Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7XZ2

TRIM E3 ubiquitin ligase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001778	biological_process	plasma membrane repair
A	0001786	molecular_function	phosphatidylserine binding
A	0003012	biological_process	muscle system process
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005886	cellular_component	plasma membrane
A	0006887	biological_process	exocytosis
A	0006900	biological_process	vesicle budding from membrane
A	0007517	biological_process	muscle organ development
A	0008270	molecular_function	zinc ion binding
A	0010832	biological_process	negative regulation of myotube differentiation
A	0016020	cellular_component	membrane
A	0016740	molecular_function	transferase activity
A	0030659	cellular_component	cytoplasmic vesicle membrane
A	0031410	cellular_component	cytoplasmic vesicle
A	0031435	molecular_function	mitogen-activated protein kinase kinase kinase binding
A	0031624	molecular_function	ubiquitin conjugating enzyme binding
A	0042383	cellular_component	sarcolemma
A	0042802	molecular_function	identical protein binding
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0043569	biological_process	negative regulation of insulin-like growth factor receptor signaling pathway
A	0045087	biological_process	innate immune response
A	0046627	biological_process	negative regulation of insulin receptor signaling pathway
A	0046872	molecular_function	metal ion binding
A	0051260	biological_process	protein homooligomerization
A	0061630	molecular_function	ubiquitin protein ligase activity
B	0001778	biological_process	plasma membrane repair
B	0001786	molecular_function	phosphatidylserine binding
B	0003012	biological_process	muscle system process
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005886	cellular_component	plasma membrane
B	0006887	biological_process	exocytosis
B	0006900	biological_process	vesicle budding from membrane
B	0007517	biological_process	muscle organ development
B	0008270	molecular_function	zinc ion binding
B	0010832	biological_process	negative regulation of myotube differentiation
B	0016020	cellular_component	membrane
B	0016740	molecular_function	transferase activity
B	0030659	cellular_component	cytoplasmic vesicle membrane
B	0031410	cellular_component	cytoplasmic vesicle
B	0031435	molecular_function	mitogen-activated protein kinase kinase kinase binding
B	0031624	molecular_function	ubiquitin conjugating enzyme binding
B	0042383	cellular_component	sarcolemma
B	0042802	molecular_function	identical protein binding
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0043569	biological_process	negative regulation of insulin-like growth factor receptor signaling pathway
B	0045087	biological_process	innate immune response
B	0046627	biological_process	negative regulation of insulin receptor signaling pathway
B	0046872	molecular_function	metal ion binding
B	0051260	biological_process	protein homooligomerization
B	0061630	molecular_function	ubiquitin protein ligase activity
C	0001778	biological_process	plasma membrane repair
C	0001786	molecular_function	phosphatidylserine binding
C	0003012	biological_process	muscle system process
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005886	cellular_component	plasma membrane
C	0006887	biological_process	exocytosis
C	0006900	biological_process	vesicle budding from membrane
C	0007517	biological_process	muscle organ development
C	0008270	molecular_function	zinc ion binding
C	0010832	biological_process	negative regulation of myotube differentiation
C	0016020	cellular_component	membrane
C	0016740	molecular_function	transferase activity
C	0030659	cellular_component	cytoplasmic vesicle membrane
C	0031410	cellular_component	cytoplasmic vesicle
C	0031435	molecular_function	mitogen-activated protein kinase kinase kinase binding
C	0031624	molecular_function	ubiquitin conjugating enzyme binding
C	0042383	cellular_component	sarcolemma
C	0042802	molecular_function	identical protein binding
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0043569	biological_process	negative regulation of insulin-like growth factor receptor signaling pathway
C	0045087	biological_process	innate immune response
C	0046627	biological_process	negative regulation of insulin receptor signaling pathway
C	0046872	molecular_function	metal ion binding
C	0051260	biological_process	protein homooligomerization
C	0061630	molecular_function	ubiquitin protein ligase activity
D	0001778	biological_process	plasma membrane repair
D	0001786	molecular_function	phosphatidylserine binding
D	0003012	biological_process	muscle system process
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005886	cellular_component	plasma membrane
D	0006887	biological_process	exocytosis
D	0006900	biological_process	vesicle budding from membrane
D	0007517	biological_process	muscle organ development
D	0008270	molecular_function	zinc ion binding
D	0010832	biological_process	negative regulation of myotube differentiation
D	0016020	cellular_component	membrane
D	0016740	molecular_function	transferase activity
D	0030659	cellular_component	cytoplasmic vesicle membrane
D	0031410	cellular_component	cytoplasmic vesicle
D	0031435	molecular_function	mitogen-activated protein kinase kinase kinase binding
D	0031624	molecular_function	ubiquitin conjugating enzyme binding
D	0042383	cellular_component	sarcolemma
D	0042802	molecular_function	identical protein binding
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0043569	biological_process	negative regulation of insulin-like growth factor receptor signaling pathway
D	0045087	biological_process	innate immune response
D	0046627	biological_process	negative regulation of insulin receptor signaling pathway
D	0046872	molecular_function	metal ion binding
D	0051260	biological_process	protein homooligomerization
D	0061630	molecular_function	ubiquitin protein ligase activity

