8CS9

Composite reconstruction of Class 1 of the erythrocyte ankyrin-1 complex

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0016020	cellular_component	membrane
A	0005198	molecular_function	structural molecule activity
A	0005200	molecular_function	structural constituent of cytoskeleton
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005886	cellular_component	plasma membrane
A	0006887	biological_process	exocytosis
A	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
A	0007010	biological_process	cytoskeleton organization
A	0007165	biological_process	signal transduction
A	0008093	molecular_function	cytoskeletal anchor activity
A	0009898	cellular_component	cytoplasmic side of plasma membrane
A	0010638	biological_process	positive regulation of organelle organization
A	0014731	cellular_component	spectrin-associated cytoskeleton
A	0016020	cellular_component	membrane
A	0016323	cellular_component	basolateral plasma membrane
A	0016529	cellular_component	sarcoplasmic reticulum
A	0019899	molecular_function	enzyme binding
A	0019903	molecular_function	protein phosphatase binding
A	0030018	cellular_component	Z disc
A	0030507	molecular_function	spectrin binding
A	0030673	cellular_component	axolemma
A	0031430	cellular_component	M band
A	0031672	cellular_component	A band
A	0042383	cellular_component	sarcolemma
A	0043005	cellular_component	neuron projection
A	0044325	molecular_function	transmembrane transporter binding
A	0045199	biological_process	maintenance of epithelial cell apical/basal polarity
A	0045211	cellular_component	postsynaptic membrane
A	0051117	molecular_function	ATPase binding
A	0072659	biological_process	protein localization to plasma membrane
A	0170014	cellular_component	ankyrin-1 complex
b	0016020	cellular_component	membrane
c	0016020	cellular_component	membrane
e	0005452	molecular_function	solute:inorganic anion antiporter activity
e	0005515	molecular_function	protein binding
e	0005886	cellular_component	plasma membrane
e	0006811	biological_process	monoatomic ion transport
e	0006820	biological_process	monoatomic anion transport
e	0006821	biological_process	chloride transport
e	0006873	biological_process	intracellular monoatomic ion homeostasis
e	0007596	biological_process	blood coagulation
e	0008509	molecular_function	monoatomic anion transmembrane transporter activity
e	0009898	cellular_component	cytoplasmic side of plasma membrane
e	0015075	molecular_function	monoatomic ion transmembrane transporter activity
e	0015106	molecular_function	bicarbonate transmembrane transporter activity
e	0015108	molecular_function	chloride transmembrane transporter activity
e	0015297	molecular_function	antiporter activity
e	0015701	biological_process	bicarbonate transport
e	0016020	cellular_component	membrane
e	0016323	cellular_component	basolateral plasma membrane
e	0017121	biological_process	plasma membrane phospholipid scrambling
e	0030018	cellular_component	Z disc
e	0030492	molecular_function	hemoglobin binding
e	0030506	molecular_function	ankyrin binding
e	0030863	cellular_component	cortical cytoskeleton
e	0035811	biological_process	negative regulation of urine volume
e	0042803	molecular_function	protein homodimerization activity
e	0043495	molecular_function	protein-membrane adaptor activity
e	0045852	biological_process	pH elevation
e	0048821	biological_process	erythrocyte development
e	0051453	biological_process	regulation of intracellular pH
e	0055085	biological_process	transmembrane transport
e	0070062	cellular_component	extracellular exosome
e	0072562	cellular_component	blood microparticle
e	0072659	biological_process	protein localization to plasma membrane
e	0098660	biological_process	inorganic ion transmembrane transport
e	0140900	molecular_function	chloride:bicarbonate antiporter activity
e	0170014	cellular_component	ankyrin-1 complex
e	1902476	biological_process	chloride transmembrane transport
e	1904539	biological_process	negative regulation of glycolytic process through fructose-6-phosphate
f	0005452	molecular_function	solute:inorganic anion antiporter activity
f	0005515	molecular_function	protein binding
f	0005886	cellular_component	plasma membrane
f	0006811	biological_process	monoatomic ion transport
f	0006820	biological_process	monoatomic anion transport
f	0006821	biological_process	chloride transport
f	0006873	biological_process	intracellular monoatomic ion homeostasis
f	0007596	biological_process	blood coagulation
f	0008509	molecular_function	monoatomic anion transmembrane transporter activity
f	0009898	cellular_component	cytoplasmic side of plasma membrane
f	0015075	molecular_function	monoatomic ion transmembrane transporter activity
