Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8CTE

Class 2 of erythrocyte ankyrin-1 complex (Composite map)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005198	molecular_function	structural molecule activity
A	0005200	molecular_function	structural constituent of cytoskeleton
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005886	cellular_component	plasma membrane
A	0006887	biological_process	exocytosis
A	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
A	0007010	biological_process	cytoskeleton organization
A	0007165	biological_process	signal transduction
A	0008093	molecular_function	cytoskeletal anchor activity
A	0009898	cellular_component	cytoplasmic side of plasma membrane
A	0014731	cellular_component	spectrin-associated cytoskeleton
A	0016020	cellular_component	membrane
A	0016323	cellular_component	basolateral plasma membrane
A	0016529	cellular_component	sarcoplasmic reticulum
A	0019899	molecular_function	enzyme binding
A	0019903	molecular_function	protein phosphatase binding
A	0030018	cellular_component	Z disc
A	0030507	molecular_function	spectrin binding
A	0030673	cellular_component	axolemma
A	0031430	cellular_component	M band
A	0031672	cellular_component	A band
A	0042383	cellular_component	sarcolemma
A	0043005	cellular_component	neuron projection
A	0044325	molecular_function	transmembrane transporter binding
A	0045199	biological_process	maintenance of epithelial cell apical/basal polarity
A	0045211	cellular_component	postsynaptic membrane
A	0048193	biological_process	Golgi vesicle transport
A	0051117	molecular_function	ATPase binding
A	0071944	cellular_component	cell periphery
A	0072659	biological_process	protein localization to plasma membrane
A	0170014	cellular_component	ankyrin-1 complex
D	0016020	cellular_component	membrane
K	0005886	cellular_component	plasma membrane
K	0008519	molecular_function	ammonium channel activity
K	0016020	cellular_component	membrane
K	0072488	biological_process	ammonium transmembrane transport
K	0097272	biological_process	ammonium homeostasis
K	0170014	cellular_component	ankyrin-1 complex
L	0005515	molecular_function	protein binding
L	0005886	cellular_component	plasma membrane
L	0006873	biological_process	intracellular monoatomic ion homeostasis
L	0008519	molecular_function	ammonium channel activity
L	0015200	molecular_function	methylammonium transmembrane transporter activity
L	0015670	biological_process	carbon dioxide transport
L	0015701	biological_process	bicarbonate transport
L	0016020	cellular_component	membrane
L	0022840	molecular_function	leak channel activity
L	0030506	molecular_function	ankyrin binding
L	0035378	biological_process	carbon dioxide transmembrane transport
L	0035379	molecular_function	carbon dioxide transmembrane transporter activity
L	0055085	biological_process	transmembrane transport
L	0072488	biological_process	ammonium transmembrane transport
L	0072489	biological_process	methylammonium transmembrane transport
L	0097272	biological_process	ammonium homeostasis
L	0170014	cellular_component	ankyrin-1 complex
M	0003091	biological_process	renal water homeostasis
M	0003097	biological_process	renal water transport
M	0005223	molecular_function	intracellularly cGMP-activated cation channel activity
M	0005267	molecular_function	potassium channel activity
M	0005372	molecular_function	water transmembrane transporter activity
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005737	cellular_component	cytoplasm
M	0005886	cellular_component	plasma membrane
M	0005903	cellular_component	brush border
M	0006813	biological_process	potassium ion transport
M	0006833	biological_process	water transport
M	0006884	biological_process	cell volume homeostasis
M	0006972	biological_process	hyperosmotic response
M	0008519	molecular_function	ammonium channel activity
M	0009925	cellular_component	basal plasma membrane
M	0009992	biological_process	intracellular water homeostasis
M	0015079	molecular_function	potassium ion transmembrane transporter activity
M	0015168	molecular_function	glycerol transmembrane transporter activity
M	0015250	molecular_function	water channel activity
M	0015267	molecular_function	channel activity
M	0015670	biological_process	carbon dioxide transport
M	0015793	biological_process	glycerol transmembrane transport
M	0016020	cellular_component	membrane
M	0016323	cellular_component	basolateral plasma membrane
M	0016324	cellular_component	apical plasma membrane
M	0019725	biological_process	cellular homeostasis
M	0021670	biological_process	lateral ventricle development
M	0022857	molecular_function	transmembrane transporter activity
