8DNT

SARS-CoV-2 specific T cell receptor

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
F	0000139	cellular_component	Golgi membrane
F	0001913	biological_process	T cell mediated cytotoxicity
F	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
F	0002237	biological_process	response to molecule of bacterial origin
F	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
F	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
F	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
F	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
F	0002726	biological_process	positive regulation of T cell cytokine production
F	0005198	molecular_function	structural molecule activity
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0005765	cellular_component	lysosomal membrane
F	0005783	cellular_component	endoplasmic reticulum
F	0005788	cellular_component	endoplasmic reticulum lumen
F	0005794	cellular_component	Golgi apparatus
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0005925	cellular_component	focal adhesion
F	0006826	biological_process	iron ion transport
F	0006879	biological_process	intracellular iron ion homeostasis
F	0006955	biological_process	immune response
F	0007608	biological_process	sensory perception of smell
F	0007611	biological_process	learning or memory
F	0009897	cellular_component	external side of plasma membrane
F	0009986	cellular_component	cell surface
F	0010977	biological_process	negative regulation of neuron projection development
F	0012507	cellular_component	ER to Golgi transport vesicle membrane
F	0016020	cellular_component	membrane
F	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
F	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
F	0023026	molecular_function	MHC class II protein complex binding
F	0030670	cellular_component	phagocytic vesicle membrane
F	0031901	cellular_component	early endosome membrane
F	0031902	cellular_component	late endosome membrane
F	0031905	cellular_component	early endosome lumen
F	0032092	biological_process	positive regulation of protein binding
F	0033077	biological_process	T cell differentiation in thymus
F	0034756	biological_process	regulation of iron ion transport
F	0035580	cellular_component	specific granule lumen
F	0042026	biological_process	protein refolding
F	0042605	molecular_function	peptide antigen binding
F	0042612	cellular_component	MHC class I protein complex
F	0042613	cellular_component	MHC class II protein complex
F	0042802	molecular_function	identical protein binding
F	0042803	molecular_function	protein homodimerization activity
F	0042824	cellular_component	MHC class I peptide loading complex
F	0045646	biological_process	regulation of erythrocyte differentiation
F	0048260	biological_process	positive regulation of receptor-mediated endocytosis
F	0050680	biological_process	negative regulation of epithelial cell proliferation
F	0050768	biological_process	negative regulation of neurogenesis
F	0050778	biological_process	positive regulation of immune response
F	0050870	biological_process	positive regulation of T cell activation
F	0051289	biological_process	protein homotetramerization
F	0055038	cellular_component	recycling endosome membrane
F	0060586	biological_process	multicellular organismal-level iron ion homeostasis
F	0070062	cellular_component	extracellular exosome
F	0071281	biological_process	cellular response to iron ion
F	0071283	biological_process	cellular response to iron(III) ion
F	0071316	biological_process	cellular response to nicotine
F	1900121	biological_process	negative regulation of receptor binding
F	1900122	biological_process	positive regulation of receptor binding
F	1904434	biological_process	positive regulation of ferrous iron binding
F	1904437	biological_process	positive regulation of transferrin receptor binding
F	1904724	cellular_component	tertiary granule lumen
F	1990000	biological_process	amyloid fibril formation
F	1990712	cellular_component	HFE-transferrin receptor complex
F	2000774	biological_process	positive regulation of cellular senescence
F	2000978	biological_process	negative regulation of forebrain neuron differentiation
L	0000139	cellular_component	Golgi membrane
L	0001913	biological_process	T cell mediated cytotoxicity
L	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
L	0002237	biological_process	response to molecule of bacterial origin
L	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
L	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
L	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
L	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
L	0002726	biological_process	positive regulation of T cell cytokine production
L	0005198	molecular_function	structural molecule activity
L	0005515	molecular_function	protein binding
L	0005576	cellular_component	extracellular region
L	0005615	cellular_component	extracellular space
L	0005765	cellular_component	lysosomal membrane
L	0005783	cellular_component	endoplasmic reticulum
L	0005788	cellular_component	endoplasmic reticulum lumen
L	0005794	cellular_component	Golgi apparatus
L	0005829	cellular_component	cytosol
L	0005886	cellular_component	plasma membrane
L	0005925	cellular_component	focal adhesion
L	0006826	biological_process	iron ion transport
L	0006879	biological_process	intracellular iron ion homeostasis
L	0006955	biological_process	immune response
L	0007608	biological_process	sensory perception of smell
L	0007611	biological_process	learning or memory
L	0009897	cellular_component	external side of plasma membrane
L	0009986	cellular_component	cell surface
L	0010977	biological_process	negative regulation of neuron projection development
L	0012507	cellular_component	ER to Golgi transport vesicle membrane
L	0016020	cellular_component	membrane
L	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
L	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
