8DPV

The crystal structure of Interleukin-11, W147A mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001960	biological_process	negative regulation of cytokine-mediated signaling pathway
A	0005125	molecular_function	cytokine activity
A	0005142	molecular_function	interleukin-11 receptor binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005737	cellular_component	cytoplasm
A	0008083	molecular_function	growth factor activity
A	0008284	biological_process	positive regulation of cell population proliferation
A	0030183	biological_process	B cell differentiation
A	0030219	biological_process	megakaryocyte differentiation
A	0033138	biological_process	positive regulation of peptidyl-serine phosphorylation
A	0038154	biological_process	interleukin-11-mediated signaling pathway
A	0043410	biological_process	positive regulation of MAPK cascade
A	0045444	biological_process	fat cell differentiation
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0046888	biological_process	negative regulation of hormone secretion
A	0050731	biological_process	positive regulation of peptidyl-tyrosine phosphorylation
A	0060302	biological_process	negative regulation of cytokine activity
A	1903659	biological_process	regulation of complement-dependent cytotoxicity
A	2000352	biological_process	negative regulation of endothelial cell apoptotic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue SO4 A 201

Chain	Residue
A	GLY10
A	SER11
A	LEU29
A	ARG33
A	ARG91
A	HIS161
A	HOH322
A	HOH325
A	HOH328

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site_id	AC2
Number of Residues	4
Details	binding site for residue CL A 202

Chain	Residue
A	ARG114
A	ARG118
A	HOH343
A	HOH393

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Region: {"description":"Important for interaction with IL11RA and for the stimulation of cell proliferation","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Site: {"description":"Important for interaction with IL6ST and for the stimulation of cell proliferation","evidences":[{"source":"UniProtKB","id":"P47873","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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