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8G1U

Structure of the methylosome-Lsm10/11 complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000387biological_processspliceosomal snRNP assembly
A0000785cellular_componentchromatin
A0002039molecular_functionp53 binding
A0003714molecular_functiontranscription corepressor activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005694cellular_componentchromosome
A0005737cellular_componentcytoplasm
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0006325biological_processchromatin organization
A0006338biological_processchromatin remodeling
A0006353biological_processDNA-templated transcription termination
A0006355biological_processregulation of DNA-templated transcription
A0006479biological_processprotein methylation
A0007088biological_processregulation of mitotic nuclear division
A0008168molecular_functionmethyltransferase activity
A0008327molecular_functionmethyl-CpG binding
A0008469molecular_functionhistone arginine N-methyltransferase activity
A0010468biological_processregulation of gene expression
A0016274molecular_functionprotein-arginine N-methyltransferase activity
A0018216biological_processpeptidyl-arginine methylation
A0032259biological_processmethylation
A0032922biological_processcircadian regulation of gene expression
A0032991cellular_componentprotein-containing complex
A0034709cellular_componentmethylosome
A0035097cellular_componenthistone methyltransferase complex
A0035243molecular_functionprotein-arginine omega-N symmetric methyltransferase activity
A0035246biological_processpeptidyl-arginine N-methylation
A0042054molecular_functionhistone methyltransferase activity
A0042118biological_processendothelial cell activation
A0042802molecular_functionidentical protein binding
A0043021molecular_functionribonucleoprotein complex binding
A0044020molecular_functionhistone H4R3 methyltransferase activity
A0044027biological_processnegative regulation of gene expression via chromosomal CpG island methylation
A0044877molecular_functionprotein-containing complex binding
A0045596biological_processnegative regulation of cell differentiation
A0045892biological_processnegative regulation of DNA-templated transcription
A0046982molecular_functionprotein heterodimerization activity
A0048026biological_processpositive regulation of mRNA splicing, via spliceosome
A0048511biological_processrhythmic process
A0048714biological_processpositive regulation of oligodendrocyte differentiation
A0070372biological_processregulation of ERK1 and ERK2 cascade
A0070888molecular_functionE-box binding
A0090161biological_processGolgi ribbon formation
A0097421biological_processliver regeneration
A0140938molecular_functionhistone H3 methyltransferase activity
A1901796biological_processregulation of signal transduction by p53 class mediator
A1904992biological_processpositive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway
B0000209biological_processprotein polyubiquitination
B0000387biological_processspliceosomal snRNP assembly
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005794cellular_componentGolgi apparatus
B0005829cellular_componentcytosol
B0006357biological_processregulation of transcription by RNA polymerase II
B0006511biological_processubiquitin-dependent protein catabolic process
B0007309biological_processoocyte axis specification
B0008284biological_processpositive regulation of cell population proliferation
B0008285biological_processnegative regulation of cell population proliferation
B0008327molecular_functionmethyl-CpG binding
B0030374molecular_functionnuclear receptor coactivator activity
B0031465cellular_componentCul4B-RING E3 ubiquitin ligase complex
B0034709cellular_componentmethylosome
B0045893biological_processpositive regulation of DNA-templated transcription
B0048026biological_processpositive regulation of mRNA splicing, via spliceosome
B0060528biological_processsecretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
B0060767biological_processepithelial cell proliferation involved in prostate gland development
B0060770biological_processnegative regulation of epithelial cell proliferation involved in prostate gland development
B1990756molecular_functionubiquitin-like ligase-substrate adaptor activity
C0000387biological_processspliceosomal snRNP assembly
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005886cellular_componentplasma membrane
C0006397biological_processmRNA processing
C0006821biological_processchloride transport
C0006884biological_processcell volume homeostasis
C0008380biological_processRNA splicing
C0034709cellular_componentmethylosome
C0034715cellular_componentpICln-Sm protein complex
