Loading
PDBj
English日本語简体中文繁體中文한국어
✖
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help
SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8CT2

Local refinement of AQP1 tetramer (C1; refinement mask included D1 of protein 4.2 and Ankyrin-1 AR1-5) in Class 2 of erythrocyte ankyrin-1 complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0003091biological_processrenal water homeostasis
A0003097biological_processrenal water transport
A0005223molecular_functionintracellularly cGMP-activated cation channel activity
A0005267molecular_functionpotassium channel activity
A0005372molecular_functionwater transmembrane transporter activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005886cellular_componentplasma membrane
A0005903cellular_componentbrush border
A0006813biological_processpotassium ion transport
A0006833biological_processwater transport
A0006884biological_processcell volume homeostasis
A0006972biological_processhyperosmotic response
A0008519molecular_functionammonium channel activity
A0009925cellular_componentbasal plasma membrane
A0009992biological_processintracellular water homeostasis
A0015079molecular_functionpotassium ion transmembrane transporter activity
A0015168molecular_functionglycerol transmembrane transporter activity
A0015250molecular_functionwater channel activity
A0015267molecular_functionchannel activity
A0015670biological_processcarbon dioxide transport
A0015793biological_processglycerol transmembrane transport
A0016020cellular_componentmembrane
A0016323cellular_componentbasolateral plasma membrane
A0016324cellular_componentapical plasma membrane
A0019725biological_processcellular homeostasis
A0021670biological_processlateral ventricle development
A0022857molecular_functiontransmembrane transporter activity
A0030157biological_processpancreatic juice secretion
A0030184molecular_functionnitric oxide transmembrane transporter activity
A0030185biological_processnitric oxide transport
A0030424cellular_componentaxon
A0030950biological_processestablishment or maintenance of actin cytoskeleton polarity
A0031526cellular_componentbrush border membrane
A0031965cellular_componentnuclear membrane
A0033326biological_processcerebrospinal fluid secretion
A0034644biological_processcellular response to UV
A0035377biological_processtransepithelial water transport
A0035378biological_processcarbon dioxide transmembrane transport
A0035379molecular_functioncarbon dioxide transmembrane transporter activity
A0042383cellular_componentsarcolemma
A0042476biological_processodontogenesis
A0042802molecular_functionidentical protein binding
A0043066biological_processnegative regulation of apoptotic process
A0045177cellular_componentapical part of cell
A0045766biological_processpositive regulation of angiogenesis
A0046875molecular_functionephrin receptor binding
A0046878biological_processpositive regulation of saliva secretion
A0048146biological_processpositive regulation of fibroblast proliferation
A0050829biological_processdefense response to Gram-negative bacterium
A0050891biological_processmulticellular organismal-level water homeostasis
A0055085biological_processtransmembrane transport
A0070062cellular_componentextracellular exosome
A0070301biological_processcellular response to hydrogen peroxide
A0071260biological_processcellular response to mechanical stimulus
A0071280biological_processcellular response to copper ion
A0071288biological_processcellular response to mercury ion
A0071300biological_processcellular response to retinoic acid
A0071320biological_processcellular response to cAMP
A0071456biological_processcellular response to hypoxia
A0071472biological_processcellular response to salt stress
A0071474biological_processcellular hyperosmotic response
A0071549biological_processcellular response to dexamethasone stimulus
A0071732biological_processcellular response to nitric oxide
A0071805biological_processpotassium ion transmembrane transport
A0072220biological_processmetanephric descending thin limb development
A0072230biological_processmetanephric proximal straight tubule development
A0072232biological_processmetanephric proximal convoluted tubule segment 2 development
A0072239biological_processmetanephric glomerulus vasculature development
A0072488biological_processammonium transmembrane transport
A0080170biological_processhydrogen peroxide transmembrane transport
A0098655biological_processmonoatomic cation transmembrane transport
A0140070molecular_functionhydrogen peroxide channel activity
A0170014cellular_componentankyrin-1 complex
B0003091biological_processrenal water homeostasis
B0003097biological_processrenal water transport
B0005223molecular_functionintracellularly cGMP-activated cation channel activity
B0005267molecular_functionpotassium channel activity
B0005372molecular_functionwater transmembrane transporter activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005886cellular_componentplasma membrane
B0005903cellular_componentbrush border
