8AS5

CryoEM structure of the human Nucleophosmin 1 core

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000055	biological_process	ribosomal large subunit export from nucleus
A	0000056	biological_process	ribosomal small subunit export from nucleus
A	0001046	molecular_function	core promoter sequence-specific DNA binding
A	0001652	cellular_component	granular component
A	0003676	molecular_function	nucleic acid binding
A	0003682	molecular_function	chromatin binding
A	0003713	molecular_function	transcription coactivator activity
A	0003723	molecular_function	RNA binding
A	0004860	molecular_function	protein kinase inhibitor activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0005813	cellular_component	centrosome
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005925	cellular_component	focal adhesion
A	0006281	biological_process	DNA repair
A	0006334	biological_process	nucleosome assembly
A	0006338	biological_process	chromatin remodeling
A	0006886	biological_process	intracellular protein transport
A	0006913	biological_process	nucleocytoplasmic transport
A	0007098	biological_process	centrosome cycle
A	0007165	biological_process	signal transduction
A	0008104	biological_process	protein localization
A	0008284	biological_process	positive regulation of cell population proliferation
A	0008285	biological_process	negative regulation of cell population proliferation
A	0010824	biological_process	regulation of centrosome duplication
A	0010826	biological_process	negative regulation of centrosome duplication
A	0016020	cellular_component	membrane
A	0019843	molecular_function	rRNA binding
A	0019901	molecular_function	protein kinase binding
A	0030957	molecular_function	Tat protein binding
A	0031616	cellular_component	spindle pole centrosome
A	0032071	biological_process	regulation of endodeoxyribonuclease activity
A	0032991	cellular_component	protein-containing complex
A	0032993	cellular_component	protein-DNA complex
A	0034644	biological_process	cellular response to UV
A	0042255	biological_process	ribosome assembly
A	0042273	biological_process	ribosomal large subunit biogenesis
A	0042274	biological_process	ribosomal small subunit biogenesis
A	0042393	molecular_function	histone binding
A	0042803	molecular_function	protein homodimerization activity
A	0043023	molecular_function	ribosomal large subunit binding
A	0043024	molecular_function	ribosomal small subunit binding
A	0043066	biological_process	negative regulation of apoptotic process
A	0044387	biological_process	negative regulation of protein kinase activity by regulation of protein phosphorylation
A	0045727	biological_process	positive regulation of translation
A	0045893	biological_process	positive regulation of DNA-templated transcription
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0046599	biological_process	regulation of centriole replication
A	0051059	molecular_function	NF-kappaB binding
A	0051082	molecular_function	unfolded protein binding
A	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
A	0060699	biological_process	regulation of endoribonuclease activity
A	0060735	biological_process	regulation of eIF2 alpha phosphorylation by dsRNA
A	0090398	biological_process	cellular senescence
A	0140297	molecular_function	DNA-binding transcription factor binding
A	1902629	biological_process	regulation of mRNA stability involved in cellular response to UV
A	1902751	biological_process	positive regulation of cell cycle G2/M phase transition
A	1990904	cellular_component	ribonucleoprotein complex
B	0000055	biological_process	ribosomal large subunit export from nucleus
B	0000056	biological_process	ribosomal small subunit export from nucleus
B	0001046	molecular_function	core promoter sequence-specific DNA binding
B	0001652	cellular_component	granular component
B	0003676	molecular_function	nucleic acid binding
B	0003682	molecular_function	chromatin binding
B	0003713	molecular_function	transcription coactivator activity
B	0003723	molecular_function	RNA binding
B	0004860	molecular_function	protein kinase inhibitor activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005730	cellular_component	nucleolus
B	0005737	cellular_component	cytoplasm
B	0005813	cellular_component	centrosome
B	0005829	cellular_component	cytosol
B	0005856	cellular_component	cytoskeleton
B	0005925	cellular_component	focal adhesion
B	0006281	biological_process	DNA repair
B	0006334	biological_process	nucleosome assembly
