8AS5

CryoEM structure of the human Nucleophosmin 1 core

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000055	biological_process	ribosomal large subunit export from nucleus
A	0000056	biological_process	ribosomal small subunit export from nucleus
A	0001046	molecular_function	core promoter sequence-specific DNA binding
A	0001652	cellular_component	granular component
A	0003676	molecular_function	nucleic acid binding
A	0003682	molecular_function	chromatin binding
A	0003713	molecular_function	transcription coactivator activity
A	0003723	molecular_function	RNA binding
A	0004860	molecular_function	protein kinase inhibitor activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0005813	cellular_component	centrosome
A	0005829	cellular_component	cytosol
A	0005925	cellular_component	focal adhesion
A	0006281	biological_process	DNA repair
A	0006334	biological_process	nucleosome assembly
A	0006338	biological_process	chromatin remodeling
A	0006606	biological_process	protein import into nucleus
A	0006886	biological_process	intracellular protein transport
A	0006913	biological_process	nucleocytoplasmic transport
A	0007098	biological_process	centrosome cycle
A	0007165	biological_process	signal transduction
A	0007249	biological_process	canonical NF-kappaB signal transduction
A	0008104	biological_process	intracellular protein localization
A	0008284	biological_process	positive regulation of cell population proliferation
A	0008285	biological_process	negative regulation of cell population proliferation
A	0010604	biological_process	positive regulation of macromolecule metabolic process
A	0010824	biological_process	regulation of centrosome duplication
A	0010826	biological_process	negative regulation of centrosome duplication
A	0015934	cellular_component	large ribosomal subunit
A	0015935	cellular_component	small ribosomal subunit
A	0016020	cellular_component	membrane
A	0016607	cellular_component	nuclear speck
A	0019843	molecular_function	rRNA binding
A	0019901	molecular_function	protein kinase binding
A	0030225	biological_process	macrophage differentiation
A	0030957	molecular_function	Tat protein binding
A	0031616	cellular_component	spindle pole centrosome
A	0032991	cellular_component	protein-containing complex
A	0032993	cellular_component	protein-DNA complex
A	0034644	biological_process	cellular response to UV
A	0042127	biological_process	regulation of cell population proliferation
A	0042254	biological_process	ribosome biogenesis
A	0042255	biological_process	ribosome assembly
A	0042273	biological_process	ribosomal large subunit biogenesis
A	0042274	biological_process	ribosomal small subunit biogenesis
A	0042393	molecular_function	histone binding
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0043023	molecular_function	ribosomal large subunit binding
A	0043024	molecular_function	ribosomal small subunit binding
A	0043066	biological_process	negative regulation of apoptotic process
A	0045893	biological_process	positive regulation of DNA-templated transcription
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0046599	biological_process	regulation of centriole replication
A	0051059	molecular_function	NF-kappaB binding
A	0051082	molecular_function	unfolded protein binding
A	0060090	molecular_function	molecular adaptor activity
A	0090398	biological_process	cellular senescence
A	0140297	molecular_function	DNA-binding transcription factor binding
A	1902629	biological_process	regulation of mRNA stability involved in cellular response to UV
A	1902751	biological_process	positive regulation of cell cycle G2/M phase transition
A	1904751	biological_process	positive regulation of protein localization to nucleolus
A	1990904	cellular_component	ribonucleoprotein complex
A	2000767	biological_process	positive regulation of cytoplasmic translation
B	0000055	biological_process	ribosomal large subunit export from nucleus
B	0000056	biological_process	ribosomal small subunit export from nucleus
B	0001046	molecular_function	core promoter sequence-specific DNA binding
B	0001652	cellular_component	granular component
B	0003676	molecular_function	nucleic acid binding
B	0003682	molecular_function	chromatin binding
B	0003713	molecular_function	transcription coactivator activity
B	0003723	molecular_function	RNA binding
B	0004860	molecular_function	protein kinase inhibitor activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005730	cellular_component	nucleolus
B	0005737	cellular_component	cytoplasm
B	0005813	cellular_component	centrosome
B	0005829	cellular_component	cytosol
B	0005925	cellular_component	focal adhesion
B	0006281	biological_process	DNA repair
B	0006334	biological_process	nucleosome assembly
B	0006338	biological_process	chromatin remodeling
B	0006606	biological_process	protein import into nucleus
B	0006886	biological_process	intracellular protein transport
B	0006913	biological_process	nucleocytoplasmic transport
B	0007098	biological_process	centrosome cycle
B	0007165	biological_process	signal transduction
B	0007249	biological_process	canonical NF-kappaB signal transduction
B	0008104	biological_process	intracellular protein localization
