8CTG
Extracellular architecture of an engineered canonical Wnt signaling ternary complex
Functional Information from GO Data
Functional Information from PROSITE/UniProt
| site_id | PS01186 |
| Number of Residues | 16 |
| Details | EGF_2 EGF-like domain signature 2. CaCpiGFelisdmktC |
| Chain | Residue | Details |
| C | CYS612-CYS627 |
| site_id | PS00028 |
| Number of Residues | 24 |
| Details | ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. CsiqtCwlqLaefrdignHlkik.H |
| Chain | Residue | Details |
| B | CYS190-HIS213 | |
| B | CYS325-HIS347 |
| site_id | PS00246 |
| Number of Residues | 10 |
| Details | WNT1 Wnt-1 family signature. CKCHGISGsC |
| Chain | Residue | Details |
| B | CYS181-CYS190 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 5 |
| Details | Region: {"description":"Wnt-binding"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 7 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 5 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Site: {"description":"Cleavage; by tiki1 and tiki2","evidences":[{"source":"PubMed","id":"22726442","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Lipidation: {"description":"O-palmitoleoyl serine","evidences":[{"source":"PubMed","id":"22653731","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"22653731","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4F0A","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 42 |
| Details | Repeat: {"description":"LDL-receptor class B 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 43 |
| Details | Repeat: {"description":"LDL-receptor class B 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 39 |
| Details | Repeat: {"description":"LDL-receptor class B 5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 42 |
| Details | Domain: {"description":"EGF-like 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 42 |
| Details | Repeat: {"description":"LDL-receptor class B 6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 42 |
| Details | Repeat: {"description":"LDL-receptor class B 7"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 43 |
| Details | Repeat: {"description":"LDL-receptor class B 8"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 40 |
| Details | Repeat: {"description":"LDL-receptor class B 9"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 41 |
| Details | Repeat: {"description":"LDL-receptor class B 10"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 261 |
| Details | Region: {"description":"Beta-propeller 2"} |
| Chain | Residue | Details |