B0006813biological_processpotassium ion transport
B0006833biological_processwater transport
B0006884biological_processcell volume homeostasis
B0006972biological_processhyperosmotic response
B0008519molecular_functionammonium channel activity
B0009925cellular_componentbasal plasma membrane
B0009992biological_processintracellular water homeostasis
B0015079molecular_functionpotassium ion transmembrane transporter activity
B0015168molecular_functionglycerol transmembrane transporter activity
B0015250molecular_functionwater channel activity
B0015267molecular_functionchannel activity
B0015670biological_processcarbon dioxide transport
B0015793biological_processglycerol transmembrane transport
B0016020cellular_componentmembrane
B0016323cellular_componentbasolateral plasma membrane
B0016324cellular_componentapical plasma membrane
B0019725biological_processcellular homeostasis
B0021670biological_processlateral ventricle development
B0022857molecular_functiontransmembrane transporter activity
B0030157biological_processpancreatic juice secretion
B0030184molecular_functionnitric oxide transmembrane transporter activity
B0030185biological_processnitric oxide transport
B0030424cellular_componentaxon
B0030950biological_processestablishment or maintenance of actin cytoskeleton polarity
B0031526cellular_componentbrush border membrane
B0031965cellular_componentnuclear membrane
B0033326biological_processcerebrospinal fluid secretion
B0034644biological_processcellular response to UV
B0035377biological_processtransepithelial water transport
B0035378biological_processcarbon dioxide transmembrane transport
B0035379molecular_functioncarbon dioxide transmembrane transporter activity
B0042383cellular_componentsarcolemma
B0042476biological_processodontogenesis
B0042802molecular_functionidentical protein binding
B0043066biological_processnegative regulation of apoptotic process
B0045177cellular_componentapical part of cell
B0045766biological_processpositive regulation of angiogenesis
B0046875molecular_functionephrin receptor binding
B0046878biological_processpositive regulation of saliva secretion
B0048146biological_processpositive regulation of fibroblast proliferation
B0050829biological_processdefense response to Gram-negative bacterium
B0050891biological_processmulticellular organismal-level water homeostasis
B0055085biological_processtransmembrane transport
B0070062cellular_componentextracellular exosome
B0070301biological_processcellular response to hydrogen peroxide
B0071260biological_processcellular response to mechanical stimulus
B0071280biological_processcellular response to copper ion
B0071288biological_processcellular response to mercury ion
B0071300biological_processcellular response to retinoic acid
B0071320biological_processcellular response to cAMP
B0071456biological_processcellular response to hypoxia
B0071472biological_processcellular response to salt stress
B0071474biological_processcellular hyperosmotic response
B0071549biological_processcellular response to dexamethasone stimulus
B0071732biological_processcellular response to nitric oxide
B0071805biological_processpotassium ion transmembrane transport
B0072220biological_processmetanephric descending thin limb development
B0072230biological_processmetanephric proximal straight tubule development
B0072232biological_processmetanephric proximal convoluted tubule segment 2 development
B0072239biological_processmetanephric glomerulus vasculature development
B0072488biological_processammonium transmembrane transport
B0080170biological_processhydrogen peroxide transmembrane transport
B0098655biological_processmonoatomic cation transmembrane transport
B0140070molecular_functionhydrogen peroxide channel activity
B0170014cellular_componentankyrin-1 complex
C0003091biological_processrenal water homeostasis
C0003097biological_processrenal water transport
C0005223molecular_functionintracellularly cGMP-activated cation channel activity
C0005267molecular_functionpotassium channel activity
C0005372molecular_functionwater transmembrane transporter activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005886cellular_componentplasma membrane
C0005903cellular_componentbrush border
C0006813biological_processpotassium ion transport
C0006833biological_processwater transport
C0006884biological_processcell volume homeostasis
C0006972biological_processhyperosmotic response
C0008519molecular_functionammonium channel activity
C0009925cellular_componentbasal plasma membrane
C0009992biological_processintracellular water homeostasis
C0015079molecular_functionpotassium ion transmembrane transporter activity
C0015168molecular_functionglycerol transmembrane transporter activity
C0015250molecular_functionwater channel activity
C0015267molecular_functionchannel activity
C0015670biological_processcarbon dioxide transport
C0015793biological_processglycerol transmembrane transport
C0016020cellular_componentmembrane
C0016323cellular_componentbasolateral plasma membrane
