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7XZ2

TRIM E3 ubiquitin ligase

Functional Information from GO Data
ChainGOidnamespacecontents
A0001778biological_processplasma membrane repair
A0001786molecular_functionphosphatidylserine binding
A0003012biological_processmuscle system process
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005886cellular_componentplasma membrane
A0006887biological_processexocytosis
A0006900biological_processvesicle budding from membrane
A0007517biological_processmuscle organ development
A0008270molecular_functionzinc ion binding
A0010832biological_processnegative regulation of myotube differentiation
A0016567biological_processprotein ubiquitination
A0030659cellular_componentcytoplasmic vesicle membrane
A0031410cellular_componentcytoplasmic vesicle
A0031435molecular_functionmitogen-activated protein kinase kinase kinase binding
A0031624molecular_functionubiquitin conjugating enzyme binding
A0042383cellular_componentsarcolemma
A0042802molecular_functionidentical protein binding
A0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
A0043569biological_processnegative regulation of insulin-like growth factor receptor signaling pathway
A0046627biological_processnegative regulation of insulin receptor signaling pathway
A0046872molecular_functionmetal ion binding
A0051260biological_processprotein homooligomerization
A0061630molecular_functionubiquitin protein ligase activity
B0001778biological_processplasma membrane repair
B0001786molecular_functionphosphatidylserine binding
B0003012biological_processmuscle system process
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005886cellular_componentplasma membrane
B0006887biological_processexocytosis
B0006900biological_processvesicle budding from membrane
B0007517biological_processmuscle organ development
B0008270molecular_functionzinc ion binding
B0010832biological_processnegative regulation of myotube differentiation
B0016567biological_processprotein ubiquitination
B0030659cellular_componentcytoplasmic vesicle membrane
B0031410cellular_componentcytoplasmic vesicle
B0031435molecular_functionmitogen-activated protein kinase kinase kinase binding
B0031624molecular_functionubiquitin conjugating enzyme binding
B0042383cellular_componentsarcolemma
B0042802molecular_functionidentical protein binding
B0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
B0043569biological_processnegative regulation of insulin-like growth factor receptor signaling pathway
B0046627biological_processnegative regulation of insulin receptor signaling pathway
B0046872molecular_functionmetal ion binding
B0051260biological_processprotein homooligomerization
B0061630molecular_functionubiquitin protein ligase activity
C0001778biological_processplasma membrane repair
C0001786molecular_functionphosphatidylserine binding
C0003012biological_processmuscle system process
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005886cellular_componentplasma membrane
C0006887biological_processexocytosis
C0006900biological_processvesicle budding from membrane
C0007517biological_processmuscle organ development
C0008270molecular_functionzinc ion binding
C0010832biological_processnegative regulation of myotube differentiation
C0016567biological_processprotein ubiquitination
C0030659cellular_componentcytoplasmic vesicle membrane
C0031410cellular_componentcytoplasmic vesicle
C0031435molecular_functionmitogen-activated protein kinase kinase kinase binding
C0031624molecular_functionubiquitin conjugating enzyme binding
C0042383cellular_componentsarcolemma
C0042802molecular_functionidentical protein binding
C0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
C0043569biological_processnegative regulation of insulin-like growth factor receptor signaling pathway
C0046627biological_processnegative regulation of insulin receptor signaling pathway
C0046872molecular_functionmetal ion binding
C0051260biological_processprotein homooligomerization
C0061630molecular_functionubiquitin protein ligase activity
D0001778biological_processplasma membrane repair
D0001786molecular_functionphosphatidylserine binding
D0003012biological_processmuscle system process
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005886cellular_componentplasma membrane
D0006887biological_processexocytosis
D0006900biological_processvesicle budding from membrane
D0007517biological_processmuscle organ development
D0008270molecular_functionzinc ion binding
D0010832biological_processnegative regulation of myotube differentiation
D0016567biological_processprotein ubiquitination
D0030659cellular_componentcytoplasmic vesicle membrane
D0031410cellular_componentcytoplasmic vesicle
D0031435molecular_functionmitogen-activated protein kinase kinase kinase binding
D0031624molecular_functionubiquitin conjugating enzyme binding
D0042383cellular_componentsarcolemma
D0042802molecular_functionidentical protein binding
D0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
D0043569biological_processnegative regulation of insulin-like growth factor receptor signaling pathway
D0046627biological_processnegative regulation of insulin receptor signaling pathway
D0046872molecular_functionmetal ion binding
D0051260biological_processprotein homooligomerization
D0061630molecular_functionubiquitin protein ligase activity
Functional Information from PROSITE/UniProt
site_idPS00518
Number of Residues10
DetailsZF_RING_1 Zinc finger RING-type signature. CgHsFCraCL
ChainResidueDetails
ACYS29-LEU38

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues172
DetailsZN_FING: RING-type => ECO:0000255|PROSITE-ProRule:PRU00175
ChainResidueDetails
ACYS14-GLN57
BCYS14-GLN57
CCYS14-GLN57
DCYS14-GLN57

site_idSWS_FT_FI2
Number of Residues164
DetailsZN_FING: B box-type => ECO:0000255|PROSITE-ProRule:PRU00024
ChainResidueDetails
AVAL81-ALA122
BVAL81-ALA122
CVAL81-ALA122
DVAL81-ALA122

site_idSWS_FT_FI3
Number of Residues16
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00024
ChainResidueDetails
ACYS86
CHIS89
CCYS108
CHIS114
DCYS86
DHIS89
DCYS108
DHIS114
AHIS89
ACYS108
AHIS114
BCYS86
BHIS89
BCYS108
BHIS114
CCYS86

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: S-nitrosocysteine => ECO:0000250|UniProtKB:Q6ZMU5
ChainResidueDetails
ASER144
BSER144
CSER144
DSER144

site_idSWS_FT_FI5
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:A0JPQ4
ChainResidueDetails
ASER255
BSER255
CSER255
DSER255

223532

PDB entries from 2024-08-07

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