f	0015106	molecular_function	bicarbonate transmembrane transporter activity
f	0015108	molecular_function	chloride transmembrane transporter activity
f	0015297	molecular_function	antiporter activity
f	0015701	biological_process	bicarbonate transport
f	0016020	cellular_component	membrane
f	0016323	cellular_component	basolateral plasma membrane
f	0017121	biological_process	plasma membrane phospholipid scrambling
f	0030018	cellular_component	Z disc
f	0030492	molecular_function	hemoglobin binding
f	0030506	molecular_function	ankyrin binding
f	0030863	cellular_component	cortical cytoskeleton
f	0035811	biological_process	negative regulation of urine volume
f	0042803	molecular_function	protein homodimerization activity
f	0043495	molecular_function	protein-membrane adaptor activity
f	0045852	biological_process	pH elevation
f	0048821	biological_process	erythrocyte development
f	0051453	biological_process	regulation of intracellular pH
f	0055085	biological_process	transmembrane transport
f	0070062	cellular_component	extracellular exosome
f	0072562	cellular_component	blood microparticle
f	0072659	biological_process	protein localization to plasma membrane
f	0098660	biological_process	inorganic ion transmembrane transport
f	0140900	molecular_function	chloride:bicarbonate antiporter activity
f	0170014	cellular_component	ankyrin-1 complex
f	1902476	biological_process	chloride transmembrane transport
f	1904539	biological_process	negative regulation of glycolytic process through fructose-6-phosphate
g	0005452	molecular_function	solute:inorganic anion antiporter activity
g	0005515	molecular_function	protein binding
g	0005886	cellular_component	plasma membrane
g	0006811	biological_process	monoatomic ion transport
g	0006820	biological_process	monoatomic anion transport
g	0006821	biological_process	chloride transport
g	0006873	biological_process	intracellular monoatomic ion homeostasis
g	0007596	biological_process	blood coagulation
g	0008509	molecular_function	monoatomic anion transmembrane transporter activity
g	0009898	cellular_component	cytoplasmic side of plasma membrane
g	0015075	molecular_function	monoatomic ion transmembrane transporter activity
g	0015106	molecular_function	bicarbonate transmembrane transporter activity
g	0015108	molecular_function	chloride transmembrane transporter activity
g	0015297	molecular_function	antiporter activity
g	0015701	biological_process	bicarbonate transport
g	0016020	cellular_component	membrane
g	0016323	cellular_component	basolateral plasma membrane
g	0017121	biological_process	plasma membrane phospholipid scrambling
g	0030018	cellular_component	Z disc
g	0030492	molecular_function	hemoglobin binding
g	0030506	molecular_function	ankyrin binding
g	0030863	cellular_component	cortical cytoskeleton
g	0035811	biological_process	negative regulation of urine volume
g	0042803	molecular_function	protein homodimerization activity
g	0043495	molecular_function	protein-membrane adaptor activity
g	0045852	biological_process	pH elevation
g	0048821	biological_process	erythrocyte development
g	0051453	biological_process	regulation of intracellular pH
g	0055085	biological_process	transmembrane transport
g	0070062	cellular_component	extracellular exosome
g	0072562	cellular_component	blood microparticle
g	0072659	biological_process	protein localization to plasma membrane
g	0098660	biological_process	inorganic ion transmembrane transport
g	0140900	molecular_function	chloride:bicarbonate antiporter activity
g	0170014	cellular_component	ankyrin-1 complex
g	1902476	biological_process	chloride transmembrane transport
g	1904539	biological_process	negative regulation of glycolytic process through fructose-6-phosphate
K	0005886	cellular_component	plasma membrane
K	0008519	molecular_function	ammonium channel activity
K	0016020	cellular_component	membrane
K	0072488	biological_process	ammonium transmembrane transport
K	0097272	biological_process	ammonium homeostasis
K	0170014	cellular_component	ankyrin-1 complex
L	0005515	molecular_function	protein binding
L	0005886	cellular_component	plasma membrane
L	0006873	biological_process	intracellular monoatomic ion homeostasis
L	0008519	molecular_function	ammonium channel activity
L	0015200	molecular_function	methylammonium transmembrane transporter activity
L	0015670	biological_process	carbon dioxide transport
L	0015701	biological_process	bicarbonate transport
L	0016020	cellular_component	membrane
L	0022840	molecular_function	leak channel activity
L	0030506	molecular_function	ankyrin binding
L	0035378	biological_process	carbon dioxide transmembrane transport
