8EZA

NHEJ Long-range complex with PAXX

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000723	biological_process	telomere maintenance
A	0000725	biological_process	recombinational repair
A	0000781	cellular_component	chromosome, telomeric region
A	0000783	cellular_component	nuclear telomere cap complex
A	0000976	molecular_function	transcription cis-regulatory region binding
A	0002218	biological_process	activation of innate immune response
A	0003677	molecular_function	DNA binding
A	0003678	molecular_function	DNA helicase activity
A	0003684	molecular_function	damaged DNA binding
A	0003690	molecular_function	double-stranded DNA binding
A	0003691	molecular_function	double-stranded telomeric DNA binding
A	0003723	molecular_function	RNA binding
A	0004386	molecular_function	helicase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005667	cellular_component	transcription regulator complex
A	0005694	cellular_component	chromosome
A	0005730	cellular_component	nucleolus
A	0005829	cellular_component	cytosol
A	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
A	0006266	biological_process	DNA ligation
A	0006281	biological_process	DNA repair
A	0006303	biological_process	double-strand break repair via nonhomologous end joining
A	0006310	biological_process	DNA recombination
A	0008094	molecular_function	ATP-dependent activity, acting on DNA
A	0010558	biological_process	negative regulation of macromolecule biosynthetic process
A	0016020	cellular_component	membrane
A	0016787	molecular_function	hydrolase activity
A	0016829	molecular_function	lyase activity
A	0016887	molecular_function	ATP hydrolysis activity
A	0030332	molecular_function	cyclin binding
A	0032508	biological_process	DNA duplex unwinding
A	0032991	cellular_component	protein-containing complex
A	0032993	cellular_component	protein-DNA complex
A	0034774	cellular_component	secretory granule lumen
A	0042162	molecular_function	telomeric DNA binding
A	0043564	cellular_component	Ku70:Ku80 complex
A	0044877	molecular_function	protein-containing complex binding
A	0045027	molecular_function	DNA end binding
A	0045087	biological_process	innate immune response
A	0045621	biological_process	positive regulation of lymphocyte differentiation
A	0045860	biological_process	positive regulation of protein kinase activity
A	0045892	biological_process	negative regulation of DNA-templated transcription
A	0045893	biological_process	positive regulation of DNA-templated transcription
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0048660	biological_process	regulation of smooth muscle cell proliferation
A	0051575	molecular_function	5'-deoxyribose-5-phosphate lyase activity
A	0070418	cellular_component	DNA-dependent protein kinase complex
A	0070419	cellular_component	nonhomologous end joining complex
A	0071475	biological_process	cellular hyperosmotic salinity response
A	0071480	biological_process	cellular response to gamma radiation
A	0071481	biological_process	cellular response to X-ray
A	0097110	molecular_function	scaffold protein binding
A	0097680	biological_process	double-strand break repair via classical nonhomologous end joining
A	1904813	cellular_component	ficolin-1-rich granule lumen
B	0000723	biological_process	telomere maintenance
B	0000725	biological_process	recombinational repair
B	0000781	cellular_component	chromosome, telomeric region
B	0000783	cellular_component	nuclear telomere cap complex
B	0000976	molecular_function	transcription cis-regulatory region binding
B	0002218	biological_process	activation of innate immune response
B	0003677	molecular_function	DNA binding
B	0003678	molecular_function	DNA helicase activity
B	0003684	molecular_function	damaged DNA binding
B	0003690	molecular_function	double-stranded DNA binding
B	0003691	molecular_function	double-stranded telomeric DNA binding
B	0003723	molecular_function	RNA binding
B	0004386	molecular_function	helicase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005694	cellular_component	chromosome
B	0005730	cellular_component	nucleolus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
B	0006281	biological_process	DNA repair
B	0006302	biological_process	double-strand break repair
B	0006303	biological_process	double-strand break repair via nonhomologous end joining
B	0006310	biological_process	DNA recombination
B	0006974	biological_process	DNA damage response
B	0008047	molecular_function	enzyme activator activity
B	0008094	molecular_function	ATP-dependent activity, acting on DNA
B	0009410	biological_process	response to xenobiotic stimulus
B	0010558	biological_process	negative regulation of macromolecule biosynthetic process
B	0016020	cellular_component	membrane
B	0016787	molecular_function	hydrolase activity
B	0016887	molecular_function	ATP hydrolysis activity
B	0022008	biological_process	neurogenesis
B	0031625	molecular_function	ubiquitin protein ligase binding
B	0032040	cellular_component	small-subunit processome
B	0032204	biological_process	regulation of telomere maintenance
B	0032212	biological_process	positive regulation of telomere maintenance via telomerase
B	0032508	biological_process	DNA duplex unwinding
B	0032991	cellular_component	protein-containing complex
B	0032993	cellular_component	protein-DNA complex
B	0034462	biological_process	small-subunit processome assembly
B	0034511	molecular_function	U3 snoRNA binding
B	0034774	cellular_component	secretory granule lumen
B	0042162	molecular_function	telomeric DNA binding
B	0042254	biological_process	ribosome biogenesis
B	0043085	biological_process	positive regulation of catalytic activity
