8FML

Cryo-EM structure of NLR family apoptosis inhibitory protein 5 (NAIP5) in complex with a full-length flagellin (FliC) ligand

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0002376	biological_process	immune system process
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0006915	biological_process	apoptotic process
A	0006954	biological_process	inflammatory response
A	0010804	biological_process	negative regulation of tumor necrosis factor-mediated signaling pathway
A	0016045	biological_process	detection of bacterium
A	0032731	biological_process	positive regulation of interleukin-1 beta production
A	0042742	biological_process	defense response to bacterium
A	0042981	biological_process	regulation of apoptotic process
A	0043027	molecular_function	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
A	0043066	biological_process	negative regulation of apoptotic process
A	0045087	biological_process	innate immune response
A	0046330	biological_process	positive regulation of JNK cascade
A	0046718	biological_process	symbiont entry into host cell
A	0046872	molecular_function	metal ion binding
A	0050829	biological_process	defense response to Gram-negative bacterium
A	0070269	biological_process	pyroptotic inflammatory response
A	0072557	cellular_component	IPAF inflammasome complex
A	0120283	molecular_function	protein serine/threonine kinase binding
B	0005198	molecular_function	structural molecule activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0007165	biological_process	signal transduction
B	0009288	cellular_component	bacterial-type flagellum
B	0048018	molecular_function	receptor ligand activity
B	0071973	biological_process	bacterial-type flagellum-dependent cell motility

Functional Information from PROSITE/UniProt

site_id	PS01282
Number of Residues	69
Details	BIR_REPEAT_1 BIR repeat. EeaRlesfed.WpfyahgtsprvlsaAGFvFtgkrDtvqCfsCggslgnWeegddpwkeHakwfPkCefL

Chain	Residue	Details
A	GLU159-LEU227
A	GLU278-LEU345

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	67
Details	Repeat: {"description":"BIR 1"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	68
Details	Repeat: {"description":"BIR 2"}

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Residue

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site_id	SWS_FT_FI3
Number of Residues	67
Details	Repeat: {"description":"BIR 3"}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	295
Details	Domain: {"description":"NACHT","evidences":[{"source":"PROSITE-ProRule","id":"PRU00136","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00029","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PubMed","id":"29182158","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5YUD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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