8CAF

N8C_Fab3b in complex with NEDD8-CUL1(WHB)

Functional Information from GO Data

Chain	GOid	namespace	contents
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0031461	cellular_component	cullin-RING ubiquitin ligase complex
E	0031625	molecular_function	ubiquitin protein ligase binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005829	cellular_component	cytosol
F	0006357	biological_process	regulation of transcription by RNA polymerase II
F	0006508	biological_process	proteolysis
F	0006511	biological_process	ubiquitin-dependent protein catabolic process
F	0008104	biological_process	protein localization
F	0009653	biological_process	anatomical structure morphogenesis
F	0016567	biological_process	protein ubiquitination
F	0019941	biological_process	modification-dependent protein catabolic process
F	0030162	biological_process	regulation of proteolysis
F	0031386	molecular_function	protein tag activity
F	0031625	molecular_function	ubiquitin protein ligase binding
F	0036211	biological_process	protein modification process
F	0045116	biological_process	protein neddylation
F	0070062	cellular_component	extracellular exosome
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005829	cellular_component	cytosol
G	0006357	biological_process	regulation of transcription by RNA polymerase II
G	0006508	biological_process	proteolysis
G	0006511	biological_process	ubiquitin-dependent protein catabolic process
G	0008104	biological_process	protein localization
G	0009653	biological_process	anatomical structure morphogenesis
G	0016567	biological_process	protein ubiquitination
G	0019941	biological_process	modification-dependent protein catabolic process
G	0030162	biological_process	regulation of proteolysis
G	0031386	molecular_function	protein tag activity
G	0031625	molecular_function	ubiquitin protein ligase binding
G	0036211	biological_process	protein modification process
G	0045116	biological_process	protein neddylation
G	0070062	cellular_component	extracellular exosome
H	0006511	biological_process	ubiquitin-dependent protein catabolic process
H	0031461	cellular_component	cullin-RING ubiquitin ligase complex
H	0031625	molecular_function	ubiquitin protein ligase binding

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH

Chain	Residue	Details
A	TYR192-HIS198
B	TYR204-HIS210

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site_id	PS00299
Number of Residues	26
Details	UBIQUITIN_1 Ubiquitin domain signature. KerVeEkegIPpqqQrLIYsGkqmnD

Chain	Residue	Details
F	LYS27-ASP52

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site_id	PS01256
Number of Residues	28
Details	CULLIN_1 Cullin family signature. IKkcIdiLIEKeYLeRvdgekdtYsYlA

Chain	Residue	Details
E	ILE749-ALA776

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	SITE: Interaction with UBE1C => ECO:0000269|PubMed:14690597

Chain	Residue	Details
F	LEU8
F	ILE44
G	LEU8
G	ILE44

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site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: (Microbial infection) Deamidated glutamine => ECO:0000269|PubMed:20688984, ECO:0000269|PubMed:21903097, ECO:0000269|PubMed:23175788, ECO:0000269|PubMed:23589306, ECO:0000269|PubMed:26632597

Chain	Residue	Details
F	GLN40
G	GLN40

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P29595

Chain	Residue	Details
F	LYS48
G	LYS48

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site_id	SWS_FT_FI4
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)

Chain	Residue	Details
F	GLY76
G	GLY76

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