C0045794biological_processnegative regulation of cell volume
C0048026biological_processpositive regulation of mRNA splicing, via spliceosome
D0003723molecular_functionRNA binding
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005683cellular_componentU7 snRNP
D0005697cellular_componenttelomerase holoenzyme complex
D0006397biological_processmRNA processing
D0006398biological_processmRNA 3'-end processing by stem-loop binding and cleavage
D0016604cellular_componentnuclear body
D0071204cellular_componenthistone pre-mRNA 3'end processing complex
D0071209molecular_functionU7 snRNA binding
D1900087biological_processpositive regulation of G1/S transition of mitotic cell cycle
D1902275biological_processregulation of chromatin organization
D1990904cellular_componentribonucleoprotein complex
E0000387biological_processspliceosomal snRNP assembly
E0000785cellular_componentchromatin
E0002039molecular_functionp53 binding
E0003714molecular_functiontranscription corepressor activity
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005694cellular_componentchromosome
E0005737cellular_componentcytoplasm
E0005794cellular_componentGolgi apparatus
E0005829cellular_componentcytosol
E0006325biological_processchromatin organization
E0006338biological_processchromatin remodeling
E0006353biological_processDNA-templated transcription termination
E0006355biological_processregulation of DNA-templated transcription
E0006479biological_processprotein methylation
E0007088biological_processregulation of mitotic nuclear division
E0008168molecular_functionmethyltransferase activity
E0008327molecular_functionmethyl-CpG binding
E0008469molecular_functionhistone arginine N-methyltransferase activity
E0010468biological_processregulation of gene expression
E0016274molecular_functionprotein-arginine N-methyltransferase activity
E0018216biological_processpeptidyl-arginine methylation
E0032259biological_processmethylation
E0032922biological_processcircadian regulation of gene expression
E0032991cellular_componentprotein-containing complex
E0034709cellular_componentmethylosome
E0035097cellular_componenthistone methyltransferase complex
E0035243molecular_functionprotein-arginine omega-N symmetric methyltransferase activity
E0035246biological_processpeptidyl-arginine N-methylation
E0042054molecular_functionhistone methyltransferase activity
E0042118biological_processendothelial cell activation
E0042802molecular_functionidentical protein binding
E0043021molecular_functionribonucleoprotein complex binding
E0044020molecular_functionhistone H4R3 methyltransferase activity
E0044027biological_processnegative regulation of gene expression via chromosomal CpG island methylation
E0044877molecular_functionprotein-containing complex binding
E0045596biological_processnegative regulation of cell differentiation
E0045892biological_processnegative regulation of DNA-templated transcription
E0046982molecular_functionprotein heterodimerization activity
E0048026biological_processpositive regulation of mRNA splicing, via spliceosome
E0048511biological_processrhythmic process
E0048714biological_processpositive regulation of oligodendrocyte differentiation
E0070372biological_processregulation of ERK1 and ERK2 cascade
E0070888molecular_functionE-box binding
E0090161biological_processGolgi ribbon formation
E0097421biological_processliver regeneration
E0140938molecular_functionhistone H3 methyltransferase activity
E1901796biological_processregulation of signal transduction by p53 class mediator
E1904992biological_processpositive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway
F0000209biological_processprotein polyubiquitination
F0000387biological_processspliceosomal snRNP assembly
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005737cellular_componentcytoplasm
F0005794cellular_componentGolgi apparatus
F0005829cellular_componentcytosol
F0006357biological_processregulation of transcription by RNA polymerase II
F0006511biological_processubiquitin-dependent protein catabolic process
F0007309biological_processoocyte axis specification
F0008284biological_processpositive regulation of cell population proliferation
F0008285biological_processnegative regulation of cell population proliferation
F0008327molecular_functionmethyl-CpG binding
F0030374molecular_functionnuclear receptor coactivator activity
F0031465cellular_componentCul4B-RING E3 ubiquitin ligase complex
F0034709cellular_componentmethylosome
F0045893biological_processpositive regulation of DNA-templated transcription
F0048026biological_processpositive regulation of mRNA splicing, via spliceosome
F0060528biological_processsecretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
F0060767biological_processepithelial cell proliferation involved in prostate gland development