M	0030157	biological_process	pancreatic juice secretion
M	0030184	molecular_function	nitric oxide transmembrane transporter activity
M	0030185	biological_process	nitric oxide transport
M	0030424	cellular_component	axon
M	0030950	biological_process	establishment or maintenance of actin cytoskeleton polarity
M	0031526	cellular_component	brush border membrane
M	0031965	cellular_component	nuclear membrane
M	0033326	biological_process	cerebrospinal fluid secretion
M	0034644	biological_process	cellular response to UV
M	0035377	biological_process	transepithelial water transport
M	0035378	biological_process	carbon dioxide transmembrane transport
M	0035379	molecular_function	carbon dioxide transmembrane transporter activity
M	0042383	cellular_component	sarcolemma
M	0042476	biological_process	odontogenesis
M	0042802	molecular_function	identical protein binding
M	0043066	biological_process	negative regulation of apoptotic process
M	0045177	cellular_component	apical part of cell
M	0045766	biological_process	positive regulation of angiogenesis
M	0046875	molecular_function	ephrin receptor binding
M	0046878	biological_process	positive regulation of saliva secretion
M	0048146	biological_process	positive regulation of fibroblast proliferation
M	0050829	biological_process	defense response to Gram-negative bacterium
M	0050891	biological_process	multicellular organismal-level water homeostasis
M	0055085	biological_process	transmembrane transport
M	0070062	cellular_component	extracellular exosome
M	0070301	biological_process	cellular response to hydrogen peroxide
M	0071260	biological_process	cellular response to mechanical stimulus
M	0071280	biological_process	cellular response to copper ion
M	0071288	biological_process	cellular response to mercury ion
M	0071300	biological_process	cellular response to retinoic acid
M	0071320	biological_process	cellular response to cAMP
M	0071456	biological_process	cellular response to hypoxia
M	0071472	biological_process	cellular response to salt stress
M	0071474	biological_process	cellular hyperosmotic response
M	0071549	biological_process	cellular response to dexamethasone stimulus
M	0071732	biological_process	cellular response to nitric oxide
M	0071805	biological_process	potassium ion transmembrane transport
M	0072220	biological_process	metanephric descending thin limb development
M	0072230	biological_process	metanephric proximal straight tubule development
M	0072232	biological_process	metanephric proximal convoluted tubule segment 2 development
M	0072239	biological_process	metanephric glomerulus vasculature development
M	0072488	biological_process	ammonium transmembrane transport
M	0080170	biological_process	hydrogen peroxide transmembrane transport
M	0098655	biological_process	monoatomic cation transmembrane transport
M	0140070	molecular_function	hydrogen peroxide channel activity
M	0170014	cellular_component	ankyrin-1 complex
N	0016020	cellular_component	membrane
O	0003091	biological_process	renal water homeostasis
O	0003097	biological_process	renal water transport
O	0005223	molecular_function	intracellularly cGMP-activated cation channel activity
O	0005267	molecular_function	potassium channel activity
O	0005372	molecular_function	water transmembrane transporter activity
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005737	cellular_component	cytoplasm
O	0005886	cellular_component	plasma membrane
O	0005903	cellular_component	brush border
O	0006813	biological_process	potassium ion transport
O	0006833	biological_process	water transport
O	0006884	biological_process	cell volume homeostasis
O	0006972	biological_process	hyperosmotic response
O	0008519	molecular_function	ammonium channel activity
O	0009925	cellular_component	basal plasma membrane
O	0009992	biological_process	intracellular water homeostasis
O	0015079	molecular_function	potassium ion transmembrane transporter activity
O	0015168	molecular_function	glycerol transmembrane transporter activity
O	0015250	molecular_function	water channel activity
O	0015267	molecular_function	channel activity
O	0015670	biological_process	carbon dioxide transport
O	0015793	biological_process	glycerol transmembrane transport
O	0016020	cellular_component	membrane
O	0016323	cellular_component	basolateral plasma membrane
O	0016324	cellular_component	apical plasma membrane
O	0019725	biological_process	cellular homeostasis
O	0021670	biological_process	lateral ventricle development
O	0022857	molecular_function	transmembrane transporter activity
O	0030157	biological_process	pancreatic juice secretion
O	0030184	molecular_function	nitric oxide transmembrane transporter activity
