7V0E

Crystal structure of the macro-oligomeric form of DNMT3B methyltransferase domain.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008168	molecular_function	methyltransferase activity
B	0008168	molecular_function	methyltransferase activity
C	0008168	molecular_function	methyltransferase activity
D	0008168	molecular_function	methyltransferase activity
E	0008168	molecular_function	methyltransferase activity
F	0008168	molecular_function	methyltransferase activity
G	0008168	molecular_function	methyltransferase activity
H	0008168	molecular_function	methyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue SAH A 901

Chain	Residue
A	PHE581
A	VAL628
A	ARG832
A	SER833
A	TRP834
A	ASP582
A	GLY583
A	ILE584
A	THR586
A	SER604
A	GLU605
A	VAL606
A	ASP627

---

site_id	AC2
Number of Residues	13
Details	binding site for residue SAH B 901

Chain	Residue
B	PHE581
B	ASP582
B	GLY583
B	ILE584
B	THR586
B	SER604
B	GLU605
B	VAL606
B	ASP627
B	VAL628
B	ARG832
B	SER833
B	TRP834

---

site_id	AC3
Number of Residues	13
Details	binding site for residue SAH C 901

Chain	Residue
C	PHE581
C	GLY583
C	ILE584
C	THR586
C	SER604
C	GLU605
C	VAL606
C	ASP627
C	VAL628
C	LEU671
C	ARG832
C	SER833
C	TRP834

---

site_id	AC4
Number of Residues	14
Details	binding site for residue SAH D 901

Chain	Residue
D	PHE581
D	ASP582
D	GLY583
D	ILE584
D	THR586
D	SER604
D	GLU605
D	VAL606
D	ASP627
D	VAL628
D	GLY648
D	ARG832
D	SER833
D	TRP834

---

site_id	AC5
Number of Residues	15
Details	binding site for residue SAH E 901

Chain	Residue
E	PHE581
E	ASP582
E	GLY583
E	ILE584
E	THR586
E	SER604
E	GLU605
E	VAL606
E	CYS607
E	ASP627
E	VAL628
E	LEU671
E	ARG832
E	SER833
E	TRP834

---

site_id	AC6
Number of Residues	15
Details	binding site for residue SAH F 901

Chain	Residue
F	PHE581
F	ASP582
F	GLY583
F	ILE584
F	THR586
F	SER604
F	GLU605
F	VAL606
F	ASP627
F	VAL628
F	LEU671
F	ARG832
F	SER833
F	TRP834
F	HOH1003

---

site_id	AC7
Number of Residues	13
Details	binding site for residue SAH G 901

Chain	Residue
G	PHE581
G	ASP582
G	GLY583
G	ILE584
G	THR586
G	SER604
G	GLU605
G	VAL606
G	ASP627
G	VAL628
G	ARG832
G	SER833
G	TRP834

---

site_id	AC8
Number of Residues	12
Details	binding site for residue SAH H 901

Chain	Residue
H	THR586
H	GLU605
H	VAL606
H	ASP627
H	VAL628
H	LEU671
H	ARG832
H	SER833
H	TRP834
H	PHE581
H	GLY583
H	ILE584

---

Functional Information from PROSITE/UniProt

site_id	PS00094
Number of Residues	13
Details	C5_MTASE_1 C-5 cytosine-specific DNA methylases active site. DlVigGsPCnDLS

Chain	Residue	Details
A	ASP643-SER655

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU01016, ECO:0000255|PROSITE-ProRule:PRU10018

Chain	Residue	Details
A	CYS651
B	CYS651
C	CYS651
D	CYS651
E	CYS651
F	CYS651
G	CYS651
H	CYS651

---

site_id	SWS_FT_FI2
Number of Residues	32
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q9Y6K1

Chain	Residue	Details
A	ASP582
C	GLU605
C	ASP627
C	ARG832
D	ASP582
D	GLU605
D	ASP627
D	ARG832
E	ASP582
E	GLU605
E	ASP627
A	GLU605
E	ARG832
F	ASP582
F	GLU605
F	ASP627
F	ARG832
G	ASP582
G	GLU605
G	ASP627
G	ARG832
H	ASP582
A	ASP627
H	GLU605
H	ASP627
H	ARG832
A	ARG832
B	ASP582
B	GLU605
B	ASP627
B	ARG832
C	ASP582

---

site_id	SWS_FT_FI3
Number of Residues	16
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LYS617
F	LYS617
G	LYS617
H	LYS617
B	LYS617
C	LYS617
D	LYS617
E	LYS617

---