B	0008284	biological_process	positive regulation of cell population proliferation
B	0008285	biological_process	negative regulation of cell population proliferation
B	0010604	biological_process	positive regulation of macromolecule metabolic process
B	0010824	biological_process	regulation of centrosome duplication
B	0010826	biological_process	negative regulation of centrosome duplication
B	0015934	cellular_component	large ribosomal subunit
B	0015935	cellular_component	small ribosomal subunit
B	0016020	cellular_component	membrane
B	0016607	cellular_component	nuclear speck
B	0019843	molecular_function	rRNA binding
B	0019901	molecular_function	protein kinase binding
B	0030225	biological_process	macrophage differentiation
B	0030957	molecular_function	Tat protein binding
B	0031616	cellular_component	spindle pole centrosome
B	0032991	cellular_component	protein-containing complex
B	0032993	cellular_component	protein-DNA complex
B	0034644	biological_process	cellular response to UV
B	0042127	biological_process	regulation of cell population proliferation
B	0042254	biological_process	ribosome biogenesis
B	0042255	biological_process	ribosome assembly
B	0042273	biological_process	ribosomal large subunit biogenesis
B	0042274	biological_process	ribosomal small subunit biogenesis
B	0042393	molecular_function	histone binding
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0043023	molecular_function	ribosomal large subunit binding
B	0043024	molecular_function	ribosomal small subunit binding
B	0043066	biological_process	negative regulation of apoptotic process
B	0045893	biological_process	positive regulation of DNA-templated transcription
B	0045944	biological_process	positive regulation of transcription by RNA polymerase II
B	0046599	biological_process	regulation of centriole replication
B	0051059	molecular_function	NF-kappaB binding
B	0051082	molecular_function	unfolded protein binding
B	0060090	molecular_function	molecular adaptor activity
B	0090398	biological_process	cellular senescence
B	0140297	molecular_function	DNA-binding transcription factor binding
B	1902629	biological_process	regulation of mRNA stability involved in cellular response to UV
B	1902751	biological_process	positive regulation of cell cycle G2/M phase transition
B	1904751	biological_process	positive regulation of protein localization to nucleolus
B	1990904	cellular_component	ribonucleoprotein complex
B	2000767	biological_process	positive regulation of cytoplasmic translation
C	0000055	biological_process	ribosomal large subunit export from nucleus
C	0000056	biological_process	ribosomal small subunit export from nucleus
C	0001046	molecular_function	core promoter sequence-specific DNA binding
C	0001652	cellular_component	granular component
C	0003676	molecular_function	nucleic acid binding
C	0003682	molecular_function	chromatin binding
C	0003713	molecular_function	transcription coactivator activity
C	0003723	molecular_function	RNA binding
C	0004860	molecular_function	protein kinase inhibitor activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005730	cellular_component	nucleolus
C	0005737	cellular_component	cytoplasm
C	0005813	cellular_component	centrosome
C	0005829	cellular_component	cytosol
C	0005925	cellular_component	focal adhesion
C	0006281	biological_process	DNA repair
C	0006334	biological_process	nucleosome assembly
C	0006338	biological_process	chromatin remodeling
C	0006606	biological_process	protein import into nucleus
C	0006886	biological_process	intracellular protein transport
C	0006913	biological_process	nucleocytoplasmic transport
C	0007098	biological_process	centrosome cycle
C	0007165	biological_process	signal transduction
C	0007249	biological_process	canonical NF-kappaB signal transduction
C	0008104	biological_process	intracellular protein localization
C	0008284	biological_process	positive regulation of cell population proliferation
C	0008285	biological_process	negative regulation of cell population proliferation
C	0010604	biological_process	positive regulation of macromolecule metabolic process
C	0010824	biological_process	regulation of centrosome duplication
C	0010826	biological_process	negative regulation of centrosome duplication
C	0015934	cellular_component	large ribosomal subunit
C	0015935	cellular_component	small ribosomal subunit
C	0016020	cellular_component	membrane
C	0016607	cellular_component	nuclear speck
C	0019843	molecular_function	rRNA binding
C	0019901	molecular_function	protein kinase binding
C	0030225	biological_process	macrophage differentiation
C	0030957	molecular_function	Tat protein binding
C	0031616	cellular_component	spindle pole centrosome
C	0032991	cellular_component	protein-containing complex
C	0032993	cellular_component	protein-DNA complex
C	0034644	biological_process	cellular response to UV
C	0042127	biological_process	regulation of cell population proliferation
C	0042254	biological_process	ribosome biogenesis
C	0042255	biological_process	ribosome assembly
C	0042273	biological_process	ribosomal large subunit biogenesis
C	0042274	biological_process	ribosomal small subunit biogenesis
C	0042393	molecular_function	histone binding
