8CAF

N8C_Fab3b in complex with NEDD8-CUL1(WHB)

Functional Information from GO Data

Chain	GOid	namespace	contents
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0031461	cellular_component	cullin-RING ubiquitin ligase complex
E	0031625	molecular_function	ubiquitin protein ligase binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006508	biological_process	proteolysis
F	0006511	biological_process	ubiquitin-dependent protein catabolic process
F	0009653	biological_process	anatomical structure morphogenesis
F	0016567	biological_process	protein ubiquitination
F	0019941	biological_process	modification-dependent protein catabolic process
F	0030162	biological_process	regulation of proteolysis
F	0031386	molecular_function	protein tag activity
F	0031625	molecular_function	ubiquitin protein ligase binding
F	0036211	biological_process	protein modification process
F	0045116	biological_process	protein neddylation
F	0070062	cellular_component	extracellular exosome
F	0072757	biological_process	cellular response to camptothecin
F	0098794	cellular_component	postsynapse
F	0098978	cellular_component	glutamatergic synapse
F	0150052	biological_process	regulation of postsynapse assembly
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006508	biological_process	proteolysis
G	0006511	biological_process	ubiquitin-dependent protein catabolic process
G	0009653	biological_process	anatomical structure morphogenesis
G	0016567	biological_process	protein ubiquitination
G	0019941	biological_process	modification-dependent protein catabolic process
G	0030162	biological_process	regulation of proteolysis
G	0031386	molecular_function	protein tag activity
G	0031625	molecular_function	ubiquitin protein ligase binding
G	0036211	biological_process	protein modification process
G	0045116	biological_process	protein neddylation
G	0070062	cellular_component	extracellular exosome
G	0072757	biological_process	cellular response to camptothecin
G	0098794	cellular_component	postsynapse
G	0098978	cellular_component	glutamatergic synapse
G	0150052	biological_process	regulation of postsynapse assembly
H	0006511	biological_process	ubiquitin-dependent protein catabolic process
H	0031461	cellular_component	cullin-RING ubiquitin ligase complex
H	0031625	molecular_function	ubiquitin protein ligase binding

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH

Chain	Residue	Details
B	TYR204-HIS210
A	TYR192-HIS198

---

site_id	PS00299
Number of Residues	26
Details	UBIQUITIN_1 Ubiquitin domain signature. KerVeEkegIPpqqQrLIYsGkqmnD

Chain	Residue	Details
F	LYS27-ASP52

---

site_id	PS01256
Number of Residues	28
Details	CULLIN_1 Cullin family signature. IKkcIdiLIEKeYLeRvdgekdtYsYlA

Chain	Residue	Details
E	ILE749-ALA776

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	120
Details	Domain: {"description":"Cullin neddylation","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in NEDD8)","evidences":[{"source":"PubMed","id":"10597293","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15537541","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18805092","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Region: {"description":"Interaction with UBE1C","evidences":[{"source":"PubMed","id":"14690597","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Site: {"description":"Interaction with UBE1C","evidences":[{"source":"PubMed","id":"14690597","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"(Microbial infection) Deamidated glutamine","evidences":[{"source":"PubMed","id":"20688984","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21903097","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23175788","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23589306","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26632597","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P29595","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)","evidences":[{"source":"PubMed","id":"38316879","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---