L	0035379	molecular_function	carbon dioxide transmembrane transporter activity
L	0048821	biological_process	erythrocyte development
L	0060586	biological_process	multicellular organismal-level iron ion homeostasis
L	0072488	biological_process	ammonium transmembrane transport
L	0072489	biological_process	methylammonium transmembrane transport
L	0097272	biological_process	ammonium homeostasis
L	0098662	biological_process	inorganic cation transmembrane transport
L	0170014	cellular_component	ankyrin-1 complex
P	0016020	cellular_component	membrane
Q	0005515	molecular_function	protein binding
Q	0005886	cellular_component	plasma membrane
Q	0006873	biological_process	intracellular monoatomic ion homeostasis
Q	0008519	molecular_function	ammonium channel activity
Q	0015200	molecular_function	methylammonium transmembrane transporter activity
Q	0015670	biological_process	carbon dioxide transport
Q	0015701	biological_process	bicarbonate transport
Q	0016020	cellular_component	membrane
Q	0022840	molecular_function	leak channel activity
Q	0030506	molecular_function	ankyrin binding
Q	0035378	biological_process	carbon dioxide transmembrane transport
Q	0035379	molecular_function	carbon dioxide transmembrane transporter activity
Q	0048821	biological_process	erythrocyte development
Q	0060586	biological_process	multicellular organismal-level iron ion homeostasis
Q	0072488	biological_process	ammonium transmembrane transport
Q	0072489	biological_process	methylammonium transmembrane transport
Q	0097272	biological_process	ammonium homeostasis
Q	0098662	biological_process	inorganic cation transmembrane transport
Q	0170014	cellular_component	ankyrin-1 complex
R	0016020	cellular_component	membrane
S	0016020	cellular_component	membrane
T	0016020	cellular_component	membrane
V	0005452	molecular_function	solute:inorganic anion antiporter activity
V	0005515	molecular_function	protein binding
V	0005886	cellular_component	plasma membrane
V	0006811	biological_process	monoatomic ion transport
V	0006820	biological_process	monoatomic anion transport
V	0006821	biological_process	chloride transport
V	0006873	biological_process	intracellular monoatomic ion homeostasis
V	0007596	biological_process	blood coagulation
V	0008509	molecular_function	monoatomic anion transmembrane transporter activity
V	0009898	cellular_component	cytoplasmic side of plasma membrane
V	0015075	molecular_function	monoatomic ion transmembrane transporter activity
V	0015106	molecular_function	bicarbonate transmembrane transporter activity
V	0015108	molecular_function	chloride transmembrane transporter activity
V	0015297	molecular_function	antiporter activity
V	0015701	biological_process	bicarbonate transport
V	0016020	cellular_component	membrane
V	0016323	cellular_component	basolateral plasma membrane
V	0017121	biological_process	plasma membrane phospholipid scrambling
V	0030018	cellular_component	Z disc
V	0030492	molecular_function	hemoglobin binding
V	0030506	molecular_function	ankyrin binding
V	0030863	cellular_component	cortical cytoskeleton
V	0035811	biological_process	negative regulation of urine volume
V	0042803	molecular_function	protein homodimerization activity
V	0043495	molecular_function	protein-membrane adaptor activity
V	0045852	biological_process	pH elevation
V	0048821	biological_process	erythrocyte development
V	0051453	biological_process	regulation of intracellular pH
V	0055085	biological_process	transmembrane transport
V	0070062	cellular_component	extracellular exosome
V	0072562	cellular_component	blood microparticle
V	0072659	biological_process	protein localization to plasma membrane
V	0098660	biological_process	inorganic ion transmembrane transport
V	0140900	molecular_function	chloride:bicarbonate antiporter activity
V	0170014	cellular_component	ankyrin-1 complex
V	1902476	biological_process	chloride transmembrane transport
V	1904539	biological_process	negative regulation of glycolytic process through fructose-6-phosphate
X	0000902	biological_process	cell morphogenesis
X	0003810	molecular_function	protein-glutamine gamma-glutamyltransferase activity
X	0005200	molecular_function	structural constituent of cytoskeleton
X	0005515	molecular_function	protein binding
X	0005524	molecular_function	ATP binding
X	0005737	cellular_component	cytoplasm
X	0005856	cellular_component	cytoskeleton
X	0005886	cellular_component	plasma membrane
X	0007010	biological_process	cytoskeleton organization
X	0008360	biological_process	regulation of cell shape
X	0016020	cellular_component	membrane
X	0018149	biological_process	peptide cross-linking
X	0020027	biological_process	hemoglobin metabolic process
X	0030863	cellular_component	cortical cytoskeleton
