7UKZ
CDK11 in complex with small molecule inhibitor OTS964
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004674 | molecular_function | protein serine/threonine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004674 | molecular_function | protein serine/threonine kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006468 | biological_process | protein phosphorylation |
| C | 0004672 | molecular_function | protein kinase activity |
| C | 0004674 | molecular_function | protein serine/threonine kinase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0006468 | biological_process | protein phosphorylation |
| D | 0004672 | molecular_function | protein kinase activity |
| D | 0004674 | molecular_function | protein serine/threonine kinase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0006468 | biological_process | protein phosphorylation |
| E | 0004672 | molecular_function | protein kinase activity |
| E | 0004674 | molecular_function | protein serine/threonine kinase activity |
| E | 0005524 | molecular_function | ATP binding |
| E | 0006468 | biological_process | protein phosphorylation |
| F | 0004672 | molecular_function | protein kinase activity |
| F | 0004674 | molecular_function | protein serine/threonine kinase activity |
| F | 0005524 | molecular_function | ATP binding |
| F | 0006468 | biological_process | protein phosphorylation |
Functional Information from PROSITE/UniProt
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IlHrDLKtsNLLL |
| Chain | Residue | Details |
| A | ILE202-LEU214 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 |
| Chain | Residue | Details |
| A | ASP206 | |
| B | ASP206 | |
| C | ASP206 | |
| D | ASP206 | |
| E | ASP206 | |
| F | ASP206 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 |
| Chain | Residue | Details |
| A | ILE88 | |
| E | LYS111 | |
| F | ILE88 | |
| F | LYS111 | |
| A | LYS111 | |
| B | ILE88 | |
| B | LYS111 | |
| C | ILE88 | |
| C | LYS111 | |
| D | ILE88 | |
| D | LYS111 | |
| E | ILE88 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | MOD_RES: Phosphoserine; by CDK7 => ECO:0000269|PubMed:16327805 |
| Chain | Residue | Details |
| A | SER126 | |
| B | SER126 | |
| C | SER126 | |
| D | SER126 | |
| E | SER126 | |
| F | SER126 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | MOD_RES: Phosphothreonine; by CDK7 => ECO:0000269|PubMed:16327805 |
| Chain | Residue | Details |
| A | THR132 | |
| B | THR132 | |
| C | THR132 | |
| D | THR132 | |
| E | THR132 | |
| F | THR132 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332 |
| Chain | Residue | Details |
| A | SER233 | |
| B | SER233 | |
| C | SER233 | |
| D | SER233 | |
| E | SER233 | |
| F | SER233 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:18669648 |
| Chain | Residue | Details |
| A | TYR238 | |
| B | TYR238 | |
| C | TYR238 | |
| D | TYR238 | |
| E | TYR238 | |
| F | TYR238 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 6 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | TPO239 | |
| B | TPO239 | |
| C | TPO239 | |
| D | TPO239 | |
| E | TPO239 | |
| F | TPO239 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 12 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| A | LYS285 | |
| F | LYS285 | |
| B | LYS285 | |
| C | LYS285 | |
| D | LYS285 | |
| E | LYS285 |
