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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8GNI

Human SARM1 bounded with NMN and Nanobody-C6, Conformation 1

Functional Information from GO Data
ChainGOidnamespacecontents
A0002376biological_processimmune system process
A0003690molecular_functiondouble-stranded DNA binding
A0003953molecular_functionNAD+ nucleosidase activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005741cellular_componentmitochondrial outer membrane
A0005829cellular_componentcytosol
A0005874cellular_componentmicrotubule
A0007165biological_processsignal transduction
A0007399biological_processnervous system development
A0009986cellular_componentcell surface
A0015630cellular_componentmicrotubule cytoskeleton
A0016787molecular_functionhydrolase activity
A0019677biological_processNAD+ catabolic process
A0030154biological_processcell differentiation
A0030424cellular_componentaxon
A0030425cellular_componentdendrite
A0031594cellular_componentneuromuscular junction
A0032991cellular_componentprotein-containing complex
A0034128biological_processnegative regulation of MyD88-independent toll-like receptor signaling pathway
A0035591molecular_functionsignaling adaptor activity
A0043068biological_processpositive regulation of programmed cell death
A0045087biological_processinnate immune response
A0045202cellular_componentsynapse
A0048678biological_processresponse to axon injury
A0048814biological_processregulation of dendrite morphogenesis
A0050135molecular_functionNADP+ nucleosidase activity
A0050877biological_processnervous system process
A0061809molecular_functionNAD+ nucleosidase activity, cyclic ADP-ribose generating
A0070585biological_processprotein localization to mitochondrion
A0098978cellular_componentglutamatergic synapse
A0099010biological_processmodification of postsynaptic structure
A0099243cellular_componentextrinsic component of synaptic membrane
A1905806biological_processregulation of synapse pruning
B0002376biological_processimmune system process
B0003690molecular_functiondouble-stranded DNA binding
B0003953molecular_functionNAD+ nucleosidase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005741cellular_componentmitochondrial outer membrane
B0005829cellular_componentcytosol
B0005874cellular_componentmicrotubule
B0007165biological_processsignal transduction
B0007399biological_processnervous system development
B0009986cellular_componentcell surface
B0015630cellular_componentmicrotubule cytoskeleton
B0016787molecular_functionhydrolase activity
B0019677biological_processNAD+ catabolic process
B0030154biological_processcell differentiation
B0030424cellular_componentaxon
B0030425cellular_componentdendrite
B0031594cellular_componentneuromuscular junction
B0032991cellular_componentprotein-containing complex
B0034128biological_processnegative regulation of MyD88-independent toll-like receptor signaling pathway
B0035591molecular_functionsignaling adaptor activity
B0043068biological_processpositive regulation of programmed cell death
B0045087biological_processinnate immune response
B0045202cellular_componentsynapse
B0048678biological_processresponse to axon injury
B0048814biological_processregulation of dendrite morphogenesis
B0050135molecular_functionNADP+ nucleosidase activity
B0050877biological_processnervous system process
B0061809molecular_functionNAD+ nucleosidase activity, cyclic ADP-ribose generating
B0070585biological_processprotein localization to mitochondrion
B0098978cellular_componentglutamatergic synapse
B0099010biological_processmodification of postsynaptic structure
B0099243cellular_componentextrinsic component of synaptic membrane
B1905806biological_processregulation of synapse pruning
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues40
DetailsRepeat: {"description":"ARM 1","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues39
DetailsRepeat: {"description":"ARM 2","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues38
DetailsRepeat: {"description":"ARM 3","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues39
DetailsRepeat: {"description":"ARM 4","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues43
DetailsRepeat: {"description":"ARM 5","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues33
DetailsRepeat: {"description":"ARM 6","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues39
DetailsRepeat: {"description":"ARM 7","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues43
DetailsRepeat: {"description":"ARM 8","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues64
DetailsDomain: {"description":"SAM 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00184","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues62
DetailsDomain: {"description":"SAM 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00184","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues13
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"33053563","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CM6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7CM7","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"30333228","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues1
DetailsActive site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00204","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"28334607","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"31439792","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"31439793","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31439792","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

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PDB entries from 2026-01-21

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