C0016324cellular_componentapical plasma membrane
C0019725biological_processcellular homeostasis
C0021670biological_processlateral ventricle development
C0022857molecular_functiontransmembrane transporter activity
C0030157biological_processpancreatic juice secretion
C0030184molecular_functionnitric oxide transmembrane transporter activity
C0030185biological_processnitric oxide transport
C0030424cellular_componentaxon
C0030950biological_processestablishment or maintenance of actin cytoskeleton polarity
C0031526cellular_componentbrush border membrane
C0031965cellular_componentnuclear membrane
C0033326biological_processcerebrospinal fluid secretion
C0034644biological_processcellular response to UV
C0035377biological_processtransepithelial water transport
C0035378biological_processcarbon dioxide transmembrane transport
C0035379molecular_functioncarbon dioxide transmembrane transporter activity
C0042383cellular_componentsarcolemma
C0042476biological_processodontogenesis
C0042802molecular_functionidentical protein binding
C0043066biological_processnegative regulation of apoptotic process
C0045177cellular_componentapical part of cell
C0045766biological_processpositive regulation of angiogenesis
C0046875molecular_functionephrin receptor binding
C0046878biological_processpositive regulation of saliva secretion
C0048146biological_processpositive regulation of fibroblast proliferation
C0050829biological_processdefense response to Gram-negative bacterium
C0050891biological_processmulticellular organismal-level water homeostasis
C0055085biological_processtransmembrane transport
C0070062cellular_componentextracellular exosome
C0070301biological_processcellular response to hydrogen peroxide
C0071260biological_processcellular response to mechanical stimulus
C0071280biological_processcellular response to copper ion
C0071288biological_processcellular response to mercury ion
C0071300biological_processcellular response to retinoic acid
C0071320biological_processcellular response to cAMP
C0071456biological_processcellular response to hypoxia
C0071472biological_processcellular response to salt stress
C0071474biological_processcellular hyperosmotic response
C0071549biological_processcellular response to dexamethasone stimulus
C0071732biological_processcellular response to nitric oxide
C0071805biological_processpotassium ion transmembrane transport
C0072220biological_processmetanephric descending thin limb development
C0072230biological_processmetanephric proximal straight tubule development
C0072232biological_processmetanephric proximal convoluted tubule segment 2 development
C0072239biological_processmetanephric glomerulus vasculature development
C0072488biological_processammonium transmembrane transport
C0080170biological_processhydrogen peroxide transmembrane transport
C0098655biological_processmonoatomic cation transmembrane transport
C0140070molecular_functionhydrogen peroxide channel activity
C0170014cellular_componentankyrin-1 complex
D0003091biological_processrenal water homeostasis
D0003097biological_processrenal water transport
D0005223molecular_functionintracellularly cGMP-activated cation channel activity
D0005267molecular_functionpotassium channel activity
D0005372molecular_functionwater transmembrane transporter activity
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005886cellular_componentplasma membrane
D0005903cellular_componentbrush border
D0006813biological_processpotassium ion transport
D0006833biological_processwater transport
D0006884biological_processcell volume homeostasis
D0006972biological_processhyperosmotic response
D0008519molecular_functionammonium channel activity
D0009925cellular_componentbasal plasma membrane
D0009992biological_processintracellular water homeostasis
D0015079molecular_functionpotassium ion transmembrane transporter activity
D0015168molecular_functionglycerol transmembrane transporter activity
D0015250molecular_functionwater channel activity
D0015267molecular_functionchannel activity
D0015670biological_processcarbon dioxide transport
D0015793biological_processglycerol transmembrane transport
D0016020cellular_componentmembrane
D0016323cellular_componentbasolateral plasma membrane
D0016324cellular_componentapical plasma membrane
D0019725biological_processcellular homeostasis
D0021670biological_processlateral ventricle development
D0022857molecular_functiontransmembrane transporter activity
D0030157biological_processpancreatic juice secretion
D0030184molecular_functionnitric oxide transmembrane transporter activity
D0030185biological_processnitric oxide transport
D0030424cellular_componentaxon
D0030950biological_processestablishment or maintenance of actin cytoskeleton polarity
D0031526cellular_componentbrush border membrane
D0031965cellular_componentnuclear membrane
D0033326biological_processcerebrospinal fluid secretion
D0034644biological_processcellular response to UV
D0035377biological_processtransepithelial water transport