F0060770biological_processnegative regulation of epithelial cell proliferation involved in prostate gland development
F1990756molecular_functionubiquitin-like ligase-substrate adaptor activity
G0000387biological_processspliceosomal snRNP assembly
G0005634cellular_componentnucleus
G0005737cellular_componentcytoplasm
G0005829cellular_componentcytosol
G0005856cellular_componentcytoskeleton
G0005886cellular_componentplasma membrane
G0006397biological_processmRNA processing
G0006821biological_processchloride transport
G0006884biological_processcell volume homeostasis
G0008380biological_processRNA splicing
G0034709cellular_componentmethylosome
G0034715cellular_componentpICln-Sm protein complex
G0045794biological_processnegative regulation of cell volume
G0048026biological_processpositive regulation of mRNA splicing, via spliceosome
H0003723molecular_functionRNA binding
H0005515molecular_functionprotein binding
H0005634cellular_componentnucleus
H0005654cellular_componentnucleoplasm
H0005683cellular_componentU7 snRNP
H0005697cellular_componenttelomerase holoenzyme complex
H0006397biological_processmRNA processing
H0006398biological_processmRNA 3'-end processing by stem-loop binding and cleavage
H0016604cellular_componentnuclear body
H0071204cellular_componenthistone pre-mRNA 3'end processing complex
H0071209molecular_functionU7 snRNA binding
H1900087biological_processpositive regulation of G1/S transition of mitotic cell cycle
H1902275biological_processregulation of chromatin organization
H1990904cellular_componentribonucleoprotein complex
I0000387biological_processspliceosomal snRNP assembly
I0000785cellular_componentchromatin
I0002039molecular_functionp53 binding
I0003714molecular_functiontranscription corepressor activity
I0005515molecular_functionprotein binding
I0005634cellular_componentnucleus
I0005654cellular_componentnucleoplasm
I0005694cellular_componentchromosome
I0005737cellular_componentcytoplasm
I0005794cellular_componentGolgi apparatus
I0005829cellular_componentcytosol
I0006325biological_processchromatin organization
I0006338biological_processchromatin remodeling
I0006353biological_processDNA-templated transcription termination
I0006355biological_processregulation of DNA-templated transcription
I0006479biological_processprotein methylation
I0007088biological_processregulation of mitotic nuclear division
I0008168molecular_functionmethyltransferase activity
I0008327molecular_functionmethyl-CpG binding
I0008469molecular_functionhistone arginine N-methyltransferase activity
I0010468biological_processregulation of gene expression
I0016274molecular_functionprotein-arginine N-methyltransferase activity
I0018216biological_processpeptidyl-arginine methylation
I0032259biological_processmethylation
I0032922biological_processcircadian regulation of gene expression
I0032991cellular_componentprotein-containing complex
I0034709cellular_componentmethylosome
I0035097cellular_componenthistone methyltransferase complex
I0035243molecular_functionprotein-arginine omega-N symmetric methyltransferase activity
I0035246biological_processpeptidyl-arginine N-methylation
I0042054molecular_functionhistone methyltransferase activity
I0042118biological_processendothelial cell activation
I0042802molecular_functionidentical protein binding
I0043021molecular_functionribonucleoprotein complex binding
I0044020molecular_functionhistone H4R3 methyltransferase activity
I0044027biological_processnegative regulation of gene expression via chromosomal CpG island methylation
I0044877molecular_functionprotein-containing complex binding
I0045596biological_processnegative regulation of cell differentiation
I0045892biological_processnegative regulation of DNA-templated transcription
I0046982molecular_functionprotein heterodimerization activity
I0048026biological_processpositive regulation of mRNA splicing, via spliceosome
I0048511biological_processrhythmic process
I0048714biological_processpositive regulation of oligodendrocyte differentiation
I0070372biological_processregulation of ERK1 and ERK2 cascade
I0070888molecular_functionE-box binding
I0090161biological_processGolgi ribbon formation
I0097421biological_processliver regeneration
I0140938molecular_functionhistone H3 methyltransferase activity
I1901796biological_processregulation of signal transduction by p53 class mediator
I1904992biological_processpositive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway
J0000209biological_processprotein polyubiquitination
J0000387biological_processspliceosomal snRNP assembly
J0005515molecular_functionprotein binding
J0005634cellular_componentnucleus
J0005654cellular_componentnucleoplasm
