8CES

Crystal structure of monkeypox virus methyltransferase VP39 in complex with inhibitor TO500

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003746	molecular_function	translation elongation factor activity
A	0004483	molecular_function	mRNA (nucleoside-2'-O-)-methyltransferase activity
A	0006370	biological_process	7-methylguanosine mRNA capping
A	0008168	molecular_function	methyltransferase activity
A	0031440	biological_process	regulation of mRNA 3'-end processing
A	0032259	biological_process	methylation
A	0044423	cellular_component	virion component
B	0003746	molecular_function	translation elongation factor activity
B	0004483	molecular_function	mRNA (nucleoside-2'-O-)-methyltransferase activity
B	0006370	biological_process	7-methylguanosine mRNA capping
B	0008168	molecular_function	methyltransferase activity
B	0031440	biological_process	regulation of mRNA 3'-end processing
B	0032259	biological_process	methylation
B	0044423	cellular_component	virion component

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: For methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00944

Chain	Residue	Details
A	LYS175
B	LYS175

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site_id	SWS_FT_FI2
Number of Residues	26
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00944

Chain	Residue	Details
A	TYR22
A	ARG177
A	ASP182
A	SER205
A	GLU233
B	TYR22
B	GLN39
B	TYR66
B	GLY68
B	GLY72
B	ASP95
A	GLN39
B	ARG97
B	VAL116
B	ASP138
B	ARG177
B	ASP182
B	SER205
B	GLU233
A	TYR66
A	GLY68
A	GLY72
A	ASP95
A	ARG97
A	VAL116
A	ASP138

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