7V0U

Local refinement of Band 3-II cytoplasmic domains, class 1 of erythrocyte ankyrin-1 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
D	0005452	molecular_function	solute:inorganic anion antiporter activity
D	0005515	molecular_function	protein binding
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0006820	biological_process	monoatomic anion transport
D	0006821	biological_process	chloride transport
D	0006873	biological_process	intracellular monoatomic ion homeostasis
D	0007596	biological_process	blood coagulation
D	0008509	molecular_function	monoatomic anion transmembrane transporter activity
D	0009898	cellular_component	cytoplasmic side of plasma membrane
D	0015075	molecular_function	monoatomic ion transmembrane transporter activity
D	0015106	molecular_function	bicarbonate transmembrane transporter activity
D	0015108	molecular_function	chloride transmembrane transporter activity
D	0015297	molecular_function	antiporter activity
D	0015701	biological_process	bicarbonate transport
D	0016020	cellular_component	membrane
D	0016323	cellular_component	basolateral plasma membrane
D	0017121	biological_process	plasma membrane phospholipid scrambling
D	0030018	cellular_component	Z disc
D	0030492	molecular_function	hemoglobin binding
D	0030506	molecular_function	ankyrin binding
D	0030863	cellular_component	cortical cytoskeleton
D	0035811	biological_process	negative regulation of urine volume
D	0042803	molecular_function	protein homodimerization activity
D	0043495	molecular_function	protein-membrane adaptor activity
D	0045852	biological_process	pH elevation
D	0048821	biological_process	erythrocyte development
D	0051453	biological_process	regulation of intracellular pH
D	0055085	biological_process	transmembrane transport
D	0070062	cellular_component	extracellular exosome
D	0072562	cellular_component	blood microparticle
D	0072659	biological_process	protein localization to plasma membrane
D	0098660	biological_process	inorganic ion transmembrane transport
D	0140900	molecular_function	chloride:bicarbonate antiporter activity
D	0170014	cellular_component	ankyrin-1 complex
D	1902476	biological_process	chloride transmembrane transport
D	1904539	biological_process	negative regulation of glycolytic process through fructose-6-phosphate
F	0005452	molecular_function	solute:inorganic anion antiporter activity
F	0005515	molecular_function	protein binding
F	0005886	cellular_component	plasma membrane
F	0006811	biological_process	monoatomic ion transport
F	0006820	biological_process	monoatomic anion transport
F	0006821	biological_process	chloride transport
F	0006873	biological_process	intracellular monoatomic ion homeostasis
F	0007596	biological_process	blood coagulation
F	0008509	molecular_function	monoatomic anion transmembrane transporter activity
F	0009898	cellular_component	cytoplasmic side of plasma membrane
F	0015075	molecular_function	monoatomic ion transmembrane transporter activity
F	0015106	molecular_function	bicarbonate transmembrane transporter activity
F	0015108	molecular_function	chloride transmembrane transporter activity
F	0015297	molecular_function	antiporter activity
F	0015701	biological_process	bicarbonate transport
F	0016020	cellular_component	membrane
F	0016323	cellular_component	basolateral plasma membrane
F	0017121	biological_process	plasma membrane phospholipid scrambling
F	0030018	cellular_component	Z disc
F	0030492	molecular_function	hemoglobin binding
F	0030506	molecular_function	ankyrin binding
F	0030863	cellular_component	cortical cytoskeleton
F	0035811	biological_process	negative regulation of urine volume
F	0042803	molecular_function	protein homodimerization activity
F	0043495	molecular_function	protein-membrane adaptor activity
F	0045852	biological_process	pH elevation
F	0048821	biological_process	erythrocyte development
F	0051453	biological_process	regulation of intracellular pH
F	0055085	biological_process	transmembrane transport
F	0070062	cellular_component	extracellular exosome
F	0072562	cellular_component	blood microparticle
F	0072659	biological_process	protein localization to plasma membrane
F	0098660	biological_process	inorganic ion transmembrane transport
F	0140900	molecular_function	chloride:bicarbonate antiporter activity
F	0170014	cellular_component	ankyrin-1 complex
F	1902476	biological_process	chloride transmembrane transport
F	1904539	biological_process	negative regulation of glycolytic process through fructose-6-phosphate

Functional Information from PROSITE/UniProt

site_id	PS00219
Number of Residues	12
Details	ANION_EXCHANGER_1 Anion exchangers family signature 1. FGGLVRDIRRRY

Chain	Residue	Details
F	PHE379-TYR390

---

site_id	PS00220
Number of Residues	15
Details	ANION_EXCHANGER_2 Anion exchangers family signature 2. FLISLIFIYETFsKL

Chain	Residue	Details
F	PHE526-LEU540

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1080
Details	TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:26542571

Chain	Residue	Details
F	MET1-PRO403
D	GLN457-LEU459
D	PHE507-ARG518
D	LYS592-ARG602
D	THR685-SER700
D	LEU738-ARG760
D	SER801-GLY838
D	ARG870-VAL911
F	GLN457-LEU459
F	PHE507-ARG518
F	LYS592-ARG602
F	THR685-SER700
F	LEU738-ARG760
F	SER801-GLY838
F	ARG870-VAL911
D	MET1-PRO403

