8DNT

SARS-CoV-2 specific T cell receptor

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
F	0000139	cellular_component	Golgi membrane
F	0002376	biological_process	immune system process
F	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
F	0002477	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class Ib
F	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
F	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
F	0002715	biological_process	regulation of natural killer cell mediated immunity
F	0002726	biological_process	positive regulation of T cell cytokine production
F	0005198	molecular_function	structural molecule activity
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0005765	cellular_component	lysosomal membrane
F	0005783	cellular_component	endoplasmic reticulum
F	0005788	cellular_component	endoplasmic reticulum lumen
F	0005794	cellular_component	Golgi apparatus
F	0005886	cellular_component	plasma membrane
F	0005925	cellular_component	focal adhesion
F	0006879	biological_process	intracellular iron ion homeostasis
F	0006955	biological_process	immune response
F	0007608	biological_process	sensory perception of smell
F	0007611	biological_process	learning or memory
F	0009897	cellular_component	external side of plasma membrane
F	0009986	cellular_component	cell surface
F	0010038	biological_process	response to metal ion
F	0012507	cellular_component	ER to Golgi transport vesicle membrane
F	0016020	cellular_component	membrane
F	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
F	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
F	0023026	molecular_function	MHC class II protein complex binding
F	0030670	cellular_component	phagocytic vesicle membrane
F	0031901	cellular_component	early endosome membrane
F	0031902	cellular_component	late endosome membrane
F	0031905	cellular_component	early endosome lumen
F	0033572	biological_process	transferrin transport
F	0034756	biological_process	regulation of iron ion transport
F	0034757	biological_process	negative regulation of iron ion transport
F	0035580	cellular_component	specific granule lumen
F	0042605	molecular_function	peptide antigen binding
F	0042612	cellular_component	MHC class I protein complex
F	0042613	cellular_component	MHC class II protein complex
F	0042802	molecular_function	identical protein binding
F	0042803	molecular_function	protein homodimerization activity
F	0042824	cellular_component	MHC class I peptide loading complex
F	0048260	biological_process	positive regulation of receptor-mediated endocytosis
F	0048261	biological_process	negative regulation of receptor-mediated endocytosis
F	0050680	biological_process	negative regulation of epithelial cell proliferation
F	0050768	biological_process	negative regulation of neurogenesis
F	0050778	biological_process	positive regulation of immune response
F	0050870	biological_process	positive regulation of T cell activation
F	0051289	biological_process	protein homotetramerization
F	0055038	cellular_component	recycling endosome membrane
F	0070062	cellular_component	extracellular exosome
F	0071281	biological_process	cellular response to iron ion
F	0071316	biological_process	cellular response to nicotine
F	1904724	cellular_component	tertiary granule lumen
F	1990000	biological_process	amyloid fibril formation
F	1990712	cellular_component	HFE-transferrin receptor complex
F	2000774	biological_process	positive regulation of cellular senescence
F	2000978	biological_process	negative regulation of forebrain neuron differentiation
L	0000139	cellular_component	Golgi membrane
L	0002376	biological_process	immune system process
L	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
L	0002477	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class Ib
L	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
L	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
L	0002715	biological_process	regulation of natural killer cell mediated immunity
L	0002726	biological_process	positive regulation of T cell cytokine production
L	0005198	molecular_function	structural molecule activity
L	0005515	molecular_function	protein binding
L	0005576	cellular_component	extracellular region
L	0005615	cellular_component	extracellular space
L	0005765	cellular_component	lysosomal membrane
L	0005783	cellular_component	endoplasmic reticulum
L	0005788	cellular_component	endoplasmic reticulum lumen
L	0005794	cellular_component	Golgi apparatus
L	0005886	cellular_component	plasma membrane
L	0005925	cellular_component	focal adhesion
L	0006879	biological_process	intracellular iron ion homeostasis
L	0006955	biological_process	immune response
L	0007608	biological_process	sensory perception of smell
L	0007611	biological_process	learning or memory
L	0009897	cellular_component	external side of plasma membrane
L	0009986	cellular_component	cell surface
L	0010038	biological_process	response to metal ion
L	0012507	cellular_component	ER to Golgi transport vesicle membrane