Functional Information from PROSITE/UniProt

site_id	PS00518
Number of Residues	10
Details	ZF_RING_1 Zinc finger RING-type signature. CgHsFCraCL

Chain	Residue	Details
A	CYS29-LEU38

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	172
Details	ZN_FING: RING-type => ECO:0000255\|PROSITE-ProRule:PRU00175

Chain	Residue	Details
A	CYS14-GLN57
B	CYS14-GLN57
C	CYS14-GLN57
D	CYS14-GLN57

site_id	SWS_FT_FI2
Number of Residues	164
Details	ZN_FING: B box-type => ECO:0000255\|PROSITE-ProRule:PRU00024

Chain	Residue	Details
A	VAL81-ALA122
B	VAL81-ALA122
C	VAL81-ALA122
D	VAL81-ALA122

site_id	SWS_FT_FI3
Number of Residues	32
Details	BINDING: BINDING => ECO:0007744\|PDB:7XYZ

Chain	Residue	Details
A	CYS14
B	CYS17
B	CYS29
B	HIS31
B	CYS34
B	CYS37
B	CYS53
B	CYS56
C	CYS14
C	CYS17
C	CYS29
A	CYS17
C	HIS31
C	CYS34
C	CYS37
C	CYS53
C	CYS56
D	CYS14
D	CYS17
D	CYS29
D	HIS31
D	CYS34
A	CYS29
D	CYS37
D	CYS53
D	CYS56
A	HIS31
A	CYS34
A	CYS37
A	CYS53
A	CYS56
B	CYS14

site_id	SWS_FT_FI4
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU00024, ECO:0007744\|PDB:7XV2, ECO:0007744\|PDB:7XYY, ECO:0007744\|PDB:7XYZ, ECO:0007744\|PDB:7XZ0, ECO:0007744\|PDB:7XZ1, ECO:0007744\|PDB:7XZ2

Chain	Residue	Details
A	CYS86
A	CYS108
B	CYS86
B	CYS108
C	CYS86
C	CYS108
D	CYS86
D	CYS108

site_id	SWS_FT_FI5
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU00024, ECO:0007744\|PDB:7XYZ

Chain	Residue	Details
A	HIS89
B	HIS89
C	HIS89
D	HIS89

site_id	SWS_FT_FI6
Number of Residues	16
Details	BINDING: BINDING => ECO:0007744\|PDB:7XV2, ECO:0007744\|PDB:7XYY, ECO:0007744\|PDB:7XYZ, ECO:0007744\|PDB:7XZ0, ECO:0007744\|PDB:7XZ1, ECO:0007744\|PDB:7XZ2

Chain	Residue	Details
A	CYS97
C	ASP100
C	CYS105
C	HIS117
D	CYS97
D	ASP100
D	CYS105
D	HIS117
A	ASP100
A	CYS105
A	HIS117
B	CYS97
B	ASP100
B	CYS105
B	HIS117
C	CYS97

site_id	SWS_FT_FI7
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU00024, ECO:0007744\|PDB:7XZ1

Chain	Residue	Details
A	HIS114
B	HIS114
C	HIS114
D	HIS114

site_id	SWS_FT_FI8
Number of Residues	4
Details	MOD_RES: S-nitrosocysteine => ECO:0000250\|UniProtKB:Q6ZMU5

Chain	Residue	Details
A	SER144
B	SER144
C	SER144
D	SER144

site_id	SWS_FT_FI9
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:A0JPQ4

Chain	Residue	Details
A	SER255
B	SER255
C	SER255
D	SER255

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)