B	0043564	cellular_component	Ku70:Ku80 complex
B	0044877	molecular_function	protein-containing complex binding
B	0045027	molecular_function	DNA end binding
B	0045087	biological_process	innate immune response
B	0045860	biological_process	positive regulation of protein kinase activity
B	0045892	biological_process	negative regulation of DNA-templated transcription
B	0048660	biological_process	regulation of smooth muscle cell proliferation
B	0050769	biological_process	positive regulation of neurogenesis
B	0051575	molecular_function	5'-deoxyribose-5-phosphate lyase activity
B	0051973	biological_process	positive regulation of telomerase activity
B	0060218	biological_process	hematopoietic stem cell differentiation
B	0070198	biological_process	protein localization to chromosome, telomeric region
B	0070418	cellular_component	DNA-dependent protein kinase complex
B	0070419	cellular_component	nonhomologous end joining complex
B	0071398	biological_process	cellular response to fatty acid
B	0071425	biological_process	hematopoietic stem cell proliferation
B	0071475	biological_process	cellular hyperosmotic salinity response
B	0071480	biological_process	cellular response to gamma radiation
B	0071481	biological_process	cellular response to X-ray
B	0090734	cellular_component	site of DNA damage
B	1904430	biological_process	negative regulation of t-circle formation
B	1990830	biological_process	cellular response to leukemia inhibitory factor
B	1990904	cellular_component	ribonucleoprotein complex
C	0000460	biological_process	maturation of 5.8S rRNA
C	0000723	biological_process	telomere maintenance
C	0000781	cellular_component	chromosome, telomeric region
C	0000785	cellular_component	chromatin
C	0001756	biological_process	somitogenesis
C	0001933	biological_process	negative regulation of protein phosphorylation
C	0002218	biological_process	activation of innate immune response
C	0002326	biological_process	B cell lineage commitment
C	0002327	biological_process	immature B cell differentiation
C	0002328	biological_process	pro-B cell differentiation
C	0002360	biological_process	T cell lineage commitment
C	0003677	molecular_function	DNA binding
C	0003690	molecular_function	double-stranded DNA binding
C	0003723	molecular_function	RNA binding
C	0004672	molecular_function	protein kinase activity
C	0004674	molecular_function	protein serine/threonine kinase activity
C	0004677	molecular_function	DNA-dependent protein kinase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005667	cellular_component	transcription regulator complex
C	0005730	cellular_component	nucleolus
C	0005829	cellular_component	cytosol
C	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
C	0006281	biological_process	DNA repair
C	0006302	biological_process	double-strand break repair
C	0006303	biological_process	double-strand break repair via nonhomologous end joining
C	0006310	biological_process	DNA recombination
C	0006338	biological_process	chromatin remodeling
C	0006468	biological_process	protein phosphorylation
C	0006974	biological_process	DNA damage response
C	0007420	biological_process	brain development
C	0007507	biological_process	heart development
C	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
C	0010212	biological_process	response to ionizing radiation
C	0010332	biological_process	response to gamma radiation
C	0016020	cellular_component	membrane
C	0016233	biological_process	telomere capping
C	0016301	molecular_function	kinase activity
C	0018105	biological_process	peptidyl-serine phosphorylation
C	0018107	biological_process	peptidyl-threonine phosphorylation
C	0019899	molecular_function	enzyme binding
C	0019904	molecular_function	protein domain specific binding
C	0030098	biological_process	lymphocyte differentiation
C	0031571	biological_process	mitotic G1 DNA damage checkpoint signaling
C	0031648	biological_process	protein destabilization
C	0032040	cellular_component	small-subunit processome
C	0032869	biological_process	cellular response to insulin stimulus
C	0032991	cellular_component	protein-containing complex
C	0032993	cellular_component	protein-DNA complex
C	0033077	biological_process	T cell differentiation in thymus
C	0033151	biological_process	V(D)J recombination
C	0033152	biological_process	immunoglobulin V(D)J recombination
C	0033153	biological_process	T cell receptor V(D)J recombination
C	0034462	biological_process	small-subunit processome assembly
C	0034511	molecular_function	U3 snoRNA binding
C	0035234	biological_process	ectopic germ cell programmed cell death
C	0035979	molecular_function	histone H2AXS139 kinase activity
C	0036211	biological_process	protein modification process
C	0042254	biological_process	ribosome biogenesis
C	0042752	biological_process	regulation of circadian rhythm
C	0043065	biological_process	positive regulation of apoptotic process
C	0043066	biological_process	negative regulation of apoptotic process
C	0045087	biological_process	innate immune response
C	0045621	biological_process	positive regulation of lymphocyte differentiation
C	0045648	biological_process	positive regulation of erythrocyte differentiation
C	0045727	biological_process	positive regulation of translation
C	0045944	biological_process	positive regulation of transcription by RNA polymerase II
C	0048511	biological_process	rhythmic process
C	0048660	biological_process	regulation of smooth muscle cell proliferation
C	0050678	biological_process	regulation of epithelial cell proliferation
C	0060255	biological_process	regulation of macromolecule metabolic process