C	0042802	molecular_function	identical protein binding
C	0042803	molecular_function	protein homodimerization activity
C	0043023	molecular_function	ribosomal large subunit binding
C	0043024	molecular_function	ribosomal small subunit binding
C	0043066	biological_process	negative regulation of apoptotic process
C	0045893	biological_process	positive regulation of DNA-templated transcription
C	0045944	biological_process	positive regulation of transcription by RNA polymerase II
C	0046599	biological_process	regulation of centriole replication
C	0051059	molecular_function	NF-kappaB binding
C	0051082	molecular_function	unfolded protein binding
C	0060090	molecular_function	molecular adaptor activity
C	0090398	biological_process	cellular senescence
C	0140297	molecular_function	DNA-binding transcription factor binding
C	1902629	biological_process	regulation of mRNA stability involved in cellular response to UV
C	1902751	biological_process	positive regulation of cell cycle G2/M phase transition
C	1904751	biological_process	positive regulation of protein localization to nucleolus
C	1990904	cellular_component	ribonucleoprotein complex
C	2000767	biological_process	positive regulation of cytoplasmic translation
D	0000055	biological_process	ribosomal large subunit export from nucleus
D	0000056	biological_process	ribosomal small subunit export from nucleus
D	0001046	molecular_function	core promoter sequence-specific DNA binding
D	0001652	cellular_component	granular component
D	0003676	molecular_function	nucleic acid binding
D	0003682	molecular_function	chromatin binding
D	0003713	molecular_function	transcription coactivator activity
D	0003723	molecular_function	RNA binding
D	0004860	molecular_function	protein kinase inhibitor activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005730	cellular_component	nucleolus
D	0005737	cellular_component	cytoplasm
D	0005813	cellular_component	centrosome
D	0005829	cellular_component	cytosol
D	0005925	cellular_component	focal adhesion
D	0006281	biological_process	DNA repair
D	0006334	biological_process	nucleosome assembly
D	0006338	biological_process	chromatin remodeling
D	0006606	biological_process	protein import into nucleus
D	0006886	biological_process	intracellular protein transport
D	0006913	biological_process	nucleocytoplasmic transport
D	0007098	biological_process	centrosome cycle
D	0007165	biological_process	signal transduction
D	0007249	biological_process	canonical NF-kappaB signal transduction
D	0008104	biological_process	intracellular protein localization
D	0008284	biological_process	positive regulation of cell population proliferation
D	0008285	biological_process	negative regulation of cell population proliferation
D	0010604	biological_process	positive regulation of macromolecule metabolic process
D	0010824	biological_process	regulation of centrosome duplication
D	0010826	biological_process	negative regulation of centrosome duplication
D	0015934	cellular_component	large ribosomal subunit
D	0015935	cellular_component	small ribosomal subunit
D	0016020	cellular_component	membrane
D	0016607	cellular_component	nuclear speck
D	0019843	molecular_function	rRNA binding
D	0019901	molecular_function	protein kinase binding
D	0030225	biological_process	macrophage differentiation
D	0030957	molecular_function	Tat protein binding
D	0031616	cellular_component	spindle pole centrosome
D	0032991	cellular_component	protein-containing complex
D	0032993	cellular_component	protein-DNA complex
D	0034644	biological_process	cellular response to UV
D	0042127	biological_process	regulation of cell population proliferation
D	0042254	biological_process	ribosome biogenesis
D	0042255	biological_process	ribosome assembly
D	0042273	biological_process	ribosomal large subunit biogenesis
D	0042274	biological_process	ribosomal small subunit biogenesis
D	0042393	molecular_function	histone binding
D	0042802	molecular_function	identical protein binding
D	0042803	molecular_function	protein homodimerization activity
D	0043023	molecular_function	ribosomal large subunit binding
D	0043024	molecular_function	ribosomal small subunit binding
D	0043066	biological_process	negative regulation of apoptotic process
D	0045893	biological_process	positive regulation of DNA-templated transcription
D	0045944	biological_process	positive regulation of transcription by RNA polymerase II
D	0046599	biological_process	regulation of centriole replication
D	0051059	molecular_function	NF-kappaB binding
D	0051082	molecular_function	unfolded protein binding
D	0060090	molecular_function	molecular adaptor activity
D	0090398	biological_process	cellular senescence
D	0140297	molecular_function	DNA-binding transcription factor binding
D	1902629	biological_process	regulation of mRNA stability involved in cellular response to UV
D	1902751	biological_process	positive regulation of cell cycle G2/M phase transition
D	1904751	biological_process	positive regulation of protein localization to nucleolus
D	1990904	cellular_component	ribonucleoprotein complex
D	2000767	biological_process	positive regulation of cytoplasmic translation
