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8D0K

Human CST-DNA polymerase alpha/primase preinitiation complex bound to 4xTEL-foldback template - PRIM2C advanced PIC

Functional Information from GO Data
ChainGOidnamespacecontents
A0000723biological_processtelomere maintenance
A0000781cellular_componentchromosome, telomeric region
A0003677molecular_functionDNA binding
A0003697molecular_functionsingle-stranded DNA binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005694cellular_componentchromosome
A0005829cellular_componentcytosol
A0006974biological_processDNA damage response
A0010389biological_processregulation of G2/M transition of mitotic cell cycle
A0010833biological_processtelomere maintenance via telomere lengthening
A0016233biological_processtelomere capping
A0032211biological_processnegative regulation of telomere maintenance via telomerase
A0035264biological_processmulticellular organism growth
A0042162molecular_functiontelomeric DNA binding
A0045740biological_processpositive regulation of DNA replication
A0048146biological_processpositive regulation of fibroblast proliferation
A0048536biological_processspleen development
A0048538biological_processthymus development
A0048539biological_processbone marrow development
A0051276biological_processchromosome organization
A0071425biological_processhematopoietic stem cell proliferation
A0090399biological_processreplicative senescence
A0098505molecular_functionG-rich strand telomeric DNA binding
A1990879cellular_componentCST complex
B0000723biological_processtelomere maintenance
B0000781cellular_componentchromosome, telomeric region
B0001650cellular_componentfibrillar center
B0003676molecular_functionnucleic acid binding
B0003677molecular_functionDNA binding
B0003697molecular_functionsingle-stranded DNA binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005694cellular_componentchromosome
B0010833biological_processtelomere maintenance via telomere lengthening
B0016233biological_processtelomere capping
B0032211biological_processnegative regulation of telomere maintenance via telomerase
B0042162molecular_functiontelomeric DNA binding
B0043047molecular_functionsingle-stranded telomeric DNA binding
B0045111cellular_componentintermediate filament cytoskeleton
B0045740biological_processpositive regulation of DNA replication
B0051052biological_processregulation of DNA metabolic process
B1990879cellular_componentCST complex
C0000781cellular_componentchromosome, telomeric region
C0003677molecular_functionDNA binding
C0003697molecular_functionsingle-stranded DNA binding
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005694cellular_componentchromosome
C0010521molecular_functiontelomerase inhibitor activity
C0016233biological_processtelomere capping
C0032211biological_processnegative regulation of telomere maintenance via telomerase
C0042162molecular_functiontelomeric DNA binding
C1990879cellular_componentCST complex
D0000287molecular_functionmagnesium ion binding
D0000428cellular_componentDNA-directed RNA polymerase complex
D0003899molecular_functionDNA-directed RNA polymerase activity
D0005515molecular_functionprotein binding
D0005654cellular_componentnucleoplasm
D0005658cellular_componentalpha DNA polymerase:primase complex
D0006260biological_processDNA replication
D0006269biological_processDNA replication, synthesis of primer
D0006270biological_processDNA replication initiation
D0008270molecular_functionzinc ion binding
D0016020cellular_componentmembrane
D0016740molecular_functiontransferase activity
D0016779molecular_functionnucleotidyltransferase activity
D0032553molecular_functionribonucleotide binding
D0046872molecular_functionmetal ion binding
E0003677molecular_functionDNA binding
E0003899molecular_functionDNA-directed RNA polymerase activity
E0005515molecular_functionprotein binding
E0005654cellular_componentnucleoplasm
E0005658cellular_componentalpha DNA polymerase:primase complex
E0006260biological_processDNA replication
E0006269biological_processDNA replication, synthesis of primer
E0006270biological_processDNA replication initiation
E0046872molecular_functionmetal ion binding
E0051536molecular_functioniron-sulfur cluster binding
E0051539molecular_function4 iron, 4 sulfur cluster binding
E0071667molecular_functionDNA/RNA hybrid binding
F0000166molecular_functionnucleotide binding
F0000731biological_processDNA synthesis involved in DNA repair
F0000785cellular_componentchromatin
F0003676molecular_functionnucleic acid binding
F0003677molecular_functionDNA binding
F0003682molecular_functionchromatin binding
F0003688molecular_functionDNA replication origin binding
F0003697molecular_functionsingle-stranded DNA binding
F0003887molecular_functionDNA-directed DNA polymerase activity
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005635cellular_componentnuclear envelope
F0005654cellular_componentnucleoplasm
F0005658cellular_componentalpha DNA polymerase:primase complex
F0005730cellular_componentnucleolus
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0006260biological_processDNA replication
F0006261biological_processDNA-templated DNA replication
F0006269biological_processDNA replication, synthesis of primer
F0006270biological_processDNA replication initiation
F0006271biological_processDNA strand elongation involved in DNA replication
F0006272biological_processleading strand elongation
F0006273biological_processlagging strand elongation
F0006281biological_processDNA repair
F0006289biological_processnucleotide-excision repair
F0006303biological_processdouble-strand break repair via nonhomologous end joining
F0008270molecular_functionzinc ion binding
F0016363cellular_componentnuclear matrix
F0016740molecular_functiontransferase activity
F0016779molecular_functionnucleotidyltransferase activity
F0019901molecular_functionprotein kinase binding
F0032479biological_processregulation of type I interferon production
F0034061molecular_functionDNA polymerase activity
F0046872molecular_functionmetal ion binding
F1902975biological_processmitotic DNA replication initiation
F1904161biological_processDNA synthesis involved in UV-damage excision repair
G0003677molecular_functionDNA binding
G0005515molecular_functionprotein binding
G0005634cellular_componentnucleus
G0005654cellular_componentnucleoplasm
G0005658cellular_componentalpha DNA polymerase:primase complex
G0005829cellular_componentcytosol
G0006260biological_processDNA replication
G0006269biological_processDNA replication, synthesis of primer
G0006270biological_processDNA replication initiation
G0006606biological_processprotein import into nucleus
G0036064cellular_componentciliary basal body
Functional Information from PROSITE/UniProt
site_idPS00116
Number of Residues9
DetailsDNA_POLYMERASE_B DNA polymerase family B signature. YGDTDSIMI
ChainResidueDetails
FTYR1000-ILE1008

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648
ChainResidueDetails
GSER126
ECYS367
ECYS424

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
GTHR127
GTHR130
FCYS1310
FCYS1315
FCYS1348
FCYS1353
FCYS1371
FCYS1374

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
GSER141
DCYS122
DCYS128
DCYS131

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
GSER147

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
GSER152

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
GSER154

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
FSER209

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P33609
ChainResidueDetails
FLYS224

site_idSWS_FT_FI9
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163
ChainResidueDetails
FTHR406

site_idSWS_FT_FI10
Number of Residues1
DetailsMOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P33609
ChainResidueDetails
FLYS970

238268

PDB entries from 2025-07-02

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