C	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
C	0070418	cellular_component	DNA-dependent protein kinase complex
C	0070419	cellular_component	nonhomologous end joining complex
C	0080090	biological_process	regulation of primary metabolic process
C	0080135	biological_process	regulation of cellular response to stress
C	0097681	biological_process	double-strand break repair via alternative nonhomologous end joining
C	0106310	molecular_function	protein serine kinase activity
C	0160049	biological_process	negative regulation of cGAS/STING signaling pathway
C	1902036	biological_process	regulation of hematopoietic stem cell differentiation
C	1905221	biological_process	positive regulation of platelet formation
C	2001034	biological_process	positive regulation of double-strand break repair via nonhomologous end joining
F	0000793	cellular_component	condensed chromosome
F	0003677	molecular_function	DNA binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005694	cellular_component	chromosome
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
F	0006281	biological_process	DNA repair
F	0006302	biological_process	double-strand break repair
F	0006303	biological_process	double-strand break repair via nonhomologous end joining
F	0006310	biological_process	DNA recombination
F	0010165	biological_process	response to X-ray
F	0016874	molecular_function	ligase activity
F	0032807	cellular_component	DNA ligase IV complex
F	0033152	biological_process	immunoglobulin V(D)J recombination
F	0035861	cellular_component	site of double-strand break
F	0042802	molecular_function	identical protein binding
F	0051103	biological_process	DNA ligation involved in DNA repair
F	0051351	biological_process	positive regulation of ligase activity
F	0070419	cellular_component	nonhomologous end joining complex
F	0070975	molecular_function	FHA domain binding
F	0071285	biological_process	cellular response to lithium ion
F	1990166	biological_process	protein localization to site of double-strand break
G	0000793	cellular_component	condensed chromosome
G	0003677	molecular_function	DNA binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005694	cellular_component	chromosome
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
G	0006281	biological_process	DNA repair
G	0006302	biological_process	double-strand break repair
G	0006303	biological_process	double-strand break repair via nonhomologous end joining
G	0006310	biological_process	DNA recombination
G	0010165	biological_process	response to X-ray
G	0016874	molecular_function	ligase activity
G	0032807	cellular_component	DNA ligase IV complex
G	0033152	biological_process	immunoglobulin V(D)J recombination
G	0035861	cellular_component	site of double-strand break
G	0042802	molecular_function	identical protein binding
G	0051103	biological_process	DNA ligation involved in DNA repair
G	0051351	biological_process	positive regulation of ligase activity
G	0070419	cellular_component	nonhomologous end joining complex
G	0070975	molecular_function	FHA domain binding
G	0071285	biological_process	cellular response to lithium ion
G	1990166	biological_process	protein localization to site of double-strand break
H	0001650	cellular_component	fibrillar center
H	0003677	molecular_function	DNA binding
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005694	cellular_component	chromosome
H	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
H	0006281	biological_process	DNA repair
H	0006302	biological_process	double-strand break repair
H	0006303	biological_process	double-strand break repair via nonhomologous end joining
H	0007417	biological_process	central nervous system development
H	0010212	biological_process	response to ionizing radiation
H	0030183	biological_process	B cell differentiation
H	0030217	biological_process	T cell differentiation
H	0032807	cellular_component	DNA ligase IV complex
H	0033152	biological_process	immunoglobulin V(D)J recombination
H	0035861	cellular_component	site of double-strand break
H	0045027	molecular_function	DNA end binding
H	0051103	biological_process	DNA ligation involved in DNA repair
H	0051351	biological_process	positive regulation of ligase activity
H	0070182	molecular_function	DNA polymerase binding
H	0070419	cellular_component	nonhomologous end joining complex
I	0001650	cellular_component	fibrillar center
I	0003677	molecular_function	DNA binding
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005694	cellular_component	chromosome
I	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
I	0006281	biological_process	DNA repair
I	0006302	biological_process	double-strand break repair
I	0006303	biological_process	double-strand break repair via nonhomologous end joining
I	0007417	biological_process	central nervous system development
I	0010212	biological_process	response to ionizing radiation
I	0030183	biological_process	B cell differentiation
I	0030217	biological_process	T cell differentiation
I	0032807	cellular_component	DNA ligase IV complex
I	0033152	biological_process	immunoglobulin V(D)J recombination
I	0035861	cellular_component	site of double-strand break
I	0045027	molecular_function	DNA end binding
I	0051103	biological_process	DNA ligation involved in DNA repair
I	0051351	biological_process	positive regulation of ligase activity
I	0070182	molecular_function	DNA polymerase binding
I	0070419	cellular_component	nonhomologous end joining complex
J	0000723	biological_process	telomere maintenance
J	0000725	biological_process	recombinational repair
