Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8CSY

Local refinement of cytoplasmic domains of band3-I in class 2 of erythrocyte ankyrin-1 complex

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0005452	molecular_function	solute:inorganic anion antiporter activity
C	0005515	molecular_function	protein binding
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0006820	biological_process	monoatomic anion transport
C	0006821	biological_process	chloride transport
C	0006873	biological_process	intracellular monoatomic ion homeostasis
C	0007596	biological_process	blood coagulation
C	0008509	molecular_function	monoatomic anion transmembrane transporter activity
C	0009898	cellular_component	cytoplasmic side of plasma membrane
C	0015075	molecular_function	monoatomic ion transmembrane transporter activity
C	0015106	molecular_function	bicarbonate transmembrane transporter activity
C	0015108	molecular_function	chloride transmembrane transporter activity
C	0015297	molecular_function	antiporter activity
C	0015701	biological_process	bicarbonate transport
C	0016020	cellular_component	membrane
C	0016323	cellular_component	basolateral plasma membrane
C	0017121	biological_process	plasma membrane phospholipid scrambling
C	0030018	cellular_component	Z disc
C	0030492	molecular_function	hemoglobin binding
C	0030506	molecular_function	ankyrin binding
C	0030863	cellular_component	cortical cytoskeleton
C	0035811	biological_process	negative regulation of urine volume
C	0042803	molecular_function	protein homodimerization activity
C	0043495	molecular_function	protein-membrane adaptor activity
C	0045852	biological_process	pH elevation
C	0048821	biological_process	erythrocyte development
C	0051453	biological_process	regulation of intracellular pH
C	0055085	biological_process	transmembrane transport
C	0070062	cellular_component	extracellular exosome
C	0072562	cellular_component	blood microparticle
C	0072659	biological_process	protein localization to plasma membrane
C	0098660	biological_process	inorganic ion transmembrane transport
C	0140900	molecular_function	chloride:bicarbonate antiporter activity
C	0170014	cellular_component	ankyrin-1 complex
C	1902476	biological_process	chloride transmembrane transport
C	1904539	biological_process	negative regulation of glycolytic process through fructose-6-phosphate
E	0005452	molecular_function	solute:inorganic anion antiporter activity
E	0005515	molecular_function	protein binding
E	0005886	cellular_component	plasma membrane
E	0006811	biological_process	monoatomic ion transport
E	0006820	biological_process	monoatomic anion transport
E	0006821	biological_process	chloride transport
E	0006873	biological_process	intracellular monoatomic ion homeostasis
E	0007596	biological_process	blood coagulation
E	0008509	molecular_function	monoatomic anion transmembrane transporter activity
E	0009898	cellular_component	cytoplasmic side of plasma membrane
E	0015075	molecular_function	monoatomic ion transmembrane transporter activity
E	0015106	molecular_function	bicarbonate transmembrane transporter activity
E	0015108	molecular_function	chloride transmembrane transporter activity
E	0015297	molecular_function	antiporter activity
E	0015701	biological_process	bicarbonate transport
E	0016020	cellular_component	membrane
E	0016323	cellular_component	basolateral plasma membrane
E	0017121	biological_process	plasma membrane phospholipid scrambling
E	0030018	cellular_component	Z disc
E	0030492	molecular_function	hemoglobin binding
E	0030506	molecular_function	ankyrin binding
E	0030863	cellular_component	cortical cytoskeleton
E	0035811	biological_process	negative regulation of urine volume
E	0042803	molecular_function	protein homodimerization activity
E	0043495	molecular_function	protein-membrane adaptor activity
E	0045852	biological_process	pH elevation
E	0048821	biological_process	erythrocyte development
E	0051453	biological_process	regulation of intracellular pH
E	0055085	biological_process	transmembrane transport
E	0070062	cellular_component	extracellular exosome
E	0072562	cellular_component	blood microparticle
E	0072659	biological_process	protein localization to plasma membrane
E	0098660	biological_process	inorganic ion transmembrane transport
E	0140900	molecular_function	chloride:bicarbonate antiporter activity
E	0170014	cellular_component	ankyrin-1 complex
E	1902476	biological_process	chloride transmembrane transport
E	1904539	biological_process	negative regulation of glycolytic process through fructose-6-phosphate

Functional Information from PROSITE/UniProt

site_id	PS00219
Number of Residues	12
Details	ANION_EXCHANGER_1 Anion exchangers family signature 1. FGGLVRDIRRRY

Chain	Residue	Details
E	PHE379-TYR390

site_id	PS00220
Number of Residues	15
Details	ANION_EXCHANGER_2 Anion exchangers family signature 2. FLISLIFIYETFsKL

Chain	Residue	Details
E	PHE526-LEU540

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1080
Details	TOPO_DOM: Cytoplasmic => ECO:0000269\|PubMed:26542571

Chain	Residue	Details
E	MET1-PRO403
C	GLN457-LEU459
C	PHE507-ARG518
C	LYS592-ARG602
C	THR685-SER700
C	LEU738-ARG760
C	SER801-GLY838
C	ARG870-VAL911
E	GLN457-LEU459
E	PHE507-ARG518
E	LYS592-ARG602
E	THR685-SER700
E	LEU738-ARG760
E	SER801-GLY838
E	ARG870-VAL911
C	MET1-PRO403

site_id	SWS_FT_FI2
Number of Residues	46
Details	TRANSMEM: Helical; Name=1 => ECO:0000269\|PubMed:26542571

