8GNK
CryoEM structure of cytosol-facing, substrate-bound ratGAT1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003333 | biological_process | amino acid transmembrane transport |
| A | 0005283 | molecular_function | amino acid:sodium symporter activity |
| A | 0005332 | molecular_function | gamma-aminobutyric acid:sodium:chloride symporter activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006836 | biological_process | neurotransmitter transport |
| A | 0006865 | biological_process | amino acid transport |
| A | 0007612 | biological_process | learning |
| A | 0007613 | biological_process | memory |
| A | 0008306 | biological_process | associative learning |
| A | 0009410 | biological_process | response to xenobiotic stimulus |
| A | 0009636 | biological_process | response to toxic substance |
| A | 0009744 | biological_process | response to sucrose |
| A | 0009986 | cellular_component | cell surface |
| A | 0010288 | biological_process | response to lead ion |
| A | 0014054 | biological_process | positive regulation of gamma-aminobutyric acid secretion |
| A | 0014074 | biological_process | response to purine-containing compound |
| A | 0015185 | molecular_function | gamma-aminobutyric acid transmembrane transporter activity |
| A | 0015293 | molecular_function | symporter activity |
| A | 0015378 | molecular_function | sodium:chloride symporter activity |
| A | 0016020 | cellular_component | membrane |
| A | 0030424 | cellular_component | axon |
| A | 0032229 | biological_process | negative regulation of synaptic transmission, GABAergic |
| A | 0032355 | biological_process | response to estradiol |
| A | 0035725 | biological_process | sodium ion transmembrane transport |
| A | 0042220 | biological_process | response to cocaine |
| A | 0042734 | cellular_component | presynaptic membrane |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0043025 | cellular_component | neuronal cell body |
| A | 0045211 | cellular_component | postsynaptic membrane |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0050808 | biological_process | synapse organization |
| A | 0051592 | biological_process | response to calcium ion |
| A | 0051939 | biological_process | gamma-aminobutyric acid import |
| A | 0098658 | biological_process | inorganic anion import across plasma membrane |
| A | 0098719 | biological_process | sodium ion import across plasma membrane |
| A | 0098793 | cellular_component | presynapse |
| A | 0098810 | biological_process | neurotransmitter reuptake |
| A | 0098982 | cellular_component | GABA-ergic synapse |
| A | 1902476 | biological_process | chloride transmembrane transport |
| A | 1904313 | biological_process | response to methamphetamine hydrochloride |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH |
| Chain | Residue | Details |
| L | TYR193-HIS199 |
| site_id | PS00610 |
| Number of Residues | 15 |
| Details | NA_NEUROTRAN_SYMP_1 Sodium:neurotransmitter symporter family signature 1. WRFPYlcgkNGGGaF |
| Chain | Residue | Details |
| A | TRP68-PHE82 |
| site_id | PS00754 |
| Number of Residues | 21 |
| Details | NA_NEUROTRAN_SYMP_2 Sodium:neurotransmitter symporter family signature 2. YLynSFTttLPWkqCdnpwNT |
| Chain | Residue | Details |
| A | TYR150-THR170 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 169 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"9169433","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 19 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 84 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"9169433","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 18 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 17 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 17 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 21 |
| Details | Transmembrane: {"description":"Helical; Name=7","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 19 |
| Details | Transmembrane: {"description":"Helical; Name=8","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 18 |
| Details | Transmembrane: {"description":"Helical; Name=9","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=10","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 19 |
| Details | Transmembrane: {"description":"Helical; Name=11","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 18 |
| Details | Transmembrane: {"description":"Helical; Name=12","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 9 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q7K4Y6","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 3 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
