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8DU5

Murine sialidase-1 (NEU1)

Functional Information from GO Data
ChainGOidnamespacecontents
A0004308molecular_functionexo-alpha-sialidase activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005764cellular_componentlysosome
A0005765cellular_componentlysosomal membrane
A0005886cellular_componentplasma membrane
A0006689biological_processganglioside catabolic process
A0009313biological_processoligosaccharide catabolic process
A0009986cellular_componentcell surface
A0010976biological_processpositive regulation of neuron projection development
A0016020cellular_componentmembrane
A0016042biological_processlipid catabolic process
A0016798molecular_functionhydrolase activity, acting on glycosyl bonds
A0016997molecular_functionalpha-sialidase activity
A0030054cellular_componentcell junction
A0031410cellular_componentcytoplasmic vesicle
A0043202cellular_componentlysosomal lumen
A0043231cellular_componentintracellular membrane-bounded organelle
A0052794molecular_functionexo-alpha-(2->3)-sialidase activity
A0052795molecular_functionexo-alpha-(2->6)-sialidase activity
A0052796molecular_functionexo-alpha-(2->8)-sialidase activity
A2000291biological_processregulation of myoblast proliferation
B0004308molecular_functionexo-alpha-sialidase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005764cellular_componentlysosome
B0005765cellular_componentlysosomal membrane
B0005886cellular_componentplasma membrane
B0006689biological_processganglioside catabolic process
B0009313biological_processoligosaccharide catabolic process
B0009986cellular_componentcell surface
B0010976biological_processpositive regulation of neuron projection development
B0016020cellular_componentmembrane
B0016042biological_processlipid catabolic process
B0016798molecular_functionhydrolase activity, acting on glycosyl bonds
B0016997molecular_functionalpha-sialidase activity
B0030054cellular_componentcell junction
B0031410cellular_componentcytoplasmic vesicle
B0043202cellular_componentlysosomal lumen
B0043231cellular_componentintracellular membrane-bounded organelle
B0052794molecular_functionexo-alpha-(2->3)-sialidase activity
B0052795molecular_functionexo-alpha-(2->6)-sialidase activity
B0052796molecular_functionexo-alpha-(2->8)-sialidase activity
B2000291biological_processregulation of myoblast proliferation
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton acceptor => ECO:0000250
ChainResidueDetails
AASP97
BASP97

site_idSWS_FT_FI2
Number of Residues4
DetailsACT_SITE: ACT_SITE => ECO:0000255
ChainResidueDetails
AGLU258
AGLU388
BGLU258
BGLU388

site_idSWS_FT_FI3
Number of Residues2
DetailsACT_SITE: Nucleophile => ECO:0000250
ChainResidueDetails
ATYR364
BTYR364

site_idSWS_FT_FI4
Number of Residues10
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
AARG72
AARG91
AGLU258
AARG274
AARG335
BARG72
BARG91
BGLU258
BARG274
BARG335

site_idSWS_FT_FI5
Number of Residues8
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN180
AASN337
AASN346
AASN372
BASN180
BASN337
BASN346
BASN372

219869

PDB entries from 2024-05-15

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