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7W1Y

Human MCM double hexamer bound to natural DNA duplex (polyAT/polyTA)

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
20000727biological_processdouble-strand break repair via break-induced replication
20000781cellular_componentchromosome, telomeric region
20000785cellular_componentchromatin
20003677molecular_functionDNA binding
20003688molecular_functionDNA replication origin binding
20003697molecular_functionsingle-stranded DNA binding
20004386molecular_functionhelicase activity
20005515molecular_functionprotein binding
20005524molecular_functionATP binding
20005634cellular_componentnucleus
20005654cellular_componentnucleoplasm
20005664cellular_componentnuclear origin of replication recognition complex
20005694cellular_componentchromosome
20005730cellular_componentnucleolus
20005737cellular_componentcytoplasm
20006259biological_processDNA metabolic process
20006260biological_processDNA replication
20006268biological_processDNA unwinding involved in DNA replication
20006270biological_processDNA replication initiation
20006334biological_processnucleosome assembly
20006915biological_processapoptotic process
20016787molecular_functionhydrolase activity
20016887molecular_functionATP hydrolysis activity
20017116molecular_functionsingle-stranded DNA helicase activity
20019899molecular_functionenzyme binding
20030174biological_processregulation of DNA-templated DNA replication initiation
20032508biological_processDNA duplex unwinding
20042393molecular_functionhistone binding
20042555cellular_componentMCM complex
20043138molecular_function3'-5' DNA helicase activity
20046872molecular_functionmetal ion binding
20071162cellular_componentCMG complex
20071353biological_processcellular response to interleukin-4
20090102biological_processcochlea development
21902975biological_processmitotic DNA replication initiation
21905775biological_processnegative regulation of DNA helicase activity
30000727biological_processdouble-strand break repair via break-induced replication
30000781cellular_componentchromosome, telomeric region
30003677molecular_functionDNA binding
30003697molecular_functionsingle-stranded DNA binding
30004386molecular_functionhelicase activity
30005515molecular_functionprotein binding
30005524molecular_functionATP binding
30005634cellular_componentnucleus
30005654cellular_componentnucleoplasm
30005658cellular_componentalpha DNA polymerase:primase complex
30005694cellular_componentchromosome
30005730cellular_componentnucleolus
30005737cellular_componentcytoplasm
30005813cellular_componentcentrosome
30006259biological_processDNA metabolic process
30006260biological_processDNA replication
30006268biological_processDNA unwinding involved in DNA replication
30006270biological_processDNA replication initiation
30006271biological_processDNA strand elongation involved in DNA replication
30016020cellular_componentmembrane
30016787molecular_functionhydrolase activity
30016887molecular_functionATP hydrolysis activity
30017116molecular_functionsingle-stranded DNA helicase activity
30030174biological_processregulation of DNA-templated DNA replication initiation
30032508biological_processDNA duplex unwinding
30042555cellular_componentMCM complex
30048471cellular_componentperinuclear region of cytoplasm
30071162cellular_componentCMG complex
31902975biological_processmitotic DNA replication initiation
40000727biological_processdouble-strand break repair via break-induced replication
40000781cellular_componentchromosome, telomeric region
40003677molecular_functionDNA binding
40003678molecular_functionDNA helicase activity
40003697molecular_functionsingle-stranded DNA binding
40004386molecular_functionhelicase activity
40005515molecular_functionprotein binding
40005524molecular_functionATP binding
40005634cellular_componentnucleus
40005654cellular_componentnucleoplasm
40005694cellular_componentchromosome
40006259biological_processDNA metabolic process
40006260biological_processDNA replication
40006268biological_processDNA unwinding involved in DNA replication
40006270biological_processDNA replication initiation
40006271biological_processDNA strand elongation involved in DNA replication
40016020cellular_componentmembrane
40016787molecular_functionhydrolase activity
40016887molecular_functionATP hydrolysis activity
40017116molecular_functionsingle-stranded DNA helicase activity
40030174biological_processregulation of DNA-templated DNA replication initiation
40032508biological_processDNA duplex unwinding
40042555cellular_componentMCM complex
40071162cellular_componentCMG complex
41902975biological_processmitotic DNA replication initiation
50000727biological_processdouble-strand break repair via break-induced replication
50000781cellular_componentchromosome, telomeric region
50003677molecular_functionDNA binding
50003688molecular_functionDNA replication origin binding
50003697molecular_functionsingle-stranded DNA binding
50004386molecular_functionhelicase activity
50005515molecular_functionprotein binding
50005524molecular_functionATP binding
50005634cellular_componentnucleus
50005654cellular_componentnucleoplasm
50005694cellular_componentchromosome
50006260biological_processDNA replication
50006268biological_processDNA unwinding involved in DNA replication
50006270biological_processDNA replication initiation
50016020cellular_componentmembrane
50016787molecular_functionhydrolase activity
50016887molecular_functionATP hydrolysis activity
50017116molecular_functionsingle-stranded DNA helicase activity
50030174biological_processregulation of DNA-templated DNA replication initiation