L	0023026	molecular_function	MHC class II protein complex binding
L	0030670	cellular_component	phagocytic vesicle membrane
L	0031901	cellular_component	early endosome membrane
L	0031902	cellular_component	late endosome membrane
L	0031905	cellular_component	early endosome lumen
L	0032092	biological_process	positive regulation of protein binding
L	0033077	biological_process	T cell differentiation in thymus
L	0034756	biological_process	regulation of iron ion transport
L	0035580	cellular_component	specific granule lumen
L	0042026	biological_process	protein refolding
L	0042605	molecular_function	peptide antigen binding
L	0042612	cellular_component	MHC class I protein complex
L	0042613	cellular_component	MHC class II protein complex
L	0042802	molecular_function	identical protein binding
L	0042803	molecular_function	protein homodimerization activity
L	0042824	cellular_component	MHC class I peptide loading complex
L	0045646	biological_process	regulation of erythrocyte differentiation
L	0048260	biological_process	positive regulation of receptor-mediated endocytosis
L	0050680	biological_process	negative regulation of epithelial cell proliferation
L	0050768	biological_process	negative regulation of neurogenesis
L	0050778	biological_process	positive regulation of immune response
L	0050870	biological_process	positive regulation of T cell activation
L	0051289	biological_process	protein homotetramerization
L	0055038	cellular_component	recycling endosome membrane
L	0060586	biological_process	multicellular organismal-level iron ion homeostasis
L	0070062	cellular_component	extracellular exosome
L	0071281	biological_process	cellular response to iron ion
L	0071283	biological_process	cellular response to iron(III) ion
L	0071316	biological_process	cellular response to nicotine
L	1900121	biological_process	negative regulation of receptor binding
L	1900122	biological_process	positive regulation of receptor binding
L	1904434	biological_process	positive regulation of ferrous iron binding
L	1904437	biological_process	positive regulation of transferrin receptor binding
L	1904724	cellular_component	tertiary granule lumen
L	1990000	biological_process	amyloid fibril formation
L	1990712	cellular_component	HFE-transferrin receptor complex
L	2000774	biological_process	positive regulation of cellular senescence
L	2000978	biological_process	negative regulation of forebrain neuron differentiation
T	0000139	cellular_component	Golgi membrane
T	0001913	biological_process	T cell mediated cytotoxicity
T	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
T	0002237	biological_process	response to molecule of bacterial origin
T	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
T	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
T	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
T	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
T	0002726	biological_process	positive regulation of T cell cytokine production
T	0005198	molecular_function	structural molecule activity
T	0005515	molecular_function	protein binding
T	0005576	cellular_component	extracellular region
T	0005615	cellular_component	extracellular space
T	0005765	cellular_component	lysosomal membrane
T	0005783	cellular_component	endoplasmic reticulum
T	0005788	cellular_component	endoplasmic reticulum lumen
T	0005794	cellular_component	Golgi apparatus
T	0005829	cellular_component	cytosol
T	0005886	cellular_component	plasma membrane
T	0005925	cellular_component	focal adhesion
T	0006826	biological_process	iron ion transport
T	0006879	biological_process	intracellular iron ion homeostasis
T	0006955	biological_process	immune response
T	0007608	biological_process	sensory perception of smell
T	0007611	biological_process	learning or memory
T	0009897	cellular_component	external side of plasma membrane
T	0009986	cellular_component	cell surface
T	0010977	biological_process	negative regulation of neuron projection development
T	0012507	cellular_component	ER to Golgi transport vesicle membrane
T	0016020	cellular_component	membrane
T	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
T	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
T	0023026	molecular_function	MHC class II protein complex binding
T	0030670	cellular_component	phagocytic vesicle membrane
T	0031901	cellular_component	early endosome membrane
T	0031902	cellular_component	late endosome membrane
T	0031905	cellular_component	early endosome lumen
T	0032092	biological_process	positive regulation of protein binding
T	0033077	biological_process	T cell differentiation in thymus
T	0034756	biological_process	regulation of iron ion transport
T	0035580	cellular_component	specific granule lumen
T	0042026	biological_process	protein refolding
T	0042605	molecular_function	peptide antigen binding
T	0042612	cellular_component	MHC class I protein complex
T	0042613	cellular_component	MHC class II protein complex
T	0042802	molecular_function	identical protein binding
T	0042803	molecular_function	protein homodimerization activity
T	0042824	cellular_component	MHC class I peptide loading complex
T	0045646	biological_process	regulation of erythrocyte differentiation
T	0048260	biological_process	positive regulation of receptor-mediated endocytosis
T	0050680	biological_process	negative regulation of epithelial cell proliferation
T	0050768	biological_process	negative regulation of neurogenesis
T	0050778	biological_process	positive regulation of immune response
T	0050870	biological_process	positive regulation of T cell activation
T	0051289	biological_process	protein homotetramerization
T	0055038	cellular_component	recycling endosome membrane
T	0060586	biological_process	multicellular organismal-level iron ion homeostasis
T	0070062	cellular_component	extracellular exosome
T	0071281	biological_process	cellular response to iron ion
