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8BJJ

ExoY Nucleotidyl Cyclase domain from Vibrio nigripulchritudo MARTX toxin, bound to ATP-Mg-actin, human profilin 1 and a sulfate ion

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0001725cellular_componentstress fiber
A0003785molecular_functionactin monomer binding
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005523molecular_functiontropomyosin binding
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0005856cellular_componentcytoskeleton
A0005865cellular_componentstriated muscle thin filament
A0005884cellular_componentactin filament
A0010628biological_processpositive regulation of gene expression
A0016787molecular_functionhydrolase activity
A0019904molecular_functionprotein domain specific binding
A0030027cellular_componentlamellipodium
A0030041biological_processactin filament polymerization
A0030175cellular_componentfilopodium
A0030240biological_processskeletal muscle thin filament assembly
A0031013molecular_functiontroponin I binding
A0031432molecular_functiontitin binding
A0031941cellular_componentfilamentous actin
A0032036molecular_functionmyosin heavy chain binding
A0032432cellular_componentactin filament bundle
A0042802molecular_functionidentical protein binding
A0044297cellular_componentcell body
A0048306molecular_functioncalcium-dependent protein binding
A0048741biological_processskeletal muscle fiber development
A0051017biological_processactin filament bundle assembly
A0090131biological_processmesenchyme migration
A0098723cellular_componentskeletal muscle myofibril
A0140660molecular_functioncytoskeletal motor activator activity
B0005576cellular_componentextracellular region
B0008294molecular_functioncalcium- and calmodulin-responsive adenylate cyclase activity
C0000774molecular_functionadenyl-nucleotide exchange factor activity
C0001784molecular_functionphosphotyrosine residue binding
C0001843biological_processneural tube closure
C0003723molecular_functionRNA binding
C0003779molecular_functionactin binding
C0003785molecular_functionactin monomer binding
C0005515molecular_functionprotein binding
C0005546molecular_functionphosphatidylinositol-4,5-bisphosphate binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005925cellular_componentfocal adhesion
C0005938cellular_componentcell cortex
C0006357biological_processregulation of transcription by RNA polymerase II
C0010634biological_processpositive regulation of epithelial cell migration
C0016020cellular_componentmembrane
C0030036biological_processactin cytoskeleton organization
C0030833biological_processregulation of actin filament polymerization
C0030837biological_processnegative regulation of actin filament polymerization
C0030838biological_processpositive regulation of actin filament polymerization
C0031267molecular_functionsmall GTPase binding
C0032232biological_processnegative regulation of actin filament bundle assembly
C0032233biological_processpositive regulation of actin filament bundle assembly
C0032781biological_processpositive regulation of ATP-dependent activity
C0044087biological_processregulation of cellular component biogenesis
C0045296molecular_functioncadherin binding
C0050804biological_processmodulation of chemical synaptic transmission
C0050821biological_processprotein stabilization
C0051497biological_processnegative regulation of stress fiber assembly
C0060074biological_processsynapse maturation
C0070062cellular_componentextracellular exosome
C0070064molecular_functionproline-rich region binding
C0072562cellular_componentblood microparticle
C0098885biological_processmodification of postsynaptic actin cytoskeleton
C0098978cellular_componentglutamatergic synapse
C0110053biological_processregulation of actin filament organization
C1900029biological_processpositive regulation of ruffle assembly
Functional Information from PROSITE/UniProt
site_idPS00406
Number of Residues11
DetailsACTINS_1 Actins signature 1. YVGDEAQs.KRG
ChainResidueDetails
ATYR53-GLY63

site_idPS00414
Number of Residues8
DetailsPROFILIN Profilin signature. .AgWNaYiD
ChainResidueDetails
CALA1-ASP8

site_idPS00432
Number of Residues9
DetailsACTINS_2 Actins signature 2. WITKqEYDE
ChainResidueDetails
ATRP356-GLU364

site_idPS01132
Number of Residues13
DetailsACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPkaNR
ChainResidueDetails
ALEU104-ARG116

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N-acetylalanine => ECO:0000269|PubMed:3342873, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:25944712
ChainResidueDetails
CALA1

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P62963
ChainResidueDetails
CSER27
AMET47

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
CSER56

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332
ChainResidueDetails
CSER84

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
CLYS104
CLYS107

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15592455
ChainResidueDetails
CTYR128

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: Phosphoserine; by ROCK1 => ECO:0000269|PubMed:18573880
ChainResidueDetails
CSER137

site_idSWS_FT_FI8
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate
ChainResidueDetails
CLYS53

227111

PDB entries from 2024-11-06

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