8CRE
Crystal structure of the Candida albicans 80S ribosome in complex with geneticin G418
This is a non-PDB format compatible entry.
Functional Information from PROSITE/UniProt
| site_id | PS00049 |
| Number of Residues | 27 |
| Details | RIBOSOMAL_L14 Ribosomal protein L14 signature. AIVIrqskpwrrr.DGvylyFedNagVI |
| Chain | Residue | Details |
| 6 | ALA76-ILE102 |
| site_id | PS00050 |
| Number of Residues | 16 |
| Details | RIBOSOMAL_L23 Ribosomal protein L23 signature. KKAYIRLTsdydaldI |
| Chain | Residue | Details |
| BS | LYS120-ILE135 |
| site_id | PS00051 |
| Number of Residues | 17 |
| Details | RIBOSOMAL_L39E Ribosomal protein L39e signature. RTdnkIryNakrRHWRR |
| Chain | Residue | Details |
| AM | ARG30-ARG46 |
| site_id | PS00052 |
| Number of Residues | 27 |
| Details | RIBOSOMAL_S7 Ribosomal protein S7 signature. ErLtnsLMmngrnnGKKlkavrIVkhA |
| Chain | Residue | Details |
| CS | GLU91-ALA117 |
| site_id | PS00053 |
| Number of Residues | 18 |
| Details | RIBOSOMAL_S8 Ribosomal protein S8 signature. GyvILTTSaGIMdheeAR |
| Chain | Residue | Details |
| Y | GLY100-ARG117 |
| site_id | PS00054 |
| Number of Residues | 23 |
| Details | RIBOSOMAL_S11 Ribosomal protein S11 signature. LrALarS.GLrIgrieDvTPvPSD |
| Chain | Residue | Details |
| Q | LEU97-ASP119 |
| site_id | PS00055 |
| Number of Residues | 8 |
| Details | RIBOSOMAL_S12 Ribosomal protein S12 signature. KqPNSAiR |
| Chain | Residue | Details |
| Z | LYS62-ARG69 |
| site_id | PS00056 |
| Number of Residues | 13 |
| Details | RIBOSOMAL_S17 Ribosomal protein S17 signature. GDvVtVgQcRPIS |
| Chain | Residue | Details |
| N | GLY120-SER132 |
| site_id | PS00299 |
| Number of Residues | 26 |
| Details | UBIQUITIN_1 Ubiquitin domain signature. KskIqDkegIPpdqQrLIFaGkqleD |
| Chain | Residue | Details |
| DS | LYS69-ASP94 |
| site_id | PS00323 |
| Number of Residues | 25 |
| Details | RIBOSOMAL_S19 Ribosomal protein S19 signature. NGKvfntveIkpemVGhyLGEFsiT |
| Chain | Residue | Details |
| R | ASN98-THR122 |
| site_id | PS00358 |
| Number of Residues | 17 |
| Details | RIBOSOMAL_L5 Ribosomal protein L5 signature. LeqLSGQtpVqSkARyT |
| Chain | Residue | Details |
| s | LEU37-THR53 |
| site_id | PS00359 |
| Number of Residues | 16 |
| Details | RIBOSOMAL_L11 Ribosomal protein L11 signature. KeIlGTaqSVGcRVdG |
| Chain | Residue | Details |
| 12 | LYS130-GLY145 |
| site_id | PS00360 |
| Number of Residues | 19 |
| Details | RIBOSOMAL_S9 Ribosomal protein S9 signature. GGGhvSQvyAirqAiAKGL |
| Chain | Residue | Details |
| S | GLY70-LEU88 |
| site_id | PS00361 |
| Number of Residues | 16 |
| Details | RIBOSOMAL_S10 Ribosomal protein S10 signature. AaqyNIvkkGPVrMPT |
| Chain | Residue | Details |
| W | ALA44-THR59 |
| site_id | PS00362 |
| Number of Residues | 31 |
| Details | RIBOSOMAL_S15 Ribosomal protein S15 signature. VrkHLeknRkDkdSkfrLilIesrihrLarY |
| Chain | Residue | Details |
| P | VAL98-TYR128 |
| site_id | PS00430 |
| Number of Residues | 67 |
| Details | TONB_DEPENDENT_REC_1 TonB-dependent receptor (TBDR) proteins signature 1. msqvapkwyqsedvpapkqtrktarpqklraslvpgtvlillagrfrgkrvvylknled........................................................NTLLVSGP |
