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7WRQ

Structure of Human IGF1/IGFBP3/ALS Ternary Complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0005520molecular_functioninsulin-like growth factor binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0007155biological_processcell adhesion
A0007165biological_processsignal transduction
A0031012cellular_componentextracellular matrix
A0042567cellular_componentinsulin-like growth factor ternary complex
A0070062cellular_componentextracellular exosome
B0000165biological_processMAPK cascade
B0001558biological_processregulation of cell growth
B0001649biological_processosteoblast differentiation
B0001933biological_processnegative regulation of protein phosphorylation
B0001968molecular_functionfibronectin binding
B0005515molecular_functionprotein binding
B0005520molecular_functioninsulin-like growth factor binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005788cellular_componentendoplasmic reticulum lumen
B0006468biological_processprotein phosphorylation
B0006915biological_processapoptotic process
B0008160molecular_functionprotein tyrosine phosphatase activator activity
B0008285biological_processnegative regulation of cell population proliferation
B0009968biological_processnegative regulation of signal transduction
B0010906biological_processregulation of glucose metabolic process
B0014912biological_processnegative regulation of smooth muscle cell migration
B0016942cellular_componentinsulin-like growth factor binding protein complex
B0019838molecular_functiongrowth factor binding
B0031994molecular_functioninsulin-like growth factor I binding
B0031995molecular_functioninsulin-like growth factor II binding
B0040008biological_processregulation of growth
B0042567cellular_componentinsulin-like growth factor ternary complex
B0043065biological_processpositive regulation of apoptotic process
B0043410biological_processpositive regulation of MAPK cascade
B0043567biological_processregulation of insulin-like growth factor receptor signaling pathway
B0043568biological_processpositive regulation of insulin-like growth factor receptor signaling pathway
B0044342biological_processtype B pancreatic cell proliferation
B0045663biological_processpositive regulation of myoblast differentiation
B0046872molecular_functionmetal ion binding
B0048662biological_processnegative regulation of smooth muscle cell proliferation
C0005179molecular_functionhormone activity
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0008083molecular_functiongrowth factor activity
Functional Information from PROSITE/UniProt
site_idPS00222
Number of Residues16
DetailsIGFBP_N_1 Insulin-like growth factor-binding protein (IGFBP) N-terminal domain signature. GCGCCltCAlsegqpC
ChainResidueDetails
BGLY39-CYS54

site_idPS00262
Number of Residues15
DetailsINSULIN Insulin family signature. CCFRsCDlrrLemyC
ChainResidueDetails
CCYS47-CYS61

site_idPS00484
Number of Residues34
DetailsTHYROGLOBULIN_1_1 Thyroglobulin type-1 repeat signature. HipnCdkk.GfYkkkQcrpskgrkrgfcWCVdky.G
ChainResidueDetails
BHIS209-GLY242

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: Phosphoserine; by FAM20C => ECO:0000269|PubMed:26091039
ChainResidueDetails
BSER121
BSER174
AASN96
AASN580

site_idSWS_FT_FI2
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:19139490
ChainResidueDetails
BASN89

site_idSWS_FT_FI3
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:14760718, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218
ChainResidueDetails
BASN109

site_idSWS_FT_FI4
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490
ChainResidueDetails
BASN172

226707

PDB entries from 2024-10-30

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