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8G1U

Structure of the methylosome-Lsm10/11 complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000387biological_processspliceosomal snRNP assembly
A0000785cellular_componentchromatin
A0002039molecular_functionp53 binding
A0003714molecular_functiontranscription corepressor activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005694cellular_componentchromosome
A0005737cellular_componentcytoplasm
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0006325biological_processchromatin organization
A0006338biological_processchromatin remodeling
A0006351biological_processDNA-templated transcription
A0006353biological_processDNA-templated transcription termination
A0006355biological_processregulation of DNA-templated transcription
A0006479biological_processprotein methylation
A0007088biological_processregulation of mitotic nuclear division
A0008168molecular_functionmethyltransferase activity
A0008327molecular_functionmethyl-CpG binding
A0010468biological_processregulation of gene expression
A0016274molecular_functionprotein-arginine N-methyltransferase activity
A0016740molecular_functiontransferase activity
A0018216biological_processpeptidyl-arginine methylation
A0032259biological_processmethylation
A0032922biological_processcircadian regulation of gene expression
A0032991cellular_componentprotein-containing complex
A0034709cellular_componentmethylosome
A0035097cellular_componenthistone methyltransferase complex
A0035243molecular_functionprotein-arginine omega-N symmetric methyltransferase activity
A0035246biological_processpeptidyl-arginine N-methylation
A0042054molecular_functionhistone methyltransferase activity
A0042118biological_processendothelial cell activation
A0042802molecular_functionidentical protein binding
A0043021molecular_functionribonucleoprotein complex binding
A0044020molecular_functionhistone H4R3 methyltransferase activity
A0044027biological_processnegative regulation of gene expression via chromosomal CpG island methylation
A0044877molecular_functionprotein-containing complex binding
A0045596biological_processnegative regulation of cell differentiation
A0045892biological_processnegative regulation of DNA-templated transcription
A0046982molecular_functionprotein heterodimerization activity
A0048026biological_processpositive regulation of mRNA splicing, via spliceosome
A0048511biological_processrhythmic process
A0048714biological_processpositive regulation of oligodendrocyte differentiation
A0070372biological_processregulation of ERK1 and ERK2 cascade
A0070888molecular_functionE-box binding
A0090161biological_processGolgi ribbon formation
A0097421biological_processliver regeneration
A0140938molecular_functionhistone H3 methyltransferase activity
A1901796biological_processregulation of signal transduction by p53 class mediator
A1904992biological_processpositive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway
A2000234biological_processpositive regulation of rRNA processing
B0000209biological_processprotein polyubiquitination
B0000387biological_processspliceosomal snRNP assembly
B0003713molecular_functiontranscription coactivator activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005794cellular_componentGolgi apparatus
B0005829cellular_componentcytosol
B0006511biological_processubiquitin-dependent protein catabolic process
B0008327molecular_functionmethyl-CpG binding
B0031465cellular_componentCul4B-RING E3 ubiquitin ligase complex
B0034709cellular_componentmethylosome
B0045893biological_processpositive regulation of DNA-templated transcription
B0048026biological_processpositive regulation of mRNA splicing, via spliceosome
B1990234cellular_componenttransferase complex
B1990756molecular_functionubiquitin-like ligase-substrate adaptor activity
B2000234biological_processpositive regulation of rRNA processing
C0000387biological_processspliceosomal snRNP assembly
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005681cellular_componentspliceosomal complex
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005886cellular_componentplasma membrane
C0005929cellular_componentcilium
C0006397biological_processmRNA processing
C0006821biological_processchloride transport
C0006884biological_processcell volume homeostasis
C0008380biological_processRNA splicing
C0015630cellular_componentmicrotubule cytoskeleton
C0034709cellular_componentmethylosome
C0034715cellular_componentpICln-Sm protein complex
C0045292biological_processmRNA cis splicing, via spliceosome
C0048026biological_processpositive regulation of mRNA splicing, via spliceosome
C0097225cellular_componentsperm midpiece
C0097228cellular_componentsperm principal piece
C0120212cellular_componentsperm head-tail coupling apparatus
D0003723molecular_functionRNA binding
