7VFI

Cryo-EM structure of the mouse TAPL (9mer-peptide bound)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005524	molecular_function	ATP binding
A	0005764	cellular_component	lysosome
A	0005765	cellular_component	lysosomal membrane
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0006518	biological_process	peptide metabolic process
A	0015031	biological_process	protein transport
A	0015421	molecular_function	ABC-type oligopeptide transporter activity
A	0015440	molecular_function	ABC-type peptide transporter activity
A	0015833	biological_process	peptide transport
A	0016020	cellular_component	membrane
A	0016887	molecular_function	ATP hydrolysis activity
A	0022857	molecular_function	transmembrane transporter activity
A	0035672	biological_process	oligopeptide transmembrane transport
A	0042626	molecular_function	ATPase-coupled transmembrane transporter activity
A	0042803	molecular_function	protein homodimerization activity
A	0043231	cellular_component	intracellular membrane-bounded organelle
A	0055085	biological_process	transmembrane transport
A	0140359	molecular_function	ABC-type transporter activity
B	0005524	molecular_function	ATP binding
B	0005764	cellular_component	lysosome
B	0005765	cellular_component	lysosomal membrane
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0006518	biological_process	peptide metabolic process
B	0015031	biological_process	protein transport
B	0015421	molecular_function	ABC-type oligopeptide transporter activity
B	0015440	molecular_function	ABC-type peptide transporter activity
B	0015833	biological_process	peptide transport
B	0016020	cellular_component	membrane
B	0016887	molecular_function	ATP hydrolysis activity
B	0022857	molecular_function	transmembrane transporter activity
B	0035672	biological_process	oligopeptide transmembrane transport
B	0042626	molecular_function	ATPase-coupled transmembrane transporter activity
B	0042803	molecular_function	protein homodimerization activity
B	0043231	cellular_component	intracellular membrane-bounded organelle
B	0055085	biological_process	transmembrane transport
B	0140359	molecular_function	ABC-type transporter activity

Functional Information from PROSITE/UniProt

site_id	PS00211
Number of Residues	15
Details	ABC_TRANSPORTER_1 ABC transporters family signature. LSGGQKQRVAMARAL

Chain	Residue	Details
A	LEU639-LEU653

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000269|PubMed:22389435

Chain	Residue	Details
C	LYS120
B	VAL47-GLY67
B	LEU84-PHE104
B	PHE116-LEU136
B	VAL181-LEU201
B	PHE221-ILE241
B	VAL315-ILE335
B	SER412-ILE432
A	VAL47-GLY67
A	LEU84-PHE104
A	PHE116-LEU136
A	VAL181-LEU201
A	PHE221-ILE241
A	VAL315-ILE335
A	SER412-ILE432
B	VAL7-PHE27

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P68431

Chain	Residue	Details
C	SER121
B	GLY535

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	SITE: Intramolecular salt bridge with Arg-57. Essential for the release from the ER => ECO:0000250|UniProtKB:Q9NP78

Chain	Residue	Details
A	ASP17
B	ASP17

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	SITE: Important for the second trafficking step from the Golgi to the endosomal and lysosomal compartments => ECO:0000250|UniProtKB:Q9NP78

Chain	Residue	Details
A	ASP45
A	ASP49
B	ASP45
B	ASP49

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	SITE: Intramolecular salt bridge with Asp-17. Essential for the release from the ER => ECO:0000250|UniProtKB:Q9NP78

Chain	Residue	Details
A	ARG57
B	ARG57

---