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7WZS

Crystal structure of Chromobacterium violaceum effector CopC in complex with host calmodulin and caspase-7

Functional Information from GO Data
ChainGOidnamespacecontents
A0005516molecular_functioncalmodulin binding
A0005576cellular_componentextracellular region
A0016829molecular_functionlyase activity
A0030430cellular_componenthost cell cytoplasm
A0051604biological_processprotein maturation
A0052040biological_processsymbiont-mediated perturbation of host programmed cell death
A0070269biological_processpyroptotic inflammatory response
A0090729molecular_functiontoxin activity
A0097191biological_processextrinsic apoptotic signaling pathway
A0097193biological_processintrinsic apoptotic signaling pathway
A0097194biological_processexecution phase of apoptosis
A0140639biological_processpositive regulation of pyroptotic inflammatory response
A0140740molecular_functionADP-riboxanase activity
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0001650cellular_componentfibrillar center
B0001778biological_processplasma membrane repair
B0003723molecular_functionRNA binding
B0003824molecular_functioncatalytic activity
B0004190molecular_functionaspartic-type endopeptidase activity
B0004197molecular_functioncysteine-type endopeptidase activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006357biological_processregulation of transcription by RNA polymerase II
B0006508biological_processproteolysis
B0006915biological_processapoptotic process
B0007507biological_processheart development
B0008233molecular_functionpeptidase activity
B0008234molecular_functioncysteine-type peptidase activity
B0009411biological_processresponse to UV
B0016485biological_processprotein processing
B0016787molecular_functionhydrolase activity
B0030163biological_processprotein catabolic process
B0042742biological_processdefense response to bacterium
B0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
B0043525biological_processpositive regulation of neuron apoptotic process
B0044346biological_processfibroblast apoptotic process
B0046513biological_processceramide biosynthetic process
B0051146biological_processstriated muscle cell differentiation
B0051402biological_processneuron apoptotic process
B0051604biological_processprotein maturation
B0070212biological_processprotein poly-ADP-ribosylation
B0070227biological_processlymphocyte apoptotic process
B0070269biological_processpyroptotic inflammatory response
B0071222biological_processcellular response to lipopolysaccharide
B0071887biological_processleukocyte apoptotic process
B0072734biological_processcellular response to staurosporine
B0097194biological_processexecution phase of apoptosis
B1905686biological_processpositive regulation of plasma membrane repair
C0000086biological_processG2/M transition of mitotic cell cycle
C0000922cellular_componentspindle pole
C0002027biological_processregulation of heart rate
C0005246molecular_functioncalcium channel regulator activity
C0005509molecular_functioncalcium ion binding
C0005513biological_processdetection of calcium ion
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005813cellular_componentcentrosome
C0005819cellular_componentspindle
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005876cellular_componentspindle microtubule
C0005886cellular_componentplasma membrane
C0005929cellular_componentcilium
C0007186biological_processG protein-coupled receptor signaling pathway
C0007259biological_processcell surface receptor signaling pathway via JAK-STAT
C0008076cellular_componentvoltage-gated potassium channel complex
C0010856molecular_functionadenylate cyclase activator activity
C0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
C0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
C0016020cellular_componentmembrane
C0016240biological_processautophagosome membrane docking
C0019855molecular_functioncalcium channel inhibitor activity
C0019901molecular_functionprotein kinase binding
C0021762biological_processsubstantia nigra development
C0030017cellular_componentsarcomere
C0030672cellular_componentsynaptic vesicle membrane
C0031432molecular_functiontitin binding
C0031514cellular_componentmotile cilium
C0031982cellular_componentvesicle
C0032465biological_processregulation of cytokinesis
C0032991cellular_componentprotein-containing complex
C0034704cellular_componentcalcium channel complex
C0035458biological_processcellular response to interferon-beta
C0042995cellular_componentcell projection
C0043209cellular_componentmyelin sheath
C0043539molecular_functionprotein serine/threonine kinase activator activity
C0044305cellular_componentcalyx of Held
C0044325molecular_functiontransmembrane transporter binding
C0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
C0046872molecular_functionmetal ion binding
C0048306molecular_functioncalcium-dependent protein binding
C0050848biological_processregulation of calcium-mediated signaling
C0051592biological_processresponse to calcium ion
C0055117biological_processregulation of cardiac muscle contraction
C0060291biological_processlong-term synaptic potentiation
C0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
C0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
C0071346biological_processcellular response to type II interferon
C0072542molecular_functionprotein phosphatase activator activity
C0097225cellular_componentsperm midpiece
C0097720biological_processcalcineurin-mediated signaling
C0098901biological_processregulation of cardiac muscle cell action potential
C0099523cellular_componentpresynaptic cytosol
C0140056biological_processorganelle localization by membrane tethering
C0140238biological_processpresynaptic endocytosis
C0141110molecular_functiontransporter inhibitor activity
C1901842biological_processnegative regulation of high voltage-gated calcium channel activity
C1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
C1902494cellular_componentcatalytic complex
C1905913biological_processnegative regulation of calcium ion export across plasma membrane
C1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DKDGDGTITtkEL
ChainResidueDetails
CASP21-LEU33
CASP57-PHE69
CASP94-LEU106
CASP130-PHE142