L	0016020	cellular_component	membrane
L	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
L	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
L	0023026	molecular_function	MHC class II protein complex binding
L	0030670	cellular_component	phagocytic vesicle membrane
L	0031901	cellular_component	early endosome membrane
L	0031902	cellular_component	late endosome membrane
L	0031905	cellular_component	early endosome lumen
L	0033572	biological_process	transferrin transport
L	0034756	biological_process	regulation of iron ion transport
L	0034757	biological_process	negative regulation of iron ion transport
L	0035580	cellular_component	specific granule lumen
L	0042605	molecular_function	peptide antigen binding
L	0042612	cellular_component	MHC class I protein complex
L	0042613	cellular_component	MHC class II protein complex
L	0042802	molecular_function	identical protein binding
L	0042803	molecular_function	protein homodimerization activity
L	0042824	cellular_component	MHC class I peptide loading complex
L	0048260	biological_process	positive regulation of receptor-mediated endocytosis
L	0048261	biological_process	negative regulation of receptor-mediated endocytosis
L	0050680	biological_process	negative regulation of epithelial cell proliferation
L	0050768	biological_process	negative regulation of neurogenesis
L	0050778	biological_process	positive regulation of immune response
L	0050870	biological_process	positive regulation of T cell activation
L	0051289	biological_process	protein homotetramerization
L	0055038	cellular_component	recycling endosome membrane
L	0070062	cellular_component	extracellular exosome
L	0071281	biological_process	cellular response to iron ion
L	0071316	biological_process	cellular response to nicotine
L	1904724	cellular_component	tertiary granule lumen
L	1990000	biological_process	amyloid fibril formation
L	1990712	cellular_component	HFE-transferrin receptor complex
L	2000774	biological_process	positive regulation of cellular senescence
L	2000978	biological_process	negative regulation of forebrain neuron differentiation
T	0000139	cellular_component	Golgi membrane
T	0002376	biological_process	immune system process
T	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
T	0002477	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class Ib
T	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
T	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
T	0002715	biological_process	regulation of natural killer cell mediated immunity
T	0002726	biological_process	positive regulation of T cell cytokine production
T	0005198	molecular_function	structural molecule activity
T	0005515	molecular_function	protein binding
T	0005576	cellular_component	extracellular region
T	0005615	cellular_component	extracellular space
T	0005765	cellular_component	lysosomal membrane
T	0005783	cellular_component	endoplasmic reticulum
T	0005788	cellular_component	endoplasmic reticulum lumen
T	0005794	cellular_component	Golgi apparatus
T	0005886	cellular_component	plasma membrane
T	0005925	cellular_component	focal adhesion
T	0006879	biological_process	intracellular iron ion homeostasis
T	0006955	biological_process	immune response
T	0007608	biological_process	sensory perception of smell
T	0007611	biological_process	learning or memory
T	0009897	cellular_component	external side of plasma membrane
T	0009986	cellular_component	cell surface
T	0010038	biological_process	response to metal ion
T	0012507	cellular_component	ER to Golgi transport vesicle membrane
T	0016020	cellular_component	membrane
T	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
T	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
T	0023026	molecular_function	MHC class II protein complex binding
T	0030670	cellular_component	phagocytic vesicle membrane
T	0031901	cellular_component	early endosome membrane
T	0031902	cellular_component	late endosome membrane
T	0031905	cellular_component	early endosome lumen
T	0033572	biological_process	transferrin transport
T	0034756	biological_process	regulation of iron ion transport
T	0034757	biological_process	negative regulation of iron ion transport
T	0035580	cellular_component	specific granule lumen
T	0042605	molecular_function	peptide antigen binding
T	0042612	cellular_component	MHC class I protein complex
T	0042613	cellular_component	MHC class II protein complex
T	0042802	molecular_function	identical protein binding
T	0042803	molecular_function	protein homodimerization activity
T	0042824	cellular_component	MHC class I peptide loading complex
T	0048260	biological_process	positive regulation of receptor-mediated endocytosis
T	0048261	biological_process	negative regulation of receptor-mediated endocytosis
T	0050680	biological_process	negative regulation of epithelial cell proliferation
T	0050768	biological_process	negative regulation of neurogenesis
T	0050778	biological_process	positive regulation of immune response
