Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8H3V

Cryo-EM structure of the full transcription activation complex NtcA-NtcB-TAC

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000428	cellular_component	DNA-directed RNA polymerase complex
A	0003677	molecular_function	DNA binding
A	0003899	molecular_function	DNA-directed RNA polymerase activity
A	0006351	biological_process	DNA-templated transcription
A	0016740	molecular_function	transferase activity
A	0016779	molecular_function	nucleotidyltransferase activity
A	0032549	molecular_function	ribonucleoside binding
A	0034062	molecular_function	5'-3' RNA polymerase activity
B	0000428	cellular_component	DNA-directed RNA polymerase complex
B	0003677	molecular_function	DNA binding
B	0003899	molecular_function	DNA-directed RNA polymerase activity
B	0006351	biological_process	DNA-templated transcription
B	0008270	molecular_function	zinc ion binding
B	0016740	molecular_function	transferase activity
B	0016779	molecular_function	nucleotidyltransferase activity
B	0034062	molecular_function	5'-3' RNA polymerase activity
B	0046872	molecular_function	metal ion binding
C	0003677	molecular_function	DNA binding
C	0003899	molecular_function	DNA-directed RNA polymerase activity
C	0006351	biological_process	DNA-templated transcription
C	0046983	molecular_function	protein dimerization activity
D	0003677	molecular_function	DNA binding
D	0003899	molecular_function	DNA-directed RNA polymerase activity
D	0006351	biological_process	DNA-templated transcription
D	0046983	molecular_function	protein dimerization activity
E	0000287	molecular_function	magnesium ion binding
E	0000428	cellular_component	DNA-directed RNA polymerase complex
E	0003677	molecular_function	DNA binding
E	0003899	molecular_function	DNA-directed RNA polymerase activity
E	0006351	biological_process	DNA-templated transcription
E	0008270	molecular_function	zinc ion binding
E	0016740	molecular_function	transferase activity
E	0016779	molecular_function	nucleotidyltransferase activity
E	0034062	molecular_function	5'-3' RNA polymerase activity
E	0046872	molecular_function	metal ion binding
F	0000428	cellular_component	DNA-directed RNA polymerase complex
F	0003677	molecular_function	DNA binding
F	0003899	molecular_function	DNA-directed RNA polymerase activity
F	0006351	biological_process	DNA-templated transcription
F	0016740	molecular_function	transferase activity
F	0016779	molecular_function	nucleotidyltransferase activity
F	0034062	molecular_function	5'-3' RNA polymerase activity
G	0003677	molecular_function	DNA binding
G	0003700	molecular_function	DNA-binding transcription factor activity
G	0005737	cellular_component	cytoplasm
G	0006352	biological_process	DNA-templated transcription initiation
G	0006355	biological_process	regulation of DNA-templated transcription
G	0010468	biological_process	regulation of gene expression
G	0016987	molecular_function	sigma factor activity
G	2000142	biological_process	regulation of DNA-templated transcription initiation
S	0003677	molecular_function	DNA binding
S	0003700	molecular_function	DNA-binding transcription factor activity
S	0005829	cellular_component	cytosol
S	0006355	biological_process	regulation of DNA-templated transcription
T	0003677	molecular_function	DNA binding
T	0003700	molecular_function	DNA-binding transcription factor activity
T	0005829	cellular_component	cytosol
T	0006355	biological_process	regulation of DNA-templated transcription
U	0003677	molecular_function	DNA binding
U	0003700	molecular_function	DNA-binding transcription factor activity
U	0005829	cellular_component	cytosol
U	0006355	biological_process	regulation of DNA-templated transcription
V	0003677	molecular_function	DNA binding
V	0003700	molecular_function	DNA-binding transcription factor activity
V	0005829	cellular_component	cytosol
V	0006355	biological_process	regulation of DNA-templated transcription
X	0003677	molecular_function	DNA binding
X	0003700	molecular_function	DNA-binding transcription factor activity
X	0005829	cellular_component	cytosol
X	0006355	biological_process	regulation of DNA-templated transcription
Y	0003677	molecular_function	DNA binding
Y	0003700	molecular_function	DNA-binding transcription factor activity
Y	0005829	cellular_component	cytosol
Y	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PROSITE/UniProt

site_id	PS00042
Number of Residues	24
Details	HTH_CRP_1 Crp-type HTH domain signature. LSHqaIAeAIGsTrvTv.TRlLgdL

Chain	Residue	Details
X	LEU174-LEU197

site_id	PS00715
Number of Residues	14
Details	SIGMA70_1 Sigma-70 factors family signature 1. DLIQeGsLGLIrAA

Chain	Residue	Details
G	ASP182-ALA195

site_id	PS00716
Number of Residues	27
Details	SIGMA70_2 Sigma-70 factors family signature 2. TleEIGqifnVTrerIrQIEakaLrkL

Chain	Residue	Details
G	THR350-LEU376

site_id	PS01166
Number of Residues	13
Details	RNA_POL_BETA RNA polymerases beta chain signature. GdKMAGrHGNKGI

Chain	Residue	Details
A	GLY849-ILE861

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	19
Details	DNA_BIND: H-T-H motif => ECO:0000255\|HAMAP-Rule:MF_00963

Chain	Residue	Details
G	LEU351-ALA370
E	CYS73
E	CYS86
E	CYS89
E	ASP467
E	ASP469
E	ASP471

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)