7V0K

Consensus refinement of human erythrocyte ankyrin-1 complex (Composite map)

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
D	0016020	cellular_component	membrane
H	0005198	molecular_function	structural molecule activity
H	0005200	molecular_function	structural constituent of cytoskeleton
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005856	cellular_component	cytoskeleton
H	0005886	cellular_component	plasma membrane
H	0006887	biological_process	exocytosis
H	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
H	0007010	biological_process	cytoskeleton organization
H	0007165	biological_process	signal transduction
H	0008093	molecular_function	cytoskeletal anchor activity
H	0009898	cellular_component	cytoplasmic side of plasma membrane
H	0010638	biological_process	positive regulation of organelle organization
H	0014731	cellular_component	spectrin-associated cytoskeleton
H	0016020	cellular_component	membrane
H	0016323	cellular_component	basolateral plasma membrane
H	0016529	cellular_component	sarcoplasmic reticulum
H	0019899	molecular_function	enzyme binding
H	0019903	molecular_function	protein phosphatase binding
H	0030018	cellular_component	Z disc
H	0030507	molecular_function	spectrin binding
H	0030673	cellular_component	axolemma
H	0031430	cellular_component	M band
H	0031672	cellular_component	A band
H	0042383	cellular_component	sarcolemma
H	0043005	cellular_component	neuron projection
H	0044325	molecular_function	transmembrane transporter binding
H	0045199	biological_process	maintenance of epithelial cell apical/basal polarity
H	0045211	cellular_component	postsynaptic membrane
H	0051117	molecular_function	ATPase binding
H	0072659	biological_process	protein localization to plasma membrane
H	0170014	cellular_component	ankyrin-1 complex
K	0005886	cellular_component	plasma membrane
K	0008519	molecular_function	ammonium channel activity
K	0016020	cellular_component	membrane
K	0072488	biological_process	ammonium transmembrane transport
K	0097272	biological_process	ammonium homeostasis
K	0170014	cellular_component	ankyrin-1 complex
L	0005515	molecular_function	protein binding
L	0005886	cellular_component	plasma membrane
L	0006873	biological_process	intracellular monoatomic ion homeostasis
L	0008519	molecular_function	ammonium channel activity
L	0015200	molecular_function	methylammonium transmembrane transporter activity
L	0015670	biological_process	carbon dioxide transport
L	0015701	biological_process	bicarbonate transport
L	0016020	cellular_component	membrane
L	0022840	molecular_function	leak channel activity
L	0030506	molecular_function	ankyrin binding
L	0035378	biological_process	carbon dioxide transmembrane transport
L	0035379	molecular_function	carbon dioxide transmembrane transporter activity
L	0048821	biological_process	erythrocyte development
L	0060586	biological_process	multicellular organismal-level iron ion homeostasis
L	0072488	biological_process	ammonium transmembrane transport
L	0072489	biological_process	methylammonium transmembrane transport
L	0097272	biological_process	ammonium homeostasis
L	0098662	biological_process	inorganic cation transmembrane transport
L	0170014	cellular_component	ankyrin-1 complex
N	0016020	cellular_component	membrane
O	0005452	molecular_function	solute:inorganic anion antiporter activity
O	0005515	molecular_function	protein binding
O	0005886	cellular_component	plasma membrane
O	0006811	biological_process	monoatomic ion transport
O	0006820	biological_process	monoatomic anion transport
O	0006821	biological_process	chloride transport
O	0006873	biological_process	intracellular monoatomic ion homeostasis
O	0007596	biological_process	blood coagulation
O	0008509	molecular_function	monoatomic anion transmembrane transporter activity
O	0009898	cellular_component	cytoplasmic side of plasma membrane
O	0015075	molecular_function	monoatomic ion transmembrane transporter activity