T	0050870	biological_process	positive regulation of T cell activation
T	0051289	biological_process	protein homotetramerization
T	0055038	cellular_component	recycling endosome membrane
T	0070062	cellular_component	extracellular exosome
T	0071281	biological_process	cellular response to iron ion
T	0071316	biological_process	cellular response to nicotine
T	1904724	cellular_component	tertiary granule lumen
T	1990000	biological_process	amyloid fibril formation
T	1990712	cellular_component	HFE-transferrin receptor complex
T	2000774	biological_process	positive regulation of cellular senescence
T	2000978	biological_process	negative regulation of forebrain neuron differentiation
Z	0000139	cellular_component	Golgi membrane
Z	0002376	biological_process	immune system process
Z	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
Z	0002477	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class Ib
Z	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
Z	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
Z	0002715	biological_process	regulation of natural killer cell mediated immunity
Z	0002726	biological_process	positive regulation of T cell cytokine production
Z	0005198	molecular_function	structural molecule activity
Z	0005515	molecular_function	protein binding
Z	0005576	cellular_component	extracellular region
Z	0005615	cellular_component	extracellular space
Z	0005765	cellular_component	lysosomal membrane
Z	0005783	cellular_component	endoplasmic reticulum
Z	0005788	cellular_component	endoplasmic reticulum lumen
Z	0005794	cellular_component	Golgi apparatus
Z	0005886	cellular_component	plasma membrane
Z	0005925	cellular_component	focal adhesion
Z	0006879	biological_process	intracellular iron ion homeostasis
Z	0006955	biological_process	immune response
Z	0007608	biological_process	sensory perception of smell
Z	0007611	biological_process	learning or memory
Z	0009897	cellular_component	external side of plasma membrane
Z	0009986	cellular_component	cell surface
Z	0010038	biological_process	response to metal ion
Z	0012507	cellular_component	ER to Golgi transport vesicle membrane
Z	0016020	cellular_component	membrane
Z	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
Z	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
Z	0023026	molecular_function	MHC class II protein complex binding
Z	0030670	cellular_component	phagocytic vesicle membrane
Z	0031901	cellular_component	early endosome membrane
Z	0031902	cellular_component	late endosome membrane
Z	0031905	cellular_component	early endosome lumen
Z	0033572	biological_process	transferrin transport
Z	0034756	biological_process	regulation of iron ion transport
Z	0034757	biological_process	negative regulation of iron ion transport
Z	0035580	cellular_component	specific granule lumen
Z	0042605	molecular_function	peptide antigen binding
Z	0042612	cellular_component	MHC class I protein complex
Z	0042613	cellular_component	MHC class II protein complex
Z	0042802	molecular_function	identical protein binding
Z	0042803	molecular_function	protein homodimerization activity
Z	0042824	cellular_component	MHC class I peptide loading complex
Z	0048260	biological_process	positive regulation of receptor-mediated endocytosis
Z	0048261	biological_process	negative regulation of receptor-mediated endocytosis
Z	0050680	biological_process	negative regulation of epithelial cell proliferation
Z	0050768	biological_process	negative regulation of neurogenesis
Z	0050778	biological_process	positive regulation of immune response
Z	0050870	biological_process	positive regulation of T cell activation
Z	0051289	biological_process	protein homotetramerization
Z	0055038	cellular_component	recycling endosome membrane
Z	0070062	cellular_component	extracellular exosome
Z	0071281	biological_process	cellular response to iron ion
Z	0071316	biological_process	cellular response to nicotine
Z	1904724	cellular_component	tertiary granule lumen
Z	1990000	biological_process	amyloid fibril formation
Z	1990712	cellular_component	HFE-transferrin receptor complex
Z	2000774	biological_process	positive regulation of cellular senescence
Z	2000978	biological_process	negative regulation of forebrain neuron differentiation

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACRVNH

Chain	Residue	Details
F	TYR79-HIS85
E	TYR257-HIS263

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI2
Number of Residues	352
Details	Domain: {"description":"Ig-like C1-type"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"Pyrrolidone carboxylic acid; in form pI 5.3","evidences":[{"source":"PubMed","id":"7554280","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis","evidences":[{"source":"PubMed","id":"7918443","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	24
Details	Glycosylation: {"description":"N-linked (Glc) (glycation) lysine; in vitro","evidences":[{"source":"PubMed","id":"7918443","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---