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8GNI

Human SARM1 bounded with NMN and Nanobody-C6, Conformation 1

Functional Information from GO Data
ChainGOidnamespacecontents
A0003953molecular_functionNAD+ nucleosidase activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005741cellular_componentmitochondrial outer membrane
A0005829cellular_componentcytosol
A0005874cellular_componentmicrotubule
A0007165biological_processsignal transduction
A0007399biological_processnervous system development
A0009749biological_processresponse to glucose
A0009986cellular_componentcell surface
A0015630cellular_componentmicrotubule cytoskeleton
A0016787molecular_functionhydrolase activity
A0019677biological_processNAD catabolic process
A0030154biological_processcell differentiation
A0030424cellular_componentaxon
A0030425cellular_componentdendrite
A0032991cellular_componentprotein-containing complex
A0034128biological_processnegative regulation of MyD88-independent toll-like receptor signaling pathway
A0035591molecular_functionsignaling adaptor activity
A0042995cellular_componentcell projection
A0043523biological_processregulation of neuron apoptotic process
A0045087biological_processinnate immune response
A0045202cellular_componentsynapse
A0048678biological_processresponse to axon injury
A0048814biological_processregulation of dendrite morphogenesis
A0050135molecular_functionNADP+ nucleosidase activity
A0050877biological_processnervous system process
A0061809molecular_functionNAD+ nucleotidase, cyclic ADP-ribose generating
A0070585biological_processprotein localization to mitochondrion
B0003953molecular_functionNAD+ nucleosidase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005741cellular_componentmitochondrial outer membrane
B0005829cellular_componentcytosol
B0005874cellular_componentmicrotubule
B0007165biological_processsignal transduction
B0007399biological_processnervous system development
B0009749biological_processresponse to glucose
B0009986cellular_componentcell surface
B0015630cellular_componentmicrotubule cytoskeleton
B0016787molecular_functionhydrolase activity
B0019677biological_processNAD catabolic process
B0030154biological_processcell differentiation
B0030424cellular_componentaxon
B0030425cellular_componentdendrite
B0032991cellular_componentprotein-containing complex
B0034128biological_processnegative regulation of MyD88-independent toll-like receptor signaling pathway
B0035591molecular_functionsignaling adaptor activity
B0042995cellular_componentcell projection
B0043523biological_processregulation of neuron apoptotic process
B0045087biological_processinnate immune response
B0045202cellular_componentsynapse
B0048678biological_processresponse to axon injury
B0048814biological_processregulation of dendrite morphogenesis
B0050135molecular_functionNADP+ nucleosidase activity
B0050877biological_processnervous system process
B0061809molecular_functionNAD+ nucleotidase, cyclic ADP-ribose generating
B0070585biological_processprotein localization to mitochondrion
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU00204, ECO:0000305|PubMed:28334607, ECO:0000305|PubMed:31439792, ECO:0000305|PubMed:31439793
ChainResidueDetails
AGLU642
BGLU642

site_idSWS_FT_FI2
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:33053563, ECO:0007744|PDB:7CM6, ECO:0007744|PDB:7CM7
ChainResidueDetails
ATRP103
AARG110
AGLU149
AHIS190
BTRP103
BARG110
BGLU149
BHIS190

site_idSWS_FT_FI3
Number of Residues4
DetailsBINDING: BINDING => ECO:0000305|PubMed:31439792
ChainResidueDetails
AARG569
AGLU599
BARG569
BGLU599

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:30333228
ChainResidueDetails
ASER548
BSER548

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q6PDS3
ChainResidueDetails
ASER558
BSER558

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PDB entries from 2024-07-10

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