X	0043249	biological_process	erythrocyte maturation
X	0048536	biological_process	spleen development
X	0050801	biological_process	monoatomic ion homeostasis
X	0060586	biological_process	multicellular organismal-level iron ion homeostasis
X	0170014	cellular_component	ankyrin-1 complex
Y	0005452	molecular_function	solute:inorganic anion antiporter activity
Y	0005515	molecular_function	protein binding
Y	0005886	cellular_component	plasma membrane
Y	0006811	biological_process	monoatomic ion transport
Y	0006820	biological_process	monoatomic anion transport
Y	0006821	biological_process	chloride transport
Y	0006873	biological_process	intracellular monoatomic ion homeostasis
Y	0007596	biological_process	blood coagulation
Y	0008509	molecular_function	monoatomic anion transmembrane transporter activity
Y	0009898	cellular_component	cytoplasmic side of plasma membrane
Y	0015075	molecular_function	monoatomic ion transmembrane transporter activity
Y	0015106	molecular_function	bicarbonate transmembrane transporter activity
Y	0015108	molecular_function	chloride transmembrane transporter activity
Y	0015297	molecular_function	antiporter activity
Y	0015701	biological_process	bicarbonate transport
Y	0016020	cellular_component	membrane
Y	0016323	cellular_component	basolateral plasma membrane
Y	0017121	biological_process	plasma membrane phospholipid scrambling
Y	0030018	cellular_component	Z disc
Y	0030492	molecular_function	hemoglobin binding
Y	0030506	molecular_function	ankyrin binding
Y	0030863	cellular_component	cortical cytoskeleton
Y	0035811	biological_process	negative regulation of urine volume
Y	0042803	molecular_function	protein homodimerization activity
Y	0043495	molecular_function	protein-membrane adaptor activity
Y	0045852	biological_process	pH elevation
Y	0048821	biological_process	erythrocyte development
Y	0051453	biological_process	regulation of intracellular pH
Y	0055085	biological_process	transmembrane transport
Y	0070062	cellular_component	extracellular exosome
Y	0072562	cellular_component	blood microparticle
Y	0072659	biological_process	protein localization to plasma membrane
Y	0098660	biological_process	inorganic ion transmembrane transport
Y	0140900	molecular_function	chloride:bicarbonate antiporter activity
Y	0170014	cellular_component	ankyrin-1 complex
Y	1902476	biological_process	chloride transmembrane transport
Y	1904539	biological_process	negative regulation of glycolytic process through fructose-6-phosphate
Z	0005452	molecular_function	solute:inorganic anion antiporter activity
Z	0005515	molecular_function	protein binding
Z	0005886	cellular_component	plasma membrane
Z	0006811	biological_process	monoatomic ion transport
Z	0006820	biological_process	monoatomic anion transport
Z	0006821	biological_process	chloride transport
Z	0006873	biological_process	intracellular monoatomic ion homeostasis
Z	0007596	biological_process	blood coagulation
Z	0008509	molecular_function	monoatomic anion transmembrane transporter activity
Z	0009898	cellular_component	cytoplasmic side of plasma membrane
Z	0015075	molecular_function	monoatomic ion transmembrane transporter activity
Z	0015106	molecular_function	bicarbonate transmembrane transporter activity
Z	0015108	molecular_function	chloride transmembrane transporter activity
Z	0015297	molecular_function	antiporter activity
Z	0015701	biological_process	bicarbonate transport
Z	0016020	cellular_component	membrane
Z	0016323	cellular_component	basolateral plasma membrane
Z	0017121	biological_process	plasma membrane phospholipid scrambling
Z	0030018	cellular_component	Z disc
Z	0030492	molecular_function	hemoglobin binding
Z	0030506	molecular_function	ankyrin binding
Z	0030863	cellular_component	cortical cytoskeleton
Z	0035811	biological_process	negative regulation of urine volume
Z	0042803	molecular_function	protein homodimerization activity
Z	0043495	molecular_function	protein-membrane adaptor activity
Z	0045852	biological_process	pH elevation
Z	0048821	biological_process	erythrocyte development
Z	0051453	biological_process	regulation of intracellular pH
Z	0055085	biological_process	transmembrane transport
Z	0070062	cellular_component	extracellular exosome
Z	0072562	cellular_component	blood microparticle
Z	0072659	biological_process	protein localization to plasma membrane
Z	0098660	biological_process	inorganic ion transmembrane transport
Z	0140900	molecular_function	chloride:bicarbonate antiporter activity
Z	0170014	cellular_component	ankyrin-1 complex
Z	1902476	biological_process	chloride transmembrane transport
Z	1904539	biological_process	negative regulation of glycolytic process through fructose-6-phosphate

