8H75
FGFR2 in complex with YJ001
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004713 | molecular_function | protein tyrosine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004713 | molecular_function | protein tyrosine kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006468 | biological_process | protein phosphorylation |
| C | 0004672 | molecular_function | protein kinase activity |
| C | 0004713 | molecular_function | protein tyrosine kinase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0006468 | biological_process | protein phosphorylation |
| D | 0004672 | molecular_function | protein kinase activity |
| D | 0004713 | molecular_function | protein tyrosine kinase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0006468 | biological_process | protein phosphorylation |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 31 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGCFGQVVmAeavgidkdkpkeavt...VAVK |
| Chain | Residue | Details |
| A | LEU487-LYS517 |
| site_id | PS00109 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. CIHrDLAARNVLV |
| Chain | Residue | Details |
| A | CYS622-VAL634 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 80 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| A | GLY490-GLU510 | |
| B | GLY490-GLU510 | |
| C | GLY490-GLU510 | |
| D | GLY490-GLU510 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028, ECO:0000269|PubMed:19060208 |
| Chain | Residue | Details |
| A | ASP738 | |
| B | ASP738 | |
| C | ASP738 | |
| D | ASP738 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:19060208 |
| Chain | Residue | Details |
| A | THR599 | |
| C | ALA629 | |
| C | ASP677 | |
| C | GLN683 | |
| D | THR599 | |
| D | ALA629 | |
| D | ASP677 | |
| D | GLN683 | |
| A | ALA629 | |
| A | ASP677 | |
| A | GLN683 | |
| B | THR599 | |
| B | ALA629 | |
| B | ASP677 | |
| B | GLN683 | |
| C | THR599 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:19060208, ECO:0000269|PubMed:19410646 |
| Chain | Residue | Details |
| A | ALA578 | |
| A | GLY700 | |
| B | ALA578 | |
| B | GLY700 | |
| C | ALA578 | |
| C | GLY700 | |
| D | ALA578 | |
| D | GLY700 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:17803937, ECO:0000269|PubMed:19060208, ECO:0000269|PubMed:19410646 |
| Chain | Residue | Details |
| A | THR698 | |
| A | GLU768 | |
| B | THR698 | |
| B | GLU768 | |
| C | THR698 | |
| C | GLU768 | |
| D | THR698 | |
| D | GLU768 |