B	0006338	biological_process	chromatin remodeling
B	0006886	biological_process	intracellular protein transport
B	0006913	biological_process	nucleocytoplasmic transport
B	0007098	biological_process	centrosome cycle
B	0007165	biological_process	signal transduction
B	0008104	biological_process	protein localization
B	0008284	biological_process	positive regulation of cell population proliferation
B	0008285	biological_process	negative regulation of cell population proliferation
B	0010824	biological_process	regulation of centrosome duplication
B	0010826	biological_process	negative regulation of centrosome duplication
B	0016020	cellular_component	membrane
B	0019843	molecular_function	rRNA binding
B	0019901	molecular_function	protein kinase binding
B	0030957	molecular_function	Tat protein binding
B	0031616	cellular_component	spindle pole centrosome
B	0032071	biological_process	regulation of endodeoxyribonuclease activity
B	0032991	cellular_component	protein-containing complex
B	0032993	cellular_component	protein-DNA complex
B	0034644	biological_process	cellular response to UV
B	0042255	biological_process	ribosome assembly
B	0042273	biological_process	ribosomal large subunit biogenesis
B	0042274	biological_process	ribosomal small subunit biogenesis
B	0042393	molecular_function	histone binding
B	0042803	molecular_function	protein homodimerization activity
B	0043023	molecular_function	ribosomal large subunit binding
B	0043024	molecular_function	ribosomal small subunit binding
B	0043066	biological_process	negative regulation of apoptotic process
B	0044387	biological_process	negative regulation of protein kinase activity by regulation of protein phosphorylation
B	0045727	biological_process	positive regulation of translation
B	0045893	biological_process	positive regulation of DNA-templated transcription
B	0045944	biological_process	positive regulation of transcription by RNA polymerase II
B	0046599	biological_process	regulation of centriole replication
B	0051059	molecular_function	NF-kappaB binding
B	0051082	molecular_function	unfolded protein binding
B	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
B	0060699	biological_process	regulation of endoribonuclease activity
B	0060735	biological_process	regulation of eIF2 alpha phosphorylation by dsRNA
B	0090398	biological_process	cellular senescence
B	0140297	molecular_function	DNA-binding transcription factor binding
B	1902629	biological_process	regulation of mRNA stability involved in cellular response to UV
B	1902751	biological_process	positive regulation of cell cycle G2/M phase transition
B	1990904	cellular_component	ribonucleoprotein complex
C	0000055	biological_process	ribosomal large subunit export from nucleus
C	0000056	biological_process	ribosomal small subunit export from nucleus
C	0001046	molecular_function	core promoter sequence-specific DNA binding
C	0001652	cellular_component	granular component
C	0003676	molecular_function	nucleic acid binding
C	0003682	molecular_function	chromatin binding
C	0003713	molecular_function	transcription coactivator activity
C	0003723	molecular_function	RNA binding
C	0004860	molecular_function	protein kinase inhibitor activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005730	cellular_component	nucleolus
C	0005737	cellular_component	cytoplasm
C	0005813	cellular_component	centrosome
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
C	0005925	cellular_component	focal adhesion
C	0006281	biological_process	DNA repair
C	0006334	biological_process	nucleosome assembly
C	0006338	biological_process	chromatin remodeling
C	0006886	biological_process	intracellular protein transport
C	0006913	biological_process	nucleocytoplasmic transport
C	0007098	biological_process	centrosome cycle
C	0007165	biological_process	signal transduction
C	0008104	biological_process	protein localization
C	0008284	biological_process	positive regulation of cell population proliferation
C	0008285	biological_process	negative regulation of cell population proliferation
C	0010824	biological_process	regulation of centrosome duplication
C	0010826	biological_process	negative regulation of centrosome duplication
C	0016020	cellular_component	membrane
C	0019843	molecular_function	rRNA binding
C	0019901	molecular_function	protein kinase binding
C	0030957	molecular_function	Tat protein binding
C	0031616	cellular_component	spindle pole centrosome
C	0032071	biological_process	regulation of endodeoxyribonuclease activity
