7ZGU
Human NLRP3-deltaPYD hexamer
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:35254907, ECO:0000305|PubMed:36142182, ECO:0000305|PubMed:36442502, ECO:0007744|PDB:7VTP, ECO:0007744|PDB:7ZGU, ECO:0007744|PDB:8EJ4 |
| Chain | Residue | Details |
| A | THR169 | |
| B | THR169 | |
| C | THR169 | |
| D | THR169 | |
| E | THR169 | |
| F | THR169 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00136, ECO:0000269|PubMed:17483456, ECO:0000305|PubMed:34687713, ECO:0000305|PubMed:35114687, ECO:0000305|PubMed:35254907, ECO:0000305|PubMed:36142182, ECO:0000305|PubMed:36442502, ECO:0007744|PDB:7ALV, ECO:0007744|PDB:7PZC, ECO:0007744|PDB:7VTP, ECO:0007744|PDB:7ZGU, ECO:0007744|PDB:8EJ4 |
| Chain | Residue | Details |
| A | GLY226 | |
| B | GLY226 | |
| C | GLY226 | |
| D | GLY226 | |
| E | GLY226 | |
| F | GLY226 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:34687713, ECO:0000305|PubMed:35114687, ECO:0000305|PubMed:35254907, ECO:0000305|PubMed:36142182, ECO:0007744|PDB:7ALV, ECO:0007744|PDB:7PZC, ECO:0007744|PDB:7VTP, ECO:0007744|PDB:7ZGU |
| Chain | Residue | Details |
| A | HIS522 | |
| B | HIS522 | |
| C | HIS522 | |
| D | HIS522 | |
| E | HIS522 | |
| F | HIS522 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 24 |
| Details | MOD_RES: Phosphotyrosine; by BTK => ECO:0000269|PubMed:34554188 |
| Chain | Residue | Details |
| A | TYR136 | |
| C | TYR140 | |
| C | TYR143 | |
| C | TYR168 | |
| D | TYR136 | |
| D | TYR140 | |
| D | TYR143 | |
| D | TYR168 | |
| E | TYR136 | |
| E | TYR140 | |
| E | TYR143 | |
| A | TYR140 | |
| E | TYR168 | |
| F | TYR136 | |
| F | TYR140 | |
| F | TYR143 | |
| F | TYR168 | |
| A | TYR143 | |
| A | TYR168 | |
| B | TYR136 | |
| B | TYR140 | |
| B | TYR143 | |
| B | TYR168 | |
| C | TYR136 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 12 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q8R4B8 |
| Chain | Residue | Details |
| A | SER161 | |
| E | SER295 | |
| F | SER161 | |
| F | SER295 | |
| A | SER295 | |
| B | SER161 | |
| B | SER295 | |
| C | SER161 | |
| C | SER295 | |
| D | SER161 | |
| D | SER295 | |
| E | SER161 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 24 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:28943315 |
| Chain | Residue | Details |
| A | SER163 | |
| C | SER334 | |
| C | SER728 | |
| C | SER975 | |
| D | SER163 | |
| D | SER334 | |
| D | SER728 | |
| D | SER975 | |
| E | SER163 | |
| E | SER334 | |
| E | SER728 | |
| A | SER334 | |
| E | SER975 | |
| F | SER163 | |
| F | SER334 | |
| F | SER728 | |
| F | SER975 | |
| A | SER728 | |
| A | SER975 | |
| B | SER163 | |
| B | SER334 | |
| B | SER728 | |
| B | SER975 | |
| C | SER163 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 6 |
| Details | MOD_RES: Phosphoserine; by MAPK8 => ECO:0000269|PubMed:35114687 |
| Chain | Residue | Details |
| A | SER198 | |
| B | SER198 | |
| C | SER198 | |
| D | SER198 | |
| E | SER198 | |
| F | SER198 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 6 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:35114687 |
| Chain | Residue | Details |
| A | SER201 | |
| B | SER201 | |
| C | SER201 | |
| D | SER201 | |
| E | SER201 | |
| F | SER201 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 18 |
| Details | MOD_RES: Phosphoserine; by CSNK1A1 => ECO:0000269|PubMed:34615873 |
| Chain | Residue | Details |
| A | SER735 | |
| D | SER735 | |
| D | SER806 | |
| D | SER1035 | |
| E | SER735 | |
| E | SER806 | |
| E | SER1035 | |
| F | SER735 | |
| F | SER806 | |
| F | SER1035 | |
| A | SER806 | |
| A | SER1035 | |
| B | SER735 | |
| B | SER806 | |
| B | SER1035 | |
| C | SER735 | |
| C | SER806 | |
| C | SER1035 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 6 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:27043286 |
| Chain | Residue | Details |
| A | TYR861 | |
| B | TYR861 | |
| C | TYR861 | |
| D | TYR861 | |
| E | TYR861 | |
| F | TYR861 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 18 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:36586411 |
| Chain | Residue | Details |
| A | CYS837 | |
| D | CYS837 | |
| D | CYS838 | |
| D | CYS844 | |
| E | CYS837 | |
| E | CYS838 | |
| E | CYS844 | |
| F | CYS837 | |
| F | CYS838 | |
| F | CYS844 | |
| A | CYS838 | |
| A | CYS844 | |
| B | CYS837 | |
| B | CYS838 | |
| B | CYS844 | |
| C | CYS837 | |
| C | CYS838 | |
| C | CYS844 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 6 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:26037928 |
| Chain | Residue | Details |
| A | LYS689 | |
| B | LYS689 | |
| C | LYS689 | |
| D | LYS689 | |
| E | LYS689 | |
| F | LYS689 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 24 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:34615873 |
| Chain | Residue | Details |
| C | LYS878 | |
| C | LYS927 | |
| C | LYS973 | |
| D | LYS878 | |
| D | LYS927 | |
| D | LYS973 | |
| E | LYS878 | |
| E | LYS927 | |
| A | LYS878 | |
| E | LYS973 | |
| F | LYS878 | |
| F | LYS927 | |
| F | LYS973 | |
| A | LYS927 | |
| A | LYS973 | |
| B | LYS878 | |
| B | LYS927 | |
| B | LYS973 |
