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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7XLQ

Structure of human R-type voltage-gated CaV2.3-alpha2/delta1-beta1 channel complex in the ligand-free (apo) state

Functional Information from GO Data
ChainGOidnamespacecontents
A0005216molecular_functionmonoatomic ion channel activity
A0005245molecular_functionvoltage-gated calcium channel activity
A0005262molecular_functioncalcium channel activity
A0005509molecular_functioncalcium ion binding
A0005886cellular_componentplasma membrane
A0005891cellular_componentvoltage-gated calcium channel complex
A0006811biological_processmonoatomic ion transport
A0006816biological_processcalcium ion transport
A0007268biological_processchemical synaptic transmission
A0008331molecular_functionhigh voltage-gated calcium channel activity
A0016020cellular_componentmembrane
A0022843molecular_functionvoltage-gated monoatomic cation channel activity
A0034220biological_processmonoatomic ion transmembrane transport
A0034702cellular_componentmonoatomic ion channel complex
A0043025cellular_componentneuronal cell body
A0045202cellular_componentsynapse
A0046872molecular_functionmetal ion binding
A0055085biological_processtransmembrane transport
A0070588biological_processcalcium ion transmembrane transport
A0098703biological_processcalcium ion import across plasma membrane
B0005245molecular_functionvoltage-gated calcium channel activity
B0005246molecular_functioncalcium channel regulator activity
B0005262molecular_functioncalcium channel activity
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0005891cellular_componentvoltage-gated calcium channel complex
B0006811biological_processmonoatomic ion transport
B0006816biological_processcalcium ion transport
B0007268biological_processchemical synaptic transmission
B0008331molecular_functionhigh voltage-gated calcium channel activity
B0030315cellular_componentT-tubule
B0034220biological_processmonoatomic ion transmembrane transport
B0034702cellular_componentmonoatomic ion channel complex
B0042383cellular_componentsarcolemma
B0045202cellular_componentsynapse
B0045933biological_processpositive regulation of muscle contraction
B0070588biological_processcalcium ion transmembrane transport
B1902514biological_processregulation of calcium ion transmembrane transport via high voltage-gated calcium channel
B1904646biological_processcellular response to amyloid-beta
D0005245molecular_functionvoltage-gated calcium channel activity
D0005262molecular_functioncalcium channel activity
D0005886cellular_componentplasma membrane
D0005891cellular_componentvoltage-gated calcium channel complex
D0006811biological_processmonoatomic ion transport
D0006816biological_processcalcium ion transport
D0016020cellular_componentmembrane
D0016529cellular_componentsarcoplasmic reticulum
D0030315cellular_componentT-tubule
D0034220biological_processmonoatomic ion transmembrane transport
D0034702cellular_componentmonoatomic ion channel complex
D0035774biological_processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
D0046872molecular_functionmetal ion binding
D0048787cellular_componentpresynaptic active zone membrane
D0051924biological_processregulation of calcium ion transport
D0060307biological_processregulation of ventricular cardiac muscle cell membrane repolarization
D0060402biological_processcalcium ion transport into cytosol
D0061577biological_processcalcium ion transmembrane transport via high voltage-gated calcium channel
D0070062cellular_componentextracellular exosome
D0070588biological_processcalcium ion transmembrane transport
D0086002biological_processcardiac muscle cell action potential involved in contraction
D0086007molecular_functionvoltage-gated calcium channel activity involved in cardiac muscle cell action potential
D0086048biological_processmembrane depolarization during bundle of His cell action potential
D0086057molecular_functionvoltage-gated calcium channel activity involved in bundle of His cell action potential
D0086091biological_processregulation of heart rate by cardiac conduction
D0098703biological_processcalcium ion import across plasma membrane
D0098903biological_processregulation of membrane repolarization during action potential
D0098982cellular_componentGABA-ergic synapse
D0098992cellular_componentneuronal dense core vesicle
D1902514biological_processregulation of calcium ion transmembrane transport via high voltage-gated calcium channel
D1904646biological_processcellular response to amyloid-beta
D1990454cellular_componentL-type voltage-gated calcium channel complex
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues18
DetailsTransmembrane: {"description":"Helical; Name=S1 of repeat I"}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues397
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues18
DetailsTransmembrane: {"description":"Helical; Name=S2 of repeat I"}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues153
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues14
DetailsTransmembrane: {"description":"Helical; Name=S3 of repeat I"}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues19
DetailsTransmembrane: {"description":"Helical; Name=S4 of repeat I"}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues20
DetailsTransmembrane: {"description":"Helical; Name=S5 of repeat I"}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues23
DetailsTransmembrane: {"description":"Helical; Name=S6 of repeat I"}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues19
DetailsTransmembrane: {"description":"Helical; Name=S1 of repeat II"}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues19
DetailsTransmembrane: {"description":"Helical; Name=S2 of repeat II"}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues18
DetailsTransmembrane: {"description":"Helical; Name=S3 of repeat II"}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues18
DetailsTransmembrane: {"description":"Helical; Name=S4 of repeat II"}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues19
DetailsTransmembrane: {"description":"Helical; Name=S5 of repeat II"}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues24
DetailsTransmembrane: {"description":"Helical; Name=S6 of repeat II"}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues16
DetailsTransmembrane: {"description":"Helical; Name=S1 of repeat III"}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues19
DetailsTransmembrane: {"description":"Helical; Name=S2 of repeat III"}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues17
DetailsTransmembrane: {"description":"Helical; Name=S4 of repeat III"}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues19
DetailsTransmembrane: {"description":"Helical; Name=S5 of repeat III"}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues23
DetailsTransmembrane: {"description":"Helical; Name=S6 of repeat III"}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues18
DetailsTransmembrane: {"description":"Helical; Name=S1 of repeat IV"}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues19
DetailsTransmembrane: {"description":"Helical; Name=S2 of repeat IV"}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues18
DetailsTransmembrane: {"description":"Helical; Name=S3 of repeat IV"}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues18
DetailsTransmembrane: {"description":"Helical; Name=S4 of repeat IV"}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues19
DetailsTransmembrane: {"description":"Helical; Name=S5 of repeat IV"}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues25
DetailsTransmembrane: {"description":"Helical; Name=S6 of repeat IV"}
ChainResidueDetails
site_idSWS_FT_FI26
Number of Residues278
DetailsRepeat: {"description":"I"}
ChainResidueDetails
site_idSWS_FT_FI27
Number of Residues244
DetailsRepeat: {"description":"II"}
ChainResidueDetails
site_idSWS_FT_FI28
Number of Residues263
DetailsRepeat: {"description":"IV"}
ChainResidueDetails
site_idSWS_FT_FI29
Number of Residues35
DetailsDomain: {"description":"EF-hand","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI30
Number of Residues3
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI31
Number of Residues4
DetailsSite: {"description":"Calcium ion selectivity and permeability","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI32
Number of Residues12
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI33
Number of Residues177
DetailsDomain: {"description":"VWFA","evidences":[{"source":"PROSITE-ProRule","id":"PRU00219","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI34
Number of Residues4
DetailsMotif: {"description":"MIDAS-like motif"}
ChainResidueDetails
site_idSWS_FT_FI35
Number of Residues3
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI36
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P54290","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI37
Number of Residues7
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"34234349","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MIX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MIY","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

247947

PDB entries from 2026-01-21

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