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7XWO

Neurokinin A bound to active human neurokinin 2 receptor in complex with G324

Functional Information from GO Data
ChainGOidnamespacecontents
B0004930molecular_functionG protein-coupled receptor activity
B0004995molecular_functiontachykinin receptor activity
B0005506molecular_functioniron ion binding
B0005886cellular_componentplasma membrane
B0007186biological_processG protein-coupled receptor signaling pathway
B0009055molecular_functionelectron transfer activity
B0016020cellular_componentmembrane
B0020037molecular_functionheme binding
B0022900biological_processelectron transport chain
B0042597cellular_componentperiplasmic space
B0046872molecular_functionmetal ion binding
C0001750cellular_componentphotoreceptor outer segment
C0001917cellular_componentphotoreceptor inner segment
C0003924molecular_functionGTPase activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005834cellular_componentheterotrimeric G-protein complex
C0005886cellular_componentplasma membrane
C0007165biological_processsignal transduction
C0007186biological_processG protein-coupled receptor signaling pathway
C0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
C0007204biological_processpositive regulation of cytosolic calcium ion concentration
C0008283biological_processcell population proliferation
C0010659biological_processcardiac muscle cell apoptotic process
C0030159molecular_functionsignaling receptor complex adaptor activity
C0030425cellular_componentdendrite
C0030507molecular_functionspectrin binding
C0042622cellular_componentphotoreceptor outer segment membrane
C0044297cellular_componentcell body
C0044877molecular_functionprotein-containing complex binding
C0045202cellular_componentsynapse
C0047391molecular_functionalkylglycerophosphoethanolamine phosphodiesterase activity
C0050909biological_processsensory perception of taste
C0051020molecular_functionGTPase binding
C0060041biological_processretina development in camera-type eye
C0071456biological_processcellular response to hypoxia
F0003924molecular_functionGTPase activity
F0005525molecular_functionGTP binding
F0007165biological_processsignal transduction
F0007186biological_processG protein-coupled receptor signaling pathway
F0019001molecular_functionguanyl nucleotide binding
F0031683molecular_functionG-protein beta/gamma-subunit complex binding
G0003924molecular_functionGTPase activity
G0005515molecular_functionprotein binding
G0005834cellular_componentheterotrimeric G-protein complex
G0005886cellular_componentplasma membrane
G0007165biological_processsignal transduction
G0007186biological_processG protein-coupled receptor signaling pathway
G0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
G0016020cellular_componentmembrane
G0031681molecular_functionG-protein beta-subunit binding
G0071380biological_processcellular response to prostaglandin E stimulus
G0071870biological_processcellular response to catecholamine stimulus
Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. VSIySMTAIAADRYMaI
ChainResidueDetails
BVAL119-ILE135

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
CLEU75-SER89
CILE162-ILE176
CLEU290-ALA304

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: Methionine amide => ECO:0000269|PubMed:3038549, ECO:0000269|PubMed:3770210
ChainResidueDetails
DMET29
BILE-4

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Cysteine methyl ester => ECO:0000269|PubMed:1903391
ChainResidueDetails
GCYS67
BPHE91-TYR107
BTHR171-LEU196
BGLY273-LEU290

site_idSWS_FT_FI3
Number of Residues1
DetailsLIPID: S-geranylgeranyl cysteine => ECO:0000269|PubMed:12764189, ECO:0000269|PubMed:1903391, ECO:0000269|PubMed:7626050
ChainResidueDetails
GCYS67

site_idSWS_FT_FI4
Number of Residues63
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
BILE57-ASN69
BASP130-LYS149
BVAL219-THR251

site_idSWS_FT_FI5
Number of Residues20
DetailsTRANSMEM: Helical; Name=2 => ECO:0000255
ChainResidueDetails
BTYR70-ASN90

site_idSWS_FT_FI6
Number of Residues21
DetailsTRANSMEM: Helical; Name=3 => ECO:0000255
ChainResidueDetails
BPHE108-ALA129

site_idSWS_FT_FI7
Number of Residues20
DetailsTRANSMEM: Helical; Name=4 => ECO:0000255
ChainResidueDetails
BALA150-SER170

site_idSWS_FT_FI8
Number of Residues21
DetailsTRANSMEM: Helical; Name=5 => ECO:0000255
ChainResidueDetails
BTYR197-SER218

site_idSWS_FT_FI9
Number of Residues20
DetailsTRANSMEM: Helical; Name=6 => ECO:0000255
ChainResidueDetails
BMET252-LEU272

site_idSWS_FT_FI10
Number of Residues19
DetailsTRANSMEM: Helical; Name=7 => ECO:0000255
ChainResidueDetails
BALA291-LEU310

site_idSWS_FT_FI11
Number of Residues1
DetailsLIPID: S-palmitoyl cysteine => ECO:0000255
ChainResidueDetails
BCYS324

site_idSWS_FT_FI12
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
BASN11
BASN19

222926

PDB entries from 2024-07-24

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