O	0030185	biological_process	nitric oxide transport
O	0030424	cellular_component	axon
O	0030950	biological_process	establishment or maintenance of actin cytoskeleton polarity
O	0031526	cellular_component	brush border membrane
O	0031965	cellular_component	nuclear membrane
O	0033326	biological_process	cerebrospinal fluid secretion
O	0034644	biological_process	cellular response to UV
O	0035377	biological_process	transepithelial water transport
O	0035378	biological_process	carbon dioxide transmembrane transport
O	0035379	molecular_function	carbon dioxide transmembrane transporter activity
O	0042383	cellular_component	sarcolemma
O	0042476	biological_process	odontogenesis
O	0042802	molecular_function	identical protein binding
O	0043066	biological_process	negative regulation of apoptotic process
O	0045177	cellular_component	apical part of cell
O	0045766	biological_process	positive regulation of angiogenesis
O	0046875	molecular_function	ephrin receptor binding
O	0046878	biological_process	positive regulation of saliva secretion
O	0048146	biological_process	positive regulation of fibroblast proliferation
O	0050829	biological_process	defense response to Gram-negative bacterium
O	0050891	biological_process	multicellular organismal-level water homeostasis
O	0055085	biological_process	transmembrane transport
O	0070062	cellular_component	extracellular exosome
O	0070301	biological_process	cellular response to hydrogen peroxide
O	0071260	biological_process	cellular response to mechanical stimulus
O	0071280	biological_process	cellular response to copper ion
O	0071288	biological_process	cellular response to mercury ion
O	0071300	biological_process	cellular response to retinoic acid
O	0071320	biological_process	cellular response to cAMP
O	0071456	biological_process	cellular response to hypoxia
O	0071472	biological_process	cellular response to salt stress
O	0071474	biological_process	cellular hyperosmotic response
O	0071549	biological_process	cellular response to dexamethasone stimulus
O	0071732	biological_process	cellular response to nitric oxide
O	0071805	biological_process	potassium ion transmembrane transport
O	0072220	biological_process	metanephric descending thin limb development
O	0072230	biological_process	metanephric proximal straight tubule development
O	0072232	biological_process	metanephric proximal convoluted tubule segment 2 development
O	0072239	biological_process	metanephric glomerulus vasculature development
O	0072488	biological_process	ammonium transmembrane transport
O	0080170	biological_process	hydrogen peroxide transmembrane transport
O	0098655	biological_process	monoatomic cation transmembrane transport
O	0140070	molecular_function	hydrogen peroxide channel activity
O	0170014	cellular_component	ankyrin-1 complex
P	0005452	molecular_function	solute:inorganic anion antiporter activity
P	0005515	molecular_function	protein binding
P	0005737	cellular_component	cytoplasm
P	0005886	cellular_component	plasma membrane
P	0006811	biological_process	monoatomic ion transport
P	0006820	biological_process	monoatomic anion transport
P	0006821	biological_process	chloride transport
P	0006873	biological_process	intracellular monoatomic ion homeostasis
P	0008092	molecular_function	cytoskeletal protein binding
P	0008509	molecular_function	monoatomic anion transmembrane transporter activity
P	0009898	cellular_component	cytoplasmic side of plasma membrane
P	0015106	molecular_function	bicarbonate transmembrane transporter activity
P	0015108	molecular_function	chloride transmembrane transporter activity
P	0015297	molecular_function	antiporter activity
P	0015701	biological_process	bicarbonate transport
P	0016020	cellular_component	membrane
P	0016323	cellular_component	basolateral plasma membrane
P	0030018	cellular_component	Z disc
P	0030492	molecular_function	hemoglobin binding
P	0030506	molecular_function	ankyrin binding
P	0030863	cellular_component	cortical cytoskeleton
P	0042803	molecular_function	protein homodimerization activity
P	0043495	molecular_function	protein-membrane adaptor activity
P	0051453	biological_process	regulation of intracellular pH
P	0055085	biological_process	transmembrane transport
P	0070062	cellular_component	extracellular exosome
P	0072562	cellular_component	blood microparticle
P	0140900	molecular_function	chloride:bicarbonate antiporter activity
P	0170014	cellular_component	ankyrin-1 complex
P	1902476	biological_process	chloride transmembrane transport
Q	0005515	molecular_function	protein binding
Q	0005886	cellular_component	plasma membrane
Q	0006873	biological_process	intracellular monoatomic ion homeostasis