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005683cellular_componentU7 snRNP
D0005697cellular_componenttelomerase holoenzyme complex
D0006397biological_processmRNA processing
D0006398biological_processmRNA 3'-end processing by stem-loop binding and cleavage
D0016604cellular_componentnuclear body
D0036261biological_process7-methylguanosine cap hypermethylation
D0071045biological_processnuclear histone mRNA catabolic process
D0071204cellular_componenthistone pre-mRNA 3'end processing complex
D0071209molecular_functionU7 snRNA binding
D1900087biological_processpositive regulation of G1/S transition of mitotic cell cycle
D1902275biological_processregulation of chromatin organization
D1990904cellular_componentribonucleoprotein complex
E0000387biological_processspliceosomal snRNP assembly
E0000785cellular_componentchromatin
E0002039molecular_functionp53 binding
E0003714molecular_functiontranscription corepressor activity
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005694cellular_componentchromosome
E0005737cellular_componentcytoplasm
E0005794cellular_componentGolgi apparatus
E0005829cellular_componentcytosol
E0006325biological_processchromatin organization
E0006338biological_processchromatin remodeling
E0006351biological_processDNA-templated transcription
E0006353biological_processDNA-templated transcription termination
E0006355biological_processregulation of DNA-templated transcription
E0006479biological_processprotein methylation
E0007088biological_processregulation of mitotic nuclear division
E0008168molecular_functionmethyltransferase activity
E0008327molecular_functionmethyl-CpG binding
E0010468biological_processregulation of gene expression
E0016274molecular_functionprotein-arginine N-methyltransferase activity
E0016740molecular_functiontransferase activity
E0018216biological_processpeptidyl-arginine methylation
E0032259biological_processmethylation
E0032922biological_processcircadian regulation of gene expression
E0032991cellular_componentprotein-containing complex
E0034709cellular_componentmethylosome
E0035097cellular_componenthistone methyltransferase complex
E0035243molecular_functionprotein-arginine omega-N symmetric methyltransferase activity
E0035246biological_processpeptidyl-arginine N-methylation
E0042054molecular_functionhistone methyltransferase activity
E0042118biological_processendothelial cell activation
E0042802molecular_functionidentical protein binding
E0043021molecular_functionribonucleoprotein complex binding
E0044020molecular_functionhistone H4R3 methyltransferase activity
E0044027biological_processnegative regulation of gene expression via chromosomal CpG island methylation
E0044877molecular_functionprotein-containing complex binding
E0045596biological_processnegative regulation of cell differentiation
E0045892biological_processnegative regulation of DNA-templated transcription
E0046982molecular_functionprotein heterodimerization activity
E0048026biological_processpositive regulation of mRNA splicing, via spliceosome
E0048511biological_processrhythmic process
E0048714biological_processpositive regulation of oligodendrocyte differentiation
E0070372biological_processregulation of ERK1 and ERK2 cascade
E0070888molecular_functionE-box binding
E0090161biological_processGolgi ribbon formation
E0097421biological_processliver regeneration
E0140938molecular_functionhistone H3 methyltransferase activity
E1901796biological_processregulation of signal transduction by p53 class mediator
E1904992biological_processpositive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway
E2000234biological_processpositive regulation of rRNA processing
F0000209biological_processprotein polyubiquitination
F0000387biological_processspliceosomal snRNP assembly
F0003713molecular_functiontranscription coactivator activity
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005737cellular_componentcytoplasm
F0005794cellular_componentGolgi apparatus
F0005829cellular_componentcytosol
F0006511biological_processubiquitin-dependent protein catabolic process
F0008327molecular_functionmethyl-CpG binding
F0031465cellular_componentCul4B-RING E3 ubiquitin ligase complex
F0034709cellular_componentmethylosome
F0045893biological_processpositive regulation of DNA-templated transcription
F0048026biological_processpositive regulation of mRNA splicing, via spliceosome
F1990234cellular_componenttransferase complex
F1990756molecular_functionubiquitin-like ligase-substrate adaptor activity
F2000234biological_processpositive regulation of rRNA processing
G0000387biological_processspliceosomal snRNP assembly
G0005634cellular_componentnucleus
G0005654cellular_componentnucleoplasm
G0005681cellular_componentspliceosomal complex
G0005829cellular_componentcytosol
G0005856cellular_componentcytoskeleton
G0005886cellular_componentplasma membrane
G0005929cellular_componentcilium