C	0032991	cellular_component	protein-containing complex
C	0032993	cellular_component	protein-DNA complex
C	0034644	biological_process	cellular response to UV
C	0042255	biological_process	ribosome assembly
C	0042273	biological_process	ribosomal large subunit biogenesis
C	0042274	biological_process	ribosomal small subunit biogenesis
C	0042393	molecular_function	histone binding
C	0042803	molecular_function	protein homodimerization activity
C	0043023	molecular_function	ribosomal large subunit binding
C	0043024	molecular_function	ribosomal small subunit binding
C	0043066	biological_process	negative regulation of apoptotic process
C	0044387	biological_process	negative regulation of protein kinase activity by regulation of protein phosphorylation
C	0045727	biological_process	positive regulation of translation
C	0045893	biological_process	positive regulation of DNA-templated transcription
C	0045944	biological_process	positive regulation of transcription by RNA polymerase II
C	0046599	biological_process	regulation of centriole replication
C	0051059	molecular_function	NF-kappaB binding
C	0051082	molecular_function	unfolded protein binding
C	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
C	0060699	biological_process	regulation of endoribonuclease activity
C	0060735	biological_process	regulation of eIF2 alpha phosphorylation by dsRNA
C	0090398	biological_process	cellular senescence
C	0140297	molecular_function	DNA-binding transcription factor binding
C	1902629	biological_process	regulation of mRNA stability involved in cellular response to UV
C	1902751	biological_process	positive regulation of cell cycle G2/M phase transition
C	1990904	cellular_component	ribonucleoprotein complex
D	0000055	biological_process	ribosomal large subunit export from nucleus
D	0000056	biological_process	ribosomal small subunit export from nucleus
D	0001046	molecular_function	core promoter sequence-specific DNA binding
D	0001652	cellular_component	granular component
D	0003676	molecular_function	nucleic acid binding
D	0003682	molecular_function	chromatin binding
D	0003713	molecular_function	transcription coactivator activity
D	0003723	molecular_function	RNA binding
D	0004860	molecular_function	protein kinase inhibitor activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005730	cellular_component	nucleolus
D	0005737	cellular_component	cytoplasm
D	0005813	cellular_component	centrosome
D	0005829	cellular_component	cytosol
D	0005856	cellular_component	cytoskeleton
D	0005925	cellular_component	focal adhesion
D	0006281	biological_process	DNA repair
D	0006334	biological_process	nucleosome assembly
D	0006338	biological_process	chromatin remodeling
D	0006886	biological_process	intracellular protein transport
D	0006913	biological_process	nucleocytoplasmic transport
D	0007098	biological_process	centrosome cycle
D	0007165	biological_process	signal transduction
D	0008104	biological_process	protein localization
D	0008284	biological_process	positive regulation of cell population proliferation
D	0008285	biological_process	negative regulation of cell population proliferation
D	0010824	biological_process	regulation of centrosome duplication
D	0010826	biological_process	negative regulation of centrosome duplication
D	0016020	cellular_component	membrane
D	0019843	molecular_function	rRNA binding
D	0019901	molecular_function	protein kinase binding
D	0030957	molecular_function	Tat protein binding
D	0031616	cellular_component	spindle pole centrosome
D	0032071	biological_process	regulation of endodeoxyribonuclease activity
D	0032991	cellular_component	protein-containing complex
D	0032993	cellular_component	protein-DNA complex
D	0034644	biological_process	cellular response to UV
D	0042255	biological_process	ribosome assembly
D	0042273	biological_process	ribosomal large subunit biogenesis
D	0042274	biological_process	ribosomal small subunit biogenesis
D	0042393	molecular_function	histone binding
D	0042803	molecular_function	protein homodimerization activity
D	0043023	molecular_function	ribosomal large subunit binding
D	0043024	molecular_function	ribosomal small subunit binding
D	0043066	biological_process	negative regulation of apoptotic process
D	0044387	biological_process	negative regulation of protein kinase activity by regulation of protein phosphorylation
D	0045727	biological_process	positive regulation of translation
