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8ENT

Interleukin-21 signaling complex with IL-21R and IL-2Rg

Functional Information from GO Data
ChainGOidnamespacecontents
A0001819biological_processpositive regulation of cytokine production
A0002314biological_processgerminal center B cell differentiation
A0002639biological_processpositive regulation of immunoglobulin production
A0005125molecular_functioncytokine activity
A0005126molecular_functioncytokine receptor binding
A0005134molecular_functioninterleukin-2 receptor binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0006955biological_processimmune response
A0007165biological_processsignal transduction
A0007260biological_processtyrosine phosphorylation of STAT protein
A0008284biological_processpositive regulation of cell population proliferation
A0030890biological_processpositive regulation of B cell proliferation
A0032729biological_processpositive regulation of type II interferon production
A0032740biological_processpositive regulation of interleukin-17 production
A0034105biological_processpositive regulation of tissue remodeling
A0042102biological_processpositive regulation of T cell proliferation
A0042531biological_processpositive regulation of tyrosine phosphorylation of STAT protein
A0045954biological_processpositive regulation of natural killer cell mediated cytotoxicity
A0048469biological_processcell maturation
A0050729biological_processpositive regulation of inflammatory response
A0051607biological_processdefense response to virus
A0061470biological_processT follicular helper cell differentiation
A0098586biological_processcellular response to virus
B0004896molecular_functioncytokine receptor activity
B0016020cellular_componentmembrane
C0004896molecular_functioncytokine receptor activity
C0016020cellular_componentmembrane
D0001819biological_processpositive regulation of cytokine production
D0002314biological_processgerminal center B cell differentiation
D0002639biological_processpositive regulation of immunoglobulin production
D0005125molecular_functioncytokine activity
D0005126molecular_functioncytokine receptor binding
D0005134molecular_functioninterleukin-2 receptor binding
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0006955biological_processimmune response
D0007165biological_processsignal transduction
D0007260biological_processtyrosine phosphorylation of STAT protein
D0008284biological_processpositive regulation of cell population proliferation
D0030890biological_processpositive regulation of B cell proliferation
D0032729biological_processpositive regulation of type II interferon production
D0032740biological_processpositive regulation of interleukin-17 production
D0034105biological_processpositive regulation of tissue remodeling
D0042102biological_processpositive regulation of T cell proliferation
D0042531biological_processpositive regulation of tyrosine phosphorylation of STAT protein
D0045954biological_processpositive regulation of natural killer cell mediated cytotoxicity
D0048469biological_processcell maturation
D0050729biological_processpositive regulation of inflammatory response
D0051607biological_processdefense response to virus
D0061470biological_processT follicular helper cell differentiation
D0098586biological_processcellular response to virus
E0004896molecular_functioncytokine receptor activity
E0016020cellular_componentmembrane
F0004896molecular_functioncytokine receptor activity
F0016020cellular_componentmembrane
G0001819biological_processpositive regulation of cytokine production
G0002314biological_processgerminal center B cell differentiation
G0002639biological_processpositive regulation of immunoglobulin production
G0005125molecular_functioncytokine activity
G0005126molecular_functioncytokine receptor binding
G0005134molecular_functioninterleukin-2 receptor binding
G0005515molecular_functionprotein binding
G0005576cellular_componentextracellular region
G0005615cellular_componentextracellular space
G0006955biological_processimmune response
G0007165biological_processsignal transduction
G0007260biological_processtyrosine phosphorylation of STAT protein
G0008284biological_processpositive regulation of cell population proliferation
G0030890biological_processpositive regulation of B cell proliferation
G0032729biological_processpositive regulation of type II interferon production
G0032740biological_processpositive regulation of interleukin-17 production
G0034105biological_processpositive regulation of tissue remodeling
G0042102biological_processpositive regulation of T cell proliferation
G0042531biological_processpositive regulation of tyrosine phosphorylation of STAT protein
G0045954biological_processpositive regulation of natural killer cell mediated cytotoxicity
G0048469biological_processcell maturation
G0050729biological_processpositive regulation of inflammatory response
G0051607biological_processdefense response to virus
G0061470biological_processT follicular helper cell differentiation
G0098586biological_processcellular response to virus
H0004896molecular_functioncytokine receptor activity
H0016020cellular_componentmembrane
I0004896molecular_functioncytokine receptor activity
I0016020cellular_componentmembrane
J0001819biological_processpositive regulation of cytokine production
J0002314biological_processgerminal center B cell differentiation
J0002639biological_processpositive regulation of immunoglobulin production
J0005125molecular_functioncytokine activity
J0005126molecular_functioncytokine receptor binding
J0005134molecular_functioninterleukin-2 receptor binding
J0005515molecular_functionprotein binding
J0005576cellular_componentextracellular region
J0005615cellular_componentextracellular space
J0006955biological_processimmune response
J0007165biological_processsignal transduction
J0007260biological_processtyrosine phosphorylation of STAT protein
J0008284biological_processpositive regulation of cell population proliferation
J0030890biological_processpositive regulation of B cell proliferation
J0032729biological_processpositive regulation of type II interferon production
J0032740biological_processpositive regulation of interleukin-17 production
J0034105biological_processpositive regulation of tissue remodeling
J0042102biological_processpositive regulation of T cell proliferation
J0042531biological_processpositive regulation of tyrosine phosphorylation of STAT protein
J0045954biological_processpositive regulation of natural killer cell mediated cytotoxicity
J0048469biological_processcell maturation
J0050729biological_processpositive regulation of inflammatory response
J0051607biological_processdefense response to virus
J0061470biological_processT follicular helper cell differentiation
J0098586biological_processcellular response to virus
K0004896molecular_functioncytokine receptor activity
K0016020cellular_componentmembrane
Functional Information from PROSITE/UniProt
site_idPS01355
Number of Residues34
DetailsHEMATOPO_REC_S_F1 Short hematopoietin receptor family 1 signature. FrkdssyelqVRagpmpgssyqgt........WSeWSdpviF
ChainResidueDetails
BPHE171-PHE204
CVAL191-TRP224

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues9
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16293754, ECO:0000269|PubMed:16477002
ChainResidueDetails
CASN49
CASN62
CASN137
FASN49
FASN62
FASN137
IASN49
IASN62
IASN137

site_idSWS_FT_FI2
Number of Residues6
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
CGLN53
HGLN85
HASP106
HGLN116
KGLN78
KGLN85
KASP106
KGLN116
CASN227
FGLN53
FASN227
IGLN53
IASN227
EASP106
EGLN116
HGLN78

site_idSWS_FT_FI3
Number of Residues4
DetailsCARBOHYD: C-linked (Man) tryptophan => ECO:0000269|PubMed:22235133
ChainResidueDetails
BTRP195
ETRP195
HTRP195
KTRP195

221716

PDB entries from 2024-06-26

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