O	0015106	molecular_function	bicarbonate transmembrane transporter activity
O	0015108	molecular_function	chloride transmembrane transporter activity
O	0015297	molecular_function	antiporter activity
O	0015701	biological_process	bicarbonate transport
O	0016020	cellular_component	membrane
O	0016323	cellular_component	basolateral plasma membrane
O	0017121	biological_process	plasma membrane phospholipid scrambling
O	0030018	cellular_component	Z disc
O	0030492	molecular_function	hemoglobin binding
O	0030506	molecular_function	ankyrin binding
O	0030863	cellular_component	cortical cytoskeleton
O	0035811	biological_process	negative regulation of urine volume
O	0042803	molecular_function	protein homodimerization activity
O	0043495	molecular_function	protein-membrane adaptor activity
O	0045852	biological_process	pH elevation
O	0048821	biological_process	erythrocyte development
O	0051453	biological_process	regulation of intracellular pH
O	0055085	biological_process	transmembrane transport
O	0070062	cellular_component	extracellular exosome
O	0072562	cellular_component	blood microparticle
O	0072659	biological_process	protein localization to plasma membrane
O	0140900	molecular_function	chloride:bicarbonate antiporter activity
O	0170014	cellular_component	ankyrin-1 complex
O	1902476	biological_process	chloride transmembrane transport
O	1904539	biological_process	negative regulation of glycolytic process through fructose-6-phosphate
P	0005452	molecular_function	solute:inorganic anion antiporter activity
P	0005515	molecular_function	protein binding
P	0005886	cellular_component	plasma membrane
P	0006811	biological_process	monoatomic ion transport
P	0006820	biological_process	monoatomic anion transport
P	0006821	biological_process	chloride transport
P	0006873	biological_process	intracellular monoatomic ion homeostasis
P	0007596	biological_process	blood coagulation
P	0008509	molecular_function	monoatomic anion transmembrane transporter activity
P	0009898	cellular_component	cytoplasmic side of plasma membrane
P	0015075	molecular_function	monoatomic ion transmembrane transporter activity
P	0015106	molecular_function	bicarbonate transmembrane transporter activity
P	0015108	molecular_function	chloride transmembrane transporter activity
P	0015297	molecular_function	antiporter activity
P	0015701	biological_process	bicarbonate transport
P	0016020	cellular_component	membrane
P	0016323	cellular_component	basolateral plasma membrane
P	0017121	biological_process	plasma membrane phospholipid scrambling
P	0030018	cellular_component	Z disc
P	0030492	molecular_function	hemoglobin binding
P	0030506	molecular_function	ankyrin binding
P	0030863	cellular_component	cortical cytoskeleton
P	0035811	biological_process	negative regulation of urine volume
P	0042803	molecular_function	protein homodimerization activity
P	0043495	molecular_function	protein-membrane adaptor activity
P	0045852	biological_process	pH elevation
P	0048821	biological_process	erythrocyte development
P	0051453	biological_process	regulation of intracellular pH
P	0055085	biological_process	transmembrane transport
P	0070062	cellular_component	extracellular exosome
P	0072562	cellular_component	blood microparticle
P	0072659	biological_process	protein localization to plasma membrane
P	0140900	molecular_function	chloride:bicarbonate antiporter activity
P	0170014	cellular_component	ankyrin-1 complex
P	1902476	biological_process	chloride transmembrane transport
P	1904539	biological_process	negative regulation of glycolytic process through fructose-6-phosphate
Q	0005515	molecular_function	protein binding
Q	0005886	cellular_component	plasma membrane
Q	0006873	biological_process	intracellular monoatomic ion homeostasis
Q	0008519	molecular_function	ammonium channel activity
Q	0015200	molecular_function	methylammonium transmembrane transporter activity
Q	0015670	biological_process	carbon dioxide transport