Q	0008519	molecular_function	ammonium channel activity
Q	0015200	molecular_function	methylammonium transmembrane transporter activity
Q	0015670	biological_process	carbon dioxide transport
Q	0015701	biological_process	bicarbonate transport
Q	0016020	cellular_component	membrane
Q	0022840	molecular_function	leak channel activity
Q	0030506	molecular_function	ankyrin binding
Q	0035378	biological_process	carbon dioxide transmembrane transport
Q	0035379	molecular_function	carbon dioxide transmembrane transporter activity
Q	0055085	biological_process	transmembrane transport
Q	0072488	biological_process	ammonium transmembrane transport
Q	0072489	biological_process	methylammonium transmembrane transport
Q	0097272	biological_process	ammonium homeostasis
Q	0170014	cellular_component	ankyrin-1 complex
R	0003091	biological_process	renal water homeostasis
R	0003097	biological_process	renal water transport
R	0005223	molecular_function	intracellularly cGMP-activated cation channel activity
R	0005267	molecular_function	potassium channel activity
R	0005372	molecular_function	water transmembrane transporter activity
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005737	cellular_component	cytoplasm
R	0005886	cellular_component	plasma membrane
R	0005903	cellular_component	brush border
R	0006813	biological_process	potassium ion transport
R	0006833	biological_process	water transport
R	0006884	biological_process	cell volume homeostasis
R	0006972	biological_process	hyperosmotic response
R	0008519	molecular_function	ammonium channel activity
R	0009925	cellular_component	basal plasma membrane
R	0009992	biological_process	intracellular water homeostasis
R	0015079	molecular_function	potassium ion transmembrane transporter activity
R	0015168	molecular_function	glycerol transmembrane transporter activity
R	0015250	molecular_function	water channel activity
R	0015267	molecular_function	channel activity
R	0015670	biological_process	carbon dioxide transport
R	0015793	biological_process	glycerol transmembrane transport
R	0016020	cellular_component	membrane
R	0016323	cellular_component	basolateral plasma membrane
R	0016324	cellular_component	apical plasma membrane
R	0019725	biological_process	cellular homeostasis
R	0021670	biological_process	lateral ventricle development
R	0022857	molecular_function	transmembrane transporter activity
R	0030157	biological_process	pancreatic juice secretion
R	0030184	molecular_function	nitric oxide transmembrane transporter activity
R	0030185	biological_process	nitric oxide transport
R	0030424	cellular_component	axon
R	0030950	biological_process	establishment or maintenance of actin cytoskeleton polarity
R	0031526	cellular_component	brush border membrane
R	0031965	cellular_component	nuclear membrane
R	0033326	biological_process	cerebrospinal fluid secretion
R	0034644	biological_process	cellular response to UV
R	0035377	biological_process	transepithelial water transport
R	0035378	biological_process	carbon dioxide transmembrane transport
R	0035379	molecular_function	carbon dioxide transmembrane transporter activity
R	0042383	cellular_component	sarcolemma
R	0042476	biological_process	odontogenesis
R	0042802	molecular_function	identical protein binding
R	0043066	biological_process	negative regulation of apoptotic process
R	0045177	cellular_component	apical part of cell
R	0045766	biological_process	positive regulation of angiogenesis
R	0046875	molecular_function	ephrin receptor binding
R	0046878	biological_process	positive regulation of saliva secretion
R	0048146	biological_process	positive regulation of fibroblast proliferation
R	0050829	biological_process	defense response to Gram-negative bacterium
R	0050891	biological_process	multicellular organismal-level water homeostasis
R	0055085	biological_process	transmembrane transport
R	0070062	cellular_component	extracellular exosome
R	0070301	biological_process	cellular response to hydrogen peroxide
R	0071260	biological_process	cellular response to mechanical stimulus
R	0071280	biological_process	cellular response to copper ion
R	0071288	biological_process	cellular response to mercury ion
R	0071300	biological_process	cellular response to retinoic acid
R	0071320	biological_process	cellular response to cAMP
R	0071456	biological_process	cellular response to hypoxia
R	0071472	biological_process	cellular response to salt stress
R	0071474	biological_process	cellular hyperosmotic response
R	0071549	biological_process	cellular response to dexamethasone stimulus
R	0071732	biological_process	cellular response to nitric oxide
