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7ZPJ

Mammalian Dicer in the "pre-dicing state" with pre-miR-15a substrate and TARBP2 subunit

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0001525biological_processangiogenesis
A0001834biological_processtrophectodermal cell proliferation
A0001932biological_processregulation of protein phosphorylation
A0001942biological_processhair follicle development
A0003677molecular_functionDNA binding
A0003723molecular_functionRNA binding
A0004386molecular_functionhelicase activity
A0004519molecular_functionendonuclease activity
A0004525molecular_functionribonuclease III activity
A0004530molecular_functiondeoxyribonuclease I activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005793cellular_componentendoplasmic reticulum-Golgi intermediate compartment
A0005829cellular_componentcytosol
A0006309biological_processapoptotic DNA fragmentation
A0006364biological_processrRNA processing
A0006396biological_processRNA processing
A0007284biological_processspermatogonial cell division
A0008283biological_processcell population proliferation
A0008593biological_processregulation of Notch signaling pathway
A0009791biological_processpost-embryonic development
A0010070biological_processzygote asymmetric cell division
A0010467biological_processgene expression
A0010468biological_processregulation of gene expression
A0010595biological_processpositive regulation of endothelial cell migration
A0010626biological_processnegative regulation of Schwann cell proliferation
A0010628biological_processpositive regulation of gene expression
A0010660biological_processregulation of muscle cell apoptotic process
A0014040biological_processpositive regulation of Schwann cell differentiation
A0014835biological_processmyoblast differentiation involved in skeletal muscle regeneration
A0016442cellular_componentRISC complex
A0016787molecular_functionhydrolase activity
A0016891molecular_functionRNA endonuclease activity, producing 5'-phosphomonoesters
A0019827biological_processstem cell population maintenance
A0021522biological_processspinal cord motor neuron differentiation
A0021675biological_processnerve development
A0021889biological_processolfactory bulb interneuron differentiation
A0021987biological_processcerebral cortex development
A0030324biological_processlung development
A0030326biological_processembryonic limb morphogenesis
A0030422biological_processsiRNA processing
A0030424cellular_componentaxon
A0030425cellular_componentdendrite
A0030426cellular_componentgrowth cone
A0030856biological_processregulation of epithelial cell differentiation
A0031047biological_processregulatory ncRNA-mediated gene silencing
A0031054biological_processpre-miRNA processing
A0031069biological_processhair follicle morphogenesis
A0031508biological_processpericentric heterochromatin formation
A0031641biological_processregulation of myelination
A0031643biological_processpositive regulation of myelination
A0032290biological_processperipheral nervous system myelin formation
A0032967biological_processpositive regulation of collagen biosynthetic process
A0035116biological_processembryonic hindlimb morphogenesis
A0035194biological_processregulatory ncRNA-mediated post-transcriptional gene silencing
A0035196biological_processmiRNA processing
A0035198molecular_functionmiRNA binding
A0035264biological_processmulticellular organism growth
A0042487biological_processregulation of odontogenesis of dentin-containing tooth
A0045069biological_processregulation of viral genome replication
A0045589biological_processregulation of regulatory T cell differentiation
A0045664biological_processregulation of neuron differentiation
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046872molecular_functionmetal ion binding
A0048255biological_processmRNA stabilization
A0048471cellular_componentperinuclear region of cytoplasm
A0048536biological_processspleen development
A0048565biological_processdigestive tract development
A0048608biological_processreproductive structure development
A0048713biological_processregulation of oligodendrocyte differentiation
A0048730biological_processepidermis morphogenesis
A0048754biological_processbranching morphogenesis of an epithelial tube
A0048812biological_processneuron projection morphogenesis
A0050727biological_processregulation of inflammatory response
A0050767biological_processregulation of neurogenesis
A0051216biological_processcartilage development
A0051225biological_processspindle assembly
A0051252biological_processregulation of RNA metabolic process
A0051607biological_processdefense response to virus
A0051726biological_processregulation of cell cycle
A0055013biological_processcardiac muscle cell development
A0060119biological_processinner ear receptor cell development
A0060253biological_processnegative regulation of glial cell proliferation
A0060576biological_processintestinal epithelial cell development
A0061309biological_processcardiac neural crest cell development involved in outflow tract morphogenesis
A0061548biological_processganglion development
A0070173biological_processregulation of enamel mineralization
A0070578cellular_componentRISC-loading complex
A0070922biological_processRISC complex assembly
A0071335biological_processhair follicle cell proliferation
A0098795biological_processglobal gene silencing by mRNA cleavage
A0098978cellular_componentglutamatergic synapse
A0099092cellular_componentpostsynaptic density, intracellular component
A1903142biological_processpositive regulation of establishment of endothelial barrier
A1904899biological_processpositive regulation of hepatic stellate cell proliferation
A1904906biological_processpositive regulation of endothelial cell-matrix adhesion via fibronectin
A1905564biological_processpositive regulation of vascular endothelial cell proliferation
A2000628biological_processregulation of miRNA metabolic process
A2000630biological_processpositive regulation of miRNA metabolic process
A2000736biological_processregulation of stem cell differentiation
D0003723molecular_functionRNA binding
D0003725molecular_functiondouble-stranded RNA binding
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0006417biological_processregulation of translation
D0007286biological_processspermatid development
D0007338biological_processsingle fertilization
D0016442cellular_componentRISC complex
D0030422biological_processsiRNA processing
D0031047biological_processregulatory ncRNA-mediated gene silencing
D0031054biological_processpre-miRNA processing
D0035196biological_processmiRNA processing
D0035197molecular_functionsiRNA binding
D0035198molecular_functionmiRNA binding
D0035264biological_processmulticellular organism growth
D0042803molecular_functionprotein homodimerization activity
D0043403biological_processskeletal muscle tissue regeneration
D0045070biological_processpositive regulation of viral genome replication
D0045727biological_processpositive regulation of translation
D0046782biological_processregulation of viral transcription
D0048471cellular_componentperinuclear region of cytoplasm
D0050689biological_processnegative regulation of defense response to virus by host
D0051149biological_processpositive regulation of muscle cell differentiation
D0061351biological_processneural precursor cell proliferation
D0070578cellular_componentRISC-loading complex
D0070883molecular_functionpre-miRNA binding
D0070920biological_processregulation of regulatory ncRNA processing
D0070921biological_processregulation of siRNA processing
D0070922biological_processRISC complex assembly
D0098795biological_processglobal gene silencing by mRNA cleavage
D1903798biological_processregulation of miRNA processing
Functional Information from PROSITE/UniProt
site_idPS00517
Number of Residues9
DetailsRNASE_3_1 Ribonuclease III family signature. QRLEFLGDA
ChainResidueDetails
AGLN1696-ALA1704

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q15633
ChainResidueDetails
DSER151
AGLU1316
AGLU1395
AGLU1398

site_idSWS_FT_FI2
Number of Residues3
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:Q9UPY3
ChainResidueDetails
AGLU1699
AASP1804
AGLU1807

site_idSWS_FT_FI3
Number of Residues1
DetailsSITE: Important for activity => ECO:0000269|PubMed:18268334
ChainResidueDetails
ALYS1800

site_idSWS_FT_FI4
Number of Residues7
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9UPY3
ChainResidueDetails
ASER413
ASER415
ASER1016
ASER1160
ASER1456
ASER1466
ASER1862

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:21183079
ChainResidueDetails
ASER1464

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PDB entries from 2024-07-24

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