50032508biological_processDNA duplex unwinding
50032991cellular_componentprotein-containing complex
50042555cellular_componentMCM complex
50043138molecular_function3'-5' DNA helicase activity
50043229cellular_componentintracellular organelle
50071162cellular_componentCMG complex
60000727biological_processdouble-strand break repair via break-induced replication
60000781cellular_componentchromosome, telomeric region
60003677molecular_functionDNA binding
60003678molecular_functionDNA helicase activity
60003697molecular_functionsingle-stranded DNA binding
60004386molecular_functionhelicase activity
60005515molecular_functionprotein binding
60005524molecular_functionATP binding
60005634cellular_componentnucleus
60005654cellular_componentnucleoplasm
60005694cellular_componentchromosome
60006259biological_processDNA metabolic process
60006260biological_processDNA replication
60006268biological_processDNA unwinding involved in DNA replication
60006270biological_processDNA replication initiation
60016787molecular_functionhydrolase activity
60016887molecular_functionATP hydrolysis activity
60030174biological_processregulation of DNA-templated DNA replication initiation
60032508biological_processDNA duplex unwinding
60042555cellular_componentMCM complex
60042802molecular_functionidentical protein binding
60071162cellular_componentCMG complex
61902969biological_processmitotic DNA replication
61990518molecular_functionsingle-stranded 3'-5' DNA helicase activity
70000727biological_processdouble-strand break repair via break-induced replication
70000781cellular_componentchromosome, telomeric region
70000785cellular_componentchromatin
70003677molecular_functionDNA binding
70003678molecular_functionDNA helicase activity
70003697molecular_functionsingle-stranded DNA binding
70004386molecular_functionhelicase activity
70005515molecular_functionprotein binding
70005524molecular_functionATP binding
70005634cellular_componentnucleus
70005654cellular_componentnucleoplasm
70005694cellular_componentchromosome
70005730cellular_componentnucleolus
70005829cellular_componentcytosol
70006259biological_processDNA metabolic process
70006260biological_processDNA replication
70006268biological_processDNA unwinding involved in DNA replication
70006270biological_processDNA replication initiation
70006271biological_processDNA strand elongation involved in DNA replication
70006974biological_processDNA damage response
70008283biological_processcell population proliferation
70016020cellular_componentmembrane
70016787molecular_functionhydrolase activity
70016887molecular_functionATP hydrolysis activity
70017116molecular_functionsingle-stranded DNA helicase activity
70030174biological_processregulation of DNA-templated DNA replication initiation
70032508biological_processDNA duplex unwinding
70042325biological_processregulation of phosphorylation
70042555cellular_componentMCM complex
70043229cellular_componentintracellular organelle
70071162cellular_componentCMG complex
70071466biological_processcellular response to xenobiotic stimulus
A0000727biological_processdouble-strand break repair via break-induced replication
A0000781cellular_componentchromosome, telomeric region
A0000785cellular_componentchromatin
A0003677molecular_functionDNA binding
A0003688molecular_functionDNA replication origin binding
A0003697molecular_functionsingle-stranded DNA binding
A0004386molecular_functionhelicase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005664cellular_componentnuclear origin of replication recognition complex
A0005694cellular_componentchromosome
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0006259biological_processDNA metabolic process
A0006260biological_processDNA replication
A0006268biological_processDNA unwinding involved in DNA replication
A0006270biological_processDNA replication initiation
A0006334biological_processnucleosome assembly
A0006915biological_processapoptotic process
A0016787molecular_functionhydrolase activity
A0016887molecular_functionATP hydrolysis activity
A0017116molecular_functionsingle-stranded DNA helicase activity
A0019899molecular_functionenzyme binding
A0030174biological_processregulation of DNA-templated DNA replication initiation
A0032508biological_processDNA duplex unwinding
A0042393molecular_functionhistone binding
A0042555cellular_componentMCM complex
A0043138molecular_function3'-5' DNA helicase activity
A0046872molecular_functionmetal ion binding
A0071162cellular_componentCMG complex
A0071353biological_processcellular response to interleukin-4
A0090102biological_processcochlea development
A1902975biological_processmitotic DNA replication initiation
A1905775biological_processnegative regulation of DNA helicase activity
B0000727biological_processdouble-strand break repair via break-induced replication
B0000781cellular_componentchromosome, telomeric region
B0003677molecular_functionDNA binding
B0003697molecular_functionsingle-stranded DNA binding
B0004386molecular_functionhelicase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005658cellular_componentalpha DNA polymerase:primase complex
B0005694cellular_componentchromosome
B0005730cellular_componentnucleolus
B0005737cellular_componentcytoplasm
B0005813cellular_componentcentrosome
B0006259biological_processDNA metabolic process
B0006260biological_processDNA replication
B0006268biological_processDNA unwinding involved in DNA replication
B0006270biological_processDNA replication initiation
B0006271biological_processDNA strand elongation involved in DNA replication
B0016020cellular_componentmembrane
B0016787molecular_functionhydrolase activity
B0016887molecular_functionATP hydrolysis activity
