8CRQ
Local refinement of Band 3-I transmembrane domains, class 1 of erythrocyte ankyrin-1 complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0016020 | cellular_component | membrane |
| C | 0005452 | molecular_function | solute:inorganic anion antiporter activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0006820 | biological_process | monoatomic anion transport |
| C | 0006821 | biological_process | chloride transport |
| C | 0006873 | biological_process | intracellular monoatomic ion homeostasis |
| C | 0007596 | biological_process | blood coagulation |
| C | 0008509 | molecular_function | monoatomic anion transmembrane transporter activity |
| C | 0009898 | cellular_component | cytoplasmic side of plasma membrane |
| C | 0015075 | molecular_function | monoatomic ion transmembrane transporter activity |
| C | 0015106 | molecular_function | bicarbonate transmembrane transporter activity |
| C | 0015108 | molecular_function | chloride transmembrane transporter activity |
| C | 0015297 | molecular_function | antiporter activity |
| C | 0015701 | biological_process | bicarbonate transport |
| C | 0016020 | cellular_component | membrane |
| C | 0016323 | cellular_component | basolateral plasma membrane |
| C | 0017121 | biological_process | plasma membrane phospholipid scrambling |
| C | 0030018 | cellular_component | Z disc |
| C | 0030492 | molecular_function | hemoglobin binding |
| C | 0030506 | molecular_function | ankyrin binding |
| C | 0030863 | cellular_component | cortical cytoskeleton |
| C | 0035811 | biological_process | negative regulation of urine volume |
| C | 0042803 | molecular_function | protein homodimerization activity |
| C | 0043495 | molecular_function | protein-membrane adaptor activity |
| C | 0045852 | biological_process | pH elevation |
| C | 0048821 | biological_process | erythrocyte development |
| C | 0051453 | biological_process | regulation of intracellular pH |
| C | 0055085 | biological_process | transmembrane transport |
| C | 0070062 | cellular_component | extracellular exosome |
| C | 0072562 | cellular_component | blood microparticle |
| C | 0072659 | biological_process | protein localization to plasma membrane |
| C | 0098660 | biological_process | inorganic ion transmembrane transport |
| C | 0140900 | molecular_function | chloride:bicarbonate antiporter activity |
| C | 0170014 | cellular_component | ankyrin-1 complex |
| C | 1902476 | biological_process | chloride transmembrane transport |
| C | 1904539 | biological_process | negative regulation of glycolytic process through fructose-6-phosphate |
| D | 0016020 | cellular_component | membrane |
| E | 0005452 | molecular_function | solute:inorganic anion antiporter activity |
| E | 0005515 | molecular_function | protein binding |
| E | 0005886 | cellular_component | plasma membrane |
| E | 0006811 | biological_process | monoatomic ion transport |
| E | 0006820 | biological_process | monoatomic anion transport |
| E | 0006821 | biological_process | chloride transport |
| E | 0006873 | biological_process | intracellular monoatomic ion homeostasis |
| E | 0007596 | biological_process | blood coagulation |
| E | 0008509 | molecular_function | monoatomic anion transmembrane transporter activity |
| E | 0009898 | cellular_component | cytoplasmic side of plasma membrane |
| E | 0015075 | molecular_function | monoatomic ion transmembrane transporter activity |
| E | 0015106 | molecular_function | bicarbonate transmembrane transporter activity |
| E | 0015108 | molecular_function | chloride transmembrane transporter activity |
| E | 0015297 | molecular_function | antiporter activity |
| E | 0015701 | biological_process | bicarbonate transport |
| E | 0016020 | cellular_component | membrane |
| E | 0016323 | cellular_component | basolateral plasma membrane |
| E | 0017121 | biological_process | plasma membrane phospholipid scrambling |
| E | 0030018 | cellular_component | Z disc |
| E | 0030492 | molecular_function | hemoglobin binding |
| E | 0030506 | molecular_function | ankyrin binding |
| E | 0030863 | cellular_component | cortical cytoskeleton |
| E | 0035811 | biological_process | negative regulation of urine volume |
| E | 0042803 | molecular_function | protein homodimerization activity |
| E | 0043495 | molecular_function | protein-membrane adaptor activity |
| E | 0045852 | biological_process | pH elevation |
| E | 0048821 | biological_process | erythrocyte development |
| E | 0051453 | biological_process | regulation of intracellular pH |
| E | 0055085 | biological_process | transmembrane transport |
| E | 0070062 | cellular_component | extracellular exosome |
| E | 0072562 | cellular_component | blood microparticle |
| E | 0072659 | biological_process | protein localization to plasma membrane |
| E | 0098660 | biological_process | inorganic ion transmembrane transport |
| E | 0140900 | molecular_function | chloride:bicarbonate antiporter activity |
| E | 0170014 | cellular_component | ankyrin-1 complex |
| E | 1902476 | biological_process | chloride transmembrane transport |
| E | 1904539 | biological_process | negative regulation of glycolytic process through fructose-6-phosphate |
Functional Information from PROSITE/UniProt
| site_id | PS00219 |
| Number of Residues | 12 |
| Details | ANION_EXCHANGER_1 Anion exchangers family signature 1. FGGLVRDIRRRY |
| Chain | Residue | Details |
| C | PHE379-TYR390 |
| site_id | PS00220 |
| Number of Residues | 15 |
| Details | ANION_EXCHANGER_2 Anion exchangers family signature 2. FLISLIFIYETFsKL |
