7UZ3
Band 3-Glycophorin A complex, outward facing
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0016020 | cellular_component | membrane |
| C | 0005452 | molecular_function | solute:inorganic anion antiporter activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0006820 | biological_process | monoatomic anion transport |
| C | 0006821 | biological_process | chloride transport |
| C | 0006873 | biological_process | intracellular monoatomic ion homeostasis |
| C | 0008092 | molecular_function | cytoskeletal protein binding |
| C | 0008509 | molecular_function | monoatomic anion transmembrane transporter activity |
| C | 0009898 | cellular_component | cytoplasmic side of plasma membrane |
| C | 0015106 | molecular_function | bicarbonate transmembrane transporter activity |
| C | 0015108 | molecular_function | chloride transmembrane transporter activity |
| C | 0015297 | molecular_function | antiporter activity |
| C | 0015701 | biological_process | bicarbonate transport |
| C | 0016020 | cellular_component | membrane |
| C | 0016323 | cellular_component | basolateral plasma membrane |
| C | 0030018 | cellular_component | Z disc |
| C | 0030492 | molecular_function | hemoglobin binding |
| C | 0030506 | molecular_function | ankyrin binding |
| C | 0030863 | cellular_component | cortical cytoskeleton |
| C | 0042803 | molecular_function | protein homodimerization activity |
| C | 0043495 | molecular_function | protein-membrane adaptor activity |
| C | 0051453 | biological_process | regulation of intracellular pH |
| C | 0055085 | biological_process | transmembrane transport |
| C | 0070062 | cellular_component | extracellular exosome |
| C | 0072562 | cellular_component | blood microparticle |
| C | 0140900 | molecular_function | chloride:bicarbonate antiporter activity |
| C | 0170014 | cellular_component | ankyrin-1 complex |
| C | 1902476 | biological_process | chloride transmembrane transport |
| D | 0016020 | cellular_component | membrane |
| E | 0005452 | molecular_function | solute:inorganic anion antiporter activity |
| E | 0005515 | molecular_function | protein binding |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005886 | cellular_component | plasma membrane |
| E | 0006811 | biological_process | monoatomic ion transport |
| E | 0006820 | biological_process | monoatomic anion transport |
| E | 0006821 | biological_process | chloride transport |
| E | 0006873 | biological_process | intracellular monoatomic ion homeostasis |
| E | 0008092 | molecular_function | cytoskeletal protein binding |
| E | 0008509 | molecular_function | monoatomic anion transmembrane transporter activity |
| E | 0009898 | cellular_component | cytoplasmic side of plasma membrane |
| E | 0015106 | molecular_function | bicarbonate transmembrane transporter activity |
| E | 0015108 | molecular_function | chloride transmembrane transporter activity |
| E | 0015297 | molecular_function | antiporter activity |
| E | 0015701 | biological_process | bicarbonate transport |
| E | 0016020 | cellular_component | membrane |
| E | 0016323 | cellular_component | basolateral plasma membrane |
| E | 0030018 | cellular_component | Z disc |
| E | 0030492 | molecular_function | hemoglobin binding |
| E | 0030506 | molecular_function | ankyrin binding |
| E | 0030863 | cellular_component | cortical cytoskeleton |
| E | 0042803 | molecular_function | protein homodimerization activity |
| E | 0043495 | molecular_function | protein-membrane adaptor activity |
| E | 0051453 | biological_process | regulation of intracellular pH |
| E | 0055085 | biological_process | transmembrane transport |
| E | 0070062 | cellular_component | extracellular exosome |
| E | 0072562 | cellular_component | blood microparticle |
| E | 0140900 | molecular_function | chloride:bicarbonate antiporter activity |
| E | 0170014 | cellular_component | ankyrin-1 complex |
| E | 1902476 | biological_process | chloride transmembrane transport |
Functional Information from PROSITE/UniProt
| site_id | PS00219 |
| Number of Residues | 12 |
| Details | ANION_EXCHANGER_1 Anion exchangers family signature 1. FGGLVRDIRRRY |
| Chain | Residue | Details |
| C | PHE379-TYR390 |
| site_id | PS00220 |
| Number of Residues | 15 |
| Details | ANION_EXCHANGER_2 Anion exchangers family signature 2. FLISLIFIYETFsKL |
| Chain | Residue | Details |
| C | PHE526-LEU540 |
| site_id | PS00312 |
| Number of Residues | 10 |
| Details | GLYCOPHORIN_A Glycophorin A signature. IIfGVMAGVI |
| Chain | Residue | Details |
| B | ILE95-ILE104 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 44 |
| Details | Transmembrane: {"description":"Helical"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 46 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"26542571","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 164 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"26542571","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"26542571","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 150 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"26542571","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 32 |
| Details | Transmembrane: {"description":"Discontinuously helical; Name=3","evidences":[{"source":"PubMed","id":"26542571","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"26542571","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 44 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"26542571","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"26542571","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"26542571","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=8","evidences":[{"source":"PubMed","id":"26542571","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 36 |
| Details | Transmembrane: {"description":"Helical; Name=9","evidences":[{"source":"PubMed","id":"26542571","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 34 |
| Details | Transmembrane: {"description":"Discontinuously helical; Name=10","evidences":[{"source":"PubMed","id":"26542571","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=11","evidences":[{"source":"PubMed","id":"26542571","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 36 |
| Details | Transmembrane: {"description":"Helical; Name=12","evidences":[{"source":"PubMed","id":"26542571","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 60 |
| Details | Intramembrane: {"description":"Discontinuously helical","evidences":[{"source":"PubMed","id":"26542571","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 142 |
| Details | Region: {"description":"Involved in anion transport"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 2 |
| Details | Site: {"description":"Important for anion transport"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI19 |
| Number of Residues | 2 |
| Details | Site: {"description":"Important for anion-proton cotransport"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI20 |
| Number of Residues | 2 |
| Details | Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"1885574","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI21 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"10861210","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24121512","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35835865","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