J0005737cellular_componentcytoplasm
J0005794cellular_componentGolgi apparatus
J0005829cellular_componentcytosol
J0006357biological_processregulation of transcription by RNA polymerase II
J0006511biological_processubiquitin-dependent protein catabolic process
J0007309biological_processoocyte axis specification
J0008284biological_processpositive regulation of cell population proliferation
J0008285biological_processnegative regulation of cell population proliferation
J0008327molecular_functionmethyl-CpG binding
J0030374molecular_functionnuclear receptor coactivator activity
J0031465cellular_componentCul4B-RING E3 ubiquitin ligase complex
J0034709cellular_componentmethylosome
J0045893biological_processpositive regulation of DNA-templated transcription
J0048026biological_processpositive regulation of mRNA splicing, via spliceosome
J0060528biological_processsecretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
J0060767biological_processepithelial cell proliferation involved in prostate gland development
J0060770biological_processnegative regulation of epithelial cell proliferation involved in prostate gland development
J1990756molecular_functionubiquitin-like ligase-substrate adaptor activity
K0000387biological_processspliceosomal snRNP assembly
K0005634cellular_componentnucleus
K0005737cellular_componentcytoplasm
K0005829cellular_componentcytosol
K0005856cellular_componentcytoskeleton
K0005886cellular_componentplasma membrane
K0006397biological_processmRNA processing
K0006821biological_processchloride transport
K0006884biological_processcell volume homeostasis
K0008380biological_processRNA splicing
K0034709cellular_componentmethylosome
K0034715cellular_componentpICln-Sm protein complex
K0045794biological_processnegative regulation of cell volume
K0048026biological_processpositive regulation of mRNA splicing, via spliceosome
L0003723molecular_functionRNA binding
L0005515molecular_functionprotein binding
L0005634cellular_componentnucleus
L0005654cellular_componentnucleoplasm
L0005683cellular_componentU7 snRNP
L0005697cellular_componenttelomerase holoenzyme complex
L0006397biological_processmRNA processing
L0006398biological_processmRNA 3'-end processing by stem-loop binding and cleavage
L0016604cellular_componentnuclear body
L0071204cellular_componenthistone pre-mRNA 3'end processing complex
L0071209molecular_functionU7 snRNA binding
L1900087biological_processpositive regulation of G1/S transition of mitotic cell cycle
L1902275biological_processregulation of chromatin organization
L1990904cellular_componentribonucleoprotein complex
M0000387biological_processspliceosomal snRNP assembly
M0000785cellular_componentchromatin
M0002039molecular_functionp53 binding
M0003714molecular_functiontranscription corepressor activity
M0005515molecular_functionprotein binding
M0005634cellular_componentnucleus
M0005654cellular_componentnucleoplasm
M0005694cellular_componentchromosome
M0005737cellular_componentcytoplasm
M0005794cellular_componentGolgi apparatus
M0005829cellular_componentcytosol
M0006325biological_processchromatin organization
M0006338biological_processchromatin remodeling
M0006353biological_processDNA-templated transcription termination
M0006355biological_processregulation of DNA-templated transcription
M0006479biological_processprotein methylation
M0007088biological_processregulation of mitotic nuclear division
M0008168molecular_functionmethyltransferase activity
M0008327molecular_functionmethyl-CpG binding
M0008469molecular_functionhistone arginine N-methyltransferase activity
M0010468biological_processregulation of gene expression
M0016274molecular_functionprotein-arginine N-methyltransferase activity
M0018216biological_processpeptidyl-arginine methylation
M0032259biological_processmethylation
M0032922biological_processcircadian regulation of gene expression
M0032991cellular_componentprotein-containing complex
M0034709cellular_componentmethylosome
M0035097cellular_componenthistone methyltransferase complex
M0035243molecular_functionprotein-arginine omega-N symmetric methyltransferase activity
M0035246biological_processpeptidyl-arginine N-methylation
M0042054molecular_functionhistone methyltransferase activity
M0042118biological_processendothelial cell activation
M0042802molecular_functionidentical protein binding
M0043021molecular_functionribonucleoprotein complex binding
M0044020molecular_functionhistone H4R3 methyltransferase activity
M0044027biological_processnegative regulation of gene expression via chromosomal CpG island methylation
M0044877molecular_functionprotein-containing complex binding
M0045596biological_processnegative regulation of cell differentiation
M0045892biological_processnegative regulation of DNA-templated transcription
