062molecular_function5'-3' RNA polymerase activity
B0046983molecular_functionprotein dimerization activity
C0000428cellular_componentDNA-directed RNA polymerase complex
C0003677molecular_functionDNA binding
C0003899molecular_functionDNA-directed RNA polymerase activity
C0006351biological_processDNA-templated transcription
C0016740molecular_functiontransferase activity
C0016779molecular_functionnucleotidyltransferase activity
C0032549molecular_functionribonucleoside binding
C0034062molecular_function5'-3' RNA polymerase activity
D0000287molecular_functionmagnesium ion binding
D0000428cellular_componentDNA-directed RNA polymerase complex
D0003677molecular_functionDNA binding
D0003899molecular_functionDNA-directed RNA polymerase activity
D0006351biological_processDNA-templated transcription
D0008270molecular_functionzinc ion binding
D0016740molecular_functiontransferase activity
D0016779molecular_functionnucleotidyltransferase activity
D0034062molecular_function5'-3' RNA polymerase activity
D0046872molecular_functionmetal ion binding
E0000345cellular_componentcytosolic DNA-directed RNA polymerase complex
E0000428cellular_componentDNA-directed RNA polymerase complex
E0001000molecular_functionbacterial-type RNA polymerase core enzyme binding
E0003677molecular_functionDNA binding
E0003899molecular_functionDNA-directed RNA polymerase activity
E0006351biological_processDNA-templated transcription
E0006352biological_processDNA-templated transcription initiation
E0016740molecular_functiontransferase activity
E0016779molecular_functionnucleotidyltransferase activity
E0034062molecular_function5'-3' RNA polymerase activity
F0000976molecular_functiontranscription cis-regulatory region binding
F0001108molecular_functionbacterial-type RNA polymerase holo enzyme binding
F0003677molecular_functionDNA binding
F0003700molecular_functionDNA-binding transcription factor activity
F0003899molecular_functionDNA-directed RNA polymerase activity
F0005515molecular_functionprotein binding
F0005737cellular_componentcytoplasm
F0006352biological_processDNA-templated transcription initiation
F0006355biological_processregulation of DNA-templated transcription
F0010468biological_processregulation of gene expression
F0016987molecular_functionsigma factor activity
F1903865cellular_componentsigma factor antagonist complex
F2000142biological_processregulation of DNA-templated transcription initiation
G0001000molecular_functionbacterial-type RNA polymerase core enzyme binding
G0001108molecular_functionbacterial-type RNA polymerase holo enzyme binding
G0005515molecular_functionprotein binding
G0008270molecular_functionzinc ion binding
G0045893biological_processpositive regulation of DNA-templated transcription
G0046677biological_processresponse to antibiotic
G0046872molecular_functionmetal ion binding
H0009303biological_processrRNA transcription
I0000160biological_processphosphorelay signal transduction system
I0003677molecular_functionDNA binding
I0006355biological_processregulation of DNA-templated transcription
J0000160biological_processphosphorelay signal transduction system
J0003677molecular_functionDNA binding
J0006355biological_processregulation of DNA-templated transcription
K0000428cellular_componentDNA-directed RNA polymerase complex
K0003677molecular_functionDNA binding
K0003899molecular_functionDNA-directed RNA polymerase activity
K0005737cellular_componentcytoplasm
K0006351biological_processDNA-templated transcription
K0009295cellular_componentnucleoid
K0016740molecular_functiontransferase activity
K0016779molecular_functionnucleotidyltransferase activity
K0034062molecular_function5'-3' RNA polymerase activity
K0046983molecular_functionprotein dimerization activity
Functional Information from PROSITE/UniProt
site_idPS00715
Number of Residues14
DetailsSIGMA70_1 Sigma-70 factors family signature 1. DLIQeGnLGLIrAV
ChainResidueDetails
FASP302-VAL315
site_idPS00716
Number of Residues27
DetailsSIGMA70_2 Sigma-70 factors family signature 2. TldEIGkvygVTrerIrQIEsktMskL
ChainResidueDetails
FTHR471-LEU497
site_idPS00867
Number of Residues8
DetailsCPSASE_2 Carbamoyl-phosphate synthase subdomain signature 2. LLEANLRL
ChainResidueDetails
FLEU278-LEU285
site_idPS01166
Number of Residues13
DetailsRNA_POL_BETA RNA polymerases beta chain signature. GdKLAGrHGNKGV
ChainResidueDetails
CGLY868-VAL880
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues225
DetailsRegion: {"description":"Alpha N-terminal domain (alpha-NTD)","evidences":[{"source":"HAMAP-Rule","id":"MF_00059","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues20
DetailsRegion: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues11
DetailsBinding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01322","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues19
DetailsDNA binding: {"description":"H-T-H motif","evidences":[{"source":"HAMAP-Rule","id":"MF_00963","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues136
DetailsRegion: {"description":"Binds RNA polymerase-binding protein RbpA"}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues70
DetailsRegion: {"description":"Sigma-70 factor domain-2","evidences":[{"source":"HAMAP-Rule","id":"MF_00963","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues76
DetailsRegion: {"description":"Sigma-70 factor domain-3","evidences":[{"source":"HAMAP-Rule","id":"MF_00963","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues53
DetailsRegion: {"description":"Sigma-70 factor domain-4","evidences":[{"source":"HAMAP-Rule","id":"MF_00963","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues3
DetailsMotif: {"description":"Interaction with polymerase core subunit RpoC"}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues3
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01483","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues192
DetailsDNA binding: {"description":"OmpR/PhoB-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU01091","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

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PDB entries from 2025-07-09

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