7VQ2
Structure of Apo-hsTRPM2 channel TM domain
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005262 | molecular_function | calcium channel activity |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0070588 | biological_process | calcium ion transmembrane transport |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0005262 | molecular_function | calcium channel activity |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0016020 | cellular_component | membrane |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0070588 | biological_process | calcium ion transmembrane transport |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0005262 | molecular_function | calcium channel activity |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0016020 | cellular_component | membrane |
| C | 0055085 | biological_process | transmembrane transport |
| C | 0070588 | biological_process | calcium ion transmembrane transport |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0005262 | molecular_function | calcium channel activity |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0016020 | cellular_component | membrane |
| D | 0055085 | biological_process | transmembrane transport |
| D | 0070588 | biological_process | calcium ion transmembrane transport |
Functional Information from PROSITE/UniProt
| site_id | PS01095 |
| Number of Residues | 9 |
| Details | GH18_1 Glycosyl hydrolases family 18 (GH18) active site signature. IDGVNFNpE |
| Chain | Residue | Details |
| A | ILE986-GLU994 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 136 |
| Details | Intramembrane: {"evidences":[{"source":"PubMed","id":"30467180","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 352 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 484 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"30467180","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 288 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 56 |
| Details | Intramembrane: {"description":"Pore-forming","evidences":[{"source":"PubMed","id":"30467180","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 12 |
| Details | Motif: {"description":"Selectivity filter","evidences":[{"source":"PubMed","id":"34788616","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"31513012","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30467180","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6PUS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6PUU","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"31513012","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30467180","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6PUS","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"30467180","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
