7USC

Cryo-EM structure of WAVE Regulatory Complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000340	molecular_function	RNA 7-methylguanosine cap binding
A	0000902	biological_process	cell morphogenesis
A	0001726	cellular_component	ruffle
A	0003779	molecular_function	actin binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005925	cellular_component	focal adhesion
A	0006417	biological_process	regulation of translation
A	0007399	biological_process	nervous system development
A	0007411	biological_process	axon guidance
A	0008360	biological_process	regulation of cell shape
A	0010592	biological_process	positive regulation of lamellipodium assembly
A	0016601	biological_process	Rac protein signal transduction
A	0017148	biological_process	negative regulation of translation
A	0030027	cellular_component	lamellipodium
A	0030032	biological_process	lamellipodium assembly
A	0030154	biological_process	cell differentiation
A	0030371	molecular_function	translation repressor activity
A	0030833	biological_process	regulation of actin filament polymerization
A	0031175	biological_process	neuron projection development
A	0031209	cellular_component	SCAR complex
A	0031252	cellular_component	cell leading edge
A	0031267	molecular_function	small GTPase binding
A	0031529	biological_process	ruffle organization
A	0034774	cellular_component	secretory granule lumen
A	0035580	cellular_component	specific granule lumen
A	0042995	cellular_component	cell projection
A	0043005	cellular_component	neuron projection
A	0045202	cellular_component	synapse
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0048675	biological_process	axon extension
A	0050890	biological_process	cognition
A	0051015	molecular_function	actin filament binding
A	0051388	biological_process	positive regulation of neurotrophin TRK receptor signaling pathway
A	0070062	cellular_component	extracellular exosome
A	0097484	biological_process	dendrite extension
A	0098794	cellular_component	postsynapse
A	0099578	biological_process	regulation of translation at postsynapse, modulating synaptic transmission
A	1904724	cellular_component	tertiary granule lumen
A	1905274	biological_process	regulation of modification of postsynaptic actin cytoskeleton
A	2000601	biological_process	positive regulation of Arp2/3 complex-mediated actin nucleation
B	0000902	biological_process	cell morphogenesis
B	0001701	biological_process	in utero embryonic development
B	0001726	cellular_component	ruffle
B	0001756	biological_process	somitogenesis
B	0001843	biological_process	neural tube closure
B	0005515	molecular_function	protein binding
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0005925	cellular_component	focal adhesion
B	0006915	biological_process	apoptotic process
B	0007354	biological_process	zygotic determination of anterior/posterior axis, embryo
B	0007417	biological_process	central nervous system development
B	0007492	biological_process	endoderm development
B	0008078	biological_process	mesodermal cell migration
B	0010172	biological_process	embryonic body morphogenesis
B	0010592	biological_process	positive regulation of lamellipodium assembly
B	0016020	cellular_component	membrane
B	0016477	biological_process	cell migration
B	0016601	biological_process	Rac protein signal transduction
B	0030027	cellular_component	lamellipodium
B	0030031	biological_process	cell projection assembly
B	0030032	biological_process	lamellipodium assembly
B	0030838	biological_process	positive regulation of actin filament polymerization
B	0030866	biological_process	cortical actin cytoskeleton organization
B	0030903	biological_process	notochord development
B	0030950	biological_process	establishment or maintenance of actin cytoskeleton polarity
B	0031209	cellular_component	SCAR complex
B	0031258	cellular_component	lamellipodium membrane
B	0031267	molecular_function	small GTPase binding
B	0031941	cellular_component	filamentous actin
B	0032880	biological_process	regulation of protein localization
B	0035050	biological_process	embryonic heart tube development
B	0042074	biological_process	cell migration involved in gastrulation
B	0042995	cellular_component	cell projection
B	0045175	biological_process	basal protein localization
B	0045176	biological_process	apical protein localization
B	0048339	biological_process	paraxial mesoderm development
B	0048340	biological_process	paraxial mesoderm morphogenesis
B	0048570	biological_process	notochord morphogenesis
B	0048617	biological_process	embryonic foregut morphogenesis
B	0048812	biological_process	neuron projection morphogenesis
B	0050821	biological_process	protein stabilization
B	0070062	cellular_component	extracellular exosome
B	0098794	cellular_component	postsynapse
B	2000601	biological_process	positive regulation of Arp2/3 complex-mediated actin nucleation
C	0003779	molecular_function	actin binding
C	0005856	cellular_component	cytoskeleton
C	0030036	biological_process	actin cytoskeleton organization
D	0001701	biological_process	in utero embryonic development
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005856	cellular_component	cytoskeleton
D	0007015	biological_process	actin filament organization
D	0008064	biological_process	regulation of actin polymerization or depolymerization
D	0010592	biological_process	positive regulation of lamellipodium assembly
D	0016601	biological_process	Rac protein signal transduction
D	0030027	cellular_component	lamellipodium
D	0030036	biological_process	actin cytoskeleton organization
D	0031209	cellular_component	SCAR complex
D	0031267	molecular_function	small GTPase binding
D	0031334	biological_process	positive regulation of protein-containing complex assembly
D	0042802	molecular_function	identical protein binding
D	0044877	molecular_function	protein-containing complex binding
D	0048144	biological_process	fibroblast proliferation
D	0048146	biological_process	positive regulation of fibroblast proliferation
D	0048870	biological_process	cell motility
D	0070062	cellular_component	extracellular exosome
D	2000601	biological_process	positive regulation of Arp2/3 complex-mediated actin nucleation

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

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site_id	SWS_FT_FI2
Number of Residues	20
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

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site_id	SWS_FT_FI3
Number of Residues	62
Details	Domain: {"description":"t-SNARE coiled-coil homology","evidences":[{"source":"PROSITE-ProRule","id":"PRU00202","evidenceCode":"ECO:0000255"}]}

Chain

Residue

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site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P62484","evidenceCode":"ECO:0000250"}]}

Chain

Residue

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