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8B41

Structure of heteromeric LRRC8A/C (1:1 co-transfected) Volume-Regulated Anion Channel in complex with synthetic nanobody Sb1

Functional Information from GO Data
ChainGOidnamespacecontents
A0001678biological_processintracellular glucose homeostasis
A0002329biological_processpre-B cell differentiation
A0005225molecular_functionvolume-sensitive anion channel activity
A0005253molecular_functionmonoatomic anion channel activity
A0005737cellular_componentcytoplasm
A0005764cellular_componentlysosome
A0005765cellular_componentlysosomal membrane
A0005886cellular_componentplasma membrane
A0006820biological_processmonoatomic anion transport
A0006884biological_processcell volume homeostasis
A0006970biological_processresponse to osmotic stress
A0007283biological_processspermatogenesis
A0009986cellular_componentcell surface
A0015734biological_processtaurine transmembrane transport
A0015810biological_processaspartate transmembrane transport
A0016020cellular_componentmembrane
A0030154biological_processcell differentiation
A0032024biological_processpositive regulation of insulin secretion
A0034214biological_processprotein hexamerization
A0034220biological_processmonoatomic ion transmembrane transport
A0034702cellular_componentmonoatomic ion channel complex
A0042802molecular_functionidentical protein binding
A0045663biological_processpositive regulation of myoblast differentiation
A0055085biological_processtransmembrane transport
A0098656biological_processmonoatomic anion transmembrane transport
A0140360molecular_functioncyclic-GMP-AMP transmembrane transporter activity
A0140361biological_processcyclic-GMP-AMP transmembrane import across plasma membrane
A1902476biological_processchloride transmembrane transport
B0001678biological_processintracellular glucose homeostasis
B0002329biological_processpre-B cell differentiation
B0005225molecular_functionvolume-sensitive anion channel activity
B0005253molecular_functionmonoatomic anion channel activity
B0005737cellular_componentcytoplasm
B0005764cellular_componentlysosome
B0005765cellular_componentlysosomal membrane
B0005886cellular_componentplasma membrane
B0006820biological_processmonoatomic anion transport
B0006884biological_processcell volume homeostasis
B0006970biological_processresponse to osmotic stress
B0007283biological_processspermatogenesis
B0009986cellular_componentcell surface
B0015734biological_processtaurine transmembrane transport
B0015810biological_processaspartate transmembrane transport
B0016020cellular_componentmembrane
B0030154biological_processcell differentiation
B0032024biological_processpositive regulation of insulin secretion
B0034214biological_processprotein hexamerization
B0034220biological_processmonoatomic ion transmembrane transport
B0034702cellular_componentmonoatomic ion channel complex
B0042802molecular_functionidentical protein binding
B0045663biological_processpositive regulation of myoblast differentiation
B0055085biological_processtransmembrane transport
B0098656biological_processmonoatomic anion transmembrane transport
B0140360molecular_functioncyclic-GMP-AMP transmembrane transporter activity
B0140361biological_processcyclic-GMP-AMP transmembrane import across plasma membrane
B1902476biological_processchloride transmembrane transport
C0001678biological_processintracellular glucose homeostasis
C0002329biological_processpre-B cell differentiation
C0005225molecular_functionvolume-sensitive anion channel activity
C0005253molecular_functionmonoatomic anion channel activity
C0005737cellular_componentcytoplasm
C0005764cellular_componentlysosome
C0005765cellular_componentlysosomal membrane
C0005886cellular_componentplasma membrane
C0006820biological_processmonoatomic anion transport
C0006884biological_processcell volume homeostasis
C0006970biological_processresponse to osmotic stress
C0007283biological_processspermatogenesis
C0009986cellular_componentcell surface
C0015734biological_processtaurine transmembrane transport
C0015810biological_processaspartate transmembrane transport
C0016020cellular_componentmembrane
C0030154biological_processcell differentiation
C0032024biological_processpositive regulation of insulin secretion
C0034214biological_processprotein hexamerization
C0034220biological_processmonoatomic ion transmembrane transport
C0034702cellular_componentmonoatomic ion channel complex
C0042802molecular_functionidentical protein binding
C0045663biological_processpositive regulation of myoblast differentiation
C0055085biological_processtransmembrane transport
C0098656biological_processmonoatomic anion transmembrane transport
C0140360molecular_functioncyclic-GMP-AMP transmembrane transporter activity
C0140361biological_processcyclic-GMP-AMP transmembrane import across plasma membrane
C1902476biological_processchloride transmembrane transport
D0001678biological_processintracellular glucose homeostasis
D0002329biological_processpre-B cell differentiation
D0005225molecular_functionvolume-sensitive anion channel activity
D0005253molecular_functionmonoatomic anion channel activity
D0005737cellular_componentcytoplasm
D0005764cellular_componentlysosome
D0005765cellular_componentlysosomal membrane
D0005886cellular_componentplasma membrane
D0006820biological_processmonoatomic anion transport
D0006884biological_processcell volume homeostasis
D0006970biological_processresponse to osmotic stress
D0007283biological_processspermatogenesis
D0009986cellular_componentcell surface
D0015734biological_processtaurine transmembrane transport
D0015810biological_processaspartate transmembrane transport
D0016020cellular_componentmembrane
D0030154biological_processcell differentiation
D0032024biological_processpositive regulation of insulin secretion
D0034214biological_processprotein hexamerization
D0034220biological_processmonoatomic ion transmembrane transport
D0034702cellular_componentmonoatomic ion channel complex
D0042802molecular_functionidentical protein binding
D0045663biological_processpositive regulation of myoblast differentiation
D0055085biological_processtransmembrane transport
D0098656biological_processmonoatomic anion transmembrane transport
D0140360molecular_functioncyclic-GMP-AMP transmembrane transporter activity
D0140361biological_processcyclic-GMP-AMP transmembrane import across plasma membrane
D1902476biological_processchloride transmembrane transport
E0005225molecular_functionvolume-sensitive anion channel activity
E0005737cellular_componentcytoplasm
E0005783cellular_componentendoplasmic reticulum
E0005789cellular_componentendoplasmic reticulum membrane
E0005886cellular_componentplasma membrane
E0015734biological_processtaurine transmembrane transport
E0015810biological_processaspartate transmembrane transport
E0034214biological_processprotein hexamerization
E0034220biological_processmonoatomic ion transmembrane transport
E0034702cellular_componentmonoatomic ion channel complex
E0045444biological_processfat cell differentiation
E0055085biological_processtransmembrane transport
E0071470biological_processcellular response to osmotic stress
E0098656biological_processmonoatomic anion transmembrane transport
E0140361biological_processcyclic-GMP-AMP transmembrane import across plasma membrane
F0005225molecular_functionvolume-sensitive anion channel activity
F0005737cellular_componentcytoplasm
F0005783cellular_componentendoplasmic reticulum
F0005789cellular_componentendoplasmic reticulum membrane
F0005886cellular_componentplasma membrane
F0015734biological_processtaurine transmembrane transport
F0015810biological_processaspartate transmembrane transport
F0034214biological_processprotein hexamerization
F0034220biological_processmonoatomic ion transmembrane transport
F0034702cellular_componentmonoatomic ion channel complex
F0045444biological_processfat cell differentiation
F0055085biological_processtransmembrane transport
F0071470biological_processcellular response to osmotic stress
F0098656biological_processmonoatomic anion transmembrane transport
F0140361biological_processcyclic-GMP-AMP transmembrane import across plasma membrane
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues160
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
ETRP23-CYS43
CTYR124-PHE142
CMET265-VAL286
CLEU317-TRP341
DTRP23-VAL47
DTYR124-PHE142
DMET265-VAL286
DLEU317-TRP341
ETYR126-PHE146
EVAL267-VAL287
EPHE321-LEU341
FTRP23-CYS43
FTYR126-PHE146
FVAL267-VAL287
FPHE321-LEU341
CTRP23-VAL47

