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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8ENT

Interleukin-21 signaling complex with IL-21R and IL-2Rg

Functional Information from GO Data
ChainGOidnamespacecontents
A0001779biological_processnatural killer cell differentiation
A0001819biological_processpositive regulation of cytokine production
A0002314biological_processgerminal center B cell differentiation
A0002639biological_processpositive regulation of immunoglobulin production
A0002729biological_processpositive regulation of natural killer cell cytokine production
A0005125molecular_functioncytokine activity
A0005126molecular_functioncytokine receptor binding
A0005134molecular_functioninterleukin-2 receptor binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0006952biological_processdefense response
A0006955biological_processimmune response
A0007165biological_processsignal transduction
A0007260biological_processtyrosine phosphorylation of STAT protein
A0008284biological_processpositive regulation of cell population proliferation
A0009615biological_processresponse to virus
A0030890biological_processpositive regulation of B cell proliferation
A0032729biological_processpositive regulation of type II interferon production
A0032733biological_processpositive regulation of interleukin-10 production
A0032740biological_processpositive regulation of interleukin-17 production
A0032825biological_processpositive regulation of natural killer cell differentiation
A0034105biological_processpositive regulation of tissue remodeling
A0042102biological_processpositive regulation of T cell proliferation
A0042267biological_processnatural killer cell mediated cytotoxicity
A0042531biological_processpositive regulation of tyrosine phosphorylation of STAT protein
A0045954biological_processpositive regulation of natural killer cell mediated cytotoxicity
A0048468biological_processcell development
A0048469biological_processcell maturation
A0050729biological_processpositive regulation of inflammatory response
A0051251biological_processpositive regulation of lymphocyte activation
A0051607biological_processdefense response to virus
A0061470biological_processT follicular helper cell differentiation
A0098586biological_processcellular response to virus
B0004896molecular_functioncytokine receptor activity
B0016020cellular_componentmembrane
C0004896molecular_functioncytokine receptor activity
C0016020cellular_componentmembrane
D0001779biological_processnatural killer cell differentiation
D0001819biological_processpositive regulation of cytokine production
D0002314biological_processgerminal center B cell differentiation
D0002639biological_processpositive regulation of immunoglobulin production
D0002729biological_processpositive regulation of natural killer cell cytokine production
D0005125molecular_functioncytokine activity
D0005126molecular_functioncytokine receptor binding
D0005134molecular_functioninterleukin-2 receptor binding
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0006952biological_processdefense response
D0006955biological_processimmune response
D0007165biological_processsignal transduction
D0007260biological_processtyrosine phosphorylation of STAT protein
D0008284biological_processpositive regulation of cell population proliferation
D0009615biological_processresponse to virus
D0030890biological_processpositive regulation of B cell proliferation
D0032729biological_processpositive regulation of type II interferon production
D0032733biological_processpositive regulation of interleukin-10 production
D0032740biological_processpositive regulation of interleukin-17 production
D0032825biological_processpositive regulation of natural killer cell differentiation
D0034105biological_processpositive regulation of tissue remodeling
D0042102biological_processpositive regulation of T cell proliferation
D0042267biological_processnatural killer cell mediated cytotoxicity
D0042531biological_processpositive regulation of tyrosine phosphorylation of STAT protein
D0045954biological_processpositive regulation of natural killer cell mediated cytotoxicity
D0048468biological_processcell development
D0048469biological_processcell maturation
D0050729biological_processpositive regulation of inflammatory response
D0051251biological_processpositive regulation of lymphocyte activation
D0051607biological_processdefense response to virus
D0061470biological_processT follicular helper cell differentiation
D0098586biological_processcellular response to virus
E0004896molecular_functioncytokine receptor activity
E0016020cellular_componentmembrane
F0004896molecular_functioncytokine receptor activity
F0016020cellular_componentmembrane
G0001779biological_processnatural killer cell differentiation
G0001819biological_processpositive regulation of cytokine production
G0002314biological_processgerminal center B cell differentiation
G0002639biological_processpositive regulation of immunoglobulin production
G0002729biological_processpositive regulation of natural killer cell cytokine production
G0005125molecular_functioncytokine activity
G0005126molecular_functioncytokine receptor binding
G0005134molecular_functioninterleukin-2 receptor binding
G0005515molecular_functionprotein binding