Q	0015701	biological_process	bicarbonate transport
Q	0016020	cellular_component	membrane
Q	0022840	molecular_function	leak channel activity
Q	0030506	molecular_function	ankyrin binding
Q	0035378	biological_process	carbon dioxide transmembrane transport
Q	0035379	molecular_function	carbon dioxide transmembrane transporter activity
Q	0048821	biological_process	erythrocyte development
Q	0060586	biological_process	multicellular organismal-level iron ion homeostasis
Q	0072488	biological_process	ammonium transmembrane transport
Q	0072489	biological_process	methylammonium transmembrane transport
Q	0097272	biological_process	ammonium homeostasis
Q	0098662	biological_process	inorganic cation transmembrane transport
Q	0170014	cellular_component	ankyrin-1 complex
W	0005452	molecular_function	solute:inorganic anion antiporter activity
W	0005515	molecular_function	protein binding
W	0005886	cellular_component	plasma membrane
W	0006811	biological_process	monoatomic ion transport
W	0006820	biological_process	monoatomic anion transport
W	0006821	biological_process	chloride transport
W	0006873	biological_process	intracellular monoatomic ion homeostasis
W	0007596	biological_process	blood coagulation
W	0008509	molecular_function	monoatomic anion transmembrane transporter activity
W	0009898	cellular_component	cytoplasmic side of plasma membrane
W	0015075	molecular_function	monoatomic ion transmembrane transporter activity
W	0015106	molecular_function	bicarbonate transmembrane transporter activity
W	0015108	molecular_function	chloride transmembrane transporter activity
W	0015297	molecular_function	antiporter activity
W	0015701	biological_process	bicarbonate transport
W	0016020	cellular_component	membrane
W	0016323	cellular_component	basolateral plasma membrane
W	0017121	biological_process	plasma membrane phospholipid scrambling
W	0030018	cellular_component	Z disc
W	0030492	molecular_function	hemoglobin binding
W	0030506	molecular_function	ankyrin binding
W	0030863	cellular_component	cortical cytoskeleton
W	0035811	biological_process	negative regulation of urine volume
W	0042803	molecular_function	protein homodimerization activity
W	0043495	molecular_function	protein-membrane adaptor activity
W	0045852	biological_process	pH elevation
W	0048821	biological_process	erythrocyte development
W	0051453	biological_process	regulation of intracellular pH
W	0055085	biological_process	transmembrane transport
W	0070062	cellular_component	extracellular exosome
W	0072562	cellular_component	blood microparticle
W	0072659	biological_process	protein localization to plasma membrane
W	0140900	molecular_function	chloride:bicarbonate antiporter activity
W	0170014	cellular_component	ankyrin-1 complex
W	1902476	biological_process	chloride transmembrane transport
W	1904539	biological_process	negative regulation of glycolytic process through fructose-6-phosphate
X	0000902	biological_process	cell morphogenesis
X	0003810	molecular_function	protein-glutamine gamma-glutamyltransferase activity
X	0005200	molecular_function	structural constituent of cytoskeleton
X	0005515	molecular_function	protein binding
X	0005524	molecular_function	ATP binding
X	0005737	cellular_component	cytoplasm
X	0005856	cellular_component	cytoskeleton
X	0005886	cellular_component	plasma membrane
X	0007010	biological_process	cytoskeleton organization
X	0008360	biological_process	regulation of cell shape
X	0016020	cellular_component	membrane
X	0018149	biological_process	peptide cross-linking
X	0020027	biological_process	hemoglobin metabolic process
X	0030863	cellular_component	cortical cytoskeleton
X	0043249	biological_process	erythrocyte maturation
X	0048536	biological_process	spleen development
X	0050801	biological_process	monoatomic ion homeostasis
X	0060586	biological_process	multicellular organismal-level iron ion homeostasis
X	0170014	cellular_component	ankyrin-1 complex

