8CTG

Extracellular architecture of an engineered canonical Wnt signaling ternary complex

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0005102	molecular_function	signaling receptor binding
B	0005576	cellular_component	extracellular region
B	0007275	biological_process	multicellular organism development
B	0016055	biological_process	Wnt signaling pathway

Functional Information from PROSITE/UniProt

site_id	PS00028
Number of Residues	24
Details	ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. CsiqtCwlqLaefrdignHlkik.H

Chain	Residue	Details
B	CYS190-HIS213
B	CYS325-HIS347

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site_id	PS00246
Number of Residues	10
Details	WNT1 Wnt-1 family signature. CKCHGISGsC

Chain	Residue	Details
B	CYS181-CYS190

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site_id	PS01186
Number of Residues	16
Details	EGF_2 EGF-like domain signature 2. CaCpiGFelisdmktC

Chain	Residue	Details
C	CYS612-CYS627

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
C	ASN42
C	ASN81
C	ASN281
C	ASN433
C	ASN486

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site_id	SWS_FT_FI2
Number of Residues	1
Details	LIPID: O-palmitoleoyl serine => ECO:0000269|PubMed:22653731

Chain	Residue	Details
B	SER187

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site_id	SWS_FT_FI3
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22653731, ECO:0007744|PDB:4F0A

Chain	Residue	Details
B	ASN104
B	ASN263

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site_id	SWS_FT_FI4
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
B	ASN282

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