7CM7

NAD+-bound Sarm1 E642A in the self-inhibited state

Summary for 7CM7

• Entry DOI: 10.2210/pdb7cm7/pdb
• EMDB information: 30403
• Descriptor: NAD(+) hydrolase SARM1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE (2 entities in total)
• Functional Keywords: nadase, arm, sam, tir, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 8
• Total formula weight: 648877.40

Authors

Zhang, Z.,Jiang, Y. (deposition date: 2020-07-25, release date: 2020-10-21, Last modification date: 2024-03-27)

• Primary citation: Jiang, Y.,Liu, T.,Lee, C.H.,Chang, Q.,Yang, J.,Zhang, Z.; The NAD + -mediated self-inhibition mechanism of pro-neurodegenerative SARM1.; Nature, 588:658-663, 2020; PubMed: 33053563; DOI: 10.1038/s41586-020-2862-z

Experimental method

ELECTRON MICROSCOPY (2.6 Å)