8E2K

Cryo-EM structure of BIRC6/HtrA2-S306A

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000922	cellular_component	spindle pole
A	0001890	biological_process	placenta development
A	0004842	molecular_function	ubiquitin-protein transferase activity
A	0004869	molecular_function	cysteine-type endopeptidase inhibitor activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005768	cellular_component	endosome
A	0005794	cellular_component	Golgi apparatus
A	0005802	cellular_component	trans-Golgi network
A	0005813	cellular_component	centrosome
A	0005815	cellular_component	microtubule organizing center
A	0005829	cellular_component	cytosol
A	0006468	biological_process	protein phosphorylation
A	0006915	biological_process	apoptotic process
A	0008283	biological_process	cell population proliferation
A	0008284	biological_process	positive regulation of cell population proliferation
A	0016020	cellular_component	membrane
A	0016567	biological_process	protein ubiquitination
A	0016740	molecular_function	transferase activity
A	0030414	molecular_function	peptidase inhibitor activity
A	0030496	cellular_component	midbody
A	0032465	biological_process	regulation of cytokinesis
A	0042127	biological_process	regulation of cell population proliferation
A	0043066	biological_process	negative regulation of apoptotic process
A	0046872	molecular_function	metal ion binding
A	0051301	biological_process	cell division
A	0060711	biological_process	labyrinthine layer development
A	0061631	molecular_function	ubiquitin conjugating enzyme activity
A	0090543	cellular_component	Flemming body
A	2001237	biological_process	negative regulation of extrinsic apoptotic signaling pathway
B	0000922	cellular_component	spindle pole
B	0001890	biological_process	placenta development
B	0004842	molecular_function	ubiquitin-protein transferase activity
B	0004869	molecular_function	cysteine-type endopeptidase inhibitor activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005768	cellular_component	endosome
B	0005794	cellular_component	Golgi apparatus
B	0005802	cellular_component	trans-Golgi network
B	0005813	cellular_component	centrosome
B	0005815	cellular_component	microtubule organizing center
B	0005829	cellular_component	cytosol
B	0006468	biological_process	protein phosphorylation
B	0006915	biological_process	apoptotic process
B	0008283	biological_process	cell population proliferation
B	0008284	biological_process	positive regulation of cell population proliferation
B	0016020	cellular_component	membrane
B	0016567	biological_process	protein ubiquitination
B	0016740	molecular_function	transferase activity
B	0030414	molecular_function	peptidase inhibitor activity
B	0030496	cellular_component	midbody
B	0032465	biological_process	regulation of cytokinesis
B	0042127	biological_process	regulation of cell population proliferation
B	0043066	biological_process	negative regulation of apoptotic process
B	0046872	molecular_function	metal ion binding
B	0051301	biological_process	cell division
B	0060711	biological_process	labyrinthine layer development
B	0061631	molecular_function	ubiquitin conjugating enzyme activity
B	0090543	cellular_component	Flemming body
B	2001237	biological_process	negative regulation of extrinsic apoptotic signaling pathway
X	0004252	molecular_function	serine-type endopeptidase activity
X	0006508	biological_process	proteolysis
Y	0004252	molecular_function	serine-type endopeptidase activity
Y	0006508	biological_process	proteolysis
Z	0004252	molecular_function	serine-type endopeptidase activity
Z	0006508	biological_process	proteolysis

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	76
Details	Repeat: {"description":"WD 1","evidences":[{"source":"PubMed","id":"36758104","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36758105","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36758106","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E2G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8E2I","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	94
Details	Repeat: {"description":"WD 3","evidences":[{"source":"PubMed","id":"36758104","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36758105","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36758106","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E2G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8E2I","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	40
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Region: {"description":"HRRAR loop; important for DIABLO/SMAC and HTRA2 binding","evidences":[{"source":"PubMed","id":"36758105","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36758106","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8ATO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8AUK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8AUW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	18
Details	Compositional bias: {"description":"Basic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"36758105","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8ATU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ATX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8AUK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8AUW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	81
Details	Domain: {"description":"PDZ","evidences":[{"source":"PROSITE-ProRule","id":"PRU00143","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	9
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"11967569","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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