R	0071805	biological_process	potassium ion transmembrane transport
R	0072220	biological_process	metanephric descending thin limb development
R	0072230	biological_process	metanephric proximal straight tubule development
R	0072232	biological_process	metanephric proximal convoluted tubule segment 2 development
R	0072239	biological_process	metanephric glomerulus vasculature development
R	0072488	biological_process	ammonium transmembrane transport
R	0080170	biological_process	hydrogen peroxide transmembrane transport
R	0098655	biological_process	monoatomic cation transmembrane transport
R	0140070	molecular_function	hydrogen peroxide channel activity
R	0170014	cellular_component	ankyrin-1 complex
S	0003091	biological_process	renal water homeostasis
S	0003097	biological_process	renal water transport
S	0005223	molecular_function	intracellularly cGMP-activated cation channel activity
S	0005267	molecular_function	potassium channel activity
S	0005372	molecular_function	water transmembrane transporter activity
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0005737	cellular_component	cytoplasm
S	0005886	cellular_component	plasma membrane
S	0005903	cellular_component	brush border
S	0006813	biological_process	potassium ion transport
S	0006833	biological_process	water transport
S	0006884	biological_process	cell volume homeostasis
S	0006972	biological_process	hyperosmotic response
S	0008519	molecular_function	ammonium channel activity
S	0009925	cellular_component	basal plasma membrane
S	0009992	biological_process	intracellular water homeostasis
S	0015079	molecular_function	potassium ion transmembrane transporter activity
S	0015168	molecular_function	glycerol transmembrane transporter activity
S	0015250	molecular_function	water channel activity
S	0015267	molecular_function	channel activity
S	0015670	biological_process	carbon dioxide transport
S	0015793	biological_process	glycerol transmembrane transport
S	0016020	cellular_component	membrane
S	0016323	cellular_component	basolateral plasma membrane
S	0016324	cellular_component	apical plasma membrane
S	0019725	biological_process	cellular homeostasis
S	0021670	biological_process	lateral ventricle development
S	0022857	molecular_function	transmembrane transporter activity
S	0030157	biological_process	pancreatic juice secretion
S	0030184	molecular_function	nitric oxide transmembrane transporter activity
S	0030185	biological_process	nitric oxide transport
S	0030424	cellular_component	axon
S	0030950	biological_process	establishment or maintenance of actin cytoskeleton polarity
S	0031526	cellular_component	brush border membrane
S	0031965	cellular_component	nuclear membrane
S	0033326	biological_process	cerebrospinal fluid secretion
S	0034644	biological_process	cellular response to UV
S	0035377	biological_process	transepithelial water transport
S	0035378	biological_process	carbon dioxide transmembrane transport
S	0035379	molecular_function	carbon dioxide transmembrane transporter activity
S	0042383	cellular_component	sarcolemma
S	0042476	biological_process	odontogenesis
S	0042802	molecular_function	identical protein binding
S	0043066	biological_process	negative regulation of apoptotic process
S	0045177	cellular_component	apical part of cell
S	0045766	biological_process	positive regulation of angiogenesis
S	0046875	molecular_function	ephrin receptor binding
S	0046878	biological_process	positive regulation of saliva secretion
S	0048146	biological_process	positive regulation of fibroblast proliferation
S	0050829	biological_process	defense response to Gram-negative bacterium
S	0050891	biological_process	multicellular organismal-level water homeostasis
S	0055085	biological_process	transmembrane transport
S	0070062	cellular_component	extracellular exosome
S	0070301	biological_process	cellular response to hydrogen peroxide
S	0071260	biological_process	cellular response to mechanical stimulus
S	0071280	biological_process	cellular response to copper ion
S	0071288	biological_process	cellular response to mercury ion
S	0071300	biological_process	cellular response to retinoic acid
S	0071320	biological_process	cellular response to cAMP
S	0071456	biological_process	cellular response to hypoxia
S	0071472	biological_process	cellular response to salt stress
S	0071474	biological_process	cellular hyperosmotic response
S	0071549	biological_process	cellular response to dexamethasone stimulus
S	0071732	biological_process	cellular response to nitric oxide
S	0071805	biological_process	potassium ion transmembrane transport
S	0072220	biological_process	metanephric descending thin limb development