G0006397biological_processmRNA processing
G0006821biological_processchloride transport
G0006884biological_processcell volume homeostasis
G0008380biological_processRNA splicing
G0015630cellular_componentmicrotubule cytoskeleton
G0034709cellular_componentmethylosome
G0034715cellular_componentpICln-Sm protein complex
G0045292biological_processmRNA cis splicing, via spliceosome
G0048026biological_processpositive regulation of mRNA splicing, via spliceosome
G0097225cellular_componentsperm midpiece
G0097228cellular_componentsperm principal piece
G0120212cellular_componentsperm head-tail coupling apparatus
H0003723molecular_functionRNA binding
H0005515molecular_functionprotein binding
H0005634cellular_componentnucleus
H0005654cellular_componentnucleoplasm
H0005683cellular_componentU7 snRNP
H0005697cellular_componenttelomerase holoenzyme complex
H0006397biological_processmRNA processing
H0006398biological_processmRNA 3'-end processing by stem-loop binding and cleavage
H0016604cellular_componentnuclear body
H0036261biological_process7-methylguanosine cap hypermethylation
H0071045biological_processnuclear histone mRNA catabolic process
H0071204cellular_componenthistone pre-mRNA 3'end processing complex
H0071209molecular_functionU7 snRNA binding
H1900087biological_processpositive regulation of G1/S transition of mitotic cell cycle
H1902275biological_processregulation of chromatin organization
H1990904cellular_componentribonucleoprotein complex
I0000387biological_processspliceosomal snRNP assembly
I0000785cellular_componentchromatin
I0002039molecular_functionp53 binding
I0003714molecular_functiontranscription corepressor activity
I0005515molecular_functionprotein binding
I0005634cellular_componentnucleus
I0005654cellular_componentnucleoplasm
I0005694cellular_componentchromosome
I0005737cellular_componentcytoplasm
I0005794cellular_componentGolgi apparatus
I0005829cellular_componentcytosol
I0006325biological_processchromatin organization
I0006338biological_processchromatin remodeling
I0006351biological_processDNA-templated transcription
I0006353biological_processDNA-templated transcription termination
I0006355biological_processregulation of DNA-templated transcription
I0006479biological_processprotein methylation
I0007088biological_processregulation of mitotic nuclear division
I0008168molecular_functionmethyltransferase activity
I0008327molecular_functionmethyl-CpG binding
I0010468biological_processregulation of gene expression
I0016274molecular_functionprotein-arginine N-methyltransferase activity
I0016740molecular_functiontransferase activity
I0018216biological_processpeptidyl-arginine methylation
I0032259biological_processmethylation
I0032922biological_processcircadian regulation of gene expression
I0032991cellular_componentprotein-containing complex
I0034709cellular_componentmethylosome
I0035097cellular_componenthistone methyltransferase complex
I0035243molecular_functionprotein-arginine omega-N symmetric methyltransferase activity
I0035246biological_processpeptidyl-arginine N-methylation
I0042054molecular_functionhistone methyltransferase activity
I0042118biological_processendothelial cell activation
I0042802molecular_functionidentical protein binding
I0043021molecular_functionribonucleoprotein complex binding
I0044020molecular_functionhistone H4R3 methyltransferase activity
I0044027biological_processnegative regulation of gene expression via chromosomal CpG island methylation
I0044877molecular_functionprotein-containing complex binding
I0045596biological_processnegative regulation of cell differentiation
I0045892biological_processnegative regulation of DNA-templated transcription
I0046982molecular_functionprotein heterodimerization activity
I0048026biological_processpositive regulation of mRNA splicing, via spliceosome
I0048511biological_processrhythmic process
I0048714biological_processpositive regulation of oligodendrocyte differentiation
I0070372biological_processregulation of ERK1 and ERK2 cascade
I0070888molecular_functionE-box binding
I0090161biological_processGolgi ribbon formation
I0097421biological_processliver regeneration
I0140938molecular_functionhistone H3 methyltransferase activity
I1901796biological_processregulation of signal transduction by p53 class mediator
I1904992biological_processpositive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway
I2000234biological_processpositive regulation of rRNA processing
J0000209biological_processprotein polyubiquitination
J0000387biological_processspliceosomal snRNP assembly
J0003713molecular_functiontranscription coactivator activity
J0005515molecular_functionprotein binding
J0005634cellular_componentnucleus
J0005654cellular_componentnucleoplasm
J0005737cellular_componentcytoplasm
J0005794cellular_componentGolgi apparatus
J0005829cellular_componentcytosol