D	0045893	biological_process	positive regulation of DNA-templated transcription
D	0045944	biological_process	positive regulation of transcription by RNA polymerase II
D	0046599	biological_process	regulation of centriole replication
D	0051059	molecular_function	NF-kappaB binding
D	0051082	molecular_function	unfolded protein binding
D	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
D	0060699	biological_process	regulation of endoribonuclease activity
D	0060735	biological_process	regulation of eIF2 alpha phosphorylation by dsRNA
D	0090398	biological_process	cellular senescence
D	0140297	molecular_function	DNA-binding transcription factor binding
D	1902629	biological_process	regulation of mRNA stability involved in cellular response to UV
D	1902751	biological_process	positive regulation of cell cycle G2/M phase transition
D	1990904	cellular_component	ribonucleoprotein complex
E	0000055	biological_process	ribosomal large subunit export from nucleus
E	0000056	biological_process	ribosomal small subunit export from nucleus
E	0001046	molecular_function	core promoter sequence-specific DNA binding
E	0001652	cellular_component	granular component
E	0003676	molecular_function	nucleic acid binding
E	0003682	molecular_function	chromatin binding
E	0003713	molecular_function	transcription coactivator activity
E	0003723	molecular_function	RNA binding
E	0004860	molecular_function	protein kinase inhibitor activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005730	cellular_component	nucleolus
E	0005737	cellular_component	cytoplasm
E	0005813	cellular_component	centrosome
E	0005829	cellular_component	cytosol
E	0005856	cellular_component	cytoskeleton
E	0005925	cellular_component	focal adhesion
E	0006281	biological_process	DNA repair
E	0006334	biological_process	nucleosome assembly
E	0006338	biological_process	chromatin remodeling
E	0006886	biological_process	intracellular protein transport
E	0006913	biological_process	nucleocytoplasmic transport
E	0007098	biological_process	centrosome cycle
E	0007165	biological_process	signal transduction
E	0008104	biological_process	protein localization
E	0008284	biological_process	positive regulation of cell population proliferation
E	0008285	biological_process	negative regulation of cell population proliferation
E	0010824	biological_process	regulation of centrosome duplication
E	0010826	biological_process	negative regulation of centrosome duplication
E	0016020	cellular_component	membrane
E	0019843	molecular_function	rRNA binding
E	0019901	molecular_function	protein kinase binding
E	0030957	molecular_function	Tat protein binding
E	0031616	cellular_component	spindle pole centrosome
E	0032071	biological_process	regulation of endodeoxyribonuclease activity
E	0032991	cellular_component	protein-containing complex
E	0032993	cellular_component	protein-DNA complex
E	0034644	biological_process	cellular response to UV
E	0042255	biological_process	ribosome assembly
E	0042273	biological_process	ribosomal large subunit biogenesis
E	0042274	biological_process	ribosomal small subunit biogenesis
E	0042393	molecular_function	histone binding
E	0042803	molecular_function	protein homodimerization activity
E	0043023	molecular_function	ribosomal large subunit binding
E	0043024	molecular_function	ribosomal small subunit binding
E	0043066	biological_process	negative regulation of apoptotic process
E	0044387	biological_process	negative regulation of protein kinase activity by regulation of protein phosphorylation
E	0045727	biological_process	positive regulation of translation
E	0045893	biological_process	positive regulation of DNA-templated transcription
E	0045944	biological_process	positive regulation of transcription by RNA polymerase II
E	0046599	biological_process	regulation of centriole replication
E	0051059	molecular_function	NF-kappaB binding
E	0051082	molecular_function	unfolded protein binding
E	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
E	0060699	biological_process	regulation of endoribonuclease activity
E	0060735	biological_process	regulation of eIF2 alpha phosphorylation by dsRNA
E	0090398	biological_process	cellular senescence
E	0140297	molecular_function	DNA-binding transcription factor binding
E	1902629	biological_process	regulation of mRNA stability involved in cellular response to UV
E	1902751	biological_process	positive regulation of cell cycle G2/M phase transition
E	1990904	cellular_component	ribonucleoprotein complex