G0005576cellular_componentextracellular region
G0005615cellular_componentextracellular space
G0006952biological_processdefense response
G0006955biological_processimmune response
G0007165biological_processsignal transduction
G0007260biological_processtyrosine phosphorylation of STAT protein
G0008284biological_processpositive regulation of cell population proliferation
G0009615biological_processresponse to virus
G0030890biological_processpositive regulation of B cell proliferation
G0032729biological_processpositive regulation of type II interferon production
G0032733biological_processpositive regulation of interleukin-10 production
G0032740biological_processpositive regulation of interleukin-17 production
G0032825biological_processpositive regulation of natural killer cell differentiation
G0034105biological_processpositive regulation of tissue remodeling
G0042102biological_processpositive regulation of T cell proliferation
G0042267biological_processnatural killer cell mediated cytotoxicity
G0042531biological_processpositive regulation of tyrosine phosphorylation of STAT protein
G0045954biological_processpositive regulation of natural killer cell mediated cytotoxicity
G0048468biological_processcell development
G0048469biological_processcell maturation
G0050729biological_processpositive regulation of inflammatory response
G0051251biological_processpositive regulation of lymphocyte activation
G0051607biological_processdefense response to virus
G0061470biological_processT follicular helper cell differentiation
G0098586biological_processcellular response to virus
H0004896molecular_functioncytokine receptor activity
H0016020cellular_componentmembrane
I0004896molecular_functioncytokine receptor activity
I0016020cellular_componentmembrane
J0001779biological_processnatural killer cell differentiation
J0001819biological_processpositive regulation of cytokine production
J0002314biological_processgerminal center B cell differentiation
J0002639biological_processpositive regulation of immunoglobulin production
J0002729biological_processpositive regulation of natural killer cell cytokine production
J0005125molecular_functioncytokine activity
J0005126molecular_functioncytokine receptor binding
J0005134molecular_functioninterleukin-2 receptor binding
J0005515molecular_functionprotein binding
J0005576cellular_componentextracellular region
J0005615cellular_componentextracellular space
J0006952biological_processdefense response
J0006955biological_processimmune response
J0007165biological_processsignal transduction
J0007260biological_processtyrosine phosphorylation of STAT protein
J0008284biological_processpositive regulation of cell population proliferation
J0009615biological_processresponse to virus
J0030890biological_processpositive regulation of B cell proliferation
J0032729biological_processpositive regulation of type II interferon production
J0032733biological_processpositive regulation of interleukin-10 production
J0032740biological_processpositive regulation of interleukin-17 production
J0032825biological_processpositive regulation of natural killer cell differentiation
J0034105biological_processpositive regulation of tissue remodeling
J0042102biological_processpositive regulation of T cell proliferation
J0042267biological_processnatural killer cell mediated cytotoxicity
J0042531biological_processpositive regulation of tyrosine phosphorylation of STAT protein
J0045954biological_processpositive regulation of natural killer cell mediated cytotoxicity
J0048468biological_processcell development
J0048469biological_processcell maturation
J0050729biological_processpositive regulation of inflammatory response
J0051251biological_processpositive regulation of lymphocyte activation
J0051607biological_processdefense response to virus
J0061470biological_processT follicular helper cell differentiation
J0098586biological_processcellular response to virus
K0004896molecular_functioncytokine receptor activity
K0016020cellular_componentmembrane
Functional Information from PROSITE/UniProt
site_idPS01355
Number of Residues34
DetailsHEMATOPO_REC_S_F1 Short hematopoietin receptor family 1 signature. FrkdssyelqVRagpmpgssyqgt........WSeWSdpviF
ChainResidueDetails
BPHE171-PHE204
CVAL191-TRP224
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues42
DetailsRegion: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues24
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues291
DetailsDomain: {"description":"Fibronectin type-III 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues218
DetailsDomain: {"description":"Fibronectin type-III 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues28
DetailsMotif: {"description":"WSXWS motif"}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"22235133","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues4
DetailsGlycosylation: {"description":"C-linked (Man) tryptophan","evidences":[{"source":"PubMed","id":"22235133","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues9
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16293754","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16477002","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

243911

PDB entries from 2025-10-29

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