Functional Information from PROSITE/UniProt

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. KYGFSSVGINLLVAAL

Chain	Residue	Details
L	LYS74-LEU89

---

site_id	PS00219
Number of Residues	12
Details	ANION_EXCHANGER_1 Anion exchangers family signature 1. FGGLVRDIRRRY

Chain	Residue	Details
W	PHE379-TYR390

---

site_id	PS00220
Number of Residues	15
Details	ANION_EXCHANGER_2 Anion exchangers family signature 2. FLISLIFIYETFsKL

Chain	Residue	Details
W	PHE526-LEU540

---

site_id	PS00312
Number of Residues	10
Details	GLYCOPHORIN_A Glycophorin A signature. IIfGVMAGVI

Chain	Residue	Details
N	ILE95-ILE104

---

site_id	PS00547
Number of Residues	18
Details	TRANSGLUTAMINASES Transglutaminases active site. GQAWVlAAVacTvLRCLG

Chain	Residue	Details
X	GLY266-GLY283

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	142
Details	TOPO_DOM: Extracellular

Chain	Residue	Details
N	SER20-GLU91
O	GLN457-LEU459
O	PHE507-ARG518
O	LYS592-ARG602
O	THR685-SER700
O	LEU738-ARG760
O	SER801-GLY838
O	ARG870-VAL911
P	MET1-PRO403
P	GLN457-LEU459
P	PHE507-ARG518
D	SER20-GLU91
P	LYS592-ARG602
P	THR685-SER700
P	LEU738-ARG760
P	SER801-GLY838
P	ARG870-VAL911
W	PHE507-ARG518
W	LYS592-ARG602
W	THR685-SER700
W	LEU738-ARG760
W	SER801-GLY838
W	ARG870-VAL911
O	MET1-PRO403

---

site_id	SWS_FT_FI2
Number of Residues	44
Details	TRANSMEM: Helical

Chain	Residue	Details
N	ILE92-ILE114
L	SER296-PHE318
L	LEU333-ALA353
L	ALA363-LEU383
Q	PHE3-PHE23
Q	PRO52-LEU72
Q	VAL80-ILE100
Q	ASN114-GLY134
Q	ILE143-PHE163
Q	ILE168-ILE188
Q	LEU209-ILE229
D	ILE92-ILE114
Q	ILE240-LEU260
Q	MET269-ILE291
Q	SER296-PHE318
Q	LEU333-ALA353
Q	ALA363-LEU383
P	GLN404-LEU427
H	SER1486
H	SER1666
H	SER1671
H	SER1686
H	SER1690
H	SER1696

---

site_id	SWS_FT_FI3
Number of Residues	70
Details	TOPO_DOM: Cytoplasmic

Chain	Residue	Details
N	ARG115-GLN150
P	SER477-GLU485
P	LYS542-THR570
P	ILE624-MET663
D	ARG115-GLN150
W	LYS542-THR570
W	ILE624-MET663
O	GLY428-MET435
O	SER477-GLU485
O	LYS542-THR570
O	ILE624-MET663
P	GLY428-MET435

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
N	THR133
D	THR133
P	GLY436-ALA456
Q	ASN355

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
N	SER138
N	SER148
D	SER138
D	SER148
H	SER1533

---

site_id	SWS_FT_FI6
Number of Residues	12
Details	CARBOHYD: O-linked (GalNAc...) serine => ECO:0000269|PubMed:1059087, ECO:0000269|PubMed:8286855

Chain	Residue	Details
N	SER21
D	SER41
D	SER63
D	SER66
N	SER30
N	SER32
N	SER41
N	SER63
N	SER66
D	SER21
D	SER30
D	SER32

---

site_id	SWS_FT_FI7
Number of Residues	14
Details	CARBOHYD: O-linked (GalNAc...) threonine => ECO:0000269|PubMed:1059087, ECO:0000269|PubMed:8286855

Chain	Residue	Details
N	THR22
D	THR29
D	THR31
D	THR44
D	THR56
D	THR69
N	THR23
N	THR29
N	THR31
N	THR44
N	THR56
N	THR69
D	THR22
D	THR23