J	0000781	cellular_component	chromosome, telomeric region
J	0000783	cellular_component	nuclear telomere cap complex
J	0000976	molecular_function	transcription cis-regulatory region binding
J	0002218	biological_process	activation of innate immune response
J	0003677	molecular_function	DNA binding
J	0003678	molecular_function	DNA helicase activity
J	0003684	molecular_function	damaged DNA binding
J	0003690	molecular_function	double-stranded DNA binding
J	0003691	molecular_function	double-stranded telomeric DNA binding
J	0003723	molecular_function	RNA binding
J	0004386	molecular_function	helicase activity
J	0005515	molecular_function	protein binding
J	0005524	molecular_function	ATP binding
J	0005576	cellular_component	extracellular region
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005667	cellular_component	transcription regulator complex
J	0005694	cellular_component	chromosome
J	0005730	cellular_component	nucleolus
J	0005829	cellular_component	cytosol
J	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
J	0006266	biological_process	DNA ligation
J	0006281	biological_process	DNA repair
J	0006303	biological_process	double-strand break repair via nonhomologous end joining
J	0006310	biological_process	DNA recombination
J	0008094	molecular_function	ATP-dependent activity, acting on DNA
J	0010558	biological_process	negative regulation of macromolecule biosynthetic process
J	0016020	cellular_component	membrane
J	0016787	molecular_function	hydrolase activity
J	0016829	molecular_function	lyase activity
J	0016887	molecular_function	ATP hydrolysis activity
J	0030332	molecular_function	cyclin binding
J	0032508	biological_process	DNA duplex unwinding
J	0032991	cellular_component	protein-containing complex
J	0032993	cellular_component	protein-DNA complex
J	0034774	cellular_component	secretory granule lumen
J	0042162	molecular_function	telomeric DNA binding
J	0043564	cellular_component	Ku70:Ku80 complex
J	0044877	molecular_function	protein-containing complex binding
J	0045027	molecular_function	DNA end binding
J	0045087	biological_process	innate immune response
J	0045621	biological_process	positive regulation of lymphocyte differentiation
J	0045860	biological_process	positive regulation of protein kinase activity
J	0045892	biological_process	negative regulation of DNA-templated transcription
J	0045893	biological_process	positive regulation of DNA-templated transcription
J	0045944	biological_process	positive regulation of transcription by RNA polymerase II
J	0048660	biological_process	regulation of smooth muscle cell proliferation
J	0051575	molecular_function	5'-deoxyribose-5-phosphate lyase activity
J	0070418	cellular_component	DNA-dependent protein kinase complex
J	0070419	cellular_component	nonhomologous end joining complex
J	0071475	biological_process	cellular hyperosmotic salinity response
J	0071480	biological_process	cellular response to gamma radiation
J	0071481	biological_process	cellular response to X-ray
J	0097110	molecular_function	scaffold protein binding
J	0097680	biological_process	double-strand break repair via classical nonhomologous end joining
J	1904813	cellular_component	ficolin-1-rich granule lumen
K	0000723	biological_process	telomere maintenance
K	0000725	biological_process	recombinational repair
K	0000781	cellular_component	chromosome, telomeric region
K	0000783	cellular_component	nuclear telomere cap complex
K	0000976	molecular_function	transcription cis-regulatory region binding
K	0002218	biological_process	activation of innate immune response
K	0003677	molecular_function	DNA binding
K	0003678	molecular_function	DNA helicase activity
K	0003684	molecular_function	damaged DNA binding
K	0003690	molecular_function	double-stranded DNA binding
K	0003691	molecular_function	double-stranded telomeric DNA binding
K	0003723	molecular_function	RNA binding
K	0004386	molecular_function	helicase activity
K	0005515	molecular_function	protein binding
K	0005524	molecular_function	ATP binding
K	0005576	cellular_component	extracellular region
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005694	cellular_component	chromosome
K	0005730	cellular_component	nucleolus
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0005886	cellular_component	plasma membrane
K	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
K	0006281	biological_process	DNA repair
K	0006302	biological_process	double-strand break repair
K	0006303	biological_process	double-strand break repair via nonhomologous end joining
K	0006310	biological_process	DNA recombination
K	0006974	biological_process	DNA damage response
K	0008047	molecular_function	enzyme activator activity
K	0008094	molecular_function	ATP-dependent activity, acting on DNA
K	0009410	biological_process	response to xenobiotic stimulus
K	0010558	biological_process	negative regulation of macromolecule biosynthetic process
K	0016020	cellular_component	membrane
K	0016787	molecular_function	hydrolase activity
K	0016887	molecular_function	ATP hydrolysis activity
K	0022008	biological_process	neurogenesis
K	0031625	molecular_function	ubiquitin protein ligase binding
K	0032040	cellular_component	small-subunit processome
K	0032204	biological_process	regulation of telomere maintenance
K	0032212	biological_process	positive regulation of telomere maintenance via telomerase
K	0032508	biological_process	DNA duplex unwinding
K	0032991	cellular_component	protein-containing complex
K	0032993	cellular_component	protein-DNA complex
K	0034462	biological_process	small-subunit processome assembly
K	0034511	molecular_function	U3 snoRNA binding