B0017116molecular_functionsingle-stranded DNA helicase activity
B0030174biological_processregulation of DNA-templated DNA replication initiation
B0032508biological_processDNA duplex unwinding
B0042555cellular_componentMCM complex
B0048471cellular_componentperinuclear region of cytoplasm
B0071162cellular_componentCMG complex
B1902975biological_processmitotic DNA replication initiation
C0000727biological_processdouble-strand break repair via break-induced replication
C0000781cellular_componentchromosome, telomeric region
C0003677molecular_functionDNA binding
C0003678molecular_functionDNA helicase activity
C0003697molecular_functionsingle-stranded DNA binding
C0004386molecular_functionhelicase activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005694cellular_componentchromosome
C0006259biological_processDNA metabolic process
C0006260biological_processDNA replication
C0006268biological_processDNA unwinding involved in DNA replication
C0006270biological_processDNA replication initiation
C0006271biological_processDNA strand elongation involved in DNA replication
C0016020cellular_componentmembrane
C0016787molecular_functionhydrolase activity
C0016887molecular_functionATP hydrolysis activity
C0017116molecular_functionsingle-stranded DNA helicase activity
C0030174biological_processregulation of DNA-templated DNA replication initiation
C0032508biological_processDNA duplex unwinding
C0042555cellular_componentMCM complex
C0071162cellular_componentCMG complex
C1902975biological_processmitotic DNA replication initiation
D0000727biological_processdouble-strand break repair via break-induced replication
D0000781cellular_componentchromosome, telomeric region
D0003677molecular_functionDNA binding
D0003688molecular_functionDNA replication origin binding
D0003697molecular_functionsingle-stranded DNA binding
D0004386molecular_functionhelicase activity
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005694cellular_componentchromosome
D0006260biological_processDNA replication
D0006268biological_processDNA unwinding involved in DNA replication
D0006270biological_processDNA replication initiation
D0016020cellular_componentmembrane
D0016787molecular_functionhydrolase activity
D0016887molecular_functionATP hydrolysis activity
D0017116molecular_functionsingle-stranded DNA helicase activity
D0030174biological_processregulation of DNA-templated DNA replication initiation
D0032508biological_processDNA duplex unwinding
D0032991cellular_componentprotein-containing complex
D0042555cellular_componentMCM complex
D0043138molecular_function3'-5' DNA helicase activity
D0043229cellular_componentintracellular organelle
D0071162cellular_componentCMG complex
E0000727biological_processdouble-strand break repair via break-induced replication
E0000781cellular_componentchromosome, telomeric region
E0003677molecular_functionDNA binding
E0003678molecular_functionDNA helicase activity
E0003697molecular_functionsingle-stranded DNA binding
E0004386molecular_functionhelicase activity
E0005515molecular_functionprotein binding
E0005524molecular_functionATP binding
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005694cellular_componentchromosome
E0006259biological_processDNA metabolic process
E0006260biological_processDNA replication
E0006268biological_processDNA unwinding involved in DNA replication
E0006270biological_processDNA replication initiation
E0016787molecular_functionhydrolase activity
E0016887molecular_functionATP hydrolysis activity
E0030174biological_processregulation of DNA-templated DNA replication initiation
E0032508biological_processDNA duplex unwinding
E0042555cellular_componentMCM complex
E0042802molecular_functionidentical protein binding
E0071162cellular_componentCMG complex
E1902969biological_processmitotic DNA replication
E1990518molecular_functionsingle-stranded 3'-5' DNA helicase activity
F0000727biological_processdouble-strand break repair via break-induced replication
F0000781cellular_componentchromosome, telomeric region
F0000785cellular_componentchromatin
F0003677molecular_functionDNA binding
F0003678molecular_functionDNA helicase activity
F0003697molecular_functionsingle-stranded DNA binding
F0004386molecular_functionhelicase activity
F0005515molecular_functionprotein binding
F0005524molecular_functionATP binding
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005694cellular_componentchromosome
F0005730cellular_componentnucleolus
F0005829cellular_componentcytosol
F0006259biological_processDNA metabolic process
F0006260biological_processDNA replication
F0006268biological_processDNA unwinding involved in DNA replication
F0006270biological_processDNA replication initiation
F0006271biological_processDNA strand elongation involved in DNA replication
F0006974biological_processDNA damage response
F0008283biological_processcell population proliferation
F0016020cellular_componentmembrane
F0016787molecular_functionhydrolase activity
F0016887molecular_functionATP hydrolysis activity
F0017116molecular_functionsingle-stranded DNA helicase activity
F0030174biological_processregulation of DNA-templated DNA replication initiation
F0032508biological_processDNA duplex unwinding
F0042325biological_processregulation of phosphorylation
F0042555cellular_componentMCM complex
F0043229cellular_componentintracellular organelle
F0071162cellular_componentCMG complex
F0071466biological_processcellular response to xenobiotic stimulus
Functional Information from PROSITE/UniProt
site_idPS00847
Number of Residues9
DetailsMCM_1 MCM family signature. GVCCIDEFD
ChainResidueDetails
7GLY440-ASP448
4GLY569-ASP577
3GLY404-ASP412
2GLY582-ASP590
5GLY440-ASP448
6GLY455-ASP463