Functional Information from PROSITE/UniProt

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. KYGFSSVGINLLVAAL

Chain	Residue	Details
L	LYS74-LEU89

---

site_id	PS00219
Number of Residues	12
Details	ANION_EXCHANGER_1 Anion exchangers family signature 1. FGGLVRDIRRRY

Chain	Residue	Details
V	PHE379-TYR390

---

site_id	PS00220
Number of Residues	15
Details	ANION_EXCHANGER_2 Anion exchangers family signature 2. FLISLIFIYETFsKL

Chain	Residue	Details
V	PHE526-LEU540

---

site_id	PS00312
Number of Residues	10
Details	GLYCOPHORIN_A Glycophorin A signature. IIlCVMAGII

Chain	Residue	Details
P	ILE66-ILE75
R	ILE95-ILE104

---

site_id	PS00547
Number of Residues	18
Details	TRANSGLUTAMINASES Transglutaminases active site. GQAWVlAAVacTvLRCLG

Chain	Residue	Details
X	GLY266-GLY283

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3240
Details	TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:26542571

Chain	Residue	Details
V	MET1-PRO403
e	GLN457-LEU459
e	PHE507-ARG518
e	LYS592-ARG602
e	THR685-SER700
e	LEU738-ARG760
e	SER801-GLY838
e	ARG870-VAL911
Y	MET1-PRO403
Y	GLN457-LEU459
Y	PHE507-ARG518
V	GLN457-LEU459
Y	LYS592-ARG602
Y	THR685-SER700
Y	LEU738-ARG760
Y	SER801-GLY838
Y	ARG870-VAL911
f	MET1-PRO403
f	GLN457-LEU459
f	PHE507-ARG518
f	LYS592-ARG602
f	THR685-SER700
V	PHE507-ARG518
f	LEU738-ARG760
f	SER801-GLY838
f	ARG870-VAL911
Z	MET1-PRO403
Z	GLN457-LEU459
Z	PHE507-ARG518
Z	LYS592-ARG602
Z	THR685-SER700
Z	LEU738-ARG760
Z	SER801-GLY838
V	LYS592-ARG602
Z	ARG870-VAL911
g	MET1-PRO403
g	GLN457-LEU459
g	PHE507-ARG518
g	LYS592-ARG602
g	THR685-SER700
g	LEU738-ARG760
g	SER801-GLY838
g	ARG870-VAL911
V	THR685-SER700
V	LEU738-ARG760
V	SER801-GLY838
V	ARG870-VAL911
e	MET1-PRO403

---

site_id	SWS_FT_FI2
Number of Residues	138
Details	TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:26542571

Chain	Residue	Details
V	GLN404-LEU427
L	SER296-PHE318
L	LEU333-ALA353
L	ALA363-LEU383
Q	PHE3-PHE23
Q	PRO52-LEU72
Q	VAL80-ILE100
Q	ASN114-GLY134
Q	ILE143-PHE163
Q	ILE168-ILE188
Q	LEU209-ILE229
e	GLN404-LEU427
Q	ILE240-LEU260
Q	MET269-ILE291
Q	SER296-PHE318
Q	LEU333-ALA353
Q	ALA363-LEU383
Y	GLN404-LEU427
f	GLN404-LEU427
Z	GLN404-LEU427
g	GLN404-LEU427
L	LEU209-ILE229
L	ILE240-LEU260
L	MET269-ILE291

---

site_id	SWS_FT_FI3
Number of Residues	492
Details	TOPO_DOM: Extracellular => ECO:0000269|PubMed:26542571