| Chain | Residue | Details |
| C | PHE526-LEU540 |
| site_id | PS00312 |
| Number of Residues | 10 |
| Details | GLYCOPHORIN_A Glycophorin A signature. IIfGVMAGVI |
| Chain | Residue | Details |
| B | ILE95-ILE104 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1080 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:26542571 |
| Chain | Residue | Details |
| C | MET1-PRO403 | |
| E | GLN457-LEU459 | |
| E | PHE507-ARG518 | |
| E | LYS592-ARG602 | |
| E | THR685-SER700 | |
| E | LEU738-ARG760 | |
| E | SER801-GLY838 | |
| E | ARG870-VAL911 | |
| C | GLN457-LEU459 | |
| C | PHE507-ARG518 | |
| C | LYS592-ARG602 | |
| C | THR685-SER700 | |
| C | LEU738-ARG760 | |
| C | SER801-GLY838 | |
| C | ARG870-VAL911 | |
| E | MET1-PRO403 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 46 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:26542571 |
| Chain | Residue | Details |
| C | GLN404-LEU427 | |
| E | GLN404-LEU427 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 164 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:26542571 |
| Chain | Residue | Details |
| C | GLY428-MET435 | |
| C | SER477-GLU485 | |
| C | LYS542-THR570 | |
| C | ILE624-MET663 | |
| E | GLY428-MET435 | |
| E | SER477-GLU485 | |
| E | LYS542-THR570 | |
| E | ILE624-MET663 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:26542571 |
| Chain | Residue | Details |
| C | GLY436-ALA456 | |
| E | GLY436-ALA456 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 32 |
| Details | TRANSMEM: Discontinuously helical; Name=3 => ECO:0000269|PubMed:26542571 |
| Chain | Residue | Details |
| C | LEU460-PHE476 | |
| E | LEU460-PHE476 | |
| D | SER138 | |
| D | SER148 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:26542571 |
| Chain | Residue | Details |
| C | TYR486-ALA506 | |
| D | SER41 | |
| D | SER63 | |
| D | SER66 | |
| E | TYR486-ALA506 | |
| B | SER32 | |
| B | SER41 | |
| B | SER63 | |
| B | SER66 | |
| D | SER21 | |
| D | SER30 | |
| D | SER32 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 44 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:26542571 |
| Chain | Residue | Details |
| C | TYR519-ILE541 | |
| D | THR29 | |
| D | THR31 | |
| D | THR44 | |
| D | THR56 | |
| D | THR69 | |
| E | TYR519-ILE541 | |
| B | THR29 | |
| B | THR31 | |
| B | THR44 | |
| B | THR56 | |
| B | THR69 | |
| D | THR22 | |
| D | THR23 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:26542571 |
| Chain | Residue | Details |
| C | ALA571-PHE591 | |
| E | ALA571-PHE591 | |
| D | THR36 | |
| D | THR52 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:26542571 |
| Chain | Residue | Details |
| C | ARG603-PHE623 | |
| E | ARG603-PHE623 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=8 => ECO:0000269|PubMed:26542571 |
| Chain | Residue | Details |
| C | MET664-ILE684 | |
| E | MET664-ILE684 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 36 |
| Details | TRANSMEM: Helical; Name=9 => ECO:0000269|PubMed:26542571 |
| Chain | Residue | Details |
| C | GLY701-PHE719 | |
| E | GLY701-PHE719 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 34 |
| Details | TRANSMEM: Discontinuously helical; Name=10 => ECO:0000269|PubMed:26542571 |
| Chain | Residue | Details |
| C | GLY720-ALA737 | |
| E | GLY720-ALA737 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=11 => ECO:0000269|PubMed:26542571 |
| Chain | Residue | Details |
| C | ILE761-SER781 | |
| E | ILE761-SER781 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 36 |
| Details | TRANSMEM: Helical; Name=12 => ECO:0000269|PubMed:26542571 |
| Chain | Residue | Details |
| C | ARG782-LEU800 | |
| E | ARG782-LEU800 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 60 |
| Details | INTRAMEM: Discontinuously helical => ECO:0000269|PubMed:26542571 |
| Chain | Residue | Details |
| C | ILE839-LEU869 | |
| E | ILE839-LEU869 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 2 |
| Details | SITE: Important for anion transport |
| Chain | Residue | Details |
| C | LYS590 | |
| E | LYS590 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 2 |
| Details | SITE: Important for anion-proton cotransport |
| Chain | Residue | Details |
| C | GLU681 | |
| E | GLU681 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 2 |
| Details | MOD_RES: N-acetylmethionine => ECO:0000269|PubMed:2790053, ECO:0000269|PubMed:701248 |
| Chain | Residue | Details |
| C | MET1 | |
| E | MET1 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:10942405, ECO:0000269|PubMed:1998697 |
| Chain | Residue | Details |
| C | TYR8 | |
| C | TYR21 | |
| E | TYR8 | |
| E | TYR21 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:1998697 |
| Chain | Residue | Details |
| C | TYR46 | |
| E | TYR46 |
| site_id | SWS_FT_FI21 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P23562 |
| Chain | Residue | Details |
| C | SER185 | |
| E | SER185 |
| site_id | SWS_FT_FI22 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P04919 |
| Chain | Residue | Details |
| C | SER350 | |
| E | SER350 |
| site_id | SWS_FT_FI23 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:10942405 |
| Chain | Residue | Details |
| C | TYR359 | |
| C | TYR904 | |
| E | TYR359 | |
| E | TYR904 |
| site_id | SWS_FT_FI24 |
| Number of Residues | 2 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:1885574 |
| Chain | Residue | Details |
| C | CYS843 | |
| E | CYS843 |
| site_id | SWS_FT_FI25 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:10861210, ECO:0000269|PubMed:24121512, ECO:0000269|PubMed:35835865 |
| Chain | Residue | Details |
| C | ASN642 | |
| E | ASN642 |