Chain	Residue	Details
E	GLN404-LEU427
C	GLN404-LEU427

site_id	SWS_FT_FI3
Number of Residues	164
Details	TOPO_DOM: Extracellular => ECO:0000269\|PubMed:26542571

Chain	Residue	Details
E	GLY428-MET435
E	SER477-GLU485
E	LYS542-THR570
E	ILE624-MET663
C	GLY428-MET435
C	SER477-GLU485
C	LYS542-THR570
C	ILE624-MET663

site_id	SWS_FT_FI4
Number of Residues	40
Details	TRANSMEM: Helical; Name=2 => ECO:0000269\|PubMed:26542571

Chain	Residue	Details
E	GLY436-ALA456
C	GLY436-ALA456

site_id	SWS_FT_FI5
Number of Residues	32
Details	TRANSMEM: Discontinuously helical; Name=3 => ECO:0000269\|PubMed:26542571

Chain	Residue	Details
E	LEU460-PHE476
C	LEU460-PHE476

site_id	SWS_FT_FI6
Number of Residues	40
Details	TRANSMEM: Helical; Name=4 => ECO:0000269\|PubMed:26542571

Chain	Residue	Details
E	TYR486-ALA506
C	TYR486-ALA506

site_id	SWS_FT_FI7
Number of Residues	44
Details	TRANSMEM: Helical; Name=5 => ECO:0000269\|PubMed:26542571

Chain	Residue	Details
E	TYR519-ILE541
C	TYR519-ILE541

site_id	SWS_FT_FI8
Number of Residues	40
Details	TRANSMEM: Helical; Name=6 => ECO:0000269\|PubMed:26542571

Chain	Residue	Details
E	ALA571-PHE591
C	ALA571-PHE591

site_id	SWS_FT_FI9
Number of Residues	40
Details	TRANSMEM: Helical; Name=7 => ECO:0000269\|PubMed:26542571

Chain	Residue	Details
E	ARG603-PHE623
C	ARG603-PHE623

site_id	SWS_FT_FI10
Number of Residues	40
Details	TRANSMEM: Helical; Name=8 => ECO:0000269\|PubMed:26542571

Chain	Residue	Details
E	MET664-ILE684
C	MET664-ILE684

site_id	SWS_FT_FI11
Number of Residues	36
Details	TRANSMEM: Helical; Name=9 => ECO:0000269\|PubMed:26542571

Chain	Residue	Details
E	GLY701-PHE719
C	GLY701-PHE719

site_id	SWS_FT_FI12
Number of Residues	34
Details	TRANSMEM: Discontinuously helical; Name=10 => ECO:0000269\|PubMed:26542571

Chain	Residue	Details
E	GLY720-ALA737
C	GLY720-ALA737

site_id	SWS_FT_FI13
Number of Residues	40
Details	TRANSMEM: Helical; Name=11 => ECO:0000269\|PubMed:26542571

Chain	Residue	Details
E	ILE761-SER781
C	ILE761-SER781

site_id	SWS_FT_FI14
Number of Residues	36
Details	TRANSMEM: Helical; Name=12 => ECO:0000269\|PubMed:26542571

Chain	Residue	Details
E	ARG782-LEU800
C	ARG782-LEU800

site_id	SWS_FT_FI15
Number of Residues	60
Details	INTRAMEM: Discontinuously helical => ECO:0000269\|PubMed:26542571

Chain	Residue	Details
E	ILE839-LEU869
C	ILE839-LEU869

site_id	SWS_FT_FI16
Number of Residues	2
Details	SITE: Important for anion transport

Chain	Residue	Details
E	LYS590
C	LYS590

site_id	SWS_FT_FI17
Number of Residues	2
Details	SITE: Important for anion-proton cotransport

Chain	Residue	Details
E	GLU681
C	GLU681

site_id	SWS_FT_FI18
Number of Residues	2
Details	MOD_RES: N-acetylmethionine => ECO:0000269\|PubMed:2790053, ECO:0000269\|PubMed:701248

Chain	Residue	Details
E	MET1
C	MET1

site_id	SWS_FT_FI19
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0000269\|PubMed:10942405, ECO:0000269\|PubMed:1998697

Chain	Residue	Details
E	TYR8
E	TYR21
C	TYR8
C	TYR21

site_id	SWS_FT_FI20
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0000269\|PubMed:1998697

Chain	Residue	Details
E	TYR46
C	TYR46

site_id	SWS_FT_FI21
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P23562

Chain	Residue	Details
E	SER185
C	SER185

site_id	SWS_FT_FI22
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P04919

Chain	Residue	Details
E	SER350
C	SER350

site_id	SWS_FT_FI23
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0000269\|PubMed:10942405

Chain	Residue	Details
E	TYR359
E	TYR904
C	TYR359
C	TYR904

site_id	SWS_FT_FI24
Number of Residues	2
Details	LIPID: S-palmitoyl cysteine => ECO:0000269\|PubMed:1885574

Chain	Residue	Details
E	CYS843
C	CYS843

site_id	SWS_FT_FI25
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269\|PubMed:10861210, ECO:0000269\|PubMed:24121512, ECO:0000269\|PubMed:35835865

Chain	Residue	Details
E	ASN642
C	ASN642

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)