8H6L
Cryo-EM structure of human exon-defined spliceosome in the early B state.
This is a non-PDB format compatible entry.
Functional Information from PROSITE/UniProt
| site_id | PS01082 |
| Number of Residues | 18 |
| Details | RIBOSOMAL_L7AE Ribosomal protein L7Ae signature. CedknVPYvfVrSKqaLG |
| Chain | Residue | Details |
| 4E | CYS73-GLY90 |
| site_id | PS00170 |
| Number of Residues | 18 |
| Details | CSA_PPIASE_1 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. YkgStFHRVIkdFMiQGG |
| Chain | Residue | Details |
| 4H | TYR60-GLY77 |
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. FVCSATH |
| Chain | Residue | Details |
| 2I | PHE287-HIS293 |
| site_id | PS01159 |
| Number of Residues | 26 |
| Details | WW_DOMAIN_1 WW/rsp5/WWP domain signature. WvegitsegyhyYYdlisga.SQWEKP |
| Chain | Residue | Details |
| 4I | TRP128-PRO153 | |
| 4I | TRP169-PRO194 |
| site_id | PS00436 |
| Number of Residues | 12 |
| Details | PEROXIDASE_2 Peroxidases active site signature. TVrvARVmWHPS |
| Chain | Residue | Details |
| 4C | THR323-SER334 |
| site_id | PS00678 |
| Number of Residues | 15 |
| Details | WD_REPEATS_1 Trp-Asp (WD) repeats signature. LGTTcyDrSWRLWDL |
| Chain | Residue | Details |
| 5E | LEU124-SER138 | |
| 5E | ILE208-LEU222 | |
| 4Z | LEU229-PHE243 | |
| 4Z | ILE364-MET378 | |
| 4C | LEU338-LEU352 | |
| 4C | ILE422-LEU436 | |
| 5E | LEU81-VAL95 | |
| 5E | VAL167-ILE181 | |
| 5E | ILE300-THR314 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | SITE: Interaction with RNA => ECO:0000269|PubMed:27720643 |
| Chain | Residue | Details |
| 2M | TYR5 | |
| 2L | CYS49 | |
| 2L | CYS58 | |
| 2L | CYS61 | |
| 2L | CYS72 | |
| 2L | CYS75 | |
| 2L | CYS85 | |
| 2M | GLY20 | |
| 2L | CYS26 | |
| 2L | CYS30 | |
| 2L | CYS33 | |
| 2L | CYS46 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylthreonine => ECO:0007744|PubMed:19413330 |
| Chain | Residue | Details |
| 2M | THR2 | |
| 4J | SER789 | |
| 2I | LYS1171 | |
| 4J | SER761 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17525332 |
| Chain | Residue | Details |
| 2M | SER9 | |
| 2G | CYS677 | |
| 2G | GLU1205 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| 2M | LYS17 | |
| 4c | LYS8 | |
| 2c | LYS6 | |
| 2c | LYS8 | |
| 2G | THR235 | |
| 2G | THR426 | |
| 4B | LYS252 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| 2F | SER369 | |
| 2L | LYS3 | |
| 2H | SER309 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| 2G | LYS554 | |
| 2G | LYS562 | |
| 2L | SER94 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| 2H | SER861 | |
| 2H | SER317 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332 |
| Chain | Residue | Details |
| 2H | SER360 | |
| 2H | SER362 | |
| 4J | SER598 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18318008, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| 2H | SER435 | |
| 2H | SER436 | |
| 2H | SER431 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | MOD_RES: Symmetric dimethylarginine; by PRMT9; alternate => ECO:0000269|PubMed:25737013 |
| Chain | Residue | Details |
| 2D | LYS131 | |
| 2D | LYS424 | |
| 2D | LYS499 | |
| 2H | ARG508 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| 2H | THR780 | |
| 4D | LYS478 | |
| 2D | LYS686 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 9 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| 2H | LYS280 | |
| 2H | LYS492 | |
| 2H | LYS543 | |
| 2H | LYS770 | |
| 2H | LYS790 | |
| 2H | LYS843 | |
| 2H | LYS857 | |
| 4J | LYS648 | |
| 4J | LYS657 | |
| 4J | LYS684 | |
| 4J | LYS699 | |
| 4J | LYS709 | |
| 4J | LYS723 | |
| 4J | LYS749 | |
| 4J | LYS758 | |
| 4J | LYS775 | |
| 4J | LYS780 | |
| 4J | LYS791 | |
| 2H | LYS10 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:25772364, ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| 2H | LYS400 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| 2H | LYS412 | |
| 4J | LYS188 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| 2G | THR227 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q99NB9 |
| Chain | Residue | Details |
| 2G | SER229 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0000269|PubMed:12105215 |
| Chain | Residue | Details |
| 2G | THR244 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0000305|PubMed:12105215 |
| Chain | Residue | Details |
| 2G | THR248 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 5 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| 2G | THR257 | |
| 2G | THR261 | |
| 2G | THR278 | |
| 2G | THR303 | |
| 2G | THR313 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18220336, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| 2G | THR267 |
| site_id | SWS_FT_FI21 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| 2G | THR273 |
| site_id | SWS_FT_FI22 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| 2G | SER287 |
| site_id | SWS_FT_FI23 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| 2G | THR296 |
| site_id | SWS_FT_FI24 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:17081983 |
| Chain | Residue | Details |
| 2G | THR299 |
| site_id | SWS_FT_FI25 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| 2G | SER322 |
| site_id | SWS_FT_FI26 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| 2G | THR326 |
| site_id | SWS_FT_FI27 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231 |
| Chain | Residue | Details |
| 2G | THR328 |
| site_id | SWS_FT_FI28 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| 2G | SER332 |
| site_id | SWS_FT_FI29 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:21406692 |
| Chain | Residue | Details |
| 2G | THR341 |
| site_id | SWS_FT_FI30 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692 |
| Chain | Residue | Details |
| 2G | SER344 |
| site_id | SWS_FT_FI31 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:21406692 |
| Chain | Residue | Details |
| 2G | SER349 |
| site_id | SWS_FT_FI32 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| 2G | THR350 | |
| 2G | THR436 |
| site_id | SWS_FT_FI33 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| 2G | THR354 |
| site_id | SWS_FT_FI34 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| 2G | SER400 |
| site_id | SWS_FT_FI35 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine; by DYRK1A => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| 2G | THR434 |
| site_id | SWS_FT_FI36 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| 2G | SER488 |
| site_id | SWS_FT_FI37 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| 2G | LYS214 |
| site_id | SWS_FT_FI38 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| 2G | LYS430 |
| site_id | SWS_FT_FI39 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25114211, ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| 2G | LYS413 |