E	0000055	biological_process	ribosomal large subunit export from nucleus
E	0000056	biological_process	ribosomal small subunit export from nucleus
E	0001046	molecular_function	core promoter sequence-specific DNA binding
E	0001652	cellular_component	granular component
E	0003676	molecular_function	nucleic acid binding
E	0003682	molecular_function	chromatin binding
E	0003713	molecular_function	transcription coactivator activity
E	0003723	molecular_function	RNA binding
E	0004860	molecular_function	protein kinase inhibitor activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005730	cellular_component	nucleolus
E	0005737	cellular_component	cytoplasm
E	0005813	cellular_component	centrosome
E	0005829	cellular_component	cytosol
E	0005925	cellular_component	focal adhesion
E	0006281	biological_process	DNA repair
E	0006334	biological_process	nucleosome assembly
E	0006338	biological_process	chromatin remodeling
E	0006606	biological_process	protein import into nucleus
E	0006886	biological_process	intracellular protein transport
E	0006913	biological_process	nucleocytoplasmic transport
E	0007098	biological_process	centrosome cycle
E	0007165	biological_process	signal transduction
E	0007249	biological_process	canonical NF-kappaB signal transduction
E	0008104	biological_process	intracellular protein localization
E	0008284	biological_process	positive regulation of cell population proliferation
E	0008285	biological_process	negative regulation of cell population proliferation
E	0010604	biological_process	positive regulation of macromolecule metabolic process
E	0010824	biological_process	regulation of centrosome duplication
E	0010826	biological_process	negative regulation of centrosome duplication
E	0015934	cellular_component	large ribosomal subunit
E	0015935	cellular_component	small ribosomal subunit
E	0016020	cellular_component	membrane
E	0016607	cellular_component	nuclear speck
E	0019843	molecular_function	rRNA binding
E	0019901	molecular_function	protein kinase binding
E	0030225	biological_process	macrophage differentiation
E	0030957	molecular_function	Tat protein binding
E	0031616	cellular_component	spindle pole centrosome
E	0032991	cellular_component	protein-containing complex
E	0032993	cellular_component	protein-DNA complex
E	0034644	biological_process	cellular response to UV
E	0042127	biological_process	regulation of cell population proliferation
E	0042254	biological_process	ribosome biogenesis
E	0042255	biological_process	ribosome assembly
E	0042273	biological_process	ribosomal large subunit biogenesis
E	0042274	biological_process	ribosomal small subunit biogenesis
E	0042393	molecular_function	histone binding
E	0042802	molecular_function	identical protein binding
E	0042803	molecular_function	protein homodimerization activity
E	0043023	molecular_function	ribosomal large subunit binding
E	0043024	molecular_function	ribosomal small subunit binding
E	0043066	biological_process	negative regulation of apoptotic process
E	0045893	biological_process	positive regulation of DNA-templated transcription
E	0045944	biological_process	positive regulation of transcription by RNA polymerase II
E	0046599	biological_process	regulation of centriole replication
E	0051059	molecular_function	NF-kappaB binding
E	0051082	molecular_function	unfolded protein binding
E	0060090	molecular_function	molecular adaptor activity
E	0090398	biological_process	cellular senescence
E	0140297	molecular_function	DNA-binding transcription factor binding
E	1902629	biological_process	regulation of mRNA stability involved in cellular response to UV
E	1902751	biological_process	positive regulation of cell cycle G2/M phase transition
E	1904751	biological_process	positive regulation of protein localization to nucleolus
E	1990904	cellular_component	ribonucleoprotein complex
E	2000767	biological_process	positive regulation of cytoplasmic translation

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	7
Details	Site: {"description":"Interaction between pentamers","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	5
Details	Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	5
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	5
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q61937","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	5
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17081983","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"17924679","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18220336","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	5
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	5
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"17081983","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	5
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25218447","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	10
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"25114211","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25218447","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25755297","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25772364","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---