K	0034774	cellular_component	secretory granule lumen
K	0042162	molecular_function	telomeric DNA binding
K	0042254	biological_process	ribosome biogenesis
K	0043085	biological_process	positive regulation of catalytic activity
K	0043564	cellular_component	Ku70:Ku80 complex
K	0044877	molecular_function	protein-containing complex binding
K	0045027	molecular_function	DNA end binding
K	0045087	biological_process	innate immune response
K	0045860	biological_process	positive regulation of protein kinase activity
K	0045892	biological_process	negative regulation of DNA-templated transcription
K	0048660	biological_process	regulation of smooth muscle cell proliferation
K	0050769	biological_process	positive regulation of neurogenesis
K	0051575	molecular_function	5'-deoxyribose-5-phosphate lyase activity
K	0051973	biological_process	positive regulation of telomerase activity
K	0060218	biological_process	hematopoietic stem cell differentiation
K	0070198	biological_process	protein localization to chromosome, telomeric region
K	0070418	cellular_component	DNA-dependent protein kinase complex
K	0070419	cellular_component	nonhomologous end joining complex
K	0071398	biological_process	cellular response to fatty acid
K	0071425	biological_process	hematopoietic stem cell proliferation
K	0071475	biological_process	cellular hyperosmotic salinity response
K	0071480	biological_process	cellular response to gamma radiation
K	0071481	biological_process	cellular response to X-ray
K	0090734	cellular_component	site of DNA damage
K	1904430	biological_process	negative regulation of t-circle formation
K	1990830	biological_process	cellular response to leukemia inhibitory factor
K	1990904	cellular_component	ribonucleoprotein complex
L	0000460	biological_process	maturation of 5.8S rRNA
L	0000723	biological_process	telomere maintenance
L	0000781	cellular_component	chromosome, telomeric region
L	0000785	cellular_component	chromatin
L	0001756	biological_process	somitogenesis
L	0001933	biological_process	negative regulation of protein phosphorylation
L	0002218	biological_process	activation of innate immune response
L	0002326	biological_process	B cell lineage commitment
L	0002327	biological_process	immature B cell differentiation
L	0002328	biological_process	pro-B cell differentiation
L	0002360	biological_process	T cell lineage commitment
L	0003677	molecular_function	DNA binding
L	0003690	molecular_function	double-stranded DNA binding
L	0003723	molecular_function	RNA binding
L	0004672	molecular_function	protein kinase activity
L	0004674	molecular_function	protein serine/threonine kinase activity
L	0004677	molecular_function	DNA-dependent protein kinase activity
L	0005515	molecular_function	protein binding
L	0005524	molecular_function	ATP binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005667	cellular_component	transcription regulator complex
L	0005730	cellular_component	nucleolus
L	0005829	cellular_component	cytosol
L	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
L	0006281	biological_process	DNA repair
L	0006302	biological_process	double-strand break repair
L	0006303	biological_process	double-strand break repair via nonhomologous end joining
L	0006310	biological_process	DNA recombination
L	0006338	biological_process	chromatin remodeling
L	0006468	biological_process	protein phosphorylation
L	0006974	biological_process	DNA damage response
L	0007420	biological_process	brain development
L	0007507	biological_process	heart development
L	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
L	0010212	biological_process	response to ionizing radiation
L	0010332	biological_process	response to gamma radiation
L	0016020	cellular_component	membrane
L	0016233	biological_process	telomere capping
L	0016301	molecular_function	kinase activity
L	0018105	biological_process	peptidyl-serine phosphorylation
L	0018107	biological_process	peptidyl-threonine phosphorylation
L	0019899	molecular_function	enzyme binding
L	0019904	molecular_function	protein domain specific binding
L	0030098	biological_process	lymphocyte differentiation
L	0031571	biological_process	mitotic G1 DNA damage checkpoint signaling
L	0031648	biological_process	protein destabilization
L	0032040	cellular_component	small-subunit processome
L	0032869	biological_process	cellular response to insulin stimulus
L	0032991	cellular_component	protein-containing complex
L	0032993	cellular_component	protein-DNA complex
L	0033077	biological_process	T cell differentiation in thymus
L	0033151	biological_process	V(D)J recombination
L	0033152	biological_process	immunoglobulin V(D)J recombination
L	0033153	biological_process	T cell receptor V(D)J recombination
L	0034462	biological_process	small-subunit processome assembly
L	0034511	molecular_function	U3 snoRNA binding
L	0035234	biological_process	ectopic germ cell programmed cell death
L	0035979	molecular_function	histone H2AXS139 kinase activity
L	0036211	biological_process	protein modification process
L	0042254	biological_process	ribosome biogenesis
L	0042752	biological_process	regulation of circadian rhythm
L	0043065	biological_process	positive regulation of apoptotic process
L	0043066	biological_process	negative regulation of apoptotic process
L	0045087	biological_process	innate immune response
L	0045621	biological_process	positive regulation of lymphocyte differentiation
L	0045648	biological_process	positive regulation of erythrocyte differentiation
L	0045727	biological_process	positive regulation of translation