| Chain | Residue | Details |
| n | MET1-PRO67 |
| site_id | PS00464 |
| Number of Residues | 25 |
| Details | RIBOSOMAL_L22 Ribosomal protein L22 signature. RrrTyRAhGRinayqstpSHIELtL |
| Chain | Residue | Details |
| x | ARG126-LEU150 |
| site_id | PS00467 |
| Number of Residues | 12 |
| Details | RIBOSOMAL_L2 Ribosomal protein L2 signature. PktRGVAmNPvD |
| Chain | Residue | Details |
| j | PRO197-ASP208 |
| site_id | PS00474 |
| Number of Residues | 24 |
| Details | RIBOSOMAL_L3 Ribosomal protein L3 signature. FeqdemiDviAvTkGHGfeGvthR |
| Chain | Residue | Details |
| k | PHE209-ARG232 |
| site_id | PS00475 |
| Number of Residues | 32 |
| Details | RIBOSOMAL_L15 Ribosomal protein L15 signature. KVLGkGrLpevp.ViVkarfVSklAeekIravG |
| Chain | Residue | Details |
| AB | LYS111-GLY142 |
| site_id | PS00526 |
| Number of Residues | 20 |
| Details | RIBOSOMAL_L19E Ribosomal protein L19e signature. QKRLaAsvigVGkrkVWLDP |
| Chain | Residue | Details |
| z | GLN7-PRO26 |
| site_id | PS00527 |
| Number of Residues | 23 |
| Details | RIBOSOMAL_S14 Ribosomal protein S14 signature. RhCsshsglirkyg.LDLCRqCFR |
| Chain | Residue | Details |
| f | ARG22-ARG44 |
| site_id | PS00528 |
| Number of Residues | 15 |
| Details | RIBOSOMAL_S4E Ribosomal protein S4e signature. HlKRLAaPshWmLdK |
| Chain | Residue | Details |
| G | HIS8-LYS22 |
| site_id | PS00529 |
| Number of Residues | 23 |
| Details | RIBOSOMAL_S24E Ribosomal protein S24e signature. FGggKStGFGlIYQSvadakrfE |
| Chain | Residue | Details |
| a | PHE64-GLU86 |
| site_id | PS00578 |
| Number of Residues | 12 |
| Details | RIBOSOMAL_S6E Ribosomal protein S6e signature. ITGGnDkqGfPM |
| Chain | Residue | Details |
| I | ILE52-MET63 |
| site_id | PS00580 |
| Number of Residues | 21 |
| Details | RIBOSOMAL_L32E Ribosomal protein L32e signature. FkRhhsdRyhRVaen..WRKqkG |
| Chain | Residue | Details |
| AF | PHE18-GLY38 |
| site_id | PS00585 |
| Number of Residues | 33 |
| Details | RIBOSOMAL_S5 Ribosomal protein S5 signature. GQrtrMkAvvVIGDsn.GhVGlGiktak.EVas.AI |
| Chain | Residue | Details |
| E | GLY88-ILE120 |
| site_id | PS00632 |
| Number of Residues | 25 |
| Details | RIBOSOMAL_S4 Ribosomal protein S4 signature. LErRLqtqVFKlglArSihhARvLI |
| Chain | Residue | Details |
| L | LEU105-ILE129 |
| site_id | PS00646 |
| Number of Residues | 14 |
| Details | RIBOSOMAL_S13_1 Ribosomal protein S13 signature. RGiRHfwGlkVRGQ |
| Chain | Residue | Details |
| U | ARG123-GLN136 |
| site_id | PS00678 |
| Number of Residues | 15 |
| Details | WD_REPEATS_1 Trp-Asp (WD) repeats signature. ALSAswDrTLRLWDL |
| Chain | Residue | Details |
| AR | ALA81-LEU95 | |
| AR | ILE123-THR137 | |
| AR | VAL166-LEU180 | |
| AR | CYS208-LEU222 |
| site_id | PS00700 |
| Number of Residues | 22 |
| Details | RIBOSOMAL_L6_2 Ribosomal protein L6 signature 2. QicrVrnKdiRkFlDGIYVseR |
| Chain | Residue | Details |
| q | GLN163-ARG184 |
| site_id | PS00709 |
| Number of Residues | 25 |
| Details | RIBOSOMAL_L30E_1 Ribosomal protein L30e signature 1. SgkytlGyKsvVKslRtGkaKlVII |