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	SITE: Interaction between pentamers => ECO:0000250

Chain	Residue	Details
A	ASP55
E	LYS80
A	LYS80
B	ASP55
B	LYS80
C	ASP55
C	LYS80
D	ASP55
D	LYS80
E	ASP55

---

site_id	SWS_FT_FI2
Number of Residues	5
Details	SITE: Breakpoint for translocation to form NPM1-MLF1 => ECO:0000269|PubMed:8570204

Chain	Residue	Details
A	ASP175
B	ASP175
C	ASP175
D	ASP175
E	ASP175

---

site_id	SWS_FT_FI3
Number of Residues	5
Details	MOD_RES: N-acetylmethionine => ECO:0000269|Ref.17, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:22223895

Chain	Residue	Details
A	MET1
B	MET1
C	MET1
D	MET1
E	MET1

---

site_id	SWS_FT_FI4
Number of Residues	5
Details	MOD_RES: Phosphoserine; by PLK1 and PLK2 => ECO:0000269|PubMed:15190079, ECO:0000269|PubMed:20352051, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER4
B	SER4
C	SER4
D	SER4
E	SER4

---

site_id	SWS_FT_FI5
Number of Residues	15
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER10
D	SER10
D	SER242
D	SER260
E	SER10
E	SER242
E	SER260
A	SER242
A	SER260
B	SER10
B	SER242
B	SER260
C	SER10
C	SER242
C	SER260

---

site_id	SWS_FT_FI6
Number of Residues	10
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861

Chain	Residue	Details
A	LYS32
E	LYS273
A	LYS273
B	LYS32
B	LYS273
C	LYS32
C	LYS273
D	LYS32
D	LYS273
E	LYS32

---

site_id	SWS_FT_FI7
Number of Residues	5
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER43
B	SER43
C	SER43
D	SER43
E	SER43

---

site_id	SWS_FT_FI8
Number of Residues	5
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q61937

Chain	Residue	Details
A	TYR67
B	TYR67
C	TYR67
D	TYR67
E	TYR67

---

site_id	SWS_FT_FI9
Number of Residues	5
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:17924679, ECO:0007744|PubMed:18220336, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	SER70
B	SER70
C	SER70
D	SER70
E	SER70

---

site_id	SWS_FT_FI10
Number of Residues	5
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648

Chain	Residue	Details
A	THR75
B	THR75
C	THR75
D	THR75
E	THR75

---

site_id	SWS_FT_FI11
Number of Residues	5
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	THR95
B	THR95
C	THR95
D	THR95
E	THR95

---

site_id	SWS_FT_FI12
Number of Residues	5
Details	MOD_RES: Phosphoserine; by CDK2 => ECO:0000269|Ref.17, ECO:0007744|PubMed:18220336, ECO:0007744|PubMed:18318008, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER125
B	SER125
C	SER125
D	SER125
E	SER125

---

site_id	SWS_FT_FI13
Number of Residues	5
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231

Chain	Residue	Details
A	SER137
B	SER137
C	SER137
D	SER137
E	SER137

---

site_id	SWS_FT_FI14
Number of Residues	5
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER139
B	SER139
C	SER139
D	SER139
E	SER139

---

site_id	SWS_FT_FI15
Number of Residues	5
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:16916647, ECO:0007744|PubMed:19608861

Chain	Residue	Details
A	LYS150
B	LYS150
C	LYS150
D	LYS150
E	LYS150

---

site_id	SWS_FT_FI16
Number of Residues	5
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:16916647

Chain	Residue	Details
A	LYS154
B	LYS154
C	LYS154
D	LYS154
E	LYS154

---

site_id	SWS_FT_FI17
Number of Residues	5
Details	MOD_RES: Phosphothreonine; by CDK1, CDK2 and CDK6 => ECO:0000269|PubMed:12058066, ECO:0000269|PubMed:20333249, ECO:0007744|PubMed:17924679, ECO:0007744|PubMed:20068231

Chain	Residue	Details
A	THR199
B	THR199
C	THR199
D	THR199
E	THR199

---

site_id	SWS_FT_FI18
Number of Residues	5
Details	MOD_RES: ADP-ribosylserine => ECO:0000269|PubMed:28190768

Chain	Residue	Details
A	SER207
B	SER207
C	SER207
D	SER207
E	SER207

---

site_id	SWS_FT_FI19
Number of Residues	5
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:16107701, ECO:0007744|PubMed:16916647

Chain	Residue	Details
A	LYS212
B	LYS212
C	LYS212
D	LYS212
E	LYS212

---

site_id	SWS_FT_FI20
Number of Residues	5
Details	MOD_RES: Phosphothreonine; by CDK1 => ECO:0000305|PubMed:12058066