L	0045944	biological_process	positive regulation of transcription by RNA polymerase II
L	0048511	biological_process	rhythmic process
L	0048660	biological_process	regulation of smooth muscle cell proliferation
L	0050678	biological_process	regulation of epithelial cell proliferation
L	0060255	biological_process	regulation of macromolecule metabolic process
L	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
L	0070418	cellular_component	DNA-dependent protein kinase complex
L	0070419	cellular_component	nonhomologous end joining complex
L	0080090	biological_process	regulation of primary metabolic process
L	0080135	biological_process	regulation of cellular response to stress
L	0097681	biological_process	double-strand break repair via alternative nonhomologous end joining
L	0106310	molecular_function	protein serine kinase activity
L	0160049	biological_process	negative regulation of cGAS/STING signaling pathway
L	1902036	biological_process	regulation of hematopoietic stem cell differentiation
L	1905221	biological_process	positive regulation of platelet formation
L	2001034	biological_process	positive regulation of double-strand break repair via nonhomologous end joining
O	0000793	cellular_component	condensed chromosome
O	0003677	molecular_function	DNA binding
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005694	cellular_component	chromosome
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
O	0006281	biological_process	DNA repair
O	0006302	biological_process	double-strand break repair
O	0006303	biological_process	double-strand break repair via nonhomologous end joining
O	0006310	biological_process	DNA recombination
O	0010165	biological_process	response to X-ray
O	0016874	molecular_function	ligase activity
O	0032807	cellular_component	DNA ligase IV complex
O	0033152	biological_process	immunoglobulin V(D)J recombination
O	0035861	cellular_component	site of double-strand break
O	0042802	molecular_function	identical protein binding
O	0051103	biological_process	DNA ligation involved in DNA repair
O	0051351	biological_process	positive regulation of ligase activity
O	0070419	cellular_component	nonhomologous end joining complex
O	0070975	molecular_function	FHA domain binding
O	0071285	biological_process	cellular response to lithium ion
O	1990166	biological_process	protein localization to site of double-strand break
P	0000793	cellular_component	condensed chromosome
P	0003677	molecular_function	DNA binding
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005694	cellular_component	chromosome
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
P	0006281	biological_process	DNA repair
P	0006302	biological_process	double-strand break repair
P	0006303	biological_process	double-strand break repair via nonhomologous end joining
P	0006310	biological_process	DNA recombination
P	0010165	biological_process	response to X-ray
P	0016874	molecular_function	ligase activity
P	0032807	cellular_component	DNA ligase IV complex
P	0033152	biological_process	immunoglobulin V(D)J recombination
P	0035861	cellular_component	site of double-strand break
P	0042802	molecular_function	identical protein binding
P	0051103	biological_process	DNA ligation involved in DNA repair
P	0051351	biological_process	positive regulation of ligase activity
P	0070419	cellular_component	nonhomologous end joining complex
P	0070975	molecular_function	FHA domain binding
P	0071285	biological_process	cellular response to lithium ion
P	1990166	biological_process	protein localization to site of double-strand break
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0005694	cellular_component	chromosome
S	0005737	cellular_component	cytoplasm
S	0006281	biological_process	DNA repair
S	0006303	biological_process	double-strand break repair via nonhomologous end joining
S	0006974	biological_process	DNA damage response
S	0035861	cellular_component	site of double-strand break
S	0042803	molecular_function	protein homodimerization activity
S	0043564	cellular_component	Ku70:Ku80 complex
S	0060090	molecular_function	molecular adaptor activity
S	0070182	molecular_function	DNA polymerase binding
S	0070419	cellular_component	nonhomologous end joining complex
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0005654	cellular_component	nucleoplasm
T	0005694	cellular_component	chromosome
T	0005737	cellular_component	cytoplasm
T	0006281	biological_process	DNA repair
T	0006303	biological_process	double-strand break repair via nonhomologous end joining
T	0006974	biological_process	DNA damage response
T	0035861	cellular_component	site of double-strand break
T	0042803	molecular_function	protein homodimerization activity
T	0043564	cellular_component	Ku70:Ku80 complex
T	0060090	molecular_function	molecular adaptor activity
T	0070182	molecular_function	DNA polymerase binding
T	0070419	cellular_component	nonhomologous end joining complex
X	0000012	biological_process	single strand break repair
X	0000287	molecular_function	magnesium ion binding
X	0000781	cellular_component	chromosome, telomeric region
X	0000793	cellular_component	condensed chromosome
X	0001701	biological_process	in utero embryonic development
X	0002328	biological_process	pro-B cell differentiation
X	0003677	molecular_function	DNA binding
X	0003909	molecular_function	DNA ligase activity
X	0003910	molecular_function	DNA ligase (ATP) activity
X	0005515	molecular_function	protein binding
X	0005524	molecular_function	ATP binding
X	0005634	cellular_component	nucleus
X	0005654	cellular_component	nucleoplasm
X	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
