8AUW
Cryo-EM structure of human BIRC6 in complex with SMAC.
This is a non-PDB format compatible entry.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000922 | cellular_component | spindle pole |
| A | 0001890 | biological_process | placenta development |
| A | 0004842 | molecular_function | ubiquitin-protein transferase activity |
| A | 0004869 | molecular_function | cysteine-type endopeptidase inhibitor activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005768 | cellular_component | endosome |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0005802 | cellular_component | trans-Golgi network |
| A | 0005813 | cellular_component | centrosome |
| A | 0005815 | cellular_component | microtubule organizing center |
| A | 0005829 | cellular_component | cytosol |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0006915 | biological_process | apoptotic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016567 | biological_process | protein ubiquitination |
| A | 0016740 | molecular_function | transferase activity |
| A | 0030414 | molecular_function | peptidase inhibitor activity |
| A | 0030496 | cellular_component | midbody |
| A | 0032465 | biological_process | regulation of cytokinesis |
| A | 0042127 | biological_process | regulation of cell population proliferation |
| A | 0043066 | biological_process | negative regulation of apoptotic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051301 | biological_process | cell division |
| A | 0061631 | molecular_function | ubiquitin conjugating enzyme activity |
| A | 0072686 | cellular_component | mitotic spindle |
| A | 0090543 | cellular_component | Flemming body |
| A | 2001237 | biological_process | negative regulation of extrinsic apoptotic signaling pathway |
| B | 0000922 | cellular_component | spindle pole |
| B | 0001890 | biological_process | placenta development |
| B | 0004842 | molecular_function | ubiquitin-protein transferase activity |
| B | 0004869 | molecular_function | cysteine-type endopeptidase inhibitor activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005768 | cellular_component | endosome |
| B | 0005794 | cellular_component | Golgi apparatus |
| B | 0005802 | cellular_component | trans-Golgi network |
| B | 0005813 | cellular_component | centrosome |
| B | 0005815 | cellular_component | microtubule organizing center |
| B | 0005829 | cellular_component | cytosol |
| B | 0006468 | biological_process | protein phosphorylation |
| B | 0006915 | biological_process | apoptotic process |
| B | 0016020 | cellular_component | membrane |
| B | 0016567 | biological_process | protein ubiquitination |
| B | 0016740 | molecular_function | transferase activity |
| B | 0030414 | molecular_function | peptidase inhibitor activity |
| B | 0030496 | cellular_component | midbody |
| B | 0032465 | biological_process | regulation of cytokinesis |
| B | 0042127 | biological_process | regulation of cell population proliferation |
| B | 0043066 | biological_process | negative regulation of apoptotic process |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0051301 | biological_process | cell division |
| B | 0061631 | molecular_function | ubiquitin conjugating enzyme activity |
| B | 0072686 | cellular_component | mitotic spindle |
| B | 0090543 | cellular_component | Flemming body |
| B | 2001237 | biological_process | negative regulation of extrinsic apoptotic signaling pathway |
| C | 0005739 | cellular_component | mitochondrion |
| C | 0006915 | biological_process | apoptotic process |
| D | 0005739 | cellular_component | mitochondrion |
| D | 0006915 | biological_process | apoptotic process |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 76 |
| Details | Repeat: {"description":"WD 1","evidences":[{"source":"PubMed","id":"36758104","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36758105","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36758106","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E2G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8E2I","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 58 |
| Details | Repeat: {"description":"WD 2","evidences":[{"source":"PubMed","id":"36758104","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36758105","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36758106","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E2G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8E2I","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 218 |
| Details | Repeat: {"description":"BIR","evidences":[{"source":"PubMed","id":"36758104","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36758105","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36758106","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 94 |
| Details | Repeat: {"description":"WD 3","evidences":[{"source":"PubMed","id":"36758104","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36758105","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36758106","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E2G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8E2I","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 76 |
| Details | Repeat: {"description":"WD 7","evidences":[{"source":"PubMed","id":"36758104","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36758105","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36758106","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E2G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8E2I","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | Region: {"description":"HRRAR loop; important for DIABLO/SMAC and HTRA2 binding","evidences":[{"source":"PubMed","id":"36758105","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36758106","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8ATO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8AUK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8AUW","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"36758105","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8ATU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ATX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8AUK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8AUW","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