site_idPS01121
Number of Residues15
DetailsCASPASE_HIS Caspase family histidine active site. HtnaaCfaCiLLSHG
ChainResidueDetails
BHIS131-GLY145

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues10
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:1474585, ECO:0000269|PubMed:25441029, ECO:0000269|PubMed:27564677, ECO:0007744|PDB:1CLL, ECO:0007744|PDB:4UMO, ECO:0007744|PDB:4V0C, ECO:0007744|PDB:5J03
ChainResidueDetails
CASP21
CGLU68
CASP23
CASP25
CTHR27
CGLU32
CASP57
CASP59
CASN61
CTHR63

site_idSWS_FT_FI2
Number of Residues5
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:1474585, ECO:0000269|PubMed:27564677, ECO:0000269|PubMed:29724949, ECO:0007744|PDB:1CLL, ECO:0007744|PDB:5J03, ECO:0007744|PDB:6CNN, ECO:0007744|PDB:6CNO
ChainResidueDetails
CASP94
CASP96
CASN98
CTYR100
CGLU105
AHIS202
APHE207
AGLU325

site_idSWS_FT_FI3
Number of Residues5
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:1474585, ECO:0000269|PubMed:27564677, ECO:0007744|PDB:1CLL, ECO:0007744|PDB:5J03
ChainResidueDetails
CASP130
CASP132
CASP134
CGLN136
CGLU141
AASN154
ALEU157
AASN167
AASP230

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: N-acetylalanine => ECO:0000269|PubMed:7093203, ECO:0000269|Ref.7, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378, ECO:0007744|PubMed:25944712
ChainResidueDetails
CALA2
BTYR223
APHE207
AASP230

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861
ChainResidueDetails
CLYS22
BSER239

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphothreonine; by CaMK4 => ECO:0000250|UniProtKB:P0DP29
ChainResidueDetails
CTHR45

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
CSER82

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
CLYS95

site_idSWS_FT_FI9
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332
ChainResidueDetails
CTYR100

site_idSWS_FT_FI10
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
CSER102

site_idSWS_FT_FI11
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569
ChainResidueDetails
CTHR111

site_idSWS_FT_FI12
Number of Residues1
DetailsMOD_RES: N6-methyllysine; alternate => ECO:0007744|PubMed:24129315
ChainResidueDetails
CLYS116

site_idSWS_FT_FI13
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19690332
ChainResidueDetails
CTYR139

site_idSWS_FT_FI14
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P62157
ChainResidueDetails
CLYS22

237423

PDB entries from 2025-06-11

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