S	0072230	biological_process	metanephric proximal straight tubule development
S	0072232	biological_process	metanephric proximal convoluted tubule segment 2 development
S	0072239	biological_process	metanephric glomerulus vasculature development
S	0072488	biological_process	ammonium transmembrane transport
S	0080170	biological_process	hydrogen peroxide transmembrane transport
S	0098655	biological_process	monoatomic cation transmembrane transport
S	0140070	molecular_function	hydrogen peroxide channel activity
S	0170014	cellular_component	ankyrin-1 complex
T	0005452	molecular_function	solute:inorganic anion antiporter activity
T	0005515	molecular_function	protein binding
T	0005737	cellular_component	cytoplasm
T	0005886	cellular_component	plasma membrane
T	0006811	biological_process	monoatomic ion transport
T	0006820	biological_process	monoatomic anion transport
T	0006821	biological_process	chloride transport
T	0006873	biological_process	intracellular monoatomic ion homeostasis
T	0008092	molecular_function	cytoskeletal protein binding
T	0008509	molecular_function	monoatomic anion transmembrane transporter activity
T	0009898	cellular_component	cytoplasmic side of plasma membrane
T	0015106	molecular_function	bicarbonate transmembrane transporter activity
T	0015108	molecular_function	chloride transmembrane transporter activity
T	0015297	molecular_function	antiporter activity
T	0015701	biological_process	bicarbonate transport
T	0016020	cellular_component	membrane
T	0016323	cellular_component	basolateral plasma membrane
T	0030018	cellular_component	Z disc
T	0030492	molecular_function	hemoglobin binding
T	0030506	molecular_function	ankyrin binding
T	0030863	cellular_component	cortical cytoskeleton
T	0042803	molecular_function	protein homodimerization activity
T	0043495	molecular_function	protein-membrane adaptor activity
T	0051453	biological_process	regulation of intracellular pH
T	0055085	biological_process	transmembrane transport
T	0070062	cellular_component	extracellular exosome
T	0072562	cellular_component	blood microparticle
T	0140900	molecular_function	chloride:bicarbonate antiporter activity
T	0170014	cellular_component	ankyrin-1 complex
T	1902476	biological_process	chloride transmembrane transport
W	0005452	molecular_function	solute:inorganic anion antiporter activity
W	0005515	molecular_function	protein binding
W	0005737	cellular_component	cytoplasm
W	0005886	cellular_component	plasma membrane
W	0006811	biological_process	monoatomic ion transport
W	0006820	biological_process	monoatomic anion transport
W	0006821	biological_process	chloride transport
W	0006873	biological_process	intracellular monoatomic ion homeostasis
W	0008092	molecular_function	cytoskeletal protein binding
W	0008509	molecular_function	monoatomic anion transmembrane transporter activity
W	0009898	cellular_component	cytoplasmic side of plasma membrane
W	0015106	molecular_function	bicarbonate transmembrane transporter activity
W	0015108	molecular_function	chloride transmembrane transporter activity
W	0015297	molecular_function	antiporter activity
W	0015701	biological_process	bicarbonate transport
W	0016020	cellular_component	membrane
W	0016323	cellular_component	basolateral plasma membrane
W	0030018	cellular_component	Z disc
W	0030492	molecular_function	hemoglobin binding
W	0030506	molecular_function	ankyrin binding
W	0030863	cellular_component	cortical cytoskeleton
W	0042803	molecular_function	protein homodimerization activity
W	0043495	molecular_function	protein-membrane adaptor activity
W	0051453	biological_process	regulation of intracellular pH
W	0055085	biological_process	transmembrane transport
W	0070062	cellular_component	extracellular exosome
W	0072562	cellular_component	blood microparticle
W	0140900	molecular_function	chloride:bicarbonate antiporter activity
W	0170014	cellular_component	ankyrin-1 complex
W	1902476	biological_process	chloride transmembrane transport
X	0003810	molecular_function	protein-glutamine gamma-glutamyltransferase activity
X	0005200	molecular_function	structural constituent of cytoskeleton
X	0005515	molecular_function	protein binding
X	0005524	molecular_function	ATP binding
X	0005856	cellular_component	cytoskeleton
X	0005886	cellular_component	plasma membrane
X	0007010	biological_process	cytoskeleton organization
X	0008360	biological_process	regulation of cell shape
X	0016020	cellular_component	membrane
X	0018149	biological_process	peptide cross-linking
X	0030863	cellular_component	cortical cytoskeleton
X	0043249	biological_process	erythrocyte maturation
X	0071944	cellular_component	cell periphery
X	0170014	cellular_component	ankyrin-1 complex