J0006511biological_processubiquitin-dependent protein catabolic process
J0008327molecular_functionmethyl-CpG binding
J0031465cellular_componentCul4B-RING E3 ubiquitin ligase complex
J0034709cellular_componentmethylosome
J0045893biological_processpositive regulation of DNA-templated transcription
J0048026biological_processpositive regulation of mRNA splicing, via spliceosome
J1990234cellular_componenttransferase complex
J1990756molecular_functionubiquitin-like ligase-substrate adaptor activity
J2000234biological_processpositive regulation of rRNA processing
K0000387biological_processspliceosomal snRNP assembly
K0005634cellular_componentnucleus
K0005654cellular_componentnucleoplasm
K0005681cellular_componentspliceosomal complex
K0005829cellular_componentcytosol
K0005856cellular_componentcytoskeleton
K0005886cellular_componentplasma membrane
K0005929cellular_componentcilium
K0006397biological_processmRNA processing
K0006821biological_processchloride transport
K0006884biological_processcell volume homeostasis
K0008380biological_processRNA splicing
K0015630cellular_componentmicrotubule cytoskeleton
K0034709cellular_componentmethylosome
K0034715cellular_componentpICln-Sm protein complex
K0045292biological_processmRNA cis splicing, via spliceosome
K0048026biological_processpositive regulation of mRNA splicing, via spliceosome
K0097225cellular_componentsperm midpiece
K0097228cellular_componentsperm principal piece
K0120212cellular_componentsperm head-tail coupling apparatus
L0003723molecular_functionRNA binding
L0005515molecular_functionprotein binding
L0005634cellular_componentnucleus
L0005654cellular_componentnucleoplasm
L0005683cellular_componentU7 snRNP
L0005697cellular_componenttelomerase holoenzyme complex
L0006397biological_processmRNA processing
L0006398biological_processmRNA 3'-end processing by stem-loop binding and cleavage
L0016604cellular_componentnuclear body
L0036261biological_process7-methylguanosine cap hypermethylation
L0071045biological_processnuclear histone mRNA catabolic process
L0071204cellular_componenthistone pre-mRNA 3'end processing complex
L0071209molecular_functionU7 snRNA binding
L1900087biological_processpositive regulation of G1/S transition of mitotic cell cycle
L1902275biological_processregulation of chromatin organization
L1990904cellular_componentribonucleoprotein complex
M0000387biological_processspliceosomal snRNP assembly
M0000785cellular_componentchromatin
M0002039molecular_functionp53 binding
M0003714molecular_functiontranscription corepressor activity
M0005515molecular_functionprotein binding
M0005634cellular_componentnucleus
M0005654cellular_componentnucleoplasm
M0005694cellular_componentchromosome
M0005737cellular_componentcytoplasm
M0005794cellular_componentGolgi apparatus
M0005829cellular_componentcytosol
M0006325biological_processchromatin organization
M0006338biological_processchromatin remodeling
M0006351biological_processDNA-templated transcription
M0006353biological_processDNA-templated transcription termination
M0006355biological_processregulation of DNA-templated transcription
M0006479biological_processprotein methylation
M0007088biological_processregulation of mitotic nuclear division
M0008168molecular_functionmethyltransferase activity
M0008327molecular_functionmethyl-CpG binding
M0010468biological_processregulation of gene expression
M0016274molecular_functionprotein-arginine N-methyltransferase activity
M0016740molecular_functiontransferase activity
M0018216biological_processpeptidyl-arginine methylation
M0032259biological_processmethylation
M0032922biological_processcircadian regulation of gene expression
M0032991cellular_componentprotein-containing complex
M0034709cellular_componentmethylosome
M0035097cellular_componenthistone methyltransferase complex
M0035243molecular_functionprotein-arginine omega-N symmetric methyltransferase activity
M0035246biological_processpeptidyl-arginine N-methylation
M0042054molecular_functionhistone methyltransferase activity
M0042118biological_processendothelial cell activation
M0042802molecular_functionidentical protein binding
M0043021molecular_functionribonucleoprotein complex binding
M0044020molecular_functionhistone H4R3 methyltransferase activity
M0044027biological_processnegative regulation of gene expression via chromosomal CpG island methylation
M0044877molecular_functionprotein-containing complex binding
M0045596biological_processnegative regulation of cell differentiation
M0045892biological_processnegative regulation of DNA-templated transcription
M0046982molecular_functionprotein heterodimerization activity
M0048026biological_processpositive regulation of mRNA splicing, via spliceosome
M0048511biological_processrhythmic process
M0048714biological_processpositive regulation of oligodendrocyte differentiation