---

site_id	SWS_FT_FI2
Number of Residues	46
Details	TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:26542571

Chain	Residue	Details
F	GLN404-LEU427
D	GLN404-LEU427

---

site_id	SWS_FT_FI3
Number of Residues	164
Details	TOPO_DOM: Extracellular => ECO:0000269|PubMed:26542571

Chain	Residue	Details
F	GLY428-MET435
F	SER477-GLU485
F	LYS542-THR570
F	ILE624-MET663
D	GLY428-MET435
D	SER477-GLU485
D	LYS542-THR570
D	ILE624-MET663

---

site_id	SWS_FT_FI4
Number of Residues	40
Details	TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:26542571

Chain	Residue	Details
F	GLY436-ALA456
D	GLY436-ALA456

---

site_id	SWS_FT_FI5
Number of Residues	32
Details	TRANSMEM: Discontinuously helical; Name=3 => ECO:0000269|PubMed:26542571

Chain	Residue	Details
F	LEU460-PHE476
D	LEU460-PHE476

---

site_id	SWS_FT_FI6
Number of Residues	40
Details	TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:26542571

Chain	Residue	Details
F	TYR486-ALA506
D	TYR486-ALA506

---

site_id	SWS_FT_FI7
Number of Residues	44
Details	TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:26542571

Chain	Residue	Details
F	TYR519-ILE541
D	TYR519-ILE541

---

site_id	SWS_FT_FI8
Number of Residues	40
Details	TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:26542571

Chain	Residue	Details
F	ALA571-PHE591
D	ALA571-PHE591

---

site_id	SWS_FT_FI9
Number of Residues	40
Details	TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:26542571

Chain	Residue	Details
F	ARG603-PHE623
D	ARG603-PHE623

---

site_id	SWS_FT_FI10
Number of Residues	40
Details	TRANSMEM: Helical; Name=8 => ECO:0000269|PubMed:26542571

Chain	Residue	Details
F	MET664-ILE684
D	MET664-ILE684

---

site_id	SWS_FT_FI11
Number of Residues	36
Details	TRANSMEM: Helical; Name=9 => ECO:0000269|PubMed:26542571

Chain	Residue	Details
F	GLY701-PHE719
D	GLY701-PHE719

---

site_id	SWS_FT_FI12
Number of Residues	34
Details	TRANSMEM: Discontinuously helical; Name=10 => ECO:0000269|PubMed:26542571

Chain	Residue	Details
F	GLY720-ALA737
D	GLY720-ALA737

---

site_id	SWS_FT_FI13
Number of Residues	40
Details	TRANSMEM: Helical; Name=11 => ECO:0000269|PubMed:26542571

Chain	Residue	Details
F	ILE761-SER781
D	ILE761-SER781

---

site_id	SWS_FT_FI14
Number of Residues	36
Details	TRANSMEM: Helical; Name=12 => ECO:0000269|PubMed:26542571

Chain	Residue	Details
F	ARG782-LEU800
D	ARG782-LEU800

---

site_id	SWS_FT_FI15
Number of Residues	60
Details	INTRAMEM: Discontinuously helical => ECO:0000269|PubMed:26542571

Chain	Residue	Details
F	ILE839-LEU869
D	ILE839-LEU869

---

site_id	SWS_FT_FI16
Number of Residues	2
Details	SITE: Important for anion transport

Chain	Residue	Details
F	LYS590
D	LYS590

---

site_id	SWS_FT_FI17
Number of Residues	2
Details	SITE: Important for anion-proton cotransport

Chain	Residue	Details
F	GLU681
D	GLU681

---

site_id	SWS_FT_FI18
Number of Residues	2
Details	MOD_RES: N-acetylmethionine => ECO:0000269|PubMed:2790053, ECO:0000269|PubMed:701248

Chain	Residue	Details
F	MET1
D	MET1

---

site_id	SWS_FT_FI19
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:10942405, ECO:0000269|PubMed:1998697

Chain	Residue	Details
F	TYR8
F	TYR21
D	TYR8
D	TYR21

---

site_id	SWS_FT_FI20
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:1998697

Chain	Residue	Details
F	TYR46
D	TYR46

---

site_id	SWS_FT_FI21
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P23562

Chain	Residue	Details
F	SER185
D	SER185

---

site_id	SWS_FT_FI22
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P04919

Chain	Residue	Details
F	SER350
D	SER350

---

site_id	SWS_FT_FI23
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:10942405

Chain	Residue	Details
F	TYR359
F	TYR904
D	TYR359
D	TYR904

---

site_id	SWS_FT_FI24
Number of Residues	2
Details	LIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:1885574

Chain	Residue	Details
F	CYS843
D	CYS843

---

site_id	SWS_FT_FI25
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:10861210, ECO:0000269|PubMed:24121512, ECO:0000269|PubMed:35835865

Chain	Residue	Details
F	ASN642
D	ASN642

---