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues16
DetailsBINDING: BINDING => ECO:0000305|PubMed:32453425, ECO:0007744|PDB:6XTX
ChainResidueDetails
7TYR345
FGLY384
FALA386
FLYS387
FSER388
FASN489
FARG514
FARG604
EARG619
EGLU622
7GLY384
7ALA386
7LYS387
7SER388
7ASN489
7ARG514
7ARG604
FTYR345

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: N-acetylalanine => ECO:0000269|Ref.7, ECO:0007744|PubMed:22223895
ChainResidueDetails
7ALA2
FALA2
ASER530
AGLN531

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
7SER121
FSER121
DSER315
DSER605

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
7SER314
7SER678
FSER314
FSER678
DLYS396
DLYS696

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231
ChainResidueDetails
7SER365
FSER365
ESER271
ESER762

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
7SER500
FSER500

site_idSWS_FT_FI7
Number of Residues6
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
7LYS15
ELYS643
7LYS28
FLYS15
FLYS28

site_idSWS_FT_FI8
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P97311
ChainResidueDetails
6SER689
ESER689

site_idSWS_FT_FI9
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:17525332
ChainResidueDetails
6THR791
ETHR791
CTHR102
CTHR110

site_idSWS_FT_FI10
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
4SER105
CSER105

site_idSWS_FT_FI11
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
4SER120
CSER120

site_idSWS_FT_FI12
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
4SER131
CSER131

site_idSWS_FT_FI13
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231
ChainResidueDetails
4SER142
4SER145
CSER142
CSER145

site_idSWS_FT_FI14
Number of Residues4
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
4LYS220
4LYS450
CLYS220
CLYS450

site_idSWS_FT_FI15
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P49717
ChainResidueDetails
4LYS858
CLYS858

site_idSWS_FT_FI16
Number of Residues6
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
4LYS439
3SER734
4LYS798
CLYS439
CLYS798

site_idSWS_FT_FI17
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:16899510, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
2SER139
ASER139

site_idSWS_FT_FI18
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
2LYS216
ALYS216

site_idSWS_FT_FI19
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692
ChainResidueDetails
2SER381
ASER381

site_idSWS_FT_FI20
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
2LYS178
ALYS178

223166

PDB entries from 2024-07-31

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