M0070372biological_processregulation of ERK1 and ERK2 cascade
M0070888molecular_functionE-box binding
M0090161biological_processGolgi ribbon formation
M0097421biological_processliver regeneration
M0140938molecular_functionhistone H3 methyltransferase activity
M1901796biological_processregulation of signal transduction by p53 class mediator
M1904992biological_processpositive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway
M2000234biological_processpositive regulation of rRNA processing
N0000209biological_processprotein polyubiquitination
N0000387biological_processspliceosomal snRNP assembly
N0003713molecular_functiontranscription coactivator activity
N0005515molecular_functionprotein binding
N0005634cellular_componentnucleus
N0005654cellular_componentnucleoplasm
N0005737cellular_componentcytoplasm
N0005794cellular_componentGolgi apparatus
N0005829cellular_componentcytosol
N0006511biological_processubiquitin-dependent protein catabolic process
N0008327molecular_functionmethyl-CpG binding
N0031465cellular_componentCul4B-RING E3 ubiquitin ligase complex
N0034709cellular_componentmethylosome
N0045893biological_processpositive regulation of DNA-templated transcription
N0048026biological_processpositive regulation of mRNA splicing, via spliceosome
N1990234cellular_componenttransferase complex
N1990756molecular_functionubiquitin-like ligase-substrate adaptor activity
N2000234biological_processpositive regulation of rRNA processing
O0000387biological_processspliceosomal snRNP assembly
O0005634cellular_componentnucleus
O0005654cellular_componentnucleoplasm
O0005681cellular_componentspliceosomal complex
O0005829cellular_componentcytosol
O0005856cellular_componentcytoskeleton
O0005886cellular_componentplasma membrane
O0005929cellular_componentcilium
O0006397biological_processmRNA processing
O0006821biological_processchloride transport
O0006884biological_processcell volume homeostasis
O0008380biological_processRNA splicing
O0015630cellular_componentmicrotubule cytoskeleton
O0034709cellular_componentmethylosome
O0034715cellular_componentpICln-Sm protein complex
O0045292biological_processmRNA cis splicing, via spliceosome
O0048026biological_processpositive regulation of mRNA splicing, via spliceosome
O0097225cellular_componentsperm midpiece
O0097228cellular_componentsperm principal piece
O0120212cellular_componentsperm head-tail coupling apparatus
P0003723molecular_functionRNA binding
P0005515molecular_functionprotein binding
P0005634cellular_componentnucleus
P0005654cellular_componentnucleoplasm
P0005683cellular_componentU7 snRNP
P0005697cellular_componenttelomerase holoenzyme complex
P0006397biological_processmRNA processing
P0006398biological_processmRNA 3'-end processing by stem-loop binding and cleavage
P0016604cellular_componentnuclear body
P0036261biological_process7-methylguanosine cap hypermethylation
P0071045biological_processnuclear histone mRNA catabolic process
P0071204cellular_componenthistone pre-mRNA 3'end processing complex
P0071209molecular_functionU7 snRNA binding
P1900087biological_processpositive regulation of G1/S transition of mitotic cell cycle
P1902275biological_processregulation of chromatin organization
P1990904cellular_componentribonucleoprotein complex
Functional Information from PROSITE/UniProt
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. AVSGskDiCIKVWDL
ChainResidueDetails
BALA140-LEU154

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues24
DetailsRegion: {"description":"Dimerization","evidences":[{"source":"PubMed","id":"23071334","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues8
DetailsActive site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"23071334","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues28
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"23071334","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues4
DetailsSite: {"description":"Critical for specifying symmetric addition of methyl groups","evidences":[{"source":"UniProtKB","id":"P46580","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues152
DetailsRepeat: {"description":"WD 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23071334","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues156
DetailsRepeat: {"description":"WD 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23071334","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues160
DetailsRepeat: {"description":"WD 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23071334","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues160
DetailsRepeat: {"description":"WD 6","evidences":[{"source":"PROSITE-ProRule","id":"PRU00221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23071334","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

247947

PDB entries from 2026-01-21

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