site_idSWS_FT_FI2
Number of Residues226
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
ETHR44-LYS125
EGLN288-SER320
FTHR44-LYS125
FGLN288-SER320
CTHR48-LYS123
CHIS287-THR316
DTHR48-LYS123
DHIS287-THR316

site_idSWS_FT_FI3
Number of Residues1160
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
ELYS147-THR266
EPHE342-ASP803
FLYS147-THR266
FPHE342-ASP803
CTRP143-TYR264
CTRP342-ALA810
DTRP143-TYR264
DTRP342-ALA810

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q8TDW0
ChainResidueDetails
ESER212
FSER212
CARG103
DARG103

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q498T9
ChainResidueDetails
ESER215
FSER215
CTHR200
DTHR200

site_idSWS_FT_FI6
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:21183079
ChainResidueDetails
ASER202
BSER202
CSER202
DSER202

site_idSWS_FT_FI7
Number of Residues4
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q8IWT6
ChainResidueDetails
ATHR215
BTHR215
CTHR215
DTHR215

site_idSWS_FT_FI8
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q8IWT6
ChainResidueDetails
ASER217
BSER217
CSER217
DSER217

site_idSWS_FT_FI9
Number of Residues8
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN66
AASN83
BASN66
BASN83
CASN66
CASN83
DASN66
DASN83

222624

PDB entries from 2024-07-17

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