| Chain | Residue | Details |
| AD | SER22-ILE46 |
| site_id | PS00712 |
| Number of Residues | 16 |
| Details | RIBOSOMAL_S17E Ribosomal protein S17e signature. IqSKrLRNkIAGYtTH |
| Chain | Residue | Details |
| T | ILE41-HIS56 |
| site_id | PS00733 |
| Number of Residues | 8 |
| Details | RIBOSOMAL_S26E Ribosomal protein S26e signature. YCVSCAIH |
| Chain | Residue | Details |
| c | TYR73-HIS80 |
| site_id | PS00783 |
| Number of Residues | 24 |
| Details | RIBOSOMAL_L13 Ribosomal protein L13 signature. IRGMIPhktarGKaalerLkVFeG |
| Chain | Residue | Details |
| w | ILE85-GLY108 |
| site_id | PS00939 |
| Number of Residues | 27 |
| Details | RIBOSOMAL_L1E Ribosomal protein L1e signature. NhneKryATaSAIaASAvtslvlaRGH |
| Chain | Residue | Details |
| l | ASN115-HIS141 |
| site_id | PS00948 |
| Number of Residues | 14 |
| Details | RIBOSOMAL_S7E Ribosomal protein S7e signature. RLtRELEKKFPdRH |
| Chain | Residue | Details |
| J | ARG72-HIS85 |
| site_id | PS00961 |
| Number of Residues | 9 |
| Details | RIBOSOMAL_S28E Ribosomal protein S28e signature. ESEREARrL |
| Chain | Residue | Details |
| e | GLU58-LEU66 |
| site_id | PS00962 |
| Number of Residues | 12 |
| Details | RIBOSOMAL_S2_1 Ribosomal protein S2 signature 1. AkLLLAANVHLG |
| Chain | Residue | Details |
| C | ALA14-GLY25 |
| site_id | PS00963 |
| Number of Residues | 25 |
| Details | RIBOSOMAL_S2_2 Ribosomal protein S2 signature 2. PrlVVVtDprtDaqaIkEssyvNIP |
| Chain | Residue | Details |
| C | PRO118-PRO142 |
| site_id | PS00993 |
| Number of Residues | 21 |
| Details | RIBOSOMAL_L30E_2 Ribosomal protein L30e signature 2. ELGTvcGKlfrvgtLsIlDaG |
| Chain | Residue | Details |
| AD | GLU78-GLY98 |
| site_id | PS00996 |
| Number of Residues | 9 |
| Details | RIBOSOMAL_S21E Ribosomal protein S21e signature. LYVPRKCSA |
| Chain | Residue | Details |
| X | LEU11-ALA19 |
| site_id | PS01073 |
| Number of Residues | 18 |
| Details | RIBOSOMAL_L24E Ribosomal protein L24e signature. FsGskIyPGrGtlFvRgD |
| Chain | Residue | Details |
| 7 | PHE8-ASP25 |
| site_id | PS01077 |
| Number of Residues | 20 |
| Details | RIBOSOMAL_L37E Ribosomal protein L37e signature. GTpSlGkRhnks.HtlCnRCG |
| Chain | Residue | Details |
| AK | GLY4-GLY23 |
| site_id | PS01082 |
| Number of Residues | 18 |
| Details | RIBOSOMAL_L7AE Ribosomal protein L7Ae signature. CkkmgVPYaiVkGKarLG |
| Chain | Residue | Details |
| p | CYS171-GLY188 |
| site_id | PS01104 |
| Number of Residues | 15 |
| Details | RIBOSOMAL_L13E Ribosomal protein L13e signature. RaGRGFTLaELkavG |
| Chain | Residue | Details |
| t | ARG70-GLY84 |
| site_id | PS01105 |
| Number of Residues | 22 |
| Details | RIBOSOMAL_L35AE Ribosomal protein L35Ae signature. GKVtRtHGnnGlVrAnFkknLP |
| Chain | Residue | Details |
| AG | GLY69-PRO90 |
| site_id | PS01106 |
| Number of Residues | 18 |
| Details | RIBOSOMAL_L18E Ribosomal protein L18e signature. KsLflSKinRPpVSVsRI |
| Chain | Residue | Details |
| y | LYS50-ILE67 |
| site_id | PS01107 |
| Number of Residues | 12 |
| Details | RIBOSOMAL_L27E Ribosomal protein L27e signature. GKNkWFFqkLHF |
| Chain | Residue | Details |