T	0071283	biological_process	cellular response to iron(III) ion
T	0071316	biological_process	cellular response to nicotine
T	1900121	biological_process	negative regulation of receptor binding
T	1900122	biological_process	positive regulation of receptor binding
T	1904434	biological_process	positive regulation of ferrous iron binding
T	1904437	biological_process	positive regulation of transferrin receptor binding
T	1904724	cellular_component	tertiary granule lumen
T	1990000	biological_process	amyloid fibril formation
T	1990712	cellular_component	HFE-transferrin receptor complex
T	2000774	biological_process	positive regulation of cellular senescence
T	2000978	biological_process	negative regulation of forebrain neuron differentiation
Z	0000139	cellular_component	Golgi membrane
Z	0001913	biological_process	T cell mediated cytotoxicity
Z	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
Z	0002237	biological_process	response to molecule of bacterial origin
Z	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
Z	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
Z	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
Z	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
Z	0002726	biological_process	positive regulation of T cell cytokine production
Z	0005198	molecular_function	structural molecule activity
Z	0005515	molecular_function	protein binding
Z	0005576	cellular_component	extracellular region
Z	0005615	cellular_component	extracellular space
Z	0005765	cellular_component	lysosomal membrane
Z	0005783	cellular_component	endoplasmic reticulum
Z	0005788	cellular_component	endoplasmic reticulum lumen
Z	0005794	cellular_component	Golgi apparatus
Z	0005829	cellular_component	cytosol
Z	0005886	cellular_component	plasma membrane
Z	0005925	cellular_component	focal adhesion
Z	0006826	biological_process	iron ion transport
Z	0006879	biological_process	intracellular iron ion homeostasis
Z	0006955	biological_process	immune response
Z	0007608	biological_process	sensory perception of smell
Z	0007611	biological_process	learning or memory
Z	0009897	cellular_component	external side of plasma membrane
Z	0009986	cellular_component	cell surface
Z	0010977	biological_process	negative regulation of neuron projection development
Z	0012507	cellular_component	ER to Golgi transport vesicle membrane
Z	0016020	cellular_component	membrane
Z	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
Z	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
Z	0023026	molecular_function	MHC class II protein complex binding
Z	0030670	cellular_component	phagocytic vesicle membrane
Z	0031901	cellular_component	early endosome membrane
Z	0031902	cellular_component	late endosome membrane
Z	0031905	cellular_component	early endosome lumen
Z	0032092	biological_process	positive regulation of protein binding
Z	0033077	biological_process	T cell differentiation in thymus
Z	0034756	biological_process	regulation of iron ion transport
Z	0035580	cellular_component	specific granule lumen
Z	0042026	biological_process	protein refolding
Z	0042605	molecular_function	peptide antigen binding
Z	0042612	cellular_component	MHC class I protein complex
Z	0042613	cellular_component	MHC class II protein complex
Z	0042802	molecular_function	identical protein binding
Z	0042803	molecular_function	protein homodimerization activity
Z	0042824	cellular_component	MHC class I peptide loading complex
Z	0045646	biological_process	regulation of erythrocyte differentiation
Z	0048260	biological_process	positive regulation of receptor-mediated endocytosis
Z	0050680	biological_process	negative regulation of epithelial cell proliferation
Z	0050768	biological_process	negative regulation of neurogenesis
Z	0050778	biological_process	positive regulation of immune response
Z	0050870	biological_process	positive regulation of T cell activation
Z	0051289	biological_process	protein homotetramerization
Z	0055038	cellular_component	recycling endosome membrane
Z	0060586	biological_process	multicellular organismal-level iron ion homeostasis
Z	0070062	cellular_component	extracellular exosome
Z	0071281	biological_process	cellular response to iron ion
Z	0071283	biological_process	cellular response to iron(III) ion
Z	0071316	biological_process	cellular response to nicotine
Z	1900121	biological_process	negative regulation of receptor binding
Z	1900122	biological_process	positive regulation of receptor binding
Z	1904434	biological_process	positive regulation of ferrous iron binding
Z	1904437	biological_process	positive regulation of transferrin receptor binding
Z	1904724	cellular_component	tertiary granule lumen
Z	1990000	biological_process	amyloid fibril formation
Z	1990712	cellular_component	HFE-transferrin receptor complex
Z	2000774	biological_process	positive regulation of cellular senescence
Z	2000978	biological_process	negative regulation of forebrain neuron differentiation

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCHVQH

Chain	Residue	Details
E	TYR257-HIS263
F	TYR79-HIS85

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	MOD_RES: Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269|PubMed:7554280

Chain	Residue	Details
F	GLN3
L	GLN3
T	GLN3
Z	GLN3

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site_id	SWS_FT_FI2
Number of Residues	4
Details	CARBOHYD: N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis => ECO:0000269|PubMed:7918443

Chain	Residue	Details
F	ILE2
L	ILE2
T	ILE2
Z	ILE2

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site_id	SWS_FT_FI3
Number of Residues	24
Details	CARBOHYD: N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443

Chain	Residue	Details
F	LYS20
L	LYS59
L	LYS92
L	LYS95
T	LYS20
T	LYS42
T	LYS49
T	LYS59
T	LYS92
T	LYS95
Z	LYS20
F	LYS42
Z	LYS42
Z	LYS49
Z	LYS59
Z	LYS92
Z	LYS95
F	LYS49
F	LYS59
F	LYS92
F	LYS95
L	LYS20
L	LYS42
L	LYS49

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