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7XBX

Cryo-EM structure of the human chemokine receptor CX3CR1 in complex with CX3CL1 and Gi1

Functional Information from GO Data
ChainGOidnamespacecontents
C0000287molecular_functionmagnesium ion binding
C0001664molecular_functionG protein-coupled receptor binding
C0003924molecular_functionGTPase activity
C0003925molecular_functionG protein activity
C0005515molecular_functionprotein binding
C0005525molecular_functionGTP binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005730cellular_componentnucleolus
C0005737cellular_componentcytoplasm
C0005765cellular_componentlysosomal membrane
C0005813cellular_componentcentrosome
C0005829cellular_componentcytosol
C0005834cellular_componentheterotrimeric G-protein complex
C0005856cellular_componentcytoskeleton
C0005886cellular_componentplasma membrane
C0005938cellular_componentcell cortex
C0007165biological_processsignal transduction
C0007186biological_processG protein-coupled receptor signaling pathway
C0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
C0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
C0007198biological_processadenylate cyclase-inhibiting serotonin receptor signaling pathway
C0010854molecular_functionadenylate cyclase regulator activity
C0016787molecular_functionhydrolase activity
C0019001molecular_functionguanyl nucleotide binding
C0019003molecular_functionGDP binding
C0030496cellular_componentmidbody
C0031683molecular_functionG-protein beta/gamma-subunit complex binding
C0031749molecular_functionD2 dopamine receptor binding
C0031821molecular_functionG protein-coupled serotonin receptor binding
C0034695biological_processresponse to prostaglandin E
C0043434biological_processresponse to peptide hormone
C0045542biological_processpositive regulation of cholesterol biosynthetic process
C0046872molecular_functionmetal ion binding
C0051301biological_processcell division
C0060236biological_processregulation of mitotic spindle organization
C0070062cellular_componentextracellular exosome
C0072678biological_processT cell migration
C1904322biological_processcellular response to forskolin
C1904778biological_processpositive regulation of protein localization to cell cortex
D0001750cellular_componentphotoreceptor outer segment
D0003924molecular_functionGTPase activity
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005765cellular_componentlysosomal membrane
D0005829cellular_componentcytosol
D0005834cellular_componentheterotrimeric G-protein complex
D0005886cellular_componentplasma membrane
D0007165biological_processsignal transduction
D0007186biological_processG protein-coupled receptor signaling pathway
D0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
D0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
D0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
D0007265biological_processRas protein signal transduction
D0008283biological_processcell population proliferation
D0016020cellular_componentmembrane
D0030159molecular_functionsignaling receptor complex adaptor activity
D0044877molecular_functionprotein-containing complex binding
D0045202cellular_componentsynapse
D0050909biological_processsensory perception of taste
D0051020molecular_functionGTPase binding
D0060041biological_processretina development in camera-type eye
D0070062cellular_componentextracellular exosome
D0071380biological_processcellular response to prostaglandin E stimulus
D0071870biological_processcellular response to catecholamine stimulus
D0097381cellular_componentphotoreceptor disc membrane
D1903561cellular_componentextracellular vesicle
E0005515molecular_functionprotein binding
E0005834cellular_componentheterotrimeric G-protein complex
E0005886cellular_componentplasma membrane
E0007165biological_processsignal transduction
E0007186biological_processG protein-coupled receptor signaling pathway
E0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
E0016020cellular_componentmembrane
E0031681molecular_functionG-protein beta-subunit binding
E0045202cellular_componentsynapse
E0048144biological_processfibroblast proliferation
E0070062cellular_componentextracellular exosome
E0071380biological_processcellular response to prostaglandin E stimulus
E0071870biological_processcellular response to catecholamine stimulus
R0004930molecular_functionG protein-coupled receptor activity
R0005576cellular_componentextracellular region
R0006935biological_processchemotaxis
R0006955biological_processimmune response
R0007155biological_processcell adhesion
R0007186biological_processG protein-coupled receptor signaling pathway
R0008009molecular_functionchemokine activity
R0016020cellular_componentmembrane
R0016495molecular_functionC-X3-C chemokine receptor activity
Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. GSIfFLTVISIDRYLaI
ChainResidueDetails
RGLY217-ILE233

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
DLEU70-SER84
DILE157-ILE171
DLEU285-ALA299

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
RASN9
CASN269

site_idSWS_FT_FI2
Number of Residues27
DetailsTRANSMEM: Helical; Name=1 => ECO:0000255
ChainResidueDetails
RVAL134-SER161
CTHR181

site_idSWS_FT_FI3
Number of Residues40
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
RLYS162-TYR171
RASP228-THR244
RGLN318-LYS333

site_idSWS_FT_FI4
Number of Residues20
DetailsTRANSMEM: Helical; Name=2 => ECO:0000255
ChainResidueDetails
RLEU172-TYR192

site_idSWS_FT_FI5
Number of Residues55
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
RLEU193-LYS205
RTHR270-THR297
RLYS359-LEU375

site_idSWS_FT_FI6
Number of Residues21
DetailsTRANSMEM: Helical; Name=3 => ECO:0000255
ChainResidueDetails
RPHE206-ILE227

site_idSWS_FT_FI7
Number of Residues24
DetailsTRANSMEM: Helical; Name=4 => ECO:0000255
ChainResidueDetails
RVAL245-PHE269

site_idSWS_FT_FI8
Number of Residues19
DetailsTRANSMEM: Helical; Name=5 => ECO:0000255
ChainResidueDetails
RASN298-ILE317

site_idSWS_FT_FI9
Number of Residues24
DetailsTRANSMEM: Helical; Name=6 => ECO:0000255
ChainResidueDetails
RLEU334-LEU358

site_idSWS_FT_FI10
Number of Residues23
DetailsTRANSMEM: Helical; Name=7 => ECO:0000255
ChainResidueDetails
RALA376-GLY399

site_idSWS_FT_FI11
Number of Residues1
DetailsLIPID: S-palmitoyl cysteine => ECO:0000250|UniProtKB:P10824
ChainResidueDetails
CCYS3

227111

PDB entries from 2024-11-06

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