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7YTJ

Cryo-EM structure of VTC complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000329cellular_componentfungal-type vacuole membrane
A0000421cellular_componentautophagosome membrane
A0003729molecular_functionmRNA binding
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005773cellular_componentvacuole
A0005774cellular_componentvacuolar membrane
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005938cellular_componentcell cortex
A0006797biological_processpolyphosphate metabolic process
A0006799biological_processpolyphosphate biosynthetic process
A0007034biological_processvacuolar transport
A0016020cellular_componentmembrane
A0016237biological_processmicroautophagy
A0031410cellular_componentcytoplasmic vesicle
A0031965cellular_componentnuclear membrane
A0033254cellular_componentvacuolar transporter chaperone complex
A0042144biological_processvacuole fusion, non-autophagic
A0061736biological_processengulfment of target by autophagosome
B0000329cellular_componentfungal-type vacuole membrane
B0000421cellular_componentautophagosome membrane
B0003729molecular_functionmRNA binding
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005773cellular_componentvacuole
B0005774cellular_componentvacuolar membrane
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005938cellular_componentcell cortex
B0006797biological_processpolyphosphate metabolic process
B0006799biological_processpolyphosphate biosynthetic process
B0007034biological_processvacuolar transport
B0016020cellular_componentmembrane
B0016237biological_processmicroautophagy
B0031410cellular_componentcytoplasmic vesicle
B0031965cellular_componentnuclear membrane
B0033254cellular_componentvacuolar transporter chaperone complex
B0042144biological_processvacuole fusion, non-autophagic
B0061736biological_processengulfment of target by autophagosome
C0000329cellular_componentfungal-type vacuole membrane
C0000421cellular_componentautophagosome membrane
C0003729molecular_functionmRNA binding
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005773cellular_componentvacuole
C0005774cellular_componentvacuolar membrane
C0005783cellular_componentendoplasmic reticulum
C0005789cellular_componentendoplasmic reticulum membrane
C0005938cellular_componentcell cortex
C0006797biological_processpolyphosphate metabolic process
C0006799biological_processpolyphosphate biosynthetic process
C0007034biological_processvacuolar transport
C0016020cellular_componentmembrane
C0016237biological_processmicroautophagy
C0031410cellular_componentcytoplasmic vesicle
C0031965cellular_componentnuclear membrane
C0033254cellular_componentvacuolar transporter chaperone complex
C0042144biological_processvacuole fusion, non-autophagic
C0061736biological_processengulfment of target by autophagosome
D0000329cellular_componentfungal-type vacuole membrane
D0000421cellular_componentautophagosome membrane
D0000822molecular_functioninositol hexakisphosphate binding
D0005515molecular_functionprotein binding
D0005516molecular_functioncalmodulin binding
D0005737cellular_componentcytoplasm
D0005773cellular_componentvacuole
D0005774cellular_componentvacuolar membrane
D0005783cellular_componentendoplasmic reticulum
D0005789cellular_componentendoplasmic reticulum membrane
D0005938cellular_componentcell cortex
D0006797biological_processpolyphosphate metabolic process
D0006799biological_processpolyphosphate biosynthetic process
D0007034biological_processvacuolar transport
D0008976molecular_functionpolyphosphate kinase activity
D0016020cellular_componentmembrane
D0016237biological_processmicroautophagy
D0016740molecular_functiontransferase activity
D0031410cellular_componentcytoplasmic vesicle
D0033254cellular_componentvacuolar transporter chaperone complex
D0042144biological_processvacuole fusion, non-autophagic
D0061736biological_processengulfment of target by autophagosome
D0071944cellular_componentcell periphery
E0000329cellular_componentfungal-type vacuole membrane
E0000421cellular_componentautophagosome membrane
E0000822molecular_functioninositol hexakisphosphate binding
E0005516molecular_functioncalmodulin binding
E0005737cellular_componentcytoplasm
E0005773cellular_componentvacuole
E0005774cellular_componentvacuolar membrane
E0005783cellular_componentendoplasmic reticulum
E0005789cellular_componentendoplasmic reticulum membrane
E0005938cellular_componentcell cortex
E0006797biological_processpolyphosphate metabolic process
E0006799biological_processpolyphosphate biosynthetic process
E0007034biological_processvacuolar transport
E0016020cellular_componentmembrane
E0016237biological_processmicroautophagy
E0030643biological_processintracellular phosphate ion homeostasis
E0031410cellular_componentcytoplasmic vesicle
E0033254cellular_componentvacuolar transporter chaperone complex
E0042144biological_processvacuole fusion, non-autophagic
E0061736biological_processengulfment of target by autophagosome
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues708
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:12584253
ChainResidueDetails
EMET30-ARG738
AHIS115-ARG132
BSER36-THR66
BHIS115-ARG132
CSER36-THR66
CHIS115-ARG132

site_idSWS_FT_FI2
Number of Residues57
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
ETRP739-SER756
ELEU765-TYR785
EGLY808-PHE828
BPHE67-PHE87
BVAL94-TYR114
BLEU133-ARG153
CPHE67-PHE87
CVAL94-TYR114
CLEU133-ARG153

site_idSWS_FT_FI3
Number of Residues7
DetailsTOPO_DOM: Vacuolar => ECO:0000305|PubMed:12584253
ChainResidueDetails
EVAL757-GLN764
BGLY88-ARG93
CGLY88-ARG93

site_idSWS_FT_FI4
Number of Residues21
DetailsTOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:12584253
ChainResidueDetails
EARG786-VAL807
BLEU154-LEU163
CLEU154-LEU163

site_idSWS_FT_FI5
Number of Residues35
DetailsTOPO_DOM: Vacuolar => ECO:0000269|PubMed:12584253
ChainResidueDetails
ELYS829-GLU864
BSER36
CSER36
DLYS282
DLYS295
DTYR360
DARG362
DASN427

site_idSWS_FT_FI6
Number of Residues2
DetailsSITE: Important for inositol polyphosphate binding => ECO:0000250|UniProtKB:P43585
ChainResidueDetails
ETYR51
ELYS55

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:19779198
ChainResidueDetails
ESER72
ESER299

site_idSWS_FT_FI8
Number of Residues3
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:19779198
ChainResidueDetails
ESER74
ESER79
ESER224

site_idSWS_FT_FI9
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:18407956
ChainResidueDetails
ETHR212

site_idSWS_FT_FI10
Number of Residues3
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198
ChainResidueDetails
ESER227
ESER650
ESER651

site_idSWS_FT_FI11
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198
ChainResidueDetails
ESER303

site_idSWS_FT_FI12
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17287358
ChainResidueDetails
ESER618

site_idSWS_FT_FI13
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17287358, ECO:0007744|PubMed:17330950
ChainResidueDetails
ESER621

223790

PDB entries from 2024-08-14

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