Chain	Residue	Details
A	THR219
B	THR219
C	THR219
D	THR219
E	THR219

---

site_id	SWS_FT_FI21
Number of Residues	5
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692

Chain	Residue	Details
A	SER227
B	SER227
C	SER227
D	SER227
E	SER227

---

site_id	SWS_FT_FI22
Number of Residues	10
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:16107701

Chain	Residue	Details
A	LYS229
E	LYS292
A	LYS292
B	LYS229
B	LYS292
C	LYS229
C	LYS292
D	LYS229
D	LYS292
E	LYS229

---

site_id	SWS_FT_FI23
Number of Residues	10
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0000269|PubMed:16107701

Chain	Residue	Details
A	LYS230
E	LYS250
A	LYS250
B	LYS230
B	LYS250
C	LYS230
C	LYS250
D	LYS230
D	LYS250
E	LYS230

---

site_id	SWS_FT_FI24
Number of Residues	5
Details	MOD_RES: Phosphothreonine; by CDK1 => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	THR234
B	THR234
C	THR234
D	THR234
E	THR234

---

site_id	SWS_FT_FI25
Number of Residues	5
Details	MOD_RES: Phosphothreonine; by CDK1 => ECO:0000269|PubMed:12058066, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	THR237
B	THR237
C	THR237
D	THR237
E	THR237

---

site_id	SWS_FT_FI26
Number of Residues	5
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	SER243
B	SER243
C	SER243
D	SER243
E	SER243

---

site_id	SWS_FT_FI27
Number of Residues	5
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17924679, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER254
B	SER254
C	SER254
D	SER254
E	SER254

---

site_id	SWS_FT_FI28
Number of Residues	5
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0000269|PubMed:16107701, ECO:0007744|PubMed:19608861

Chain	Residue	Details
A	LYS257
B	LYS257
C	LYS257
D	LYS257
E	LYS257

---

site_id	SWS_FT_FI29
Number of Residues	5
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q61937

Chain	Residue	Details
A	LYS267
B	LYS267
C	LYS267
D	LYS267
E	LYS267

---

site_id	SWS_FT_FI30
Number of Residues	5
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18220336, ECO:0007744|PubMed:20068231

Chain	Residue	Details
A	THR279
B	THR279
C	THR279
D	THR279
E	THR279

---

site_id	SWS_FT_FI31
Number of Residues	5
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25218447

Chain	Residue	Details
A	LYS27
B	LYS27
C	LYS27
D	LYS27
E	LYS27

---

site_id	SWS_FT_FI32
Number of Residues	25
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733

Chain	Residue	Details
B	LYS273
C	LYS150
C	LYS263
C	LYS267
C	LYS273
D	LYS150
D	LYS263
D	LYS267
A	LYS150
D	LYS273
E	LYS150
E	LYS263
E	LYS267
E	LYS273
A	LYS263
A	LYS267
A	LYS273
B	LYS150
B	LYS263
B	LYS267

---

site_id	SWS_FT_FI33
Number of Residues	5
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25114211, ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:25772364, ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LYS32
B	LYS32
C	LYS32
D	LYS32
E	LYS32

---

site_id	SWS_FT_FI34
Number of Residues	5
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LYS141
B	LYS141
C	LYS141
D	LYS141
E	LYS141

---

site_id	SWS_FT_FI35
Number of Residues	5
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25772364, ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LYS215
B	LYS215
C	LYS215
D	LYS215
E	LYS215

---

site_id	SWS_FT_FI36
Number of Residues	5
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate

Chain	Residue	Details
A	LYS230
B	LYS230
C	LYS230
D	LYS230
E	LYS230

---

site_id	SWS_FT_FI37
Number of Residues	5
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25114211, ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LYS248
B	LYS248
C	LYS248
D	LYS248
E	LYS248

---

site_id	SWS_FT_FI38
Number of Residues	5
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LYS250
B	LYS250
C	LYS250
D	LYS250
E	LYS250

---

site_id	SWS_FT_FI39
Number of Residues	5
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25114211, ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LYS257
B	LYS257
C	LYS257
D	LYS257
E	LYS257

---