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7YI2

Cryo-EM structure of Rpd3S in loose-state Rpd3S-NCP complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000086biological_processG2/M transition of mitotic cell cycle
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0000785cellular_componentchromatin
A0003713molecular_functiontranscription coactivator activity
A0003714molecular_functiontranscription corepressor activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0006303biological_processdouble-strand break repair via nonhomologous end joining
A0006325biological_processchromatin organization
A0006334biological_processnucleosome assembly
A0006355biological_processregulation of DNA-templated transcription
A0006357biological_processregulation of transcription by RNA polymerase II
A0016479biological_processnegative regulation of transcription by RNA polymerase I
A0030174biological_processregulation of DNA-templated DNA replication initiation
A0032221cellular_componentRpd3S complex
A0033698cellular_componentRpd3L complex
A0034605biological_processcellular response to heat
A0042802molecular_functionidentical protein binding
A0044804biological_processnucleophagy
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0051301biological_processcell division
A0051321biological_processmeiotic cell cycle
A0061186biological_processnegative regulation of silent mating-type cassette heterochromatin formation
A0061188biological_processnegative regulation of rDNA heterochromatin formation
A0070210cellular_componentRpd3L-Expanded complex
A0070550biological_processrDNA chromatin condensation
A0070822cellular_componentSin3-type complex
B0000082biological_processG1/S transition of mitotic cell cycle
B0000086biological_processG2/M transition of mitotic cell cycle
B0000118cellular_componenthistone deacetylase complex
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0003713molecular_functiontranscription coactivator activity
B0003714molecular_functiontranscription corepressor activity
B0004407molecular_functionhistone deacetylase activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0006325biological_processchromatin organization
B0006334biological_processnucleosome assembly
B0006355biological_processregulation of DNA-templated transcription
B0006357biological_processregulation of transcription by RNA polymerase II
B0006368biological_processtranscription elongation by RNA polymerase II
B0006979biological_processresponse to oxidative stress
B0006995biological_processcellular response to nitrogen starvation
B0008270molecular_functionzinc ion binding
B0016239biological_processpositive regulation of macroautophagy
B0016479biological_processnegative regulation of transcription by RNA polymerase I
B0016787molecular_functionhydrolase activity
B0030174biological_processregulation of DNA-templated DNA replication initiation
B0031507biological_processheterochromatin formation
B0032221cellular_componentRpd3S complex
B0033698cellular_componentRpd3L complex
B0034399cellular_componentnuclear periphery
B0034503biological_processprotein localization to nucleolar rDNA repeats
B0034605biological_processcellular response to heat
B0044804biological_processnucleophagy
B0045128biological_processnegative regulation of reciprocal meiotic recombination
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0051321biological_processmeiotic cell cycle
B0061186biological_processnegative regulation of silent mating-type cassette heterochromatin formation
B0061188biological_processnegative regulation of rDNA heterochromatin formation
B0070210cellular_componentRpd3L-Expanded complex
B0070211cellular_componentSnt2C complex
B0070550biological_processrDNA chromatin condensation
B0070822cellular_componentSin3-type complex
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0000123cellular_componenthistone acetyltransferase complex
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0006281biological_processDNA repair
C0006325biological_processchromatin organization
C0006334biological_processnucleosome assembly
C0006335biological_processDNA replication-dependent chromatin assembly
C0006337biological_processnucleosome disassembly
C0006338biological_processchromatin remodeling
C0006351biological_processDNA-templated transcription
C0006355biological_processregulation of DNA-templated transcription
C0006357biological_processregulation of transcription by RNA polymerase II
C0006368biological_processtranscription elongation by RNA polymerase II
C0009889biological_processregulation of biosynthetic process
C0030174biological_processregulation of DNA-templated DNA replication initiation
C0032221cellular_componentRpd3S complex
C0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
C0035064molecular_functionmethylated histone binding
C0035267cellular_componentNuA4 histone acetyltransferase complex
C0043487biological_processregulation of RNA stability
C0045892biological_processnegative regulation of DNA-templated transcription
C0060195biological_processnegative regulation of antisense RNA transcription
C1990453cellular_componentnucleosome disassembly/reassembly complex
D0000118cellular_componenthistone deacetylase complex
D0000122biological_processnegative regulation of transcription by RNA polymerase II
D0005634cellular_componentnucleus
D0006325biological_processchromatin organization
D0006334biological_processnucleosome assembly
D0006357biological_processregulation of transcription by RNA polymerase II
D0006368biological_processtranscription elongation by RNA polymerase II
D0008270molecular_functionzinc ion binding
D0030174biological_processregulation of DNA-templated DNA replication initiation
D0032221cellular_componentRpd3S complex
D0045944biological_processpositive regulation of transcription by RNA polymerase II
D0046872molecular_functionmetal ion binding
D0060195biological_processnegative regulation of antisense RNA transcription
E0000118cellular_componenthistone deacetylase complex
E0000122biological_processnegative regulation of transcription by RNA polymerase II
E0005634cellular_componentnucleus
E0006325biological_processchromatin organization
E0006334biological_processnucleosome assembly
E0006357biological_processregulation of transcription by RNA polymerase II
E0006368biological_processtranscription elongation by RNA polymerase II
E0008270molecular_functionzinc ion binding
E0030174biological_processregulation of DNA-templated DNA replication initiation
E0032221cellular_componentRpd3S complex
E0045944biological_processpositive regulation of transcription by RNA polymerase II
E0046872molecular_functionmetal ion binding
E0060195biological_processnegative regulation of antisense RNA transcription
Functional Information from PROSITE/UniProt
site_idPS01359
Number of Residues44
DetailsZF_PHD_1 Zinc finger PHD-type signature. CsaCnqsgsf.......................................LcCdt..Cpks.FHflCldppidpnnlpkgd...............................WhCneC
ChainResidueDetails
DCYS263-CYS306

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues98
DetailsZN_FING: PHD-type 1 => ECO:0000255|PROSITE-ProRule:PRU00146
ChainResidueDetails
DGLU260-LYS309
EGLU260-LYS309

site_idSWS_FT_FI2
Number of Residues116
DetailsZN_FING: PHD-type 2; atypical => ECO:0000255|PROSITE-ProRule:PRU00146
ChainResidueDetails
DPHE414-THR472
EPHE414-THR472

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: N-acetylmethionine => ECO:0007744|PubMed:22814378
ChainResidueDetails
DMET1
EMET1

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18407956
ChainResidueDetails
DSER68
ESER68

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198
ChainResidueDetails
DSER683
ESER683

226707

PDB entries from 2024-10-30

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