M0046982molecular_functionprotein heterodimerization activity
M0048026biological_processpositive regulation of mRNA splicing, via spliceosome
M0048511biological_processrhythmic process
M0048714biological_processpositive regulation of oligodendrocyte differentiation
M0070372biological_processregulation of ERK1 and ERK2 cascade
M0070888molecular_functionE-box binding
M0090161biological_processGolgi ribbon formation
M0097421biological_processliver regeneration
M0140938molecular_functionhistone H3 methyltransferase activity
M1901796biological_processregulation of signal transduction by p53 class mediator
M1904992biological_processpositive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway
N0000209biological_processprotein polyubiquitination
N0000387biological_processspliceosomal snRNP assembly
N0005515molecular_functionprotein binding
N0005634cellular_componentnucleus
N0005654cellular_componentnucleoplasm
N0005737cellular_componentcytoplasm
N0005794cellular_componentGolgi apparatus
N0005829cellular_componentcytosol
N0006357biological_processregulation of transcription by RNA polymerase II
N0006511biological_processubiquitin-dependent protein catabolic process
N0007309biological_processoocyte axis specification
N0008284biological_processpositive regulation of cell population proliferation
N0008285biological_processnegative regulation of cell population proliferation
N0008327molecular_functionmethyl-CpG binding
N0030374molecular_functionnuclear receptor coactivator activity
N0031465cellular_componentCul4B-RING E3 ubiquitin ligase complex
N0034709cellular_componentmethylosome
N0045893biological_processpositive regulation of DNA-templated transcription
N0048026biological_processpositive regulation of mRNA splicing, via spliceosome
N0060528biological_processsecretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
N0060767biological_processepithelial cell proliferation involved in prostate gland development
N0060770biological_processnegative regulation of epithelial cell proliferation involved in prostate gland development
N1990756molecular_functionubiquitin-like ligase-substrate adaptor activity
O0000387biological_processspliceosomal snRNP assembly
O0005634cellular_componentnucleus
O0005737cellular_componentcytoplasm
O0005829cellular_componentcytosol
O0005856cellular_componentcytoskeleton
O0005886cellular_componentplasma membrane
O0006397biological_processmRNA processing
O0006821biological_processchloride transport
O0006884biological_processcell volume homeostasis
O0008380biological_processRNA splicing
O0034709cellular_componentmethylosome
O0034715cellular_componentpICln-Sm protein complex
O0045794biological_processnegative regulation of cell volume
O0048026biological_processpositive regulation of mRNA splicing, via spliceosome
P0003723molecular_functionRNA binding
P0005515molecular_functionprotein binding
P0005634cellular_componentnucleus
P0005654cellular_componentnucleoplasm
P0005683cellular_componentU7 snRNP
P0005697cellular_componenttelomerase holoenzyme complex
P0006397biological_processmRNA processing
P0006398biological_processmRNA 3'-end processing by stem-loop binding and cleavage
P0016604cellular_componentnuclear body
P0071204cellular_componenthistone pre-mRNA 3'end processing complex
P0071209molecular_functionU7 snRNA binding
P1900087biological_processpositive regulation of G1/S transition of mitotic cell cycle
P1902275biological_processregulation of chromatin organization
P1990904cellular_componentribonucleoprotein complex
Functional Information from PROSITE/UniProt
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. AVSGskDiCIKVWDL
ChainResidueDetails
BALA140-LEU154

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues12
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
DSER15
PSER15
PSER154
PSER280
DSER154
DSER280
HSER15
HSER154
HSER280
LSER15
LSER154
LSER280

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163
ChainResidueDetails
DSER21
ELYS333
EGLU392
EASP419
EGLU435
EGLU444
ITYR324
IPHE327
ILYS333
IGLU392
IASP419
HSER21
IGLU435
IGLU444
MTYR324
MPHE327
MLYS333
MGLU392
MASP419
MGLU435
MGLU444
LSER21
PSER21
AASP419
AGLU435
AGLU444
ETYR324
EPHE327

site_idSWS_FT_FI3
Number of Residues4
DetailsMOD_RES: Omega-N-methylarginine => ECO:0000250|UniProtKB:Q8BUV6
ChainResidueDetails
DARG41
GSER-14
KSER-80
KSER-31
KSER-29
KSER-26
KSER-14
OSER-80
OSER-31
OSER-29
OSER-26
HARG41
OSER-14
LARG41
PARG41
CSER-14
GSER-80
GSER-31
GSER-29
GSER-26

site_idSWS_FT_FI4
Number of Residues8
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
DLYS120
GTHR-1
HLYS120
OTHR-1
LLYS120
PLYS120

225946

PDB entries from 2024-10-09

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