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	CARBOHYD: O-linked (GalNAc...) threonine => ECO:0000269|PubMed:8286855

Chain	Residue	Details
N	THR36
N	THR52
D	THR36
D	THR52

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	CARBOHYD: O-linked (GalNAc...) serine => ECO:0000269|PubMed:8286855

Chain	Residue	Details
N	SER38
D	SER38
P	ARG603-PHE623

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:1059087, ECO:0000269|PubMed:8286855

Chain	Residue	Details
N	ASN45
D	ASN45
P	MET664-ILE684

---

site_id	SWS_FT_FI11
Number of Residues	54
Details	TRANSMEM: Helical; Name=9 => ECO:0000269|PubMed:26542571

Chain	Residue	Details
W	GLY701-PHE719
O	GLY701-PHE719
P	GLY701-PHE719

---

site_id	SWS_FT_FI12
Number of Residues	51
Details	TRANSMEM: Discontinuously helical; Name=10 => ECO:0000269|PubMed:26542571

Chain	Residue	Details
W	GLY720-ALA737
O	GLY720-ALA737
P	GLY720-ALA737

---

site_id	SWS_FT_FI13
Number of Residues	60
Details	TRANSMEM: Helical; Name=11 => ECO:0000269|PubMed:26542571

Chain	Residue	Details
W	ILE761-SER781
O	ILE761-SER781
P	ILE761-SER781

---

site_id	SWS_FT_FI14
Number of Residues	54
Details	TRANSMEM: Helical; Name=12 => ECO:0000269|PubMed:26542571

Chain	Residue	Details
W	ARG782-LEU800
O	ARG782-LEU800
P	ARG782-LEU800

---

site_id	SWS_FT_FI15
Number of Residues	90
Details	INTRAMEM: Discontinuously helical => ECO:0000269|PubMed:26542571

Chain	Residue	Details
W	ILE839-LEU869
O	ILE839-LEU869
P	ILE839-LEU869

---

site_id	SWS_FT_FI16
Number of Residues	3
Details	SITE: Important for anion transport

Chain	Residue	Details
W	LYS590
O	LYS590
P	LYS590

---

site_id	SWS_FT_FI17
Number of Residues	3
Details	SITE: Important for anion-proton cotransport

Chain	Residue	Details
W	GLU681
O	GLU681
P	GLU681

---

site_id	SWS_FT_FI18
Number of Residues	3
Details	MOD_RES: N-acetylmethionine => ECO:0000269|PubMed:2790053, ECO:0000269|PubMed:701248

Chain	Residue	Details
W	MET1
O	MET1
P	MET1

---

site_id	SWS_FT_FI19
Number of Residues	6
Details	MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:10942405, ECO:0000269|PubMed:1998697

Chain	Residue	Details
W	TYR8
W	TYR21
O	TYR8
O	TYR21
P	TYR8
P	TYR21

---

site_id	SWS_FT_FI20
Number of Residues	3
Details	MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:1998697

Chain	Residue	Details
W	TYR46
O	TYR46
P	TYR46

---

site_id	SWS_FT_FI21
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P23562

Chain	Residue	Details
W	SER185
O	SER185
P	SER185

---

site_id	SWS_FT_FI22
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P04919

Chain	Residue	Details
W	SER350
O	SER350
P	SER350

---

site_id	SWS_FT_FI23
Number of Residues	6
Details	MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:10942405

Chain	Residue	Details
W	TYR359
W	TYR904
O	TYR359
O	TYR904
P	TYR359
P	TYR904

---

site_id	SWS_FT_FI24
Number of Residues	3
Details	LIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:1885574

Chain	Residue	Details
W	CYS843
O	CYS843
P	CYS843

---

site_id	SWS_FT_FI25
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:10861210, ECO:0000269|PubMed:24121512, ECO:0000269|PubMed:35835865

Chain	Residue	Details
W	ASN642
O	ASN642
P	ASN642

---