Functional Information from PROSITE/UniProt

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. KYGFSSVGINLLVAAL

Chain	Residue	Details
L	LYS74-LEU89

site_id	PS00219
Number of Residues	12
Details	ANION_EXCHANGER_1 Anion exchangers family signature 1. FGGLVRDIRRRY

Chain	Residue	Details
W	PHE379-TYR390

site_id	PS00220
Number of Residues	15
Details	ANION_EXCHANGER_2 Anion exchangers family signature 2. FLISLIFIYETFsKL

Chain	Residue	Details
W	PHE526-LEU540

site_id	PS00221
Number of Residues	9
Details	MIP MIP family signature. HLNPAVTLG

Chain	Residue	Details
S	HIS74-GLY82

site_id	PS00312
Number of Residues	10
Details	GLYCOPHORIN_A Glycophorin A signature. IIfGVMAGVI

Chain	Residue	Details
N	ILE95-ILE104

site_id	PS00547
Number of Residues	18
Details	TRANSGLUTAMINASES Transglutaminases active site. GQAWVlAAVacTvLRCLG

Chain	Residue	Details
X	GLY266-GLY283

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	29
Details	Repeat: {"description":"ANK 1"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	29
Details	Repeat: {"description":"ANK 2"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	29
Details	Repeat: {"description":"ANK 3"}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	29
Details	Repeat: {"description":"ANK 4"}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	27
Details	Repeat: {"description":"ANK 5"}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	29
Details	Repeat: {"description":"ANK 6"}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	29
Details	Repeat: {"description":"ANK 7"}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	29
Details	Repeat: {"description":"ANK 8"}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	29
Details	Repeat: {"description":"ANK 9"}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	29
Details	Repeat: {"description":"ANK 10"}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	29
Details	Repeat: {"description":"ANK 11"}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	29
Details	Repeat: {"description":"ANK 12"}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	3
Details	Modified residue: {"description":"(3S)-3-hydroxyasparagine; by HIF1AN; partial","evidences":[{"source":"PubMed","id":"21177872","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	18
Details	Region: {"description":"(Microbial infection) Interaction with P.falciparum (isolate K1) FBPA","evidences":[{"source":"PubMed","id":"2204832","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"10942405","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"1998697","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	46
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"26542571","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	164
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"26542571","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"26542571","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	150
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"26542571","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	32
Details	Transmembrane: {"description":"Discontinuously helical; Name=3","evidences":[{"source":"PubMed","id":"26542571","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"26542571","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	44
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"26542571","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI24
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"26542571","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI25
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"26542571","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI26
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=8","evidences":[{"source":"PubMed","id":"26542571","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI27
Number of Residues	36
Details	Transmembrane: {"description":"Helical; Name=9","evidences":[{"source":"PubMed","id":"26542571","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI28
Number of Residues	34
Details	Transmembrane: {"description":"Discontinuously helical; Name=10","evidences":[{"source":"PubMed","id":"26542571","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI29
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=11","evidences":[{"source":"PubMed","id":"26542571","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI30
Number of Residues	36
Details	Transmembrane: {"description":"Helical; Name=12","evidences":[{"source":"PubMed","id":"26542571","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI31
Number of Residues	60
Details	Intramembrane: {"description":"Discontinuously helical","evidences":[{"source":"PubMed","id":"26542571","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI32
