Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8CA4

Cryo-EM structure NDUFS4 knockout complex I from Mus musculus heart (Class 2 N-domain).

Functional Information from GO Data

Chain	GOid	namespace	contents
E	0003954	molecular_function	NADH dehydrogenase activity
E	0005739	cellular_component	mitochondrion
E	0005743	cellular_component	mitochondrial inner membrane
E	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
E	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
E	0007399	biological_process	nervous system development
E	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
E	0009060	biological_process	aerobic respiration
E	0016491	molecular_function	oxidoreductase activity
E	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
E	0043209	cellular_component	myelin sheath
E	0045271	cellular_component	respiratory chain complex I
E	0046872	molecular_function	metal ion binding
E	0048738	biological_process	cardiac muscle tissue development
E	0051537	molecular_function	2 iron, 2 sulfur cluster binding
E	0070469	cellular_component	respirasome
E	1902600	biological_process	proton transmembrane transport
F	0005515	molecular_function	protein binding
F	0005739	cellular_component	mitochondrion
F	0005743	cellular_component	mitochondrial inner membrane
F	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
F	0005829	cellular_component	cytosol
F	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
F	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
F	0009060	biological_process	aerobic respiration
F	0010181	molecular_function	FMN binding
F	0016491	molecular_function	oxidoreductase activity
F	0042775	biological_process	mitochondrial ATP synthesis coupled electron transport
F	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
F	0045271	cellular_component	respiratory chain complex I
F	0046872	molecular_function	metal ion binding
F	0051287	molecular_function	NAD binding
F	0051539	molecular_function	4 iron, 4 sulfur cluster binding
F	0070469	cellular_component	respirasome
F	1902600	biological_process	proton transmembrane transport
G	0005515	molecular_function	protein binding
G	0005739	cellular_component	mitochondrion
G	0005743	cellular_component	mitochondrial inner membrane
G	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
G	0005758	cellular_component	mitochondrial intermembrane space
G	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
G	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
G	0008637	biological_process	apoptotic mitochondrial changes
G	0009055	molecular_function	electron transfer activity
G	0009060	biological_process	aerobic respiration
G	0016020	cellular_component	membrane
G	0016491	molecular_function	oxidoreductase activity
G	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
G	0032981	biological_process	mitochondrial respiratory chain complex I assembly
G	0042773	biological_process	ATP synthesis coupled electron transport
G	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
G	0043209	cellular_component	myelin sheath
G	0045271	cellular_component	respiratory chain complex I
G	0045333	biological_process	cellular respiration
G	0046034	biological_process	ATP metabolic process
G	0046872	molecular_function	metal ion binding
G	0051536	molecular_function	iron-sulfur cluster binding
G	0051537	molecular_function	2 iron, 2 sulfur cluster binding
G	0051539	molecular_function	4 iron, 4 sulfur cluster binding
G	0051881	biological_process	regulation of mitochondrial membrane potential
G	0070469	cellular_component	respirasome
G	0072593	biological_process	reactive oxygen species metabolic process
G	1902600	biological_process	proton transmembrane transport
s	0005739	cellular_component	mitochondrion
s	0005743	cellular_component	mitochondrial inner membrane
s	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
s	0009060	biological_process	aerobic respiration
s	0042775	biological_process	mitochondrial ATP synthesis coupled electron transport
s	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
s	0045271	cellular_component	respiratory chain complex I
s	0070469	cellular_component	respirasome
S	0001835	biological_process	blastocyst hatching
S	0005739	cellular_component	mitochondrion
S	0005743	cellular_component	mitochondrial inner membrane
S	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
S	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
S	0009060	biological_process	aerobic respiration
S	0031966	cellular_component	mitochondrial membrane
S	0032981	biological_process	mitochondrial respiratory chain complex I assembly
S	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
S	0045271	cellular_component	respiratory chain complex I
S	0070469	cellular_component	respirasome
S	1902600	biological_process	proton transmembrane transport

Functional Information from PROSITE/UniProt

site_id	PS00641
Number of Residues	18
Details	COMPLEX1_75K_1 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 1. PrfCYherlsvaGnCRmC

Chain	Residue	Details
G	PRO38-CYS55

site_id	PS00642
Number of Residues	13
Details	COMPLEX1_75K_2 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 2. CPiCDqGGeCdLQ

Chain	Residue	Details
G	CYS105-GLN117

site_id	PS00643
Number of Residues	11
Details	COMPLEX1_75K_3 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 3. RCIqCtRCIrF

Chain	Residue	Details
G	ARG152-PHE162

site_id	PS00644
Number of Residues	16
Details	COMPLEX1_51K_1 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 1. GAGAYICGEETALIES

Chain	Residue	Details
F	GLY180-SER195

site_id	PS00645
Number of Residues	12
Details	COMPLEX1_51K_2 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2. ESCGqCtPCReG

Chain	Residue	Details
F	GLU357-GLY368

site_id	PS01099
Number of Residues	19
Details	COMPLEX1_24K Respiratory-chain NADH dehydrogenase 24 Kd subunit signature. DklFTlieveCLGaCvnAP

Chain	Residue	Details
E	ASP134-PRO152

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P56181

Chain	Residue	Details
s	SER66
G	CYS52
G	CYS55
G	CYS69
G	CYS153
G	CYS156
G	CYS159
G	CYS203

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0007744\|PubMed:23806337

Chain	Residue	Details
S	LYS63
G	CYS105
G	CYS108
G	CYS114

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0007744\|PubMed:23576753

Chain	Residue	Details
S	LYS74
G	LYS444
G	LYS476
G	LYS686

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:21183079

Chain	Residue	Details
G	SER438
F	LYS355

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Omega-N-methylarginine => ECO:0007744\|PubMed:24129315

Chain	Residue	Details
F	ARG237

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)