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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8H3V

Cryo-EM structure of the full transcription activation complex NtcA-NtcB-TAC

Functional Information from GO Data
ChainGOidnamespacecontents
A0000428cellular_componentDNA-directed RNA polymerase complex
A0003677molecular_functionDNA binding
A0003899molecular_functionDNA-directed RNA polymerase activity
A0006351biological_processDNA-templated transcription
A0016740molecular_functiontransferase activity
A0016779molecular_functionnucleotidyltransferase activity
A0032549molecular_functionribonucleoside binding
A0034062molecular_function5'-3' RNA polymerase activity
B0000428cellular_componentDNA-directed RNA polymerase complex
B0003677molecular_functionDNA binding
B0003899molecular_functionDNA-directed RNA polymerase activity
B0006351biological_processDNA-templated transcription
B0008270molecular_functionzinc ion binding
B0016740molecular_functiontransferase activity
B0016779molecular_functionnucleotidyltransferase activity
B0034062molecular_function5'-3' RNA polymerase activity
B0046872molecular_functionmetal ion binding
C0003677molecular_functionDNA binding
C0003899molecular_functionDNA-directed RNA polymerase activity
C0006351biological_processDNA-templated transcription
C0046983molecular_functionprotein dimerization activity
D0003677molecular_functionDNA binding
D0003899molecular_functionDNA-directed RNA polymerase activity
D0006351biological_processDNA-templated transcription
D0046983molecular_functionprotein dimerization activity
E0000287molecular_functionmagnesium ion binding
E0000428cellular_componentDNA-directed RNA polymerase complex
E0003677molecular_functionDNA binding
E0003899molecular_functionDNA-directed RNA polymerase activity
E0006351biological_processDNA-templated transcription
E0008270molecular_functionzinc ion binding
E0016740molecular_functiontransferase activity
E0016779molecular_functionnucleotidyltransferase activity
E0034062molecular_function5'-3' RNA polymerase activity
E0046872molecular_functionmetal ion binding
F0000428cellular_componentDNA-directed RNA polymerase complex
F0003677molecular_functionDNA binding
F0003899molecular_functionDNA-directed RNA polymerase activity
F0006351biological_processDNA-templated transcription
F0016740molecular_functiontransferase activity
F0016779molecular_functionnucleotidyltransferase activity
F0034062molecular_function5'-3' RNA polymerase activity
G0003677molecular_functionDNA binding
G0003700molecular_functionDNA-binding transcription factor activity
G0005737cellular_componentcytoplasm
G0006352biological_processDNA-templated transcription initiation
G0006355biological_processregulation of DNA-templated transcription
G0010468biological_processregulation of gene expression
G0016987molecular_functionsigma factor activity
G2000142biological_processregulation of DNA-templated transcription initiation
S0003677molecular_functionDNA binding
S0003700molecular_functionDNA-binding transcription factor activity
S0005829cellular_componentcytosol
S0006355biological_processregulation of DNA-templated transcription
T0003677molecular_functionDNA binding
T0003700molecular_functionDNA-binding transcription factor activity
T0005829cellular_componentcytosol
T0006355biological_processregulation of DNA-templated transcription
U0003677molecular_functionDNA binding
U0003700molecular_functionDNA-binding transcription factor activity
U0005829cellular_componentcytosol
U0006355biological_processregulation of DNA-templated transcription
V0003677molecular_functionDNA binding
V0003700molecular_functionDNA-binding transcription factor activity
V0005829cellular_componentcytosol
V0006355biological_processregulation of DNA-templated transcription
X0003677molecular_functionDNA binding
X0003700molecular_functionDNA-binding transcription factor activity
X0005829cellular_componentcytosol
X0006355biological_processregulation of DNA-templated transcription
Y0003677molecular_functionDNA binding
Y0003700molecular_functionDNA-binding transcription factor activity
Y0005829cellular_componentcytosol
Y0006355biological_processregulation of DNA-templated transcription
Functional Information from PROSITE/UniProt
site_idPS00042
Number of Residues24
DetailsHTH_CRP_1 Crp-type HTH domain signature. LSHqaIAeAIGsTrvTv.TRlLgdL
ChainResidueDetails
XLEU174-LEU197
site_idPS00715
Number of Residues14
DetailsSIGMA70_1 Sigma-70 factors family signature 1. DLIQeGsLGLIrAA
ChainResidueDetails
GASP182-ALA195
site_idPS00716
Number of Residues27
DetailsSIGMA70_2 Sigma-70 factors family signature 2. TleEIGqifnVTrerIrQIEakaLrkL
ChainResidueDetails
GTHR350-LEU376
site_idPS01166
Number of Residues13
DetailsRNA_POL_BETA RNA polymerases beta chain signature. GdKMAGrHGNKGI
ChainResidueDetails
AGLY849-ILE861
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01324","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues7
DetailsBinding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01323","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues19
DetailsDNA binding: {"description":"H-T-H motif","evidences":[{"source":"HAMAP-Rule","id":"MF_00963","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues70
DetailsRegion: {"description":"Sigma-70 factor domain-2","evidences":[{"source":"HAMAP-Rule","id":"MF_00963","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues75
DetailsRegion: {"description":"Sigma-70 factor domain-3","evidences":[{"source":"HAMAP-Rule","id":"MF_00963","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues53
DetailsRegion: {"description":"Sigma-70 factor domain-4","evidences":[{"source":"HAMAP-Rule","id":"MF_00963","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues3
DetailsMotif: {"description":"Interaction with polymerase core subunit RpoC"}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues146
DetailsDomain: {"description":"HTH crp-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00387","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues38
DetailsDNA binding: {"description":"H-T-H motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU00387","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

242500

PDB entries from 2025-10-01

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