X	0006266	biological_process	DNA ligation
X	0006281	biological_process	DNA repair
X	0006297	biological_process	nucleotide-excision repair, DNA gap filling
X	0006302	biological_process	double-strand break repair
X	0006303	biological_process	double-strand break repair via nonhomologous end joining
X	0006310	biological_process	DNA recombination
X	0007417	biological_process	central nervous system development
X	0008283	biological_process	cell population proliferation
X	0010165	biological_process	response to X-ray
X	0010212	biological_process	response to ionizing radiation
X	0010332	biological_process	response to gamma radiation
X	0016874	molecular_function	ligase activity
X	0022008	biological_process	neurogenesis
X	0032807	cellular_component	DNA ligase IV complex
X	0033077	biological_process	T cell differentiation in thymus
X	0033151	biological_process	V(D)J recombination
X	0033152	biological_process	immunoglobulin V(D)J recombination
X	0033153	biological_process	T cell receptor V(D)J recombination
X	0035019	biological_process	somatic stem cell population maintenance
X	0043231	cellular_component	intracellular membrane-bounded organelle
X	0043524	biological_process	negative regulation of neuron apoptotic process
X	0045190	biological_process	isotype switching
X	0046872	molecular_function	metal ion binding
X	0048144	biological_process	fibroblast proliferation
X	0048146	biological_process	positive regulation of fibroblast proliferation
X	0050769	biological_process	positive regulation of neurogenesis
X	0051102	biological_process	DNA ligation involved in DNA recombination
X	0051103	biological_process	DNA ligation involved in DNA repair
X	0051276	biological_process	chromosome organization
X	0051301	biological_process	cell division
X	0051402	biological_process	neuron apoptotic process
X	0070419	cellular_component	nonhomologous end joining complex
X	0071285	biological_process	cellular response to lithium ion
X	0071479	biological_process	cellular response to ionizing radiation
X	0071897	biological_process	DNA biosynthetic process
X	0072089	biological_process	stem cell proliferation
X	0075713	biological_process	establishment of integrated proviral latency
X	0097680	biological_process	double-strand break repair via classical nonhomologous end joining
X	1904155	biological_process	DN2 thymocyte differentiation
X	2001252	biological_process	positive regulation of chromosome organization
Y	0000012	biological_process	single strand break repair
Y	0000287	molecular_function	magnesium ion binding
Y	0000781	cellular_component	chromosome, telomeric region
Y	0000793	cellular_component	condensed chromosome
Y	0001701	biological_process	in utero embryonic development
Y	0002328	biological_process	pro-B cell differentiation
Y	0003677	molecular_function	DNA binding
Y	0003909	molecular_function	DNA ligase activity
Y	0003910	molecular_function	DNA ligase (ATP) activity
Y	0005515	molecular_function	protein binding
Y	0005524	molecular_function	ATP binding
Y	0005634	cellular_component	nucleus
Y	0005654	cellular_component	nucleoplasm
Y	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
Y	0006266	biological_process	DNA ligation
Y	0006281	biological_process	DNA repair
Y	0006297	biological_process	nucleotide-excision repair, DNA gap filling
Y	0006302	biological_process	double-strand break repair
Y	0006303	biological_process	double-strand break repair via nonhomologous end joining
Y	0006310	biological_process	DNA recombination
Y	0007417	biological_process	central nervous system development
Y	0008283	biological_process	cell population proliferation
Y	0010165	biological_process	response to X-ray
Y	0010212	biological_process	response to ionizing radiation
Y	0010332	biological_process	response to gamma radiation
Y	0016874	molecular_function	ligase activity
Y	0022008	biological_process	neurogenesis
Y	0032807	cellular_component	DNA ligase IV complex
Y	0033077	biological_process	T cell differentiation in thymus
Y	0033151	biological_process	V(D)J recombination
Y	0033152	biological_process	immunoglobulin V(D)J recombination
Y	0033153	biological_process	T cell receptor V(D)J recombination
Y	0035019	biological_process	somatic stem cell population maintenance
Y	0043231	cellular_component	intracellular membrane-bounded organelle
Y	0043524	biological_process	negative regulation of neuron apoptotic process
Y	0045190	biological_process	isotype switching
Y	0046872	molecular_function	metal ion binding
Y	0048144	biological_process	fibroblast proliferation
Y	0048146	biological_process	positive regulation of fibroblast proliferation
Y	0050769	biological_process	positive regulation of neurogenesis
Y	0051102	biological_process	DNA ligation involved in DNA recombination
Y	0051103	biological_process	DNA ligation involved in DNA repair
Y	0051276	biological_process	chromosome organization
Y	0051301	biological_process	cell division
Y	0051402	biological_process	neuron apoptotic process
Y	0070419	cellular_component	nonhomologous end joining complex
Y	0071285	biological_process	cellular response to lithium ion
Y	0071479	biological_process	cellular response to ionizing radiation
Y	0071897	biological_process	DNA biosynthetic process
Y	0072089	biological_process	stem cell proliferation
Y	0075713	biological_process	establishment of integrated proviral latency
Y	0097680	biological_process	double-strand break repair via classical nonhomologous end joining
Y	1904155	biological_process	DN2 thymocyte differentiation
Y	2001252	biological_process	positive regulation of chromosome organization