Chain	Residue	Details
V	GLY428-MET435
Y	SER477-GLU485
Y	LYS542-THR570
Y	ILE624-MET663
f	GLY428-MET435
f	SER477-GLU485
f	LYS542-THR570
f	ILE624-MET663
Z	GLY428-MET435
Z	SER477-GLU485
Z	LYS542-THR570
V	SER477-GLU485
Z	ILE624-MET663
g	GLY428-MET435
g	SER477-GLU485
g	LYS542-THR570
g	ILE624-MET663
V	LYS542-THR570
V	ILE624-MET663
e	GLY428-MET435
e	SER477-GLU485
e	LYS542-THR570
e	ILE624-MET663
Y	GLY428-MET435

---

site_id	SWS_FT_FI4
Number of Residues	120
Details	TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:26542571

Chain	Residue	Details
V	GLY436-ALA456
e	GLY436-ALA456
Y	GLY436-ALA456
f	GLY436-ALA456
Z	GLY436-ALA456
g	GLY436-ALA456

---

site_id	SWS_FT_FI5
Number of Residues	96
Details	TRANSMEM: Discontinuously helical; Name=3 => ECO:0000269|PubMed:26542571

Chain	Residue	Details
V	LEU460-PHE476
T	SER148
c	SER138
c	SER148
e	LEU460-PHE476
Y	LEU460-PHE476
f	LEU460-PHE476
Z	LEU460-PHE476
g	LEU460-PHE476
b	SER138
b	SER148
T	SER138

---

site_id	SWS_FT_FI6
Number of Residues	120
Details	TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:26542571

Chain	Residue	Details
V	TYR486-ALA506
a	SER41
a	SER63
a	SER66
S	SER21
S	SER30
S	SER32
S	SER41
S	SER63
S	SER66
b	SER21
e	TYR486-ALA506
b	SER30
b	SER32
b	SER41
b	SER63
b	SER66
T	SER21
T	SER30
T	SER32
T	SER41
T	SER63
Y	TYR486-ALA506
T	SER66
c	SER21
c	SER30
c	SER32
c	SER41
c	SER63
c	SER66
f	TYR486-ALA506
Z	TYR486-ALA506
g	TYR486-ALA506
a	SER21
a	SER30
a	SER32

---

site_id	SWS_FT_FI7
Number of Residues	132
Details	TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:26542571

Chain	Residue	Details
V	TYR519-ILE541
a	THR29
a	THR31
a	THR44
a	THR56
a	THR69
S	THR22
S	THR23
S	THR29
S	THR31
S	THR44
e	TYR519-ILE541
S	THR56
S	THR69
b	THR22
b	THR23
b	THR29
b	THR31
b	THR44
b	THR56
b	THR69
T	THR22
Y	TYR519-ILE541
T	THR23
T	THR29
T	THR31
T	THR44
T	THR56
T	THR69
c	THR22
c	THR23
c	THR29
c	THR31
f	TYR519-ILE541
c	THR44
c	THR56
c	THR69
Z	TYR519-ILE541
g	TYR519-ILE541
R	THR69
a	THR22
a	THR23

---

site_id	SWS_FT_FI8
Number of Residues	120
Details	TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:26542571

Chain	Residue	Details
V	ALA571-PHE591
T	THR52
c	THR36
c	THR52
e	ALA571-PHE591
Y	ALA571-PHE591
f	ALA571-PHE591
Z	ALA571-PHE591
g	ALA571-PHE591
b	THR36
b	THR52
T	THR36

---

site_id	SWS_FT_FI9
Number of Residues	120
Details	TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:26542571

Chain	Residue	Details
V	ARG603-PHE623
e	ARG603-PHE623
Y	ARG603-PHE623
f	ARG603-PHE623
Z	ARG603-PHE623
g	ARG603-PHE623

---

site_id	SWS_FT_FI10
Number of Residues	120
Details	TRANSMEM: Helical; Name=8 => ECO:0000269|PubMed:26542571

Chain	Residue	Details
V	MET664-ILE684
e	MET664-ILE684
Y	MET664-ILE684
f	MET664-ILE684
Z	MET664-ILE684
g	MET664-ILE684

---

site_id	SWS_FT_FI11
Number of Residues	108
Details	TRANSMEM: Helical; Name=9 => ECO:0000269|PubMed:26542571