D0035378biological_processcarbon dioxide transmembrane transport
D0035379molecular_functioncarbon dioxide transmembrane transporter activity
D0042383cellular_componentsarcolemma
D0042476biological_processodontogenesis
D0042802molecular_functionidentical protein binding
D0043066biological_processnegative regulation of apoptotic process
D0045177cellular_componentapical part of cell
D0045766biological_processpositive regulation of angiogenesis
D0046875molecular_functionephrin receptor binding
D0046878biological_processpositive regulation of saliva secretion
D0048146biological_processpositive regulation of fibroblast proliferation
D0050829biological_processdefense response to Gram-negative bacterium
D0050891biological_processmulticellular organismal-level water homeostasis
D0055085biological_processtransmembrane transport
D0070062cellular_componentextracellular exosome
D0070301biological_processcellular response to hydrogen peroxide
D0071260biological_processcellular response to mechanical stimulus
D0071280biological_processcellular response to copper ion
D0071288biological_processcellular response to mercury ion
D0071300biological_processcellular response to retinoic acid
D0071320biological_processcellular response to cAMP
D0071456biological_processcellular response to hypoxia
D0071472biological_processcellular response to salt stress
D0071474biological_processcellular hyperosmotic response
D0071549biological_processcellular response to dexamethasone stimulus
D0071732biological_processcellular response to nitric oxide
D0071805biological_processpotassium ion transmembrane transport
D0072220biological_processmetanephric descending thin limb development
D0072230biological_processmetanephric proximal straight tubule development
D0072232biological_processmetanephric proximal convoluted tubule segment 2 development
D0072239biological_processmetanephric glomerulus vasculature development
D0072488biological_processammonium transmembrane transport
D0080170biological_processhydrogen peroxide transmembrane transport
D0098655biological_processmonoatomic cation transmembrane transport
D0140070molecular_functionhydrogen peroxide channel activity
D0170014cellular_componentankyrin-1 complex
Functional Information from PROSITE/UniProt
site_idPS00221
Number of Residues9
DetailsMIP MIP family signature. HLNPAVTLG
ChainResidueDetails
DHIS74-GLY82
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues68
DetailsTransmembrane: {"description":"Helical; Name=Helix 1","evidences":[{"source":"PubMed","id":"35835865","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8CT2","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues196
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"7507481","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues72
DetailsTransmembrane: {"description":"Helical; Name=Helix 2","evidences":[{"source":"PubMed","id":"35835865","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8CT2","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues44
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"7507481","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues100
DetailsIntramembrane: {"evidences":[{"source":"PubMed","id":"35835865","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8CT2","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues72
DetailsTransmembrane: {"description":"Helical; Name=Helix 3","evidences":[{"source":"PubMed","id":"35835865","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8CT2","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues76
DetailsTransmembrane: {"description":"Helical; Name=Helix 4","evidences":[{"source":"PubMed","id":"35835865","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8CT2","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues68
DetailsTransmembrane: {"description":"Helical; Name=Helix 5","evidences":[{"source":"PubMed","id":"35835865","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8CT2","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues68
DetailsTransmembrane: {"description":"Helical; Name=Helix 6","evidences":[{"source":"PubMed","id":"35835865","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8CT2","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues8
DetailsMotif: {"description":"NPA 1","evidences":[{"source":"PubMed","id":"11532455","evidenceCode":"ECO:0000303"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues8
DetailsMotif: {"description":"NPA 2","evidences":[{"source":"PubMed","id":"11532455","evidenceCode":"ECO:0000303"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues4
DetailsSite: {"description":"Hg(2+)-sensitive residue","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases","authoringGroup":["SeattleSNPs variation discovery resource"]}}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues8
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

246905

PDB entries from 2025-12-31

PDB statisticsPDBj update infoContact PDBjnumon