Number of Residues	9
Details	Region: {"description":"Interaction with ANK1","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI33
Number of Residues	142
Details	Region: {"description":"Involved in anion transport"}

Chain

Residue

Details

site_id	SWS_FT_FI34
Number of Residues	2
Details	Site: {"description":"Important for anion transport"}

Chain

Residue

Details

site_id	SWS_FT_FI35
Number of Residues	2
Details	Site: {"description":"Important for anion-proton cotransport"}

Chain

Residue

Details

site_id	SWS_FT_FI36
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P23562","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI37
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P04919","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI38
Number of Residues	2
Details	Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"1885574","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI39
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"10861210","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24121512","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35835865","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI40
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"1998697","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI41
Number of Residues	8
Details	Region: {"description":"Band 3 binding","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI42
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by PKA","evidences":[{"source":"PubMed","id":"8499466","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI43
Number of Residues	648
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI44
Number of Residues	156
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI45
Number of Residues	70
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI46
Number of Residues	10
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI47
Number of Residues	44
Details	Transmembrane: {"description":"Helical"}

Chain

Residue

Details

site_id	SWS_FT_FI48
Number of Residues	68
Details	Transmembrane: {"description":"Helical; Name=Helix 1","evidences":[{"source":"PubMed","id":"35835865","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8CT2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI49
Number of Residues	196
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"7507481","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI50
Number of Residues	72
Details	Transmembrane: {"description":"Helical; Name=Helix 2","evidences":[{"source":"PubMed","id":"35835865","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8CT2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI51
Number of Residues	44
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"7507481","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI52
Number of Residues	100
Details	Intramembrane: {"evidences":[{"source":"PubMed","id":"35835865","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8CT2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI53
Number of Residues	72
Details	Transmembrane: {"description":"Helical; Name=Helix 3","evidences":[{"source":"PubMed","id":"35835865","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8CT2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI54
Number of Residues	76
Details	Transmembrane: {"description":"Helical; Name=Helix 4","evidences":[{"source":"PubMed","id":"35835865","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8CT2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI55
Number of Residues	68
Details	Transmembrane: {"description":"Helical; Name=Helix 5","evidences":[{"source":"PubMed","id":"35835865","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8CT2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI56
Number of Residues	68
Details	Transmembrane: {"description":"Helical; Name=Helix 6","evidences":[{"source":"PubMed","id":"35835865","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8CT2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI57
Number of Residues	8
Details	Motif: {"description":"NPA 1","evidences":[{"source":"PubMed","id":"11532455","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

site_id	SWS_FT_FI58
Number of Residues	8
Details	Motif: {"description":"NPA 2","evidences":[{"source":"PubMed","id":"11532455","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

site_id	SWS_FT_FI59
Number of Residues	4
Details	Site: {"description":"Hg(2+)-sensitive residue","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases","authoringGroup":["SeattleSNPs variation discovery resource"]}}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)