Chain	Residue	Details
V	GLY701-PHE719
e	GLY701-PHE719
Y	GLY701-PHE719
f	GLY701-PHE719
Z	GLY701-PHE719
g	GLY701-PHE719

---

site_id	SWS_FT_FI12
Number of Residues	102
Details	TRANSMEM: Discontinuously helical; Name=10 => ECO:0000269|PubMed:26542571

Chain	Residue	Details
V	GLY720-ALA737
e	GLY720-ALA737
Y	GLY720-ALA737
f	GLY720-ALA737
Z	GLY720-ALA737
g	GLY720-ALA737

---

site_id	SWS_FT_FI13
Number of Residues	120
Details	TRANSMEM: Helical; Name=11 => ECO:0000269|PubMed:26542571

Chain	Residue	Details
V	ILE761-SER781
e	ILE761-SER781
Y	ILE761-SER781
f	ILE761-SER781
Z	ILE761-SER781
g	ILE761-SER781

---

site_id	SWS_FT_FI14
Number of Residues	108
Details	TRANSMEM: Helical; Name=12 => ECO:0000269|PubMed:26542571

Chain	Residue	Details
V	ARG782-LEU800
e	ARG782-LEU800
Y	ARG782-LEU800
f	ARG782-LEU800
Z	ARG782-LEU800
g	ARG782-LEU800

---

site_id	SWS_FT_FI15
Number of Residues	180
Details	INTRAMEM: Discontinuously helical => ECO:0000269|PubMed:26542571

Chain	Residue	Details
V	ILE839-LEU869
e	ILE839-LEU869
Y	ILE839-LEU869
f	ILE839-LEU869
Z	ILE839-LEU869
g	ILE839-LEU869

---

site_id	SWS_FT_FI16
Number of Residues	6
Details	SITE: Important for anion transport

Chain	Residue	Details
V	LYS590
e	LYS590
Y	LYS590
f	LYS590
Z	LYS590
g	LYS590

---

site_id	SWS_FT_FI17
Number of Residues	6
Details	SITE: Important for anion-proton cotransport

Chain	Residue	Details
V	GLU681
e	GLU681
Y	GLU681
f	GLU681
Z	GLU681
g	GLU681

---

site_id	SWS_FT_FI18
Number of Residues	6
Details	MOD_RES: N-acetylmethionine => ECO:0000269|PubMed:2790053, ECO:0000269|PubMed:701248

Chain	Residue	Details
V	MET1
e	MET1
Y	MET1
f	MET1
Z	MET1
g	MET1

---

site_id	SWS_FT_FI19
Number of Residues	12
Details	MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:10942405, ECO:0000269|PubMed:1998697

Chain	Residue	Details
V	TYR8
Z	TYR21
g	TYR8
g	TYR21
V	TYR21
e	TYR8
e	TYR21
Y	TYR8
Y	TYR21
f	TYR8
f	TYR21
Z	TYR8

---

site_id	SWS_FT_FI20
Number of Residues	6
Details	MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:1998697

Chain	Residue	Details
V	TYR46
e	TYR46
Y	TYR46
f	TYR46
Z	TYR46
g	TYR46

---

site_id	SWS_FT_FI21
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P23562

Chain	Residue	Details
V	SER185
e	SER185
Y	SER185
f	SER185
Z	SER185
g	SER185

---

site_id	SWS_FT_FI22
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P04919

Chain	Residue	Details
V	SER350
e	SER350
Y	SER350
f	SER350
Z	SER350
g	SER350

---

site_id	SWS_FT_FI23
Number of Residues	12
Details	MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:10942405

Chain	Residue	Details
V	TYR359
Z	TYR904
g	TYR359
g	TYR904
V	TYR904
e	TYR359
e	TYR904
Y	TYR359
Y	TYR904
f	TYR359
f	TYR904
Z	TYR359

---

site_id	SWS_FT_FI24
Number of Residues	6
Details	LIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:1885574

Chain	Residue	Details
V	CYS843
e	CYS843
Y	CYS843
f	CYS843
Z	CYS843
g	CYS843

---

site_id	SWS_FT_FI25
Number of Residues	6
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:10861210, ECO:0000269|PubMed:24121512, ECO:0000269|PubMed:35835865

Chain	Residue	Details
V	ASN642
e	ASN642
Y	ASN642
f	ASN642
Z	ASN642
g	ASN642

---