| AA | GLY125-PHE136 |
| site_id | PS01108 |
| Number of Residues | 18 |
| Details | RIBOSOMAL_L24 Ribosomal protein L24 signature. NDeVlVVrGskKGse.GkV |
| Chain | Residue | Details |
| 9 | ASN53-VAL70 |
| site_id | PS01144 |
| Number of Residues | 15 |
| Details | RIBOSOMAL_L31E Ribosomal protein L31e signature. VRLDpkLNiAiWkRG |
| Chain | Residue | Details |
| AE | VAL48-GLY62 |
| site_id | PS01145 |
| Number of Residues | 14 |
| Details | RIBOSOMAL_L34E Ribosomal protein L34e signature. TrSnKikvvKTPGG |
| Chain | Residue | Details |
| AH | THR15-GLY28 |
| site_id | PS01168 |
| Number of Residues | 33 |
| Details | RIBOSOMAL_S27E Ribosomal protein S27e signature. KCqgClnittvFShAqtavtCdsCStvLctPtG |
| Chain | Residue | Details |
| d | LYS36-GLY68 |
| site_id | PS01170 |
| Number of Residues | 19 |
| Details | RIBOSOMAL_L6E Ribosomal protein L6e signature. NgvPLRRvnarYVIATSt.K |
| Chain | Residue | Details |
| n | ASN71-LYS89 |
| site_id | PS01171 |
| Number of Residues | 26 |
| Details | RIBOSOMAL_L21E Ribosomal protein L21e signature. GDiVdikangsiqk.GmpHkyYhGkTG |
| Chain | Residue | Details |
| 2 | GLY37-GLY62 |
| site_id | PS01172 |
| Number of Residues | 12 |
| Details | RIBOSOMAL_L44E Ribosomal protein L44e signature. KtTKKvvLRleC |
| Chain | Residue | Details |
| AP | LYS63-CYS74 |
| site_id | PS01189 |
| Number of Residues | 19 |
| Details | RIBOSOMAL_S12E Ribosomal protein S12e signature. ALKvvLrtSlvhDGLarGL |
| Chain | Residue | Details |
| O | ALA27-LEU45 |
| site_id | PS01190 |
| Number of Residues | 11 |
| Details | RIBOSOMAL_L36E Ribosomal protein L36e signature. PYERRlIELIR |
| Chain | Residue | Details |
| AJ | PRO51-ARG61 |
| site_id | PS01191 |
| Number of Residues | 13 |
| Details | RIBOSOMAL_S3AE Ribosomal protein S3Ae signature. LkGRVfEvCLaDL |
| Chain | Residue | Details |
| D | LEU61-LEU73 |
| site_id | PS01193 |
| Number of Residues | 20 |
| Details | RIBOSOMAL_S8E Ribosomal protein S8e signature. RsaTGAkraqf.RkKrKfELG |
| Chain | Residue | Details |
| K | ARG11-GLY30 |
| site_id | PS01194 |
| Number of Residues | 24 |
| Details | RIBOSOMAL_L15E Ribosomal protein L15e signature. DKARrLGYkAkqGFVIYRiRVrRG |
| Chain | Residue | Details |
| v | ASP46-GLY69 |
| site_id | PS01199 |
| Number of Residues | 20 |
| Details | RIBOSOMAL_L1 Ribosomal protein L1 signature. IkqIprlLGptLSKAGkFPT |
| Chain | Residue | Details |
| L1 | ILE117-THR136 |
| site_id | PS01257 |
| Number of Residues | 22 |
| Details | RIBOSOMAL_L10E Ribosomal protein L10e signature. ADRlqqGMRgAWGKPhGlaARV |
| Chain | Residue | Details |
| r | ALA108-VAL129 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:35613268, ECO:0007744|PDB:7PZY |
| Chain | Residue | Details |
| h | LYS121 | |
| h | VAL126 | |
| h | LYS141 | |
| h | VAL144 | |
| DS | LYS121 | |
| DS | VAL126 | |
| DS | LYS141 | |
| DS | VAL144 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) => ECO:0000255|PROSITE-ProRule:PRU00214 |
| Chain | Residue | Details |
| h | GLU76 | |
| AK | CYS22 | |
| DS | GLU76 | |
| AK | CYS37 | |
| CE | CYS19 | |
| CE | CYS22 | |
| CE | CYS34 | |
| CE | CYS37 |
