7WRQ
Structure of Human IGF1/IGFBP3/ALS Ternary Complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005520 | molecular_function | insulin-like growth factor binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0007155 | biological_process | cell adhesion |
| A | 0007165 | biological_process | signal transduction |
| A | 0038023 | molecular_function | signaling receptor activity |
| A | 0042567 | cellular_component | insulin-like growth factor ternary complex |
| A | 0070062 | cellular_component | extracellular exosome |
| B | 0001649 | biological_process | osteoblast differentiation |
| B | 0001933 | biological_process | negative regulation of protein phosphorylation |
| B | 0001968 | molecular_function | fibronectin binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005520 | molecular_function | insulin-like growth factor binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | extracellular space |
| B | 0005634 | cellular_component | nucleus |
| B | 0005788 | cellular_component | endoplasmic reticulum lumen |
| B | 0006468 | biological_process | protein phosphorylation |
| B | 0006915 | biological_process | apoptotic process |
| B | 0008160 | molecular_function | protein tyrosine phosphatase activator activity |
| B | 0008285 | biological_process | negative regulation of cell population proliferation |
| B | 0009968 | biological_process | negative regulation of signal transduction |
| B | 0014912 | biological_process | negative regulation of smooth muscle cell migration |
| B | 0016942 | cellular_component | insulin-like growth factor binding protein complex |
| B | 0019838 | molecular_function | growth factor binding |
| B | 0031994 | molecular_function | insulin-like growth factor I binding |
| B | 0031995 | molecular_function | insulin-like growth factor II binding |
| B | 0042567 | cellular_component | insulin-like growth factor ternary complex |
| B | 0043065 | biological_process | positive regulation of apoptotic process |
| B | 0043567 | biological_process | regulation of insulin-like growth factor receptor signaling pathway |
| B | 0045663 | biological_process | positive regulation of myoblast differentiation |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0048662 | biological_process | negative regulation of smooth muscle cell proliferation |
| C | 0005179 | molecular_function | hormone activity |
| C | 0005576 | cellular_component | extracellular region |
| C | 0005615 | cellular_component | extracellular space |
| C | 0008083 | molecular_function | growth factor activity |
Functional Information from PROSITE/UniProt
| site_id | PS00222 |
| Number of Residues | 16 |
| Details | IGFBP_N_1 Insulin-like growth factor-binding protein (IGFBP) N-terminal domain signature. GCGCCltCAlsegqpC |
| Chain | Residue | Details |
| B | GLY39-CYS54 |
| site_id | PS00262 |
| Number of Residues | 15 |
| Details | INSULIN Insulin family signature. CCFRsCDlrrLemyC |
| Chain | Residue | Details |
| C | CYS47-CYS61 |
| site_id | PS00484 |
| Number of Residues | 34 |
| Details | THYROGLOBULIN_1_1 Thyroglobulin type-1 repeat signature. HipnCdkk.GfYkkkQcrpskgrkrgfcWCVdky.G |
| Chain | Residue | Details |
| B | HIS209-GLY242 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 7"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 8"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 9"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 10"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 11"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 12"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 13"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 14"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 15"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 16"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 17"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 18"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI19 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 19"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI20 |
| Number of Residues | 69 |
| Details | Domain: {"description":"LRRCT"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI21 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI22 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI23 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI24 |
| Number of Residues | 75 |
| Details | Domain: {"description":"Thyroglobulin type-1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00500","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI25 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"19139490","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI26 |
| Number of Residues | 28 |
| Details | Region: {"description":"B"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI27 |
| Number of Residues | 11 |
| Details | Region: {"description":"C"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI28 |
| Number of Residues | 20 |
| Details | Region: {"description":"A"} |
| Chain | Residue | Details |
