8BX2

Oct4/Sox2 protein:DNA complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000981	molecular_function	DNA-binding transcription factor activity, RNA polymerase II-specific
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PROSITE/UniProt

site_id	PS00027
Number of Residues	24
Details	HOMEOBOX_1 'Homeobox' domain signature. IAnqLgLEkdVVRVWFsNrrqkgK

Chain	Residue	Details
A	ILE126-LYS149

---

site_id	PS00035
Number of Residues	13
Details	POU_1 POU-specific (POUs) domain signature 1. KRItLGYtQaDVG

Chain	Residue	Details
A	LYS19-GLY31

---

site_id	PS00465
Number of Residues	14
Details	POU_2 POU-specific (POUs) domain signature 2. SQTTISRFEaLqLS

Chain	Residue	Details
A	SER43-SER56

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	59
Details	DNA_BIND: Homeobox => ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:23376973

Chain	Residue	Details
A	ARG93-SER152

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:23376973, ECO:0007744|PDB:3L1P

Chain	Residue	Details
A	ARG20
A	GLN27

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q01860

Chain	Residue	Details
A	THR98

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q01860

Chain	Residue	Details
A	SER99
A	SER152

---