Functional Information from PROSITE/UniProt

site_id	PS00333
Number of Residues	25
Details	DNA_LIGASE_A2 ATP-dependent DNA ligase signature 2. EGIMVKqplsi...YKpdk...RgegwlKIK

Chain	Residue	Details
X	GLU427-LYS451

---

site_id	PS00697
Number of Residues	9
Details	DNA_LIGASE_A1 ATP-dependent DNA ligase AMP-binding site. ETKLDGERM

Chain	Residue	Details
X	GLU271-MET279

---

site_id	PS00915
Number of Residues	15
Details	PI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. VKgg.EDLRQDqrveQ

Chain	Residue	Details
L	VAL3752-GLN3766

---

site_id	PS00916
Number of Residues	21
Details	PI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. ShAlicIshWILgIgDRHlnN

Chain	Residue	Details
L	SER3907-ASN3927

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	SITE: Cleavage; by caspase-3 => ECO:0000305|PubMed:33725486

Chain	Residue	Details
F	ASP265
B	LYS665
G	ASP265
O	ASP265
P	ASP265
K	LYS665
B	LYS144
B	LYS265
B	LYS332
B	LYS660

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PRKDC => ECO:0000269|PubMed:14599745

Chain	Residue	Details
F	SER53
L	LYS3642
C	LYS117
C	LYS828
C	LYS1209
C	LYS1970
C	LYS2259
C	LYS3241
C	LYS3260
C	LYS3621
C	LYS3638
G	SER53
C	LYS3642
O	SER53
P	SER53
I	SER132
I	SER203
I	SER245
I	SER251
L	LYS3638

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	MOD_RES: Phosphoserine; by PRKDC => ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:22228831, ECO:0000269|PubMed:28500754

Chain	Residue	Details
F	SER193
C	SER841
C	SER1065
C	SER2789
C	SER3731
C	SER3821
F	SER315
G	SER193
G	SER315
O	SER193
O	SER315
P	SER193
P	SER315
C	SER687

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
F	TYR229
G	TYR229
O	TYR229
P	TYR229
A	LYS31
A	LYS331
A	LYS338
A	LYS461

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:28453785

Chain	Residue	Details
F	SER232
G	SER232
O	SER232
P	SER232

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: Phosphothreonine; by CK2 => ECO:0000269|PubMed:15385968, ECO:0000269|PubMed:20852255, ECO:0000269|PubMed:28453785, ECO:0007744|PubMed:24275569

Chain	Residue	Details
F	THR233
G	THR233
O	THR233
P	THR233

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
F	SER237
G	SER237
O	SER237
P	SER237

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231

Chain	Residue	Details
F	SER256
B	LYS532
B	LYS534
B	LYS566
B	LYS669
B	LYS688
G	SER256
O	SER256
P	SER256
K	LYS566
K	LYS669
K	LYS688
B	LYS195

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PRKDC => ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:15177042, ECO:0000269|PubMed:22228831, ECO:0000269|PubMed:28500754, ECO:0000269|PubMed:30247612, ECO:0007744|PubMed:23186163

Chain	Residue	Details
F	SER260
G	SER260
O	SER260
P	SER260

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PRKDC => ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:22228831

Chain	Residue	Details
F	SER303
G	SER303
O	SER303
P	SER303

---

site_id	SWS_FT_FI11
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PRKDC => ECO:0000269|PubMed:28500754, ECO:0007744|PubMed:23186163

Chain	Residue	Details
F	SER304
G	SER304
O	SER304
P	SER304

---

site_id	SWS_FT_FI12
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PRKDC => ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:15177042, ECO:0000269|PubMed:22228831, ECO:0000269|PubMed:26666690, ECO:0000269|PubMed:28500754, ECO:0007744|PubMed:23186163

Chain	Residue	Details
F	SER320
G	SER320
O	SER320
P	SER320

---

site_id	SWS_FT_FI13
Number of Residues	4
Details	MOD_RES: Phosphothreonine; by PRKDC => ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:22228831, ECO:0000269|PubMed:28500754

Chain	Residue	Details
F	THR323
G	THR323
O	THR323
P	THR323

---

site_id	SWS_FT_FI14
Number of Residues	8
Details	MOD_RES: Phosphoserine; by PRKDC => ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:22228831, ECO:0000269|PubMed:26774286, ECO:0000269|PubMed:28500754, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332

Chain	Residue	Details
F	SER327
F	SER328
G	SER327
G	SER328
O	SER327
O	SER328
P	SER327
P	SER328

---

site_id	SWS_FT_FI15
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269|PubMed:16478998

Chain	Residue	Details
F	LYS210
G	LYS210
O	LYS210
P	LYS210

---

site_id	SWS_FT_FI16
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:26774286

Chain	Residue	Details
F